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Sacral Neuromodulation Changes Pelvic Floor Activity in Overactive Bladder Patients �Possible New Insights in Mechanism of Action: A Pilot Study
ConclusionsThis is the first study to describe in detail the neurophysiological characteristics of the PFM, and the changes over time upon sacral spinal root stimulation, in responders and nonresponders to SNM. More research is needed to investigate the full potential of EPFMR as a response indicator. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 21, 2021 Category: Biotechnology Authors: Jeroen Voorham, Donald Vagan �e, Petra Voorham?van der Zalm, Guus Lycklama � Nijeholt, Hein Putter, Stefan De Wachter Tags: Clinical Research Source Type: research

Sacral Neuromodulation Changes Pelvic Floor Activity in Overactive Bladder Patients —Possible New Insights in Mechanism of Action: A Pilot Study
ConclusionsThis is the first study to describe in detail the neurophysiological characteristics of the PFM, and the changes over time upon sacral spinal root stimulation, in responders and nonresponders to SNM. More research is needed to investigate the full potential of EPFMR as a response indicator. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 21, 2021 Category: Biotechnology Authors: Jeroen Voorham, Donald Vagan ée, Petra Voorham‐van der Zalm, Guus Lycklama à Nijeholt, Hein Putter, Stefan De Wachter Tags: Clinical Research Source Type: research

Cognitive Outcome After Deep Brain Stimulation for Refractory Obsessive �Compulsive Disorder: A Systematic Review
ConclusionAlthough individual studies generally do not report cognitive deterioration after DBS for OCD, the variability of study designs and the multitude of cognitive measures used, precluded a meta-analysis to confirm its safety, and recognition of a cognitive pattern through which the efficacy of DBS for OCD might be explained. In future, prospective studies should preferably include a standardized neuropsychological assessment battery specifically addressing executive functioning and have a longer-term follow-up in order to demonstrate the cognitive safety of the procedure. Such prospective and more uniform data colle...
Source: Neuromodulation: Technology at the Neural Interface - September 21, 2021 Category: Biotechnology Authors: Tim A. M. Bouwens van der Vlis, Annelien Duits, M �gan M. G. H. Veerdonk, Anne E. P. Mulders, Koen R. J. Schruers, Yasin Temel, Linda Ackermans, Albert F. G. Leentjens Tags: Review Article Source Type: research

Cognitive Outcome After Deep Brain Stimulation for Refractory Obsessive –Compulsive Disorder: A Systematic Review
ConclusionAlthough individual studies generally do not report cognitive deterioration after DBS for OCD, the variability of study designs and the multitude of cognitive measures used, precluded a meta-analysis to confirm its safety, and recognition of a cognitive pattern through which the efficacy of DBS for OCD might be explained. In future, prospective studies should preferably include a standardized neuropsychological assessment battery specifically addressing executive functioning and have a longer-term follow-up in order to demonstrate the cognitive safety of the procedure. Such prospective and more uniform data colle...
Source: Neuromodulation: Technology at the Neural Interface - September 21, 2021 Category: Biotechnology Authors: Tim A. M. Bouwens van der Vlis, Annelien Duits, M égan M. G. H. Veerdonk, Anne E. P. Mulders, Koen R. J. Schruers, Yasin Temel, Linda Ackermans, Albert F. G. Leentjens Tags: Review Article Source Type: research

Intrathecal Drug Delivery for the Treatment of Cancer ‐Associated Chronic Pain in Children
ConclusionsThere exist children with cancer whose pain is refractory to the standard approaches and may benefit from IT drug delivery. The existing data, although limited and of low tier evidence, suggest that IT drug delivery has been effective in the pediatric cancer population. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 15, 2021 Category: Biotechnology Authors: Meaghan Kenfield, Nicholas Zacharias, Alaa Abd ‐Elsayed Tags: Review Article Source Type: research

Intrathecal Drug Delivery for the Treatment of Cancer ?Associated Chronic Pain in Children
ConclusionsThere exist children with cancer whose pain is refractory to the standard approaches and may benefit from IT drug delivery. The existing data, although limited and of low tier evidence, suggest that IT drug delivery has been effective in the pediatric cancer population. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 14, 2021 Category: Biotechnology Authors: Meaghan Kenfield, Nicholas Zacharias, Alaa Abd ?Elsayed Tags: Review Article Source Type: research

Thalamic Deep Brain Stimulation May Improve Restless Legs Syndrome in Patients With Essential Tremor
ConclusionsWe report for the first time improvement of RLS in patients with ET after bilateral thalamic DBS. Although many ET patients with nonrechargeable DBS systems switch off their stimulator at night to conserve battery life, those with RLS may potentially benefit from keeping their stimulator ON at night to relieve their RLS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 14, 2021 Category: Biotechnology Authors: Virgilio Gerald H. Evidente, Danica H. Evidente, Francisco A. Ponce, Maris H. Evidente, Margaret Lambert, Robin Garrett Tags: Clinical Research Source Type: research

