Frontal Cortex Myo-Inositol Is Associated with Sleep and Depression in Adolescents: A Proton Magnetic Resonance Spectroscopy Study
Conclusion: Lower frontal cortex mI may indicate a disturbed second messenger system. Frontal cortical mI may thus be linked to the pathophysiology of depression and concomitant sleep symptoms among maturing adolescents. Short sleep and daytime sleepiness may be associated with frontal cortex mI independently from depression.Neuropsychobiology 2017;75:21-31 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 25, 2017 Category: Psychiatry & Psychology Source Type: research
Potential Gender-Related Aging Processes Occur Earlier and Faster in the Vermis of Patients with Bipolar Disorder: An MRI Study
Conclusions: Our study provides evidence of the impact of aging on the vermis in BD, potentially related to earlier and faster gender-related neurodegenerative phenomena occurring during the progression of the disease.Neuropsychobiology 2017;75:32-38 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 25, 2017 Category: Psychiatry & Psychology Source Type: research
Plasma BDNF Level in Major Depression: Biomarker of the Val66Met BDNF Polymorphism and of the Clinical Course in Met Carrier Patients
Conclusion: Our results show a measurable, coherent, and functional BDNF pathway based on the BDNF Val66Met polymorphism and plasma BDNF levels in patients with a current MDE. This pathway is related to the clinical course of major depression, plasma BDNF levels being associated with the long-term history of MDD in Met carriers. Further studies assessing central BDNF are needed to understand the underlying mechanisms of this association.Neuropsychobiology 2017;75:39-45 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 25, 2017 Category: Psychiatry & Psychology Source Type: research
Erratum
Neuropsychobiology 2017;75:52 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 25, 2017 Category: Psychiatry & Psychology Source Type: research
Valeriana officinalis Root Extract Modulates Cortical Excitatory Circuits in Humans
Conclusion: A single oral dose of VE modulates intracortical facilitatory circuits. Our results in healthy subjects could be predictive markers of treatment response in patients and further support the use of pharmaco-TMS to investigate the neuropsychiatric effects of herbal therapies in humans.Neuropsychobiology 2017;75:46-51 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 25, 2017 Category: Psychiatry & Psychology Source Type: research
Comparisons between Psychiatric Symptoms of Patients with Anti-NMDAR Encephalitis and New-Onset Psychiatric Patients
This study aimed to explore the clinical features and psychiatric symptoms of anti-NMDAR encephalitis and the association between antibody titers and psychiatric symptoms.Methods: In this retrospective study, 43 patients with anti-NMDAR encephalitis and 70 new-onset psychiatric patients were enrolled. Psychiatric symptoms were assessed by trained psychiatrists using the Positive and Negative Syndrome Scale.Results: There were significant differences in psychiatric symptoms between the antibody-positive and antibody-negative groups. The item scores for poor rapport (p (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 25, 2017 Category: Psychiatry & Psychology Source Type: research
Dose-Dependent Effects of Binge-Like Methamphetamine Dosing on Dopamine and Neurotrophin Levels in Rat Brain
This study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in addition to assessing the behavioural effects and dopamine neurotransmitter changes produced. Male Sprague-Dawley rats received 4 subcutaneous doses of methamphetamine (0.5, 1, 2, and 4 mg/kg, or saline as a control) 2 h apart. Methamphetamine had a dose-dependent stimulatory effect on locomotor activity over the 8 h of observation. A significant increase in dopamine concentration was observed in the frontal c...
