Acute Phencyclidine Alters Neural Oscillations Evoked by Tones in the Auditory Cortex of Rats

Conclusions: Findings suggest that acute PCP-induced NMDAr hypofunction has differential effects on neural power and synchrony which vary with dose, time course of administration and EEG frequency. EEG synchrony and power appear to be sensitive translational biomarkers for disrupted NMDAr function, which may contribute to the pathophysiology of schizophrenia and other neuropsychiatric disorders.Neuropsychobiology 2017;75:53-62
Source: Neuropsychobiology - Category: Psychiatry & Psychology Source Type: research