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The Dorsal Root Ganglion as a Novel Neuromodulatory Target to Evoke Strong and Reproducible Motor Responses in Chronic Motor Complete Spinal Cord Injury: A Case Series of Five Patients
ConclusionThe current paper provides first evidence that bilateral L4 DRG stimulation can evoke reproducible motor responses in the upper leg, sufficient for assisted weight bearing in patients with chronic motor complete SCI. As such, a new target for SCI treatment has surfaced, using existing stimulation devices, making the technique directly clinically accessible. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Authors: Sadaf Soloukey, Judith D. Rooij, Rutger Osterthun, Judith Drenthen, Chris I. De Zeeuw, Frank J. P. M. Huygen, Biswadjiet S. Harhangi Tags: Clinical Research Source Type: research

Utilization of Concurrent Dorsal Root Ganglion Stimulation and Dorsal Column Spinal Cord Stimulation in Complex Regional Pain Syndrome
ConclusionBoth t-SCS and DRG-S have been shown to be effective in treatment of patients with CRPS. In our study, concurrent use of t-SCS and DRG-S provided significant improvement in pain and function as compared to using either device alone. This suggests the potential that combination therapy with t-SCS and DRG-S may be beneficial in patients with CRPS. Further prospective studies are required to evaluate this concept. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Authors: Priyanka Ghosh, Semih Gungor Tags: Clinical Research Source Type: research

Transgrade Dorsal Root Ganglion Stimulation as a Salvage Technique for Three Different Anatomical Barriers: A Case Series
ConclusionBarriers to anterograde foraminal access including previous implantation, previous instrumentation, and epidural adhesions may prevent DRGS placement in certain indicated patients. This can be especially challenging in patients who have failed other neuromodulation options like dorsal column stimulation. Our case series demonstrated that the transgrade technique can be successfully used in these cases to increase access to DRGS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Authors: Gregory Lawson Smith, Erika A. Petersen, Christopher Paul, Johnathan H. Goree Tags: Clinical Research Source Type: research

Cost ‐Effectiveness of Dorsal Root Ganglion Stimulation or Spinal Cord Stimulation for Complex Regional Pain Syndrome
ConclusionsDRG and SCS are cost-effective treatments for chronic pain secondary to CRPS-I and II compared to CMM. DRG accrued higher cost due to higher conversion from trial to permanent implant and shorter battery life, but DRG was the most beneficial therapy due to more patients receiving permanent implants and experiencing higher quality of life compared to SCS. New DRG technology has improved battery life, which we expect to make DRG more cost-effective compared to both CMM and SCS in the future. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Authors: Nagy Mekhail, Timothy R. Deer, Lawrence Poree, Peter S. Staats, Allen W. Burton, Allison T. Connolly, Edward Karst, Diana S. Mehanny, Youssef Saweris, Robert M. Levy Tags: Clinical Research Source Type: research

Three ‐Year Outcomes After Dorsal Root Ganglion Stimulation in the Treatment of Neuropathic Pain After Peripheral Nerve Injury of Upper and Lower Extremities
ConclusionsDRG neuromodulation appears to be a safe, effective, and durable option for treating neuropathic pain caused by PNI. The treatment allows cessation of often ineffective pharmacotherapy (including opioid misuse) and significantly improves quality of life. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Authors: Michael Kretzschmar, Marco Reining, Marcus A. Schwarz Tags: Clinical Research Source Type: research

A Prospective Analysis of the Use of Intraoperative Neuromonitoring for Mapping the S1 Dorsal Root Ganglion Location to Determine Ideal Lead Positioning and Predict Postoperative Programming
ConclusionsThis prospective analysis further demonstrates the utility and accuracy of IONM. The use of DRG IONM is reliable for confirming dorsal placement along the S1 DRG, mapping its position, and guiding postoperative programming. The S1 DRG is located at the border of the foramen and canal in most, but not all cases. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Authors: Steven M. Falowski Tags: Clinical Research Source Type: research

Complications and Effects of Dorsal Root Ganglion Stimulation in the Treatment of Chronic Neuropathic Pain: A Nationwide Cohort Study in Denmark
ConclusionsThis study suggests a significant, clinically relevant effect of DRG stimulation on neuropathic pain, but also demonstrates substantial problems with maintenance and revision of currently available systems. Consequently, treatment with equipment marketed specifically for DRG stimulation is currently paused in Denmark. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Authors: Mattias Horan, Anne Helene Jacobsen, Christian Scherer, Christina Rosenlund, Helga Angela Gulisano, Morten S øe, Jens Christian Hedemann Sørensen, Kaare Meier, Morten Rune Blichfeldt‐Eckhardt Tags: Clinical Research Source Type: research

Dorsal Root Ganglion Stimulation for Chronic Postoperative Pain Following Thoracic Surgery: A Pilot Study
ConclusionsOur preliminary results show that DRG-S is an effective therapy for PTPS after thoracic surgery. In addition, thoracic paravertebral blocks performed prior to DRG-S correlated with a positive outcome with treatment. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Authors: Giuliano Lo Bianco, Alfonso Papa, Giuseppe Gazzerro, Marco Rispoli, Dario Tammaro, Maria Teresa Di Dato, Federica Vernuccio, Michael Schatman Tags: Clinical Research Source Type: research

Multicenter Retrospective Analysis of Dorsal Root Ganglion Stimulator Placement Using Intraoperative Neuromonitoring in Asleep Patients During Early Periods of Adoption
ConclusionThis retrospective series demonstrates the utility and accuracy of IONM in not only confirming proper dorsal placement of a DRG electrode but also in maintaining a low adverse event profile. It further demonstrates that its utility in the real world with new users can be safe and accurate with an ease of integration. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Authors: Steven M. Falowski, Tim Deer, Goran Tubic, Pankaj Mehta Tags: Clinical Research Source Type: research

The Effect of Clinically Controllable Factors on Neural Activation During Dorsal Root Ganglion Stimulation
ConclusionsOur results suggest that DRGS applied with stimulation parameters within typical clinical ranges predominantly activates A β-mechanoreceptors. In general, varying clinically controllable parameters affects the number of Aβ-mechanoreceptors activated, although longer pulse widths can increase Aδ-neuron activation. Our data support several Neuromodulation Appropriateness Consensus Committee guidelines on the clinical i mplementation of DRGS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Authors: Robert D. Graham, Tim M. Bruns, Bo Duan, Scott F. Lempka Tags: Basic Research Source Type: research

Effects of Translumbosacral Neuromodulation Therapy on Gut and Brain Interactions and Anorectal Neuropathy in Fecal Incontinence: A Randomized Study
ConclusionsTNT significantly improves afferent ano-cortical signaling, efferent lumbo-anal and sacro-anal neuropathy and anorectal sensorimotor function. These neurobiologic effects were most prominent with 1  Hz frequency. TNT improves FI by modifying the underlying pathophysiology possibly through neuromodulation. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 22, 2021 Category: Biotechnology Authors: Satish S. C. Rao, Yun Yan, Xuelian Xiang, Amol Sharma, Deepak Ayyala, Shaheen Hamdy Tags: Clinical Research Source Type: research

Men and Women Respond Equally Well to Spinal Cord and Dorsal Root Ganglion Stimulation
ConclusionGender may play an influential role in pain severity at baseline but have little effect at follow-up. To help identify which patients may undergo a revision or explant, gender and age could be important factors and should be further scrutinized. Even though men and women responded equally well to SCS and DRG stimulation, more men had a revision due to lead fractures, and more women were explanted due to insufficient pain relief. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 22, 2021 Category: Biotechnology Authors: Beatrice Bretherton, Dirk de Ridder, Tracey Crowther, Sheila Black, Andy Whelan, Ganesan Baranidharan Tags: Case Series Source Type: research

Increased Subthalamic Nucleus Deep Brain Stimulation Amplitude Impairs Inhibitory Control of Eye Movements in Parkinson's Disease
ConclusionsOur findings suggest that higher stimulation amplitude settings can be modulatory for inhibitory control. Some individual variability in the effect of stimulation amplitude can be explained by active contact location and VTA-STN overlap. Higher stimulation amplitudes are more deleterious if the active contacts fall outside of the STN resulting in a smaller VTA-STN overlap. This is clinically significant as it can inform clinical optimization of STN DBS parameters. Further studies are needed to determine stimulation amplitude effects on other aspects of cognition and whether inhibitory control deficits on the ant...
Source: Neuromodulation: Technology at the Neural Interface - June 18, 2021 Category: Biotechnology Authors: Miranda J. Munoz, Lisa C. Goelz, Gian D. Pal, Jessica A. Karl, Leo Verhagen Metman, Sepehr Sani, Joshua M. Rosenow, Jody D. Ciolino, Ajay S. Kurani, Daniel M. Corcos, Fabian J. David Tags: Clinical Research Source Type: research

Two ‐Week Cervical Vagus Nerve Stimulation in Chronic Pancreatitis Patients Induces Functional Connectivity Changes of Limbic Structures
ConclusionIn our population of CP patients, cervical nVNS compared with sham treatment induced reduced functional connectivity of limbic structures, as also observed in other patient groups. The findings are relevant, since we have previously demonstrated an effect on pain scores in CP patients for both nVNS and sham treatment. Our results elucidate the effects in the central nervous system following nVNS treatment of CP patients, pointing at potential beneficial effects in this patient group. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 15, 2021 Category: Biotechnology Authors: Janusiya Anajan Muthulingam, Tine Maria Hansen, S øren Schou Olesen, Asbjørn Mohr Drewes, Jens Brøndum Frøkjær Tags: Clinical Research Source Type: research

Two ?Week Cervical Vagus Nerve Stimulation in Chronic Pancreatitis Patients Induces Functional Connectivity Changes of Limbic Structures
ConclusionIn our population of CP patients, cervical nVNS compared with sham treatment induced reduced functional connectivity of limbic structures, as also observed in other patient groups. The findings are relevant, since we have previously demonstrated an effect on pain scores in CP patients for both nVNS and sham treatment. Our results elucidate the effects in the central nervous system following nVNS treatment of CP patients, pointing at potential beneficial effects in this patient group. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 15, 2021 Category: Biotechnology Authors: Janusiya Anajan Muthulingam, Tine Maria Hansen, S ren Schou Olesen, Asbjrn Mohr Drewes, Jens Brndum Frkjr Tags: Clinical Research Source Type: research