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Abstracts of Award-Winning Posters
Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - May 9, 2018 Category: Psychiatry & Psychology Source Type: research

A Twelve-Week Moderate Exercise Programme Improved Symptoms of Depression, Insomnia, and Verbal Learning in Post-Aneurysmal Subarachnoid Haemorrhage Patients: A Comparison with Meningioma Patients and Healthy Controls
Conclusions: An exercise programme had a positive effect on symptoms of depression, insomnia, and verbal learning in patients following aSAH. No positive changes in other domains were observed. This may be due to the cautious approach taken with regard to exercise intensity.Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - April 25, 2018 Category: Psychiatry & Psychology Source Type: research

Kynurenine Pathway in Autism Spectrum Disorders in Children
Conclusion: Our study indicates that there is an increased neurotoxic potential and also a possible lower KYN aminotransferase activity in ASD.Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - April 25, 2018 Category: Psychiatry & Psychology Source Type: research

Contents Vol. 75, 2017
Neuropsychobiology 2017;75:I –IV (Source: Neuropsychobiology)
Source: Neuropsychobiology - April 20, 2018 Category: Psychiatry & Psychology Source Type: research

Female Gender, Marital and Family Problems, and Feelings of Guilt Are Related to Self-Immolation Suicide Attempts
Conclusions: The prevalence of SI was surprisingly high. Marital and family conflicts as a proxy for highly distressing social interactions, along with female gender and feelings of guilt and shame were strongly associated with SI. Family and couple counseling specifically tailored to difficulties experienced by women might reduce the risk of SI.Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - April 12, 2018 Category: Psychiatry & Psychology Source Type: research

Association of Polymorphisms of Serotonin Transporter (5HTTLPR) and 5-HT2C Receptor Genes with Criminal Behavior in Russian Criminal Offenders
Conclusions: The lack of biological differences between the 2 groups of prisoners indicates that the studied 5HT-related genes do not differentiate between the types of crimes committed.Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - April 5, 2018 Category: Psychiatry & Psychology Source Type: research

Epigenetic Effects of Intravenous Diacetylmorphine on the Methylation of < b > < i > POMC < /i > < /b > and < b > < i > NR3C1 < /i > < /b >
The administration of diacetylmorphine (DAM) reduces the activation of the hypothalamic-pituitary-adrenal (HPA) axis in opioid-maintained patients. However, the epigenetic effects of DAM on addiction-related genes have not been investigated yet. In a randomized controlled study, we examined the immediate effects of intravenous DAM versus placebo on the promoter methylation of thePOMC (pro- opiomelanocortin) andNR3C1 (glucocorticoid receptor 1) genes. Twenty-eight heroin-dependent patients on DAM-assisted treatment received either DAM or saline in a randomized crossover design and 17 healthy participants received saline onl...
Source: Neuropsychobiology - March 6, 2018 Category: Psychiatry & Psychology Source Type: research

Healthy and Pathological Brain Aging: From the Perspective of Oscillations, Functional Connectivity, and Signal Complexity
Healthy aging is associated with impairment in cognitive information processing. Several neuroimaging methods such as functional magnetic resonance imaging, positron emission tomography and near-infrared spectroscopy have been used to explore healthy and pathological aging by relying on hemodynamic or metabolic changes that occur in response to brain activity. Since electroencephalography (EEG) and magnetoencephalography (MEG) are able to measure neural activity directly with a high temporal resolution of milliseconds, these neurophysiological techniques are particularly important to investigate the dynamics of brain activ...
Source: Neuropsychobiology - February 21, 2018 Category: Psychiatry & Psychology Source Type: research

Parallel Effects of Methamphetamine on Anxiety and CCL3 in Humans and a Genetic Mouse Model of High Methamphetamine Intake
Conclusions: The results highlight the complex effects of MA on immune and behavioral function and suggest that alterations in CCL3 signaling may contribute to the mood impairments observed during remission from MA addiction.Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - January 18, 2018 Category: Psychiatry & Psychology Source Type: research