Cortical, Spinal, Sacral, and Peripheral Neuromodulations as Therapeutic Approaches for the Treatment of Lower Urinary Tract Symptoms in Multiple Sclerosis Patients: A Review
DiscussionPTNS and SNM seem to be effective and safe therapeutic options for treating lower urinary tract symptoms in MS patients principally in case of overactive bladder (OAB) symptoms. Similarly, also SCS and TMS have been shown to be effective, despite the very limited number of patients and the small number of studies found in the literature. Interestingly, these techniques are effective even in patients who do not respond well to conservative therapies, such as anticholinergics. Furthermore, given their safety and efficacy, stimulations such as PTNS could be considered as a first-line treatment for OAB in MS patients...
Source: Neuromodulation: Technology at the Neural Interface - September 9, 2021 Category: Biotechnology Authors: Martina Pericolini, Gabriel Miget, Claire Hentzen, Enrico Finazzi Agr ò, Camille Chesnel, Philippe Lagnau, Rebecca Haddad, Matthieu Grasland, Gerard Amarenco Tags: Review Article Source Type: research

Factors Contributing to Spinal Cord Stimulation Outcomes for Chronic Pain
ConclusionsPatient outcome was associated with diagnosis, postimplantation falls, and device manufacturer. Further investigation is recommended to confirm associations through prospective studies that can more accurately quantify patient outcome over longer periods. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 8, 2021 Category: Biotechnology Authors: Dakota T. Graham, Margaret Lambert, Zaman Mirzadeh, Francisco A. Ponce Tags: Clinical Research Source Type: research

The Intraoperative Microlesion Effect Positively Correlates With the Short ‐Term Clinical Effect of Deep Brain Stimulation in Parkinson's Disease
ConclusionThe MLE has a clinically relevant correlation with the effect of DBS in PD patients. These results suggest that the MLE can be relied upon as evidence of a clinically effective DBS electrode placement. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 8, 2021 Category: Biotechnology Authors: St èfan F. Lange, Naomi I. Kremer, Teus van Laar, Fiete Lange, T. Elien Steendam‐Oldekamp, D. L. Marinus Oterdoom, Anthony R. Absalom, J. Marc C. van Dijk, Gea Drost Tags: Clinical Research Source Type: research

The Intraoperative Microlesion Effect Positively Correlates With the Short ?Term Clinical Effect of Deep Brain Stimulation in Parkinson's Disease
ConclusionThe MLE has a clinically relevant correlation with the effect of DBS in PD patients. These results suggest that the MLE can be relied upon as evidence of a clinically effective DBS electrode placement. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 8, 2021 Category: Biotechnology Authors: St �fan F. Lange, Naomi I. Kremer, Teus van Laar, Fiete Lange, T. Elien Steendam?Oldekamp, D. L. Marinus Oterdoom, Anthony R. Absalom, J. Marc C. van Dijk, Gea Drost Tags: Clinical Research Source Type: research

A Case Series of Neuropsychological Outcome After Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Refractory Obsessive –Compulsive Disorder
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 7, 2021 Category: Biotechnology Authors: Tim A. M. Bouwens van der Vlis, Annelien A. Duits Tags: Clinical Letter Source Type: research

A Rare Case of Anchor Fracture Manifesting with New ‐Onset Neuropathic Pain after Spinal Cord Stimulator Implantation
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 7, 2021 Category: Biotechnology Authors: Ryan S. D'Souza, Christine L. Hunt Tags: Clinical Letter Source Type: research

A Rare Case of Anchor Fracture Manifesting with New ?Onset Neuropathic Pain after Spinal Cord Stimulator Implantation
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 6, 2021 Category: Biotechnology Authors: Ryan S. D'Souza, Christine L. Hunt Tags: Clinical Letter Source Type: research

Effects of High ?Voltage Pulsed Radiofrequency on the Ultrastructure and Nav1.7 Level of the Dorsal Root Ganglion in Rats With Spared Nerve Injury
ConclusionsThe HV-PRF produces a better analgesic effect than SV-PRF applied to the DRG in SNI rats. The underlying mechanisms may be associated with improving the histopathological prognosis and the downregulation of Nav1.7 levels in the DRG. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 6, 2021 Category: Biotechnology Authors: Zhisen Dai, Xueru Xu, Yanqin Chen, Chun Lin, Fan Lin, Rongguo Liu Tags: Basic Research Source Type: research