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The Prevalence of Elevated Impedances and Magnetic Resonance Imaging Ineligibility Following Implantation of 10  kHz Spinal Cord Stimulation Devices: A Retrospective Review
ConclusionWe found the prevalence of elevated impedances above 10,000 Ω to be 4% of implanted patients. This information is important for patients and physicians alike and should be considered when device selection is occurring in the pre-operative visits. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 11, 2021 Category: Biotechnology Authors: Jonathan M. Hagedorn, James B. Parmele, Jason S. Wolff, Markus A. Bendel, Ryan S. D'Souza Tags: Clinical Research Source Type: research

Lesser ?Known Aspects of Deep Brain Stimulation for Parkinson's Disease: Programming Sessions, Hardware Surgeries, Residential Care Admissions, and Deaths
ConclusionsData from a large cohort of patients with PD treated with DBS found that the median life ?span after surgery is ten?years. Repeat hardware surgery, including of the intracranial electrodes, is common. These findings support development of technologies to reduce therapy burden such as enhanced surgical navigation, hardware miniaturization, and improved battery efficiency. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 11, 2021 Category: Biotechnology Authors: San San Xu, Charles B. Malpas, Kristian J. Bulluss, Hugh J. McDermott, Tomas Kalincik, Wesley Thevathasan Tags: Clinical Research Source Type: research

Lesser ‐Known Aspects of Deep Brain Stimulation for Parkinson's Disease: Programming Sessions, Hardware Surgeries, Residential Care Admissions, and Deaths
ConclusionsData from a large cohort of patients with PD treated with DBS found that the median life  span after surgery is ten years. Repeat hardware surgery, including of the intracranial electrodes, is common. These findings support development of technologies to reduce therapy burden such as enhanced surgical navigation, hardware miniaturization, and improved battery efficiency. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 11, 2021 Category: Biotechnology Authors: San San Xu, Charles B. Malpas, Kristian J. Bulluss, Hugh J. McDermott, Tomas Kalincik, Wesley Thevathasan Tags: Clinical Research Source Type: research

Safety and Efficacy of 10  kHz Spinal Cord Stimulation for the Treatment of Refractory Chronic Migraine: A Prospective Long‐Term Open‐Label Study
Conclusion10  kHz SCS may a be safe and effective neurostimulation option for rCM patients. The paresthesia-free waveform constitutes an unprecedented advantage for future methodologically sound sham-controlled studies in headache neuromodulation. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 10, 2021 Category: Biotechnology Authors: Adnan Al ‐Kaisy, Stefano Palmisani, Roy Carganillo, Samuel Wesley, David Pang, Anand Rotte, Angela Santos, Giorgio Lambru Tags: Clinical Research Source Type: research

Evaluation of Sagittal Spinopelvic Balance in Spinal Cord Stimulator Patients
ConclusionsThis retrospective cohort analysis of SCS patients did not demonstrate any relationship between poor sagittal alignment and failure of SCS therapy. Further studies of larger databases should be performed to determine how many patients ultimately go on to have additional structural spinal surgery after failure of SCS and whether or not those patients go on to have positive outcomes. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 10, 2021 Category: Biotechnology Authors: Royce W. Woodroffe, Eli A. Perez, Scott C. Seaman, Brian J. Park, Russ P. Nockels, Matthew A. Howard, Saul Wilson Tags: Clinical Research Source Type: research

Safety and Efficacy of 10 �kHz Spinal Cord Stimulation for the Treatment of Refractory Chronic Migraine: A Prospective Long?Term Open?Label Study
Conclusion10 ?kHz SCS may a be safe and effective neurostimulation option for rCM patients. The paresthesia-free waveform constitutes an unprecedented advantage for future methodologically sound sham-controlled studies in headache neuromodulation. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 10, 2021 Category: Biotechnology Authors: Adnan Al ?Kaisy, Stefano Palmisani, Roy Carganillo, Samuel Wesley, David Pang, Anand Rotte, Angela Santos, Giorgio Lambru Tags: Clinical Research Source Type: research

Simultaneous Sphenopalatine and Occipital Nerve Stimulation in Treatment of Chronic Refractory Cluster Headache: A Case Report
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 10, 2021 Category: Biotechnology Authors: Vidzhai M. Dzhafarov, Konstantin V. Slavin Tags: Clinical Letter Source Type: research

Biomarkers for Deep Brain Stimulation in Animal Models of Depression
ConclusionsOverall, DBS is a promising therapeutic modality for treatment-resistant depression. Different outcomes have been used to assess its efficacy in animal studies. From the review, electrophysiological and biochemical markers appear to offer the greatest potential as biomarkers for depression. However, to develop closed-loop DBS for depression, additional preclinical and clinical studies with a focus on identifying reliable, safe, and effective biomarkers are warranted. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 9, 2021 Category: Biotechnology Authors: Jason Yuen, Aaron E. Rusheen, Joshua Blair Price, Abhijeet S. Barath, Hojin Shin, Abbas Z. Kouzani, Michael Berk, Charles D. Blaha, Kendall H. Lee, Yoonbae Oh Tags: Review Article Source Type: research