Impulsivity and Saliva Cortisol in Patients with Suicide Attempt and Controls
Conclusions: Saliva cortisol may be a useful marker that reveals alterations in nonsuicidal patients suffering from depression, adjustment disorder, anxiety, or eating disorders who might be at risk.Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - January 18, 2018 Category: Psychiatry & Psychology Source Type: research

Further Evidence of the Positive Influence of Repetitive Transcranial Magnetic Stimulation on Speech and Language in Patients with Aphasia after Stroke: Results from a Double-Blind Intervention with Sham Condition
Conclusions: Among patients with SRA, compared to a sham condition, adjuvant rTMS improved speech and language skills. The present results add to the accumulating evidence that rTMS as a neuromodulation technique has the capacity to enhance the effect of conventional SLT.Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - January 16, 2018 Category: Psychiatry & Psychology Source Type: research

Proinflammatory Cytokines and Oxidative Stress Decrease the Transport of Dopamine Precursor Tyrosine in Human Fibroblasts
Conclusion: This study demonstrates that proinflammatory cytokines and oxidative stress decrease the transport of tyrosine (47% and 33%, respectively), which can alter dopamine synthesis. The functionality of the tyrosine transporter could be a new potential biomarker to target for discovering new drugs to counteract the effects of proinflammatory cytokines and oxidative stress in the pathophysiology of neuropsychiatric disorders.Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - January 16, 2018 Category: Psychiatry & Psychology Source Type: research

Diffusion Tensor Imaging Investigation of Uncinate Fasciculus Anatomy in Healthy Controls: Description of a Subgenual Stem
The uncinate fasciculus is the largest white matter association tract connecting the prefrontal cortex and the anteromedial temporal lobe. The traditional anatomical description outlines a temporal stem that hooks around the posterior insula, a subinsular body, and 2 prefrontal stems extending to the lateral orbital gyri and the frontopolar cortex. Recent imaging studies of the white matter tracts deep to the subgenual cingulate gyrus (Brodmann area 25: BA25) suggest the presence of white matter fibers extending from BA25 to the amygdala, via a route that would run in close proximity to the uncinate fasciculus, that are of...
Source: Neuropsychobiology - January 12, 2018 Category: Psychiatry & Psychology Source Type: research

Association between the Intron 8 VNTR Polymorphism of the < b > < i > DAT1 < /i > < /b > Gene and Crack Cocaine Addiction
Conclusions: Our results are consistent with the role ofDAT1 in the neurobiology of drug addiction. Nevertheless, the study of other genes, environmental factors, and their interactions is also important to gain a broader understanding of this condition.Neuropsychobiology 2017;75:141 –144 (Source: Neuropsychobiology)
Source: Neuropsychobiology - January 12, 2018 Category: Psychiatry & Psychology Source Type: research

Both Serum Brain-Derived Neurotrophic Factor and Interleukin-6 Levels Are Not Associated with Therapeutic Response to Lamotrigine Augmentation Therapy in Treatment-Resistant Depressive Disorder
Conclusion: The present study suggests that the acute effect of lamotrigine augmentation therapy for a major depressive episode is not related to either BDNF or IL-6, at least in patients with treatment-resistant depressive disorder.Neuropsychobiology 2017;75:145 –150 (Source: Neuropsychobiology)
Source: Neuropsychobiology - January 12, 2018 Category: Psychiatry & Psychology Source Type: research

SyNoPsis
Neuropsychobiology 2017;75:97 –97 (Source: Neuropsychobiology)
Source: Neuropsychobiology - January 10, 2018 Category: Psychiatry & Psychology Source Type: research

Titelseite Synopsis
Neuropsychobiology 2017;75:97 –97 (Source: Neuropsychobiology)
Source: Neuropsychobiology - December 20, 2017 Category: Psychiatry & Psychology Source Type: research

