Healthy Volunteers Immediately Adapt to Submental Stimulation During Swallowing
AbstractObjectivesTranscutaneous stimulation above and below the hyoid is used to assist patients with swallowing disorders (dysphagia) but has shown different effects. Previously, infrahyoid transcutaneous stimulation lowered the hyoid and larynx resisting swallowing movement while suprahyoid stimulation had no effects on hyolaryngeal movement either at rest or during swallowing. More recently, large submental electrodes, covering the submental region, are used for swallowing therapy in combination with resistance therapy. To gain insight into the effects of these electrodes on movement during swallowing, we studied healt...
Source: Neuromodulation: Technology at the Neural Interface - September 30, 2021 Category: Biotechnology Authors: Mohammed F. Safi, Sandra Martin, Lincoln Gray, Christy L. Ludlow Tags: Clinical Research Source Type: research

Heart Rate Variability Features as Predictors of Intermittent Theta ‐Burst Stimulation Response in Posttraumatic Stress Disorder
ConclusionsOur findings indicate that autonomic activity is a potential low-cost and technically simple predictive biomarker of iTBS response in PTSD. Less autonomic dysfunction was associated with superior clinical improvements with iTBS. Future studies might consider HRV acquisition during iTBS, as well as prospective testing of these findings in patients with elevated hyperarousal. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 27, 2021 Category: Biotechnology Authors: Camila Cosmo, Antonia V. Seligowski, Emily M. Aiken, Mascha van't Wout ‐Frank, Noah S. Philip Tags: Clinical Research Source Type: research

Five ‐Session Dual‐Transcranial Direct Current Stimulation With Task‐Specific Training Does Not Improve Gait and Lower Limb Performance Over Training Alone in Subacute Stroke: A Pilot Randomized Controlled Trial
ConclusionThe combined intervention showed no benefit over training alone in improving gait variables and lower-limb performance. However, some performances were saturated at some point, as moderate to high function participants were recruited in the present study. Future studies should consider recruiting participants with more varied motor impairment levels and may need to determine the optimal stimulation protocols and parameters to improve gait and lower-limb performance. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 21, 2021 Category: Biotechnology Authors: Benchaporn Aneksan, Montawan Sawatdipan, Sunee Bovonsunthonchai, Jarugool Tretriluxana, Roongtiwa Vachalathiti, Paradee Auvichayapat, Anuchai Pheungphrarattanatrai, Pagamas Piriyaprasarth, Wanalee Klomjai Tags: Clinical Research Source Type: research

Sacral Neuromodulation Changes Pelvic Floor Activity in Overactive Bladder Patients —Possible New Insights in Mechanism of Action: A Pilot Study
AbstractObjectivesTo evaluate if electrodiagnostic tools can advance the understanding in the effect of sacral neuromodulation (SNM) on pelvic floor activity, more specifically if SNM induces changes in pelvic floor muscle (PFM) contraction.Materials and MethodsSingle tertiary center, prospective study (October 2017 –May 2018) including patients with overactive bladder syndrome undergoing SNM. Electromyography of the PFM was recorded using the Multiple Array Probe Leiden. The procedure consisted of consecutive stimulations of the lead electrodes with increasing intensity (1–3, 5, 7, 10 V). Recordings were ...
Source: Neuromodulation: Technology at the Neural Interface - September 21, 2021 Category: Biotechnology Authors: Jeroen Voorham, Donald Vagan ée, Petra Voorham‐van der Zalm, Guus Lycklama à Nijeholt, Hein Putter, Stefan De Wachter Tags: Clinical Research Source Type: research

Cognitive Outcome After Deep Brain Stimulation for Refractory Obsessive –Compulsive Disorder: A Systematic Review
ConclusionAlthough individual studies generally do not report cognitive deterioration after DBS for OCD, the variability of study designs and the multitude of cognitive measures used, precluded a meta-analysis to confirm its safety, and recognition of a cognitive pattern through which the efficacy of DBS for OCD might be explained. In future, prospective studies should preferably include a standardized neuropsychological assessment battery specifically addressing executive functioning and have a longer-term follow-up in order to demonstrate the cognitive safety of the procedure. Such prospective and more uniform data colle...
Source: Neuromodulation: Technology at the Neural Interface - September 21, 2021 Category: Biotechnology Authors: Tim A. M. Bouwens van der Vlis, Annelien Duits, M égan M. G. H. Veerdonk, Anne E. P. Mulders, Koen R. J. Schruers, Yasin Temel, Linda Ackermans, Albert F. G. Leentjens Tags: Review Article Source Type: research