Infectious Complications of Dorsal Root Ganglion Stimulation: A Systematic Review and Pooled Analysis of Incidence
ConclusionsThis is the first systematic review and pooled analysis that followed PRISMA guidelines to report infectious complications of DRGS by stage (trial vs. implant vs. revision). DRGS trial appears to be low risk for infection but that risk is significantly increased with DRGS implant. Our findings highlight the need for further study of infectious complications, their risks, and optimal prophylaxis. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 7, 2021 Category: Biotechnology Authors: Rajat N. Moman, Ashley A. Peterson, Dermot P. Maher, Ilhan Eli, Jonathan M. Hagedorn, Markus A. Bendel, Danielle Gerberi, M. Hassan Murad, W. Michael Hooten Tags: Review Article Source Type: research

Analgesic Effects of Tonic and Burst Dorsal Root Ganglion Stimulation in Rats With Painful Tibial Nerve Injury
ConclusionsDRG stimulation using burst waveform might be also suitable for treating neuropathic pain. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 7, 2021 Category: Biotechnology Authors: Guoliang Yu, Ian Segel, Hai Tran, Hyun ‐Joo Park, Erika Ross, Quinn H. Hogan, Bin Pan Tags: Basic Research Source Type: research

Dura Fistula: A Rare Complication of Simultaneous Placement of Neurostimulation Leads and an Intrathecal Catheter
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 3, 2021 Category: Biotechnology Authors: Denis Dupoiron, Timothy Deer Tags: Clinical Letter Source Type: research

Dorsal Root Ganglion Stimulation for Chronic Groin Pain: A Review
ConclusionDRG stimulation has emerged as an alternative neuromodulatory technique for patients with chronic groin pain. While previous studies suggest substantial sustained pain relief with DRG stimulation in this patient population, prospective randomized controlled studies are necessary before formal recommendations can be made. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 2, 2021 Category: Biotechnology Authors: Steven Char, Ross A. Barman, Timothy R. Deer, Jonathan M. Hagedorn Tags: Review Article Source Type: research

Tonic, Burst, and Burst Cycle Spinal Cord Stimulation Lead to Differential Brain Activation Patterns as Detected by Functional Magnetic Resonance Imaging
ConclusionThe high-resolution fMRI study using rat model demonstrated the potential of different SCS modes to act on several pain-matrix related regions of the brain in response to noxious stimulation. The burst and burst-cycle SCS exhibited greater brain activity reduction in response to noxious hindlimb stimulation in caudate putamen, insula, and secondary somatosensory cortex compared to tonic stimulation. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 2, 2021 Category: Biotechnology Authors: Mohammad Saber, David Schwabe, Hyun ‐Joo Park, John Tessmer, Zan Khan, Yujie Ding, Maraika Robinson, Quinn H. Hogan, Christopher P. Pawela Tags: Basic Research Source Type: research

Is Allodynia a Determinant Factor in the Effectiveness of Transcranial Direct Current Stimulation in the Prophylaxis of Migraine?
ConclusionstDCS is a safe, efficacious, and fast method for migraine prophylaxis. However, the administration of tDCS before allodynia occurs, that is, before central sensitization develops, will provide increased responsiveness to the treatment.SignificancetDCS is more effective before the development of allodynia, but it also improves the quality of life even after the development of allodynia. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 1, 2021 Category: Biotechnology Authors: Tuba Cerraho ğlu Şirin, Serkan Aksu, Buse Rahime Hasirci Bayir, Çağrı Ulukan, Sacit Karamürsel, Adnan Kurt, Betül Baykan Tags: Clinical Research Source Type: research

Higher Pain Sensitivity Predicts Efficacy of a Wearable Transcutaneous Electrical Nerve Stimulation Device for Persons With Fibromyalgia: A Randomized Double ‐Blind Sham‐Controlled Trial
ConclusionThis study found no differences between those who were exposed to maximal-frequency active stimulation or minimal-frequency sham stimulation from a wearable TENS in reducing FM-related symptoms. However, those with greater hypersensitivity showed most benefit from TENS. Additional studies to help determine the role individual differences play in the use of TENS in managing FM-related symptoms are needed. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 31, 2021 Category: Biotechnology Authors: Robert N. Jamison, Samantha Curran, Limeng Wan, Edgar L. Ross, Christopher J. Gilligan, Robert R. Edwards Tags: Clinical Research Source Type: research