SyNoPsis: A Novel Perspective on Schizophrenia
Neuropsychobiology 2017;75:98 –99 (Source: Neuropsychobiology)
Source: Neuropsychobiology - December 19, 2017 Category: Psychiatry & Psychology Source Type: research

A New Step Forward in “Carving Nature by its Joints” in Psychopathology/Psychosis
Neuropsychobiology 2017;75:117 –118 (Source: Neuropsychobiology)
Source: Neuropsychobiology - December 19, 2017 Category: Psychiatry & Psychology Source Type: research

Systems Neuroscience of Psychosis (SyNoPsis) Provides a Promising Framework for Advancing the Field
Neuropsychobiology 2017;75:119 –121 (Source: Neuropsychobiology)
Source: Neuropsychobiology - December 19, 2017 Category: Psychiatry & Psychology Source Type: research

Commentary on “Systems Neuroscience of Psychosis (SyNoPsis): Mapping Schizophrenia Symptoms onto Brain Systems”
Neuropsychobiology 2017;75:122 –123 (Source: Neuropsychobiology)
Source: Neuropsychobiology - December 19, 2017 Category: Psychiatry & Psychology Source Type: research

SyNoPsis: Disruptive Innovation for Mapping Schizophrenia onto the Brain
Neuropsychobiology 2017;75:124 –125 (Source: Neuropsychobiology)
Source: Neuropsychobiology - December 19, 2017 Category: Psychiatry & Psychology Source Type: research

Deconstructing Schizophrenia
Neuropsychobiology 2017;75:126 –128 (Source: Neuropsychobiology)
Source: Neuropsychobiology - December 19, 2017 Category: Psychiatry & Psychology Source Type: research

SyNoPsis: Response to the Commentators
Neuropsychobiology 2017;75:129 –131 (Source: Neuropsychobiology)
Source: Neuropsychobiology - December 19, 2017 Category: Psychiatry & Psychology Source Type: research

Systems Neuroscience of Psychosis: Mapping Schizophrenia Symptoms onto Brain Systems
Schizophrenia research has been in a deadlock for many decades. Despite important advances in clinical treatment, there are still major concerns regarding long-term psychosocial reintegration and disease management, biological heterogeneity, unsatisfactory predictors of individual course and treatment strategies, and a confusing variety of controversial theories about its etiology and pathophysiological mechanisms. In the present perspective on schizophrenia research, we first discuss a methodological pitfall in contemporary schizophrenia research inherent in the attempt to link mental phenomena with the brain: we claim th...
Source: Neuropsychobiology - December 19, 2017 Category: Psychiatry & Psychology Source Type: research

Psychoacoustics and Neurophysiological Alterations after 30-36 Hours of Sleep Deprivation
Conclusions: SD results in alterations of central auditory processing perception and delays of brain neurophysiological responses, with some correlations between the psychoacoustics and neurophysiological tests. These alterations may relate to other cognitive alterations that deserve more research in future studies.Neuropsychobiology 2017;75:89-95 (Source: Neuropsychobiology)
Source: Neuropsychobiology - November 17, 2017 Category: Psychiatry & Psychology Source Type: research

Therapeutic Response to Paroxetine in Major Depressive Disorder Predicted by DNA Methylation
Background: Antidepressants have variable therapeutic effects, depending on genetic and environmental factors. Approximately 30% of major depressive disorder (MDD) patients do not respond significantly to antidepressants such as paroxetine, a selective serotonin reuptake inhibitor (SSRI). However, the biological mechanisms behind this phenomenon are mostly unknown. Here, we examined the role of patients' epigenetic background in SSRI efficacy.Methods: Genome-wide DNA methylation analysis of the peripheral blood of Japanese MDD patients was performed by using the Infinium HumanMethylation450 BeadChip.Results: We compared th...
Source: Neuropsychobiology - November 3, 2017 Category: Psychiatry & Psychology Source Type: research

