Influence of Simvastatin as Augmentative Therapy in the Treatment of Generalized Anxiety Disorder: A Pilot Randomized, Placebo-Controlled Study
Conclusions: The results from this clinical study did not support the potential efficacy of adjunctive simvastatin in the treatment of patients with GAD. Thus, large-scale and long-term clinical trials are required to more accurately assess the potential efficacy of statins in the treatment of patients with anxiety disorders.Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - October 16, 2020 Category: Psychiatry & Psychology Source Type: research
The Continuum from Temperament to Mental Illness: Dynamical Perspectives
Temperament in healthy individuals and mental illness have been conjectured to lie along a continuum of neurobehavioral regulation. This continuum is frequently regarded in dimensional terms, with temperament and mental illness lying at opposite poles along various dimensional descriptors. However, temperament and mental illness are quintessentially dynamical phenomena, and as such there is value in examining what insights can be arrived at through the lens of our current understanding of dynamical systems. The formal study of dynamical systems has led to the development of a host of markers which serve to characterize and...
Source: Neuropsychobiology - August 27, 2020 Category: Psychiatry & Psychology Source Type: research
Large Projects Investigating the Microbiota-Gut-Brain Axis and Fecal Transplant Studies Are Needed for Treating Mental Illnesses
Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - August 20, 2020 Category: Psychiatry & Psychology Source Type: research
Editorial
Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - July 31, 2020 Category: Psychiatry & Psychology Source Type: research
Association of Serum Biomarker Levels and BDNF Gene Polymorphism with Response to Selective Serotonin Reuptake Inhibitors in Indian Patients with Major Depressive Disorder
Conclusions: Baseline serum levels of hsCRP and BDNF predicted response to SSRIs in major depressive disorder, and Val/Val patients responded better when compared to patients carrying the Met allele.Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - July 30, 2020 Category: Psychiatry & Psychology Source Type: research
Regional Brain Perfusion Is Associated with Endothelial Dysfunction Markers in Major Depressive Disorder
Conclusion: ED markers in patients with MDD are associated with significant changes in rCBF which are features of depression. These findings suggest that systemic damage/activation of the endothelium may contribute to the abnormal rCBF observed in MDD patients.Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - July 29, 2020 Category: Psychiatry & Psychology Source Type: research
Impaired Cognitive Flexibility and Working Memory Precedes Depression: A Rat Model to Study Depression
Conclusion: In a rat model of depression, cognitive impairment preceded depression, but it might be caused by anxiety-like behavior that occurred in early stimulation of chronic unpredictable mild stress.Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - July 24, 2020 Category: Psychiatry & Psychology Source Type: research
Psychiatric Symptoms as the First or Solitary Manifestation of Somatic Illnesses: Hyperammonaemia Type II
Conclusion: Somatic comorbidity in psychiatric inpatients is commonly found; however, such disorders are rarely diagnosed or even treated adequately.Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - July 20, 2020 Category: Psychiatry & Psychology Source Type: research
Activation and Blockade of Serotonin-4 Receptors in the Lateral Habenula Produce Antidepressant Effects in the Hemiparkinsonian Rat
Conclusions: All these results suggest that activation or blockade of the LHb 5-HT4Rs produce antidepressant effects in the 6-OHDA-lesioned rats, which are related to the changes of monoamines in the limbic and limbic-related regions.Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - July 14, 2020 Category: Psychiatry & Psychology Source Type: research
Association of Testosterone Levels and Steroid 5-Alpha-Reductase 2 Polymorphisms with Opioid Craving
Conclusion: Our data show a possible role of testosterone metabolism in opioid dependence, which may be relevant for the establishment of future treatment strategies.Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - July 13, 2020 Category: Psychiatry & Psychology Source Type: research
Subject Index
Neuropsychobiology 2020;79:367 (Source: Neuropsychobiology)
Source: Neuropsychobiology - July 3, 2020 Category: Psychiatry & Psychology Source Type: research
Author Index
Neuropsychobiology 2020;79:366 (Source: Neuropsychobiology)
Source: Neuropsychobiology - July 3, 2020 Category: Psychiatry & Psychology Source Type: research
Vorspann
Neuropsychobiology 2020;79:245 –248 (Source: Neuropsychobiology)
Source: Neuropsychobiology - July 3, 2020 Category: Psychiatry & Psychology Source Type: research
Differential Methylation Pattern of Schizophrenia Candidate Genes in Tetrahydrocannabinol-Consuming Treatment-Resistant Schizophrenic Patients Compared to Non-Consumer Patients and Healthy Controls
Conclusion: InMAPT andNRXN1 mean methylation rates were lower in non-consumer patients compared with controls, which seems to be a compensatory mechanism. With consumption of THC, mean methylation rates were increased: in the case ofMAPT compared with controls, and inNRXN1 even significantly beyond that. Methylation ofNRG1 andDISC1 seems not to be affected by the psychiatric disorder or by consumption of THC.Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - June 29, 2020 Category: Psychiatry & Psychology Source Type: research
Diosgenin Attenuates Cognitive Impairment in Streptozotocin-Induced Diabetic Rats: Underlying Mechanisms
Conclusions: Taken together, diosgenin is capable of ameliorating cognitive deficits in STZ-diabetic animals, partly due to its amelioration of oxidative stress, inflammation, astrogliosis, and possibly improvement of cholinergic function in addition to its neuroprotective potential.Neuropsychobiology (Source: Neuropsychobiology)
Source: Neuropsychobiology - June 11, 2020 Category: Psychiatry & Psychology Source Type: research