Intrathecal Drug Delivery for the Treatment of Cancer ‐Associated Chronic Pain in Children
ConclusionsThere exist children with cancer whose pain is refractory to the standard approaches and may benefit from IT drug delivery. The existing data, although limited and of low tier evidence, suggest that IT drug delivery has been effective in the pediatric cancer population. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 15, 2021 Category: Biotechnology Authors: Meaghan Kenfield, Nicholas Zacharias, Alaa Abd ‐Elsayed Tags: Review Article Source Type: research

Thalamic Deep Brain Stimulation May Improve Restless Legs Syndrome in Patients With Essential Tremor
ConclusionsWe report for the first time improvement of RLS in patients with ET after bilateral thalamic DBS. Although many ET patients with nonrechargeable DBS systems switch off their stimulator at night to conserve battery life, those with RLS may potentially benefit from keeping their stimulator ON at night to relieve their RLS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 14, 2021 Category: Biotechnology Authors: Virgilio Gerald H. Evidente, Danica H. Evidente, Francisco A. Ponce, Maris H. Evidente, Margaret Lambert, Robin Garrett Tags: Clinical Research Source Type: research

Cortical, Spinal, Sacral, and Peripheral Neuromodulations as Therapeutic Approaches for the Treatment of Lower Urinary Tract Symptoms in Multiple Sclerosis Patients: A Review
DiscussionPTNS and SNM seem to be effective and safe therapeutic options for treating lower urinary tract symptoms in MS patients principally in case of overactive bladder (OAB) symptoms. Similarly, also SCS and TMS have been shown to be effective, despite the very limited number of patients and the small number of studies found in the literature. Interestingly, these techniques are effective even in patients who do not respond well to conservative therapies, such as anticholinergics. Furthermore, given their safety and efficacy, stimulations such as PTNS could be considered as a first-line treatment for OAB in MS patients...
Source: Neuromodulation: Technology at the Neural Interface - September 9, 2021 Category: Biotechnology Authors: Martina Pericolini, Gabriel Miget, Claire Hentzen, Enrico Finazzi Agr ò, Camille Chesnel, Philippe Lagnau, Rebecca Haddad, Matthieu Grasland, Gerard Amarenco Tags: Review Article Source Type: research

Factors Contributing to Spinal Cord Stimulation Outcomes for Chronic Pain
ConclusionsPatient outcome was associated with diagnosis, postimplantation falls, and device manufacturer. Further investigation is recommended to confirm associations through prospective studies that can more accurately quantify patient outcome over longer periods. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 8, 2021 Category: Biotechnology Authors: Dakota T. Graham, Margaret Lambert, Zaman Mirzadeh, Francisco A. Ponce Tags: Clinical Research Source Type: research

The Intraoperative Microlesion Effect Positively Correlates With the Short ‐Term Clinical Effect of Deep Brain Stimulation in Parkinson's Disease
The objective of this study was to determine the correlation between the intraoperative MLE and the clinical effect of DBS.Materials and MethodsThirty Parkinson's disease (PD) patients with Movement Disorder Society (MDS) Unified Parkinson's Disease Rating Scale (UPDRS) part III (MDS-UPDRS III) scores during bilateral STN-DBS implantation were included in this retrospective study. MDS-UPDRS III subscores (resting tremor, rigidity, and bradykinesia) of the contralateral upper extremity were used. During surgery, these subscores were assessed directly before and after insertion of the electrode. Also, these subscores were de...
Source: Neuromodulation: Technology at the Neural Interface - September 8, 2021 Category: Biotechnology Authors: St èfan F. Lange, Naomi I. Kremer, Teus van Laar, Fiete Lange, T. Elien Steendam‐Oldekamp, D. L. Marinus Oterdoom, Anthony R. Absalom, J. Marc C. van Dijk, Gea Drost Tags: Clinical Research Source Type: research

A Case Series of Neuropsychological Outcome After Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Refractory Obsessive –Compulsive Disorder
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 7, 2021 Category: Biotechnology Authors: Tim A. M. Bouwens van der Vlis, Annelien A. Duits Tags: Clinical Letter Source Type: research

A Rare Case of Anchor Fracture Manifesting with New ‐Onset Neuropathic Pain after Spinal Cord Stimulator Implantation
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 7, 2021 Category: Biotechnology Authors: Ryan S. D'Souza, Christine L. Hunt Tags: Clinical Letter Source Type: research

Effects of High ‐Voltage Pulsed Radiofrequency on the Ultrastructure and Nav1.7 Level of the Dorsal Root Ganglion in Rats With Spared Nerve Injury
AbstractObjectivesTo investigate the analgesic effect of high-voltage pulsed radiofrequency (HV-PRF) on the dorsal root ganglion (DRG) for neuropathic pain induced by spared nerve injury (SNI) in rats, especially the influence of this treatment on the DRG ultrastructure and voltage-gated sodium channel 1.7 (Nav1.7) level in the DRG.Materials and MethodsOne hundred fifty adult male Sprague-Dawley rats were randomly divided into five groups: Sham, SNI, Free-PRF, standard-voltage PRF (SV-PRF), and HV-PRF. The 45V-PRF and 85V-PRF procedures applied to the left L5 DRG were performed in SV-PRF group and the HV-PRF group respecti...
Source: Neuromodulation: Technology at the Neural Interface - September 6, 2021 Category: Biotechnology Authors: Zhisen Dai, Xueru Xu, Yanqin Chen, Chun Lin, Fan Lin, Rongguo Liu Tags: Basic Research Source Type: research

A Comprehensive Review of Vagus Nerve Stimulation for Depression
ConclusionsThe mood effects of VNS were discovered from clinical trials investigating the use of VNS for reducing seizures in epileptic patients. Since then, VNS has gone on to be FDA approved for depression. The field of VNS is growing, and as noninvasive VNS quickly advances, it is important to consider a historical perspective to develop future brain stimulation therapies. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 6, 2021 Category: Biotechnology Authors: Christopher W. Austelle, Georgia H. O'Leary, Sean Thompson, Elise Gruber, Alex Kahn, Andrew J. Manett, Baron Short, Bashar W. Badran Tags: Review Article Source Type: research

Pulsed Electromagnetic Fields: A Novel Attractive Therapeutic Opportunity for Neuroprotection After Acute Cerebral Ischemia
ConclusionsAltogether, these data demonstrate the efficacy of PEMFs against several mechanisms underlying ischemic damage and suggest that PEMFs might represent a novel noninvasive adjunctive treatment for acute ischemic stroke, providing neuroprotection and reducing functional deficits following ischemia. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 5, 2021 Category: Biotechnology Authors: Fioravante Capone, Simona Salati, Fabrizio Vincenzi, Micaela Liberti, Giorgio Aicardi, Francesca Apollonio, Katia Varani, Ruggero Cadossi, Vincenzo Di Lazzaro Tags: Review Article Source Type: research

Low Intensity Focused Ultrasound Increases Duration of Anti ‐Nociceptive Responses in Female Common Peroneal Nerve Injury Rats
AbstractObjectiveChronic pain affects 7% –10% of Americans, occurs more frequently and severely in females, and available treatments have been shown to have less efficacy in female patients. Preclinical models addressing sex-specific treatment differences in the treatment of chronic pain have been limited. Here we examine the sex-specifi c effects of low intensity focused ultrasound (liFUS) in a modified sciatic nerve injury (SNI) model.Materials and MethodsA modified SNI performed by ligating the common peroneal nerve (CPN) was used to measure sensory, behavioral pain responses, and nerve conduction studies in femal...
Source: Neuromodulation: Technology at the Neural Interface - September 3, 2021 Category: Biotechnology Authors: Andrea Liss, Abigail Hellman, Vraj J. Patel, Teresa Maietta, Kanakaharini Byraju, Rachel Trowbridge, Jenica Acheta, Drishti Panse, Adithya Srikanthan, Paul Neubauer, Clif Burdette, Goutam Ghoshal, Emery Williams, Jiang Qian, Julie G. Pilitsi Tags: Basic Research Source Type: research

Calendar of Events
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 28, 2021 Category: Biotechnology Tags: Professional Development Source Type: research

Table of Contents
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 28, 2021 Category: Biotechnology Tags: Issue Information – Table of Contents Source Type: research

Aims and Scope
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 28, 2021 Category: Biotechnology Tags: Issue Information – Aims and Scope Source Type: research

Editorial Board
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 28, 2021 Category: Biotechnology Tags: Issue Information – Editorial Board Source Type: research

Peripheral Nerve Stimulation for Treatment of Severe Refractory Upper Extremity Post ‐Amputation Pain
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 28, 2021 Category: Biotechnology Authors: Michael J. Jung, Scott G. Pritzlaff Tags: Letter to the Editor Source Type: research

Scope for Vagus Nerve Stimulation in Traumatic Brain Injury
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 28, 2021 Category: Biotechnology Authors: Ashwin Kumaria, Christos M. Tolias Tags: Letter to the Editor Source Type: research

A Longitudinal Approach to Stimulation at the C2 ‐3 Medial Branches Over Lamina to Relieve Occipital Neuralgia: Case Report
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 28, 2021 Category: Biotechnology Authors: Anna Woodbury Tags: Letter To The Editor Source Type: research

The Predictive Value of Transcutaneous Electrical Nerve Stimulation for Patient Selection in Peripheral Nerve Field Stimulation for Chronic Low Back Pain: A Prospective Study
ConclusionTENS can be predictive for patient selection in PNFS, as TENS positive patients showed significant correlation with a positive PNFS trial period. Therefore, TENS positive patients might be justifiable to be directly implanted with leads and IPG. TENS positive patients further tend to show a better improvement in the follow-up. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 28, 2021 Category: Biotechnology Authors: Frank Patrick Schwarm, Marc Ott, Jasmin Nagl, Michael Bender, Marco Stein, Eberhard Uhl, Hagen Maxeiner, Malgorzata A. Kolodziej Tags: Clinical Research Source Type: research

Short ‐Term Peripheral Nerve Stimulation Relieve Pain for Elder Herpes Zoster Ophthalmicus Patients: A Retrospective Study
AbstractObjectiveOphthalmic postherpetic neuralgia (PHN) is the final stage of herpes zoster (HZ) ophthalmicus and a severe refractory neuropathic pain, thus there is no curative treatment that could alleviate pain and reduce the incidence of ophthalmic PHN now. The purpose of this study is to evaluate therapeutic efficacy of short-term peripheral nerve stimulation (PNS) for elder patients with HZ ophthalmicus.Materials and MethodsWe performed a retrospective study from March 2015 to August 2019 in our pain department. All the HZ ophthalmicus patients underwent supraorbital nerve short-term PNS were included. The patients'...
Source: Neuromodulation: Technology at the Neural Interface - August 28, 2021 Category: Biotechnology Authors: Cheng ‐fu Wan, Tao Song Tags: Clinical Research Source Type: research

Pudendal Nerve Block by Low ‐Frequency (≤1 kHz) Biphasic Electrical Stimulation
AbstractObjectivesTo test the hypothesis that poststimulation block of nerve conduction can be achieved by low-frequency ( ≤1 kHz) biphasic stimulation (LFBS).Materials and MethodsA tripolar cuff electrode was placed around the pudendal nerve in cats to deliver LFBS (1  kHz, 500 Hz, and 100 Hz). Two bipolar hook electrodes were placed central and distal to the cuff electrode to induce external urethral sphincter (EUS) contractions. A catheter was inserted into the urethra to record EUS contraction pressure. Pudendal nerve block by LFBS was confirmed by the fail ure of the central hook electrode stimu...
Source: Neuromodulation: Technology at the Neural Interface - August 28, 2021 Category: Biotechnology Authors: Katherine Shapiro, Wenbin Guo, Kody Armann, Natalie Pace, Bing Shen, Jicheng Wang, Jonathan Beckel, William Groat, Changfeng Tai Tags: Basic Research Source Type: research

Long ‐Term Outcomes of Occipital Nerve Stimulation for New Daily Persistent Headache With Migrainous Features
ConclusionOur experience suggests that ONS is not effective in the treatment of NDPH with migrainous features even in centers with experience in treating chronic migraine with ONS. The difference in response rates of chronic migraine and NDPH with migrainous features supports the concept of a different pathophysiology to the two conditions. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 28, 2021 Category: Biotechnology Authors: Susie Lagrata, Sanjay Cheema, Laurence Watkins, Manjit Matharu Tags: Clinical Research Source Type: research

Impact of Cardiac ‐Based Vagus Nerve Stimulation Closed‐Loop Stimulation on the Seizure Outcome of Patients With Generalized Epilepsy: A Prospective, Individual‐Control Study
AbstractObjectivesWe designed a prospective, individual-controlled study to evaluate the effect of cardiac-based VNS (cbVNS) in a cohort of patients with generalized epilepsy (GE).Materials and MethodsTwenty patients were included. They were followed up for six  months under regular VNS (rVNS) and subsequently for six months during cbVNS. Stimulation parameters were 500 μsec, 30 Hz, and up to 2.5 mA. Seizure frequency was documented after two, four, and six months during the rVNS and cbVNS phases. Patients with at least 50% seizure frequency r eduction were considered responders...
Source: Neuromodulation: Technology at the Neural Interface - August 28, 2021 Category: Biotechnology Authors: Arthur Cukiert, Cristine Mella Cukiert, Pedro Paulo Mariani, Jose Augusto Burattini Tags: Clinical Research Source Type: research

Reassessment of the Effect of Transcutaneous Auricular Vagus Nerve Stimulation Using a Novel Burst Paradigm on Cardiac Autonomic Function in Healthy Young Adults
ConclusionThe burst parameter could be used as an alternative strategy for regulating cardiac parasympathetic function by taVNS, which has the potential to be used as a complementary paradigm to traditional tonic taVNS for promoting clinical treatment efficacy. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 27, 2021 Category: Biotechnology Authors: Lin ‐Lin Shen, Jin‐Bo Sun, Xue‐Juan Yang, Hui Deng, Wei Qin, Meng‐Yu Du, Ling‐Xia Meng, Nan Li, Xiao‐Yu Guo, Wen‐Zhou Qiao, Wei‐Qi Yang, Peng Liu, Xiao Zeng Tags: Basic Research Source Type: research

Role of Microelectrode Recording in Deep Brain Stimulation of  the Pedunculopontine Nucleus: A Physiological Study of Two Cases
ConclusionsEstimation of stimulation site within the PPN is possible by combining physiological guidance using MER and MRI findings. The PPN is a potential target for gait disturbances, although the efficacy of PPN DBS may depend on the location of the electrode and the stimulation parameters. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 26, 2021 Category: Biotechnology Authors: Takehiro Yako, Kazuo Kitazawa, Shigeaki Kobayashi, Shoji Yomo, Hiromasa Sato, Luke A. Johnson, Jerrold L. Vitek, Takao Hashimoto Tags: Clinical Research Source Type: research

Cross ‐Country Differences in Pain Medication Before and After Spinal Cord Stimulation: A Pooled Analysis of Individual Patient Data From Two Prospective Studies in the United Kingdom and Belgium
ConclusionsOur combined analysis revealed differences in prescription practice in patients scheduled for SCS implantation between Belgium and United Kingdom. NSAIDs and neuropathic mood agents are more frequently used in the United Kingdom, presumably due to easier access to repeat prescriptions and over the counter medications. After three  months of SCS, a decrease in medication use is observed in both countries, with higher reductions in Belgium, presumably due to strict regulations concerning reimbursement criteria. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 25, 2021 Category: Biotechnology Authors: Lisa Goudman, Rui V. Duarte, Ann De Smedt, Sue Copley, Sam Eldabe, Maarten Moens Tags: Clinical Research Source Type: research

Systematic Literature Review of Spinal Cord Stimulation in Patients With Chronic Back Pain Without Prior Spine Surgery
ConclusionFindings suggest that SCS is a promising, safe, minimally invasive, and reversible alternative option for managing chronic back pain in patients who have not undergone spinal surgery. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 19, 2021 Category: Biotechnology Authors: Jan M. Eckermann, Julie G. Pilitsis, Christopher Vannaboutathong, Belinda J. Wagner, Rose Province ‐Azalde, Markus A. Bendel Tags: Review Article Source Type: research

Local Field Potential ‐Based Programming: A Proof‐of‐Concept Pilot Study
ConclusionsThe approach presented in this pilot proof-of-concept study may inform and streamline the DBS programming for conditions requiring clinicians and patients to wait weeks before appreciating any clinical benefit. Prospective studies on larger samples of patients are warranted. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 18, 2021 Category: Biotechnology Authors: Alfonso Fasano, Carolina Gorodetsky, Darcia Paul, J ürgen Germann, Aaron Loh, Han Yan, Peter L. Carlen, Sara Breitbart, Andres M. Lozano, George M. Ibrahim, Suneil K. Kalia Tags: Clinical Research Source Type: research

Efficacy of Transcutaneous Electrical Nerve Stimulation and Interferential Current on Tactile Acuity of Individuals With Nonspecific Chronic Low Back Pain
AbstractObjectivesTranscutaneous electrical nerve stimulation (TENS) and interferential currents (IFC) are pain electrotherapies with questioned efficacy. Studies of their effects on tactile acuity of individuals with nonspecific chronic low back pain (NSCLBP) are limited, hence, this study.Materials and MethodsThirty-three individuals with NSCLBP randomly allocated into three groups completed this study. Data collected from participants included age, gender, and anthropometric characteristics of height, weight, body mass index, and percentage body fat measured with standard instruments. Also, participants' tactile acuity,...
Source: Neuromodulation: Technology at the Neural Interface - August 18, 2021 Category: Biotechnology Authors: Bosede Abidemi Tella, Saturday Nicholas Oghumu, Caleb Ademola Omuwa Gbiri Tags: Clinical Research Source Type: research

Combining Trauma Script Exposure With rTMS to Reduce Symptoms of Post ‐Traumatic Stress Disorder: Randomized Controlled Trial
ConclusionWe found no evidence of difference in clinical improvement or remission rates between the 110% HF and 70% LF stimulation. These findings may reflect the importance of exposure procedure and that larger number of participants is needed. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 17, 2021 Category: Biotechnology Authors: Sarah Thierr ée, Marie Raulin‐Briot, Marc Legrand, Amélie Le Gouge, Alexis Vancappel, Andrei‐Cristian Tudorache, Bruno Brizard, David Clarys, Agnès Caille, Wissam El‐Hage Tags: Clinical Research Source Type: research

Short ‐ and Long‐Term Response of Vagus Nerve Stimulation Therapy in Drug‐Resistant Epilepsy: A Systematic Review and Meta‐Analysis
ConclusionsThe estimating of efficacy and tolerability, using data from the existing literature, indicated VNS therapy is a safe and effective treatment option for patients with DRE. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 15, 2021 Category: Biotechnology Authors: Hongliang Mao, Yonghao Chen, Qintao Ge, Lei Ye, Hongwei Cheng Tags: Review Article Source Type: research

Preoperative Thoracic Spine Magnetic Resonance Imaging for Spinal Cord Stimulation: Should Such a Recommendation Be an Absolute Requirement?
ConclusionsThis is the largest case series assessing the impact of preoperative thoracic MRI on surgical planning for patients undergoing paddle SCS placement. Twenty-two percent of patients had MRI findings that impacted surgical planning with 3% requiring additional surgical decompression for safe paddle lead placement. Without advanced imaging to inform surgical planning, unnecessary risk may have been placed on these patients. Although such imaging has been recommended by consensus committees in published guidelines, our study is the first to present a large institutional experience of real-world data that demonstrates...
Source: Neuromodulation: Technology at the Neural Interface - August 12, 2021 Category: Biotechnology Authors: Benjamin J. Best, Mokshal H. Porwal, Peter A. Pahapill Tags: Clinical Research Source Type: research

Optogenetic Neuromodulation of the Urinary Bladder
ConclusionOptogenetics offers a powerful tool to investigate the neural circuit of bladder storage and voiding and provides a promising approach for manipulating neurons and muscles. It is possible to achieve coordinated modulation of the bladder and its sphincter through a “closed-loop” system. Optogenetics neuromodulation could also be applied in urinary bladder control in the clinic in the future. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 11, 2021 Category: Biotechnology Authors: Zhonghan Zhou, Limin Liao Tags: Review Article Source Type: research

Initial Intrathecal Dose Titration and Predictors of Early Dose Escalation in Patients With Cancer Using a 100:1 Oral to Intrathecal Morphine Conversion Ratio
ConclusionsAn oral-to-intrathecal morphine conversion ratio of approximately 100:1 for initiation of IDD in patients with cancer pain was safe and well  tolerated and may facilitate rapid elimination of systemic opioids. Dose reduction was rare, while a majority of patients required further dose escalation prior to discharge. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 10, 2021 Category: Biotechnology Authors: Jill E. Sindt, Daniel W. Odell, Rayhan Tariq, Angela P. Presson, Chong Zhang, Shane E. Brogan Tags: Clinical Research Source Type: research

A Randomized, Sham ‐Controlled Trial of Repetitive Transcranial Magnetic Stimulation Targeting M1 and S2 in Central Poststroke Pain: A Pilot Trial
ConclusionsS2 is a promising nrTMS target in the treatment of CPSP. TheDRD2 T/T genotype might be a biomarker for M1 nrTMS response, but this needs confirmation from a larger study. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 9, 2021 Category: Biotechnology Authors: Juhani Ojala, Jukka Vanhanen, Hanna Harno, Pantelis Lioumis, Selja Vaalto, Mari A. Kaunisto, Jukka Putaala, Marko Kangasniemi, Erika Kirveskari, Jyrki P. M äkelä, Eija Kalso Tags: Clinical Research Source Type: research

Long ‐Term Changes in Thecal Sac Compression and Decreased Cerebrospinal Fluid Space Following Paddle Lead Spinal Cord Stimulation at T9: A Long‐Term Follow‐Up via Three‐Dimensional Myelographic Computed Tomography
ConclusionsSignificant early reduction and late partial restoration occurred in the thecal sac and spinal cord and the width of the anterior and posterior CSF spaces in the T9 5-column paddle lead SCS. Thecal sac compromise was expected to some extent after paddle lead implantation, but the degree is significant, and the cross-sectional area of the spinal cord as well as the thecal sac is affected. Fortunately, these anatomical changes did not cause any clinical problems except for intercostal root irritation. The shape and flat contours of the five-column paddle leads clearly affected the results. (Source: Neuromodulation...
Source: Neuromodulation: Technology at the Neural Interface - August 9, 2021 Category: Biotechnology Authors: Sanghyuk Im, Byung ‐chul Son Tags: Clinical Research Source Type: research

Using Extracochlear Multichannel Electrical Stimulation to Relieve Tinnitus and Reverse Tinnitus ‐Related Auditory‐Somatosensory Plasticity in the Cochlear Nucleus
ConclusionsThis study demonstrated that the novel EES strategy could effectively relieve tinnitus without impairment to hearing and cochlear structure of tinnitus animals. The reversal of tinnitus-related auditory-somatosensory plasticity in the cochlear nucleus was correlated with the tinnitus relief induced by the EES. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 4, 2021 Category: Biotechnology Authors: Min Chen, Shiyao Min, Chen Zhang, Xuerui Hu, Shufeng Li Tags: Basic Research Source Type: research

Percutaneous Neuromodulation of the Brachial Plexus and Sciatic Nerve for the Treatment of Acute Pain Following Surgery: Secondary Outcomes From a Multicenter, Randomized, Controlled Pilot Study
AbstractObjectivesWe recently reported that percutaneous peripheral nerve stimulation (PNS or “neuromodulation”) decreased pain and opioid consumption within the first two weeks following ambulatory surgery. However, the anatomic lead locations were combined for the analysis, and benefits for each location remain unknown. We therefore now report the effects of percutaneous PNS for brac hial plexus and sciatic nerve leads separately.Materials and MethodsBefore surgery, leads were implanted percutaneously to target the brachial plexus (N = 21) for rotator cuff repair or sciatic nerve (N =&nb...
Source: Neuromodulation: Technology at the Neural Interface - August 3, 2021 Category: Biotechnology Authors: Brian M. Ilfeld, Anthony Plunkett, Alice M. Vijjeswarapu, Robert Hackworth, Sandeep Dhanjal, Alparslan Turan, Steven P. Cohen, James C. Eisenach, Scott Griffith, Steven Hanling, Daniel I. Sessler, Edward J. Mascha, Yanyan Han, Joseph W. Boggs Tags: Clinical Research Source Type: research

Glucocorticoid Receptor Contributes to Electroacupuncture ‐Induced Analgesia by Inhibiting Nav1.7 Expression in Rats With Inflammatory Pain Induced by Complete Freund's Adjuvant
ConclusionsThe present study demonstrated that EA exerted anti-hyperalgesic effects by inhibiting GR expression, which led to Nav1.7 expression modulation in the rat model of CFA-induced inflammatory pain. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 2, 2021 Category: Biotechnology Authors: Huiying Luo, Yidan Zhang, Jingjing Zhang, Jinping Shao, Xiuhua Ren, Weidong Zang, Jing Cao, Bo Xu Tags: Basic Research Source Type: research

