A Review of the Evidence and Current Applications of Portable Translingual Neurostimulation Technology
ConclusionsTLNS is a promising treatment modality for various chronic neurological conditions that are often refractory to conventional therapy. However, TLNS technology remains largely investigational as high-quality RCTs are still required to elucidate efficacy, optimal dosages, necessary treatment durations, and treatment durability. Further research to develop an appropriate control group is needed for scientifically valid comparisons of TLNS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Dion Diep, Andrew C. L. Lam, Gordon Ko Tags: Review Article Source Type: research

Explantation Rates of High Frequency Spinal Cord Stimulation in Two Outpatient Clinics
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Tags: Corrigendum Source Type: research

Calendar of Events
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Tags: Professional Development Source Type: research

Table of Contents
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Tags: Issue Information – Table of Contents Source Type: research

Aims and Scope
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Tags: Issue Information – Aims and Scope Source Type: research

Editorial Board
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Tags: Issue Information – Editorial Board Source Type: research

Examining the Need to Standardize Implanted Stimulator Connectors: NANS Survey Results
ConclusionThose who responded to our survey support the development of standard connectors for implanted stimulators, with voluntary compliance by manufacturers, to mitigate the need for adapters and facilitate interchanging components when appropriate. Other advantages to patients and manufacturers might accrue from the adoption of standards, as technology evolves and diversifies. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Richard B. North, Peter E. Konrad, Jack W. Judy, Andrew J. Ries, Robert Stevenson Tags: Case Series Source Type: research

Response to “Negative Results Call for More Delicate Experimental Design in Cortical Excitability Change of taVNS Intervention”
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Ann Mertens, Kristl Vonck Tags: Letter to the Editor Source Type: research

A Prospective, Multicenter Study to Assess the Safety and Efficacy of Translingual Neurostimulation Plus Physical Therapy for the Treatment of a Chronic Balance Deficit Due to Mild ‐to‐Moderate Traumatic Brain Injury
This study was designed to assess the safety and efficacy of TLNS plus targeted physical therapy (PT) in people with a chronic balance deficit after mild-to-moderate traumatic brain injury (mmTBI).Materials and MethodsThis international, multicenter, randomized study enrolled 122 participants with a chronic balance deficit who had undergone PT following an mmTBI and had plateaued in recovery. Randomized participants received PT plus either high-frequency pulse (HFP;n = 59) or low-frequency pulse (LFP;n = 63) TLNS. The primary efficacy and safety endpoints were the proportion of sensory organization test...
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Alain Ptito, Linda Papa, Kenton Gregory, Robert L. Folmer, William C. Walker, Vivek Prabhakaran, Rima Wardini, Kim Skinner, Michael Yochelson Tags: Clinical Research Source Type: research

Behavioral Survey of Effects of Pulsed Radiofrequency on Neuropathic and Nociceptive Pain in Rats: Treatment Profile and Device Implantation
ConclusionsPRF temporarily attenuates neuropathic and inflammatory pain. Bipolar PRF generates significant analgesia with a much lower electrical power than unipolar PRF. Meanwhile, the minor variant effects between PRF-DRG and PRF-SN may indicate distinct mechanisms. The sustained-analgesia by repetitive treatments suggests implantation technique could be a promising choice. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Ren ‐Yu Huang, Lawrence Poree, Kok‐Yuen Ho, Shih‐Ying Tsai, Yu‐Chen Liu, Ping‐Heng Tan, Yeong‐Ray Wen Tags: Basic Research Source Type: research

Annual Number of Spinal Cord Stimulation Procedures Performed in the State of Florida During 2018: Implications for Establishing Neuromodulation Centers of Excellence
ObjectiveTo assess the volume of spinal cord stimulation procedures performed by physicians in the state of Florida in 2018.Materials and MethodsWe obtained information from publicly available state databases for all patients undergoing procedures in 2018 at Florida hospitals, hospital-owned facilities, and independent ambulatory surgery centers. Cases in which a spinal cord stimulation procedure was performed were identified. We estimated for each physician office-based spinal cord stimulation trials (not subject to state reporting) based on the published Florida conversion factor of 25.6% of the total number of such proc...
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Richard H. Epstein, Franklin Dexter, Edward M. Podgorski, Amy C. S. Pearson Tags: Clinical Research Source Type: research