< b > < i > Valeriana officinalis < /i > < /b > Root Extract Modulates Cortical Excitatory Circuits in Humans
Conclusion: A single oral dose of VE modulates intracortical facilitatory circuits. Our results in healthy subjects could be predictive markers of treatment response in patients and further support the use of pharmaco-TMS to investigate the neuropsychiatric effects of herbal therapies in humans.Neuropsychobiology 2017;75:46-51 (Source: Neuropsychobiology)
Source: Neuropsychobiology - November 1, 2017 Category: Psychiatry & Psychology Source Type: research

Contents Vol. 74, 2016
Neuropsychobiology 2016;74:I-IV (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 25, 2017 Category: Psychiatry & Psychology Source Type: research

In Individuals Following Aneurysmal Subarachnoid Haemorrhage, Hair Cortisol Concentrations Are Higher and More Strongly Associated with Psychological Functioning and Sleep Complaints than in Healthy Controls
Conclusions: Our findings indicate that a dysregulation of HPA-AA is associated with some of the long-term impairments in psychological functioning and sleep in aSAH survivors. While the direction of association remained unclear, a dysregulated HPA-AA may be causally linked with the maintenance of poor psychological functioning and poor sleep. The overall findings should be considered in the planning of long-term treatment aimed at improving psychological functioning and sleep in aSAH patients.Neuropsychobiology 2017;75:12-20 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 25, 2017 Category: Psychiatry & Psychology Source Type: research

Frontal Cortex Myo-Inositol Is Associated with Sleep and Depression in Adolescents: A Proton Magnetic Resonance Spectroscopy Study
Conclusion: Lower frontal cortex mI may indicate a disturbed second messenger system. Frontal cortical mI may thus be linked to the pathophysiology of depression and concomitant sleep symptoms among maturing adolescents. Short sleep and daytime sleepiness may be associated with frontal cortex mI independently from depression.Neuropsychobiology 2017;75:21-31 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 25, 2017 Category: Psychiatry & Psychology Source Type: research

Potential Gender-Related Aging Processes Occur Earlier and Faster in the Vermis of Patients with Bipolar Disorder: An MRI Study
Conclusions: Our study provides evidence of the impact of aging on the vermis in BD, potentially related to earlier and faster gender-related neurodegenerative phenomena occurring during the progression of the disease.Neuropsychobiology 2017;75:32-38 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 25, 2017 Category: Psychiatry & Psychology Source Type: research

Plasma BDNF Level in Major Depression: Biomarker of the Val66Met BDNF Polymorphism and of the Clinical Course in Met Carrier Patients
Conclusion: Our results show a measurable, coherent, and functional BDNF pathway based on the BDNF Val66Met polymorphism and plasma BDNF levels in patients with a current MDE. This pathway is related to the clinical course of major depression, plasma BDNF levels being associated with the long-term history of MDD in Met carriers. Further studies assessing central BDNF are needed to understand the underlying mechanisms of this association.Neuropsychobiology 2017;75:39-45 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 25, 2017 Category: Psychiatry & Psychology Source Type: research

Erratum
Neuropsychobiology 2017;75:52 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 25, 2017 Category: Psychiatry & Psychology Source Type: research

Valeriana officinalis Root Extract Modulates Cortical Excitatory Circuits in Humans
Conclusion: A single oral dose of VE modulates intracortical facilitatory circuits. Our results in healthy subjects could be predictive markers of treatment response in patients and further support the use of pharmaco-TMS to investigate the neuropsychiatric effects of herbal therapies in humans.Neuropsychobiology 2017;75:46-51 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 25, 2017 Category: Psychiatry & Psychology Source Type: research

