Recurrence of Primary Breast Lymphoma Presenting as Bilateral Vitreoretinal Lymphoma
Conclusion: Relapsed PBL can present as bilateral VRL.Ocul Oncol Pathol
CONCLUSIONS: DI is frequent in Sjögrenser patients, mainly in the form of autoimmune disorders, and seem to be associated with a more severe phenotype. Our results suggest that DI should be evaluated in pSS patients, especially those with more severe disease. PMID: 33025900 [PubMed - as supplied by publisher]
CONCLUSIONS: The proposed method for DSC-PWI time-intensity curve normalization renders comparable curves beyond technical and patient variability. Normalized time-intensity curves performed satisfactorily for the presurgical identification of primary central nervous system lymphoma.
The epidemiology of lymphomas has changed since the use of antiretroviral therapy. The incidence of Non-Hodgkin Lymphomas (NHL) has significantly decreased in high income countries but not in low and middle-income countries where AIDS-related events remain high. This observational study describes the characteristics, infectious complications and main outcomes of patients diagnosed with HIV and lymphoma at the Instituto Nacional de Cancerología. All adults>18 years diagnosed with HIV and lymphoma from January 2010 to December 2017 were included. Information on HIV and lymphoma was collected, as well as the occurr...
Publication date: November 2020Source: Journal of Clinical Neuroscience, Volume 81Author(s): Junji Ikeda, Yasuhiro Shimojima, Tsuneaki Yoshinaga, Minori Kodaira, Sayaka Nishina, Kiyoshi Ito, Yoshiki Sekijima
We report here the occurrence of secondary failure of platelet recovery (SFPR) in three out of 24 patients who received high-dose thiotepa and busulfan followed by ASCT. Although there was no obvious abnormality in the primary platelet engraftment as well as the recovery of other blood cells, they developed SFPR with a median time to onset of day 38, and the platelets gradually recovered over several months with steroid therapy. During the same period, there was no development of SFPR among 50 patients who received ASCT with a conditioning regimen of MEAM (ranimustine, etoposide, cytarabine, and melphalan) or high-dose mel...
Conclusions: Neuropsychiatric symptoms are a rare but notable symptom before the presentation of CNSL. There is an increasing awareness of neurological illness presenting as pure psychiatric disturbance, prompting the need to exclude organic and treatable diseases, particularly in elderly patients. Acknowledgment and diagnosis are important for an appropriate management as there is a significant impact on patient and caregiver quality of life.
Publication date: Available online 18 September 2020Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Xiaoli Chang, Yixian Guo, Li Su, Yunxiu Zhang, Wuhan Hui, Hong Zhao, Ronghua Hu, Wanling Sun
We report a patient with multifocal PCNSL involving the choroid plexus, who presented with abnormal gait and episodic confusion and memory loss. PCNSL should be considered in the differential diagnosis of acute encephalopathy among immunocompetent older individuals who have choroid plexus enhancing lesions.
This prospective study was to investigate the influence of the methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism on high dose methotrexate related toxicity in rare PCNS-DLBCL patients. A total of 148 cycles of 32 patients were included. The homozygous mutation at nucleotide 677 increases the risk on HD-MTX-related toxicity and can be used as a predictive marker for PCNS-DLBCL patients.
This case highlights the need for both tissue biopsy for diagnosis in suspected CNS malignancy and comprehensive immune profiling for accurate subclassification. AbstractThis case highlights the need for both tissue biopsy for diagnosis in suspected CNS malignancy and comprehensive immune profiling for accurate subclassification.