Conscious Sedation Using Dexmedetomidine During Surgical Paddle Lead Placement Improves Outcome in Spinal Cord Stimulation: A Case Series of 25 Consecutive Patients
ConclusionsImplantation of spinal cord stimulation electrodes through a surgical laminectomy using dexmedetomidine is a safe and feasible procedure with adequate comfort for patient and surgeon. This way of working increases the optimal position of the electrode resulting in the most convenient stimulation pattern and avoiding revisions. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Dimitri J. Vanhauwaert, Tim Couvreur, Anneleen Vandebroek, Olivier De Coster, Karel Hanssens Tags: Case Series Source Type: research

Accuracy of Electrode Position in Sphenopalatine Ganglion Stimulation in Correlation With Clinical Efficacy
ConclusionThere was no significant correlation regarding aberrations of lead position from the planned position with clinical outcome. However, this study might be underpowered to detect such a correlation. The closest electrode contact to the vidian canal was in the stimulation area in all but one patient in the final programming. This indicates that, overall, the lead location does play a crucial role in SPG stimulation for cluster headache. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Guilherme S. Piedade, Jan Vesper, Rahel Hoyer, Thomas Klenzner, Philipp J. Slotty Tags: Clinical Research Source Type: research

Input –Output Functions in Human Heads Obtained With Cochlear Implant and Transcranial Electric Stimulation
ConclusionThese results provide a novel objective measure of electric stimulation in the human head, which can help to optimize stimulation parameters that improve neural excitation of deep structures by reducing the influence of current spread.Conflict of InterestThe authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Phillip Tran, Matthew L. Richardson, Fan ‐Gang Zeng Tags: Basic Research Source Type: research

Tissue Temperature Increases by a 10 kHz Spinal Cord Stimulation System: Phantom and Bioheat Model
ConclusionsHeating of spinal tissues by this 10 kHz SCS system theoretically increases quickly with stimulation level and load impedance, while dampened by IPG pulse bandwidth and voltage compliance limitations. If validated in vivo as a mechanism of kHz SCS, bioheat models informed by IPG limitations allow prediction and optimization of temperature changes. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Adantchede L. Zannou, Niranjan Khadka, Mohamad FallahRad, Dennis Q. Truong, Brian H. Kopell, Marom Bikson Tags: Basic Research Source Type: research

Localization of the Sphenopalatine Ganglion Within the Pterygopalatine Fossa on Computed Tomography Angiography —A Potential Role in the Setting of Sphenopalatine Ganglion Microstimulator Implantation
ConclusionsSince localization of SPG on CTAs is feasible and reproducible, it has future clinical potential to aid placement, optimal positioning and individualized programming of the electrode array. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Loizos Siakallis, Steve E. J. Connor Tags: Clinical Research Source Type: research

Implantable Pulse Generator Site May Be Associated With Spinal Cord Stimulation Revision Surgeries
ConclusionAlthough this study found a significant association between IPG site and revision surgeries, the effect of IPG site was not found to be predictive. The IPG site likely influences whether a patient will require revision surgery, but further investigation is required to establish this association. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Shyle H. Mehta, Christian M. Hoelscher, Ashwini D. Sharan, Sara Thalheimer, Chengyuan Wu Tags: Clinical Research Source Type: research

Pulsed Radiofrequency Neuromodulation Contributes to Activation of Platelet ‐Rich Plasma in In Vitro Conditions
ConclusionsWe confirmed that PRF may activate PRP without additional platelet activators. So, a combination of both methods PRF and PRP application may provide a more effective opportunity for tissue regeneration in dentistry, surgery, dermatology, or in orthopedics. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Anna Michno, Zbigniew Kirkor, Ewelina Gojtowska, Marek Suchorzewski, Irmina Śmietańska, Bartosz Baścik Tags: Basic Research Source Type: research

Control of Functional Electrical Stimulation Systems Using Simultaneous Pulse Width, Amplitude, and Frequency Modulations
ConclