Extranodal Rosai-Dorfman of the Pancreas Presents with Bilateral Granulomatous Anterior Uveitis
Conclusion: Although rare, ocular involvement, including eyelid and orbital masses, and anterior uveitis, can herald the development of other systemic manifestations or RDD and can aid in the diagnosis of this systemic disease.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - October 25, 2018 Category: Opthalmology Source Type: research
Hyphema from Iris Melanocytoma
Using multimodal imaging, we demonstrate a classic iris melanocytoma presenting with recurrent, spontaneous hyphema in a young female patient. The patient has been observed without tumor growth. Hyphema has not been previously reported to occur with iris melanocytoma.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - October 25, 2018 Category: Opthalmology Source Type: research
Monte Carlo Simulation of the Treatment of Uveal Melanoma Using Measured Heterogeneous < sup > 106 < /sup > Ru Plaques
Conclusions: The emitter map distribution of the plaque and the computerized tomography of the patient used in a Monte Carlo simulation allow an accurate determination of the plaque position with respect to the tumor with the potential to reduce the dose to sensitive structures.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - October 15, 2018 Category: Opthalmology Source Type: research
Novel Eye Plaque Designs for Brachytherapy of Iris and Ciliary Body Melanoma and the First Clinical Application
Conclusion: The novel dome-shaped plaques for the treatment of iris melanoma provide effective dose distribution, improved surgical maneuverability, and increased tolerability for the patient. This plaque model can be used to treat iris melanoma of various sizes, configurations, and locations, including the ciliary body. The need for a customized plaque platform for each patient is minimized.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - October 11, 2018 Category: Opthalmology Source Type: research
Suprachoroidal Hemorrhage Simulating Melanoma in Idiopathic Thrombocytopenic Purpura
Conclusion: Ocular manifestations of ITP are uncommon. Rarely, spontaneous suprachoroidal hemorrhage simulating melanoma can occur. A thorough clinical evaluation with multimodal imaging is critical to establishing the appropriate diagnosis.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - October 11, 2018 Category: Opthalmology Source Type: research
A Case of a Cavitary Iris Melanoma with Aqueous Cytological Modulation
Malignant melanoma is the most common primary malignant tumour of the iris, but represents a small proportion of all uveal melanomas. The authors describe a 34-year-old male with a pigmented lesion of the iris. The lesion remained stable for 7 years, but the patient re-presented after this time with sudden enlargement of the mass and hyphaema. Excisional biopsy confirmed cavitary melanoma of the iris. This is the first reported case of cavitation in a primary iris melanoma. The patient has not had any further adjuvant treatment and remains metastasis free at 5 years of follow-up.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - October 10, 2018 Category: Opthalmology Source Type: research
Chemoreduction of Orbital Recurrence of Uveal Melanoma by Intra-Arterial Melphalan
Conclusion: This case demonstrates that intra-arterial melphalan can result in nonsustained tumor regression of recurrent orbital uveal melanoma. It suggests that local delivery of high-dose melphalan may be helpful as a neoadjuvant treatment for uveal melanoma, and future studies will be useful to confirm the value of this approach in additional cases of recurrent and possibly in primary uveal melanoma.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - October 9, 2018 Category: Opthalmology Source Type: research
A Rare Case of Congenital Orbital Cystic Neuroblastoma in an Infant
Neuroblastoma, a relatively common tumor in infants, is rarely present at birth. A solid mass is the typical appearance of this neoplasm, while cystic formation is uncommon. Congenital cystic neuroblastoma is extremely rare and no previous report exists of its occurrence in the orbit. A newborn girl was referred with an extremely large mass on the right side of her face on the third day of her life. Prenatal ultrasonography had revealed a large mass (80 × 80 mm) in the frontal area. MRI revealed a heterogeneous mass composed of cystic and solid, contrast-enhancing components. Excisional biopsy was successfully performed a...
Source: Ocular Oncology and Pathology - October 5, 2018 Category: Opthalmology Source Type: research
Tumour Expression of Histone Deacetylases in Uveal Melanoma
Conclusion: Uveal melanoma tumour cells express histone deacetylases 1, 2, 3, 4 and 6 and sirtuin 2, confirming potential tissue targets for histone deacetylase inhibitors.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - September 18, 2018 Category: Opthalmology Source Type: research
Uveal Melanoma in Ireland
Conclusion: Based on this data, the incidence of uveal melanoma in Ireland is high when compared with other reported incidence rates in Europe and worldwide. Relative and observed survival were in keeping with other reported European survival rates.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - September 17, 2018 Category: Opthalmology Source Type: research
Precision Intravitreal Chemotherapy for Localized Vitreous Seeding of Retinoblastoma
Conclusions: With direct delivery of chemotherapy to within 3 –4 mm of vitreous seed activity, P-IVitC provided complete control of localized vitreous seeds with minimal toxicity.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - September 17, 2018 Category: Opthalmology Source Type: research
Malignant Eyelid Tumors in India: A Study of 536 Asian Indian Patients
Conclusion: In Asian Indians, SGC is twice as common as BCC and 3 times more common than SCC. SGC is associated with poorer prognosis compared to other eyelid malignant tumors.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - September 17, 2018 Category: Opthalmology Source Type: research
Choroidal Ischemia Sparing the Watershed Zone following Intra-Arterial Chemotherapy for Retinoblastoma
Conclusion: The pathophysiology of choroidal ischemia is not well understood, but the fortuitous watershed zone preservation in this case could represent uneven distribution of the chemotherapeutic drug, resulting in partial chemo-dilution of the medication in the watershed region, which represents the final downstream overlapping choroidal perfusion from both medial and lateral posterior ciliary arteries.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - September 17, 2018 Category: Opthalmology Source Type: research
Pyogenic Granuloma of the Retina: A Case Series
Conclusions: Pyogenic granulomas (granulation tissue) may emanate from the retina in cases of endophthalmitis. This is distinct from neovascularization that may occur in proliferative diabetic retinopathy, central retinal vein occlusion, or other etiologies.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - September 10, 2018 Category: Opthalmology Source Type: research
Amelanotic Ciliochoroidal Melanoma in a Patient with Oculocutaneous Albinism
To report a case of amelanotic ciliochoroidal melanoma in a patient with oculocutaneous albinism. A 76-year-old Caucasian male with a past medical history of oculocutaneous albinism and recurrent urothelial carcinoma was found to have a mass in the left eye, suspicious for ciliochoroidal melanoma. On examination, visual acuity was 20/400 in both eyes (OU). External examination showed iris transillumination defects. Funduscopic examination OU revealed blonde fundus, optic nerve hypoplasia, and foveal hypoplasia, confirmed on optical coherence tomography. Funduscopic examination of the left eye revealed an inferonasal amelan...
Source: Ocular Oncology and Pathology - September 7, 2018 Category: Opthalmology Source Type: research