Comparisons between Psychiatric Symptoms of Patients with Anti-NMDAR Encephalitis and New-Onset Psychiatric Patients
This study aimed to explore the clinical features and psychiatric symptoms of anti-NMDAR encephalitis and the association between antibody titers and psychiatric symptoms.Methods: In this retrospective study, 43 patients with anti-NMDAR encephalitis and 70 new-onset psychiatric patients were enrolled. Psychiatric symptoms were assessed by trained psychiatrists using the Positive and Negative Syndrome Scale.Results: There were significant differences in psychiatric symptoms between the antibody-positive and antibody-negative groups. The item scores for poor rapport (p (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 25, 2017 Category: Psychiatry & Psychology Source Type: research

Dose-Dependent Effects of Binge-Like Methamphetamine Dosing on Dopamine and Neurotrophin Levels in Rat Brain
This study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in addition to assessing the behavioural effects and dopamine neurotransmitter changes produced. Male Sprague-Dawley rats received 4 subcutaneous doses of methamphetamine (0.5, 1, 2, and 4 mg/kg, or saline as a control) 2 h apart. Methamphetamine had a dose-dependent stimulatory effect on locomotor activity over the 8 h of observation. A significant increase in dopamine concentration was observed in the frontal c...
Source: Neuropsychobiology - October 25, 2017 Category: Psychiatry & Psychology Source Type: research

Acute Phencyclidine Alters Neural Oscillations Evoked by Tones in the Auditory Cortex of Rats
Conclusions: Findings suggest that acute PCP-induced NMDAr hypofunction has differential effects on neural power and synchrony which vary with dose, time course of administration and EEG frequency. EEG synchrony and power appear to be sensitive translational biomarkers for disrupted NMDAr function, which may contribute to the pathophysiology of schizophrenia and other neuropsychiatric disorders.Neuropsychobiology 2017;75:53-62 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 25, 2017 Category: Psychiatry & Psychology Source Type: research

Comparisons between Psychiatric Symptoms of Patients with Anti-NMDAR Encephalitis and New-Onset Psychiatric Patients
This study aimed to explore the clinical features and psychiatric symptoms of anti-NMDAR encephalitis and the association between antibody titers and psychiatric symptoms.Methods: In this retrospective study, 43 patients with anti-NMDAR encephalitis and 70 new-onset psychiatric patients were enrolled. Psychiatric symptoms were assessed by trained psychiatrists using the Positive and Negative Syndrome Scale.Results: There were significant differences in psychiatric symptoms between the antibody-positive and antibody-negative groups. The item scores for poor rapport (p (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 24, 2017 Category: Psychiatry & Psychology Source Type: research

Dose-Dependent Effects of Binge-Like Methamphetamine Dosing on Dopamine and Neurotrophin Levels in Rat Brain
This study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in addition to assessing the behavioural effects and dopamine neurotransmitter changes produced. Male Sprague-Dawley rats received 4 subcutaneous doses of methamphetamine (0.5, 1, 2, and 4 mg/kg, or saline as a control) 2 h apart. Methamphetamine had a dose-dependent stimulatory effect on locomotor activity over the 8 h of observation. A significant increase in dopamine concentration was observed in the frontal c...
Source: Neuropsychobiology - October 24, 2017 Category: Psychiatry & Psychology Source Type: research

Acute Phencyclidine Alters Neural Oscillations Evoked by Tones in the Auditory Cortex of Rats
Conclusions: Findings suggest that acute PCP-induced NMDAr hypofunction has differential effects on neural power and synchrony which vary with dose, time course of administration and EEG frequency. EEG synchrony and power appear to be sensitive translational biomarkers for disrupted NMDAr function, which may contribute to the pathophysiology of schizophrenia and other neuropsychiatric disorders.Neuropsychobiology 2017;75:53-62 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 24, 2017 Category: Psychiatry & Psychology Source Type: research

Valeriana officinalis Root Extract Modulates Cortical Excitatory Circuits in Humans
Conclusion: A single oral dose of VE modulates intracortical facilitatory circuits. Our results in healthy subjects could be predictive markers of treatment response in patients and further support the use of pharmaco-TMS to investigate the neuropsychiatric effects of herbal therapies in humans.Neuropsychobiology 2017;75:46-51 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 17, 2017 Category: Psychiatry & Psychology Source Type: research