Pallidal and Cortical Oscillations in Freely Moving Patients With Dystonia
ConclusionsNeck/upper limbs voluntary movements and gait suppressed the GPi-LFPs —cortical-EEG coherence and differently impacted both EEG and LFPs low frequency activity. These findings suggest a selective modulation of the cortico-basal ganglia network activity in dystonia. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 31, 2021 Category: Biotechnology Authors: Alberto Averna, Mattia Arlotti, Manuela Rosa, St éphan Chabardès, Eric Seigneuret, Alberto Priori, Elena Moro, Sara Meoni Tags: Clinical Research Source Type: research

Use of Spinal Cord Stimulators in Patients With Pacemakers or Implantable Cardiac Defibrillators: A Review of Documented Accounts of Interference
ConclusionsInterference between cardiac devices and SCSs is a rare occurrence. As there are currently no published guidelines, devices should be interrogated on a case-by-case basis in the SCS trial period (if implanted after cardiac device), during permanent implantation, and during scheduled follow-up visits. Peri-operative testing should include increasing the SCS settings to maximally tolerated levels with cardiac device set at its maximum sensitivity. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 30, 2021 Category: Biotechnology Authors: Joshua Manuel Martens, Kenneth Fiala, Christopher Glover, Nicholas Zacharias, Alaa Abd ‐Elsayed Tags: Review Article Source Type: research

Ultra ‐Low Energy Cycled Burst Spinal Cord Stimulation Yields Robust Outcomes in Pain, Function, and Affective Domains: A Subanalysis From Two Prospective, Multicenter, International Clinical Trials
DiscussionIntermittent cycling of burst SCS lowers the overall electric charge delivered to the spinal cord and preserves battery consumption, without compromising pain relief and associated symptoms. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 28, 2021 Category: Biotechnology Authors: Timothy Deer, Derron Wilson, David Schultz, Steven Falowski, Ed Tavel, Gregory Moore, Robert Heros, Denis Patterson, Marie Fahey, Robyn Capobianco, Magdalena Anitescu Tags: Clinical Research Source Type: research

Deep Brain Stimulation of Caudal Zona Incerta for Parkinson's Disease: One ‐Year Follow‐Up and Electric Field Simulations
We report the one-year results of bilateral cZi-DBS in 15 patients with PD. Patients were evaluated on/off medication and stimulation using the Unified Parkinson's Disease Rating Scale (UPDRS). Main outcomes were changes in motor symptoms (UPDRS-III) and quality of life according to Parkinson's Disease Questionnaire-39 (PDQ-39). Secondary outcomes included efficacy profile according to sub-items of UPDRS-III, and simulation of the electric field distribution around the DBS lead using the finite element method. Simulations from all patients were transformed to one common magnetic resonance imaging template space for creatio...
Source: Neuromodulation: Technology at the Neural Interface - July 27, 2021 Category: Biotechnology Authors: Rasmus Stenmark Persson, Teresa Nordin, Gun ‐Marie Hariz, Karin Wårdell, Lars Forsgren, Marwan Hariz, Patric Blomstedt Tags: Clinical Research Source Type: research

Wireless Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Trigeminal Pain: A Single Center Experience
ConclusionThe partially implantable sTNFS device seems to be safe, effective, and reliable. Compared to conventional devices, the equipment is not limited to the length of trial stimulation. Furthermore, the daily stimulation duration was much shorter compared to previous reports. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 27, 2021 Category: Biotechnology Authors: Mohammad Mehdi Hajiabadi, Martin Jakobs, Andreas Unterberg, Rezvan Ahmadi Tags: Clinical Research Source Type: research

Stability and Effect of Parkinsonian State on Deep Brain Stimulation Cortical Evoked Potentials
AbstractObjectivesTo characterize and compare the stability of cortical potentials evoked by deep brain stimulation (DBS) of the subthalamic nucleus (STN) across the na ïve, parkinsonian, and pharmacologically treated parkinsonian states. To advance cortical potentials as possible biomarkers for DBS programming.Materials and MethodsSerial electrocorticographic (ECoG) recordings were made more than nine months from a single non-human primate instrumented with bilateral ECoG grids spanning anterior parietal to prefrontal cortex. Cortical evoked potentials (CEPs) were generated through time-lock averaging of the ECoG rec...
Source: Neuromodulation: Technology at the Neural Interface - July 27, 2021 Category: Biotechnology Authors: Brett A. Campbell, Hanbin Cho, Riley M. Faulhammer, Olivia Hogue, Jenny Peih ‐Chir Tsai, M. Shazam Hussain, Andre G. Machado, Kenneth B. Baker Tags: Basic Research Source Type: research