Source: Neuropsychobiology - October 25, 2017 Category: Psychiatry & Psychology Source Type: research
Acute Phencyclidine Alters Neural Oscillations Evoked by Tones in the Auditory Cortex of Rats
Conclusions: Findings suggest that acute PCP-induced NMDAr hypofunction has differential effects on neural power and synchrony which vary with dose, time course of administration and EEG frequency. EEG synchrony and power appear to be sensitive translational biomarkers for disrupted NMDAr function, which may contribute to the pathophysiology of schizophrenia and other neuropsychiatric disorders.Neuropsychobiology 2017;75:53-62 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 25, 2017 Category: Psychiatry & Psychology Source Type: research
Comparisons between Psychiatric Symptoms of Patients with Anti-NMDAR Encephalitis and New-Onset Psychiatric Patients
This study aimed to explore the clinical features and psychiatric symptoms of anti-NMDAR encephalitis and the association between antibody titers and psychiatric symptoms.Methods: In this retrospective study, 43 patients with anti-NMDAR encephalitis and 70 new-onset psychiatric patients were enrolled. Psychiatric symptoms were assessed by trained psychiatrists using the Positive and Negative Syndrome Scale.Results: There were significant differences in psychiatric symptoms between the antibody-positive and antibody-negative groups. The item scores for poor rapport (p (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 24, 2017 Category: Psychiatry & Psychology Source Type: research
Dose-Dependent Effects of Binge-Like Methamphetamine Dosing on Dopamine and Neurotrophin Levels in Rat Brain
This study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in addition to assessing the behavioural effects and dopamine neurotransmitter changes produced. Male Sprague-Dawley rats received 4 subcutaneous doses of methamphetamine (0.5, 1, 2, and 4 mg/kg, or saline as a control) 2 h apart. Methamphetamine had a dose-dependent stimulatory effect on locomotor activity over the 8 h of observation. A significant increase in dopamine concentration was observed in the frontal c...
Source: Neuropsychobiology - October 24, 2017 Category: Psychiatry & Psychology Source Type: research
Acute Phencyclidine Alters Neural Oscillations Evoked by Tones in the Auditory Cortex of Rats
Conclusions: Findings suggest that acute PCP-induced NMDAr hypofunction has differential effects on neural power and synchrony which vary with dose, time course of administration and EEG frequency. EEG synchrony and power appear to be sensitive translational biomarkers for disrupted NMDAr function, which may contribute to the pathophysiology of schizophrenia and other neuropsychiatric disorders.Neuropsychobiology 2017;75:53-62 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 24, 2017 Category: Psychiatry & Psychology Source Type: research
Valeriana officinalis Root Extract Modulates Cortical Excitatory Circuits in Humans
Conclusion: A single oral dose of VE modulates intracortical facilitatory circuits. Our results in healthy subjects could be predictive markers of treatment response in patients and further support the use of pharmaco-TMS to investigate the neuropsychiatric effects of herbal therapies in humans.Neuropsychobiology 2017;75:46-51 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 17, 2017 Category: Psychiatry & Psychology Source Type: research
< b > < i > Valeriana officinalis < /i > < /b > Root Extract Modulates Cortical Excitatory Circuits in Humans
Conclusion: A single oral dose of VE modulates intracortical facilitatory circuits. Our results in healthy subjects could be predictive markers of treatment response in patients and further support the use of pharmaco-TMS to investigate the neuropsychiatric effects of herbal therapies in humans.Neuropsychobiology 2017;75:46-51 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 16, 2017 Category: Psychiatry & Psychology Source Type: research
Erratum
Neuropsychobiology 2017;75:52 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 13, 2017 Category: Psychiatry & Psychology Source Type: research
Plasma BDNF Level in Major Depression: Biomarker of the Val66Met BDNF Polymorphism and of the Clinical Course in Met Carrier Patients
Conclusion: Our results show a measurable, coherent, and functional BDNF pathway based on the BDNF Val66Met polymorphism and plasma BDNF levels in patients with a current MDE. This pathway is related to the clinical course of major depression, plasma BDNF levels being associated with the long-term history of MDD in Met carriers. Further studies assessing central BDNF are needed to understand the underlying mechanisms of this association.Neuropsychobiology 2017;75:39-45 (Source: Neuropsychobiology)
Source: Neuropsychobiology - August 22, 2017 Category: Psychiatry & Psychology Source Type: research
