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Multimodal Elements of Suicidality Reduction After Transcranial Magnetic Stimulation
ConclusionsTargeted reduction of fronto ‐striatal connectivity with TMS may be a promising treatment for suicidality. Future research can build on this multimodal approach to advance individualized stimulation approaches in high‐risk patients. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - March 9, 2021 Category: Biotechnology Authors: Jennifer Barredo, Yosef Berlow, Hannah R. Swearingen, Benjamin D. Greenberg, Linda L. Carpenter, Noah S. Philip Tags: Clinical Research Source Type: research

The Effects of Electroacupuncture via Chronically Implanted Electrodes on Alcohol Drinking and Withdrawal Signs in Rats
ConclusionsThis work shows the potential of this novel method of EA for the treatment of AUD. Further studies are warranted to investigate the mechanisms through which EA exerts its effects. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - February 27, 2021 Category: Biotechnology Authors: Hanaa S. Sallam, Haixia Li, Jiande D.Z. Chen Tags: Basic Research Source Type: research

Effect of Anodic Transcranial Direct Current Stimulation Combined With Speech Language Therapy on Nonfluent Poststroke Aphasia
ConclusionOur results suggest that left inferior gyrus frontalis anodic transcranial direct current stimulation is an effective adjuvant to conventional speech language therapy for patients with nonfluent PSA. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - February 24, 2021 Category: Biotechnology Authors: Qi Zhao, Jing Wang, Zheng Li, Luping Song, Xiaoli Li Tags: Clinical Research Source Type: research

The Effect of Measured Radiotherapy Dose on Intrathecal Drug Delivery System Function
ConclusionsWe found no evidence that RT in patients with IDDS led to device failure or dysfunction. While radiation oncologists and pain specialists should coordinate patient care, it does not appear that RT dose impacts the function of the IDDS to warrant significant clinical concern. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - February 24, 2021 Category: Biotechnology Authors: Daniel W. Odell, Richard D. Albrechtsen, Jill E. Sindt, Ryan Gole, Spencer Brown, Matthew W. Parsons, Adam B. Paxton, Vikren Sarkar, Shane Lloyd, Shane E. Brogan, Randa Tao Tags: Clinical Research Source Type: research

Association of Outcomes of Spinal Cord Stimulation for Chronic Low Back Pain and Psoas Measurements Based on Size of Iliopsoas Muscles
ConclusionsOur study showed that psoas measurements correlated with various pain outcomes specifically. P/VBA was most predictive in females and P/BMI in males. Depression correlated with P/BMI, reinforcing the complex relationship between depression and constant chronic pain. Tertile analyses further showed a relationship between iliopsoas CSA and depression in males and females. We provide preliminary data of sex ‐specific psoas measurements as a risk factor for worse SCS outcomes. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - February 22, 2021 Category: Biotechnology Authors: Breanna L. Sheldon, Marisa DiMarzio, Sung Hwan Chung, Justin Tram, Olga Khazen, Michael D. Staudt, Melanie Bondoc, Julie G. Pilitsis Tags: Clinical Research Source Type: research

Optimized Tibial Nerve Stimulation Partially Reduces Visceral Hypersensitivity in Rats Mediated via Autonomic and Opioid Mechanisms
ConclusionsTNS with parameters of 14 Hz, 330  μsec, and 40% motor threshold is effective in improving visceral hypersensitivity in rodent models of colonic hypersensitivity via the modulation of autonomic and opioid mechanisms. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - February 22, 2021 Category: Biotechnology Authors: Liuqin Jiang, Shengai Zhang, Nina Zhang, Jiande D.Z. Chen Tags: Basic Research Source Type: research

Deep Brain Stimulation ‐Related Surgical Site Infections: A Systematic Review and Meta‐Analysis
ConclusionThe present study confirms the still high prevalence of SSIs, especially for newer indications of DBS and provides evidence that preventive measures, such as the implementation of topical vancomycin, seem promising in reducing the risk of DBS ‐related SSIs. Large clinical trials are needed to confirm the efficacy and safety of such measures. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - February 18, 2021 Category: Biotechnology Authors: Maria Kantzanou, Stefanos Korfias, Ioannis Panourias, Damianos E. Sakas, Maria A. Karalexi Tags: Review Article Source Type: research

Anterior Cingulate Cortex in Addiction: New Insights for Neuromodulation
ConclusionFirst, we illustrate that the ACC serves as a central “hub” in addiction‐related neural networks of cognitive functions, including, but not limited to, decision‐making, cognitive inhibition, emotion, and motivation. Then, we summarize the literature targeting the ACC to treat SUDs via available neuromodulation approaches. Finally, we propose po tential directions to improve the effect of stimulating the ACC in SUD treatment. We emphasize that the ACC can be divided into at least four sub‐regions, which have distinctive functions and connections. Studies focusing on these sub‐regions may help to develo...
Source: Neuromodulation: Technology at the Neural Interface - February 18, 2021 Category: Biotechnology Authors: Yijie Zhao, Samantha N. Sallie, Hailun Cui, Ningning Zeng, Jiang Du, Tifei Yuan, Dianyou Li, Dirk De Ridder, Chencheng Zhang Tags: Review Article Source Type: research

Deep Brain Stimulation for Alzheimer's Disease: Tackling Circuit Dysfunction
ConclusionsDBS is an intriguing potential treatment for Alzheimer's disease, targeting circuit dysfunction as a novel therapeutic target. However, further exploration of the basic disease pathology and underlying mechanisms of DBS is necessary to better understand how circuit dysfunction can be restored. Additionally, robust clinical data in the form of ongoing phase III clinical trials are needed to validate the efficacy of DBS as a viable treatment. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - February 18, 2021 Category: Biotechnology Authors: Jordan Lam, Justin Lee, Charles Y. Liu, Andres M. Lozano, Darrin J. Lee Tags: Review Article Source Type: research