< b > < i > Valeriana officinalis < /i > < /b > Root Extract Modulates Cortical Excitatory Circuits in Humans
Conclusion: A single oral dose of VE modulates intracortical facilitatory circuits. Our results in healthy subjects could be predictive markers of treatment response in patients and further support the use of pharmaco-TMS to investigate the neuropsychiatric effects of herbal therapies in humans.Neuropsychobiology 2017;75:46-51 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 16, 2017 Category: Psychiatry & Psychology Source Type: research

Erratum
Neuropsychobiology 2017;75:52 (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 13, 2017 Category: Psychiatry & Psychology Source Type: research

Plasma BDNF Level in Major Depression: Biomarker of the Val66Met BDNF Polymorphism and of the Clinical Course in Met Carrier Patients
Conclusion: Our results show a measurable, coherent, and functional BDNF pathway based on the BDNF Val66Met polymorphism and plasma BDNF levels in patients with a current MDE. This pathway is related to the clinical course of major depression, plasma BDNF levels being associated with the long-term history of MDD in Met carriers. Further studies assessing central BDNF are needed to understand the underlying mechanisms of this association.Neuropsychobiology 2017;75:39-45 (Source: Neuropsychobiology)
Source: Neuropsychobiology - August 22, 2017 Category: Psychiatry & Psychology Source Type: research

Potential Gender-Related Aging Processes Occur Earlier and Faster in the Vermis of Patients with Bipolar Disorder: An MRI Study
Conclusions: Our study provides evidence of the impact of aging on the vermis in BD, potentially related to earlier and faster gender-related neurodegenerative phenomena occurring during the progression of the disease.Neuropsychobiology 2017;75:32-38 (Source: Neuropsychobiology)
Source: Neuropsychobiology - August 11, 2017 Category: Psychiatry & Psychology Source Type: research

Frontal Cortex Myo-Inositol Is Associated with Sleep and Depression in Adolescents: A Proton Magnetic Resonance Spectroscopy Study
Conclusion: Lower frontal cortex mI may indicate a disturbed second messenger system. Frontal cortical mI may thus be linked to the pathophysiology of depression and concomitant sleep symptoms among maturing adolescents. Short sleep and daytime sleepiness may be associated with frontal cortex mI independently from depression.Neuropsychobiology 2017;75:21-31 (Source: Neuropsychobiology)
Source: Neuropsychobiology - August 9, 2017 Category: Psychiatry & Psychology Source Type: research

In Individuals Following Aneurysmal Subarachnoid Haemorrhage, Hair Cortisol Concentrations Are Higher and More Strongly Associated with Psychological Functioning and Sleep Complaints than in Healthy Controls
Conclusions: Our findings indicate that a dysregulation of HPA-AA is associated with some of the long-term impairments in psychological functioning and sleep in aSAH survivors. While the direction of association remained unclear, a dysregulated HPA-AA may be causally linked with the maintenance of poor psychological functioning and poor sleep. The overall findings should be considered in the planning of long-term treatment aimed at improving psychological functioning and sleep in aSAH patients.Neuropsychobiology 2017;75:12-20 (Source: Neuropsychobiology)
Source: Neuropsychobiology - July 27, 2017 Category: Psychiatry & Psychology Source Type: research

Acknowledgement to Reviewers
Neuropsychobiology 2016;74:262 (Source: Neuropsychobiology)
Source: Neuropsychobiology - July 14, 2017 Category: Psychiatry & Psychology Source Type: research

Author and Subject Index Vol. 74, No. 4, 2016
Neuropsychobiology 2016;74:261 (Source: Neuropsychobiology)
Source: Neuropsychobiology - July 14, 2017 Category: Psychiatry & Psychology Source Type: research