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Optimizing Deep Brain Stimulation Parameters in Obsessive –Compulsive Disorder
ConclusionsDecision ‐making in stimulation parameter optimization needs to be sensitive to the particular time‐courses on which various symptoms and side effects change. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - February 18, 2021 Category: Biotechnology Authors: Maarten Westen, Erik Rietveld, Isidoor O. Bergfeld, Pelle Koning, Nienke Vullink, Pieter Ooms, Ilse Graat, Luka Liebrand, Pepijn Munckhof, Rick Schuurman, Damiaan Denys Tags: Clinical Research Source Type: research

Effects of Subthalamic Deep Brain Stimulation With Different Frequencies in a Parkinsonian Rat Model
ConclusionSTN ‐HFS (130 Hz) and sham operation for one week can significantly improve the exercise performance of PD rats. The exercise performance of PD rats in LFS group (30 Hz) is worse compared with HFS group (130 Hz). HFS plays a role in neuroprotection and improvement of exercise performance of PD rats. M oreover, DTI can be used as an effective technique to assess the therapeutic effects and severity of PD. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - February 18, 2021 Category: Biotechnology Authors: Zhimin Li, Yi Guo, Xinjie Bao, Jianfeng Lei, Zhiwei Shen, Xin Wang, Luming Li, Yongning Li, Renzhi Wang Tags: Basic Research Source Type: research

Directional Deep Brain Stimulation of the Thalamic Ventral Intermediate Area for Essential Tremor Increases Therapeutic Window
ConclusionsdDBS for ET widens therapeutic window due to reduction of therapeutic threshold. Larger volume of neural activation for dDBS at side effect threshold supports the notion of persistent directionality even at higher intensities. dDBS may compensate for slightly misplaced leads and should be considered first line for PSA/VIM ‐DBS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - February 18, 2021 Category: Biotechnology Authors: Sabine Bruno, Petyo Nikolov, Christian J. Hartmann, Carlos Trenado, Philipp J. Slotty, Jan Vesper, Alfons Schnitzler, Stefan J. Groiss Tags: Clinical Research Source Type: research

A Custom Made Electrode Construct and Reliable Implantation Method That Allows for Long ‐Term Bilateral Deep Brain Stimulation in Mice
ConclusionThe DBS electrode construct and implantation method described can be used for long ‐term DBS studies to further investigate the mechanisms underlying DBS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - February 18, 2021 Category: Biotechnology Authors: Sylvana Pol, Yasin Temel, Ali Jahanshahi Tags: Basic Research Source Type: research

Deep Brain Stimulation of the Internal Pallidum in Lesch –Nyhan Syndrome: Clinical Outcomes and Connectivity Analysis
ConclusionCombined bilateral stimulation of the anteromedial and posteroventral GPi may be considered as an option for managing refractory dystonia and self ‐harm behavior in LNS patients. A multidisciplinary team‐based approach is essential for patient selection and management, to support children and families, to achieve functional improvement and alleviate the overall disease burden for patients and caregivers. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - February 18, 2021 Category: Biotechnology Authors: Kantharuby Tambirajoo, Luciano Furlanetti, Harutomo Hasegawa, Ahmed Raslan, Hortensia Gimeno, Jean ‐Pierre Lin, Richard Selway, Keyoumars Ashkan Tags: Clinical Research Source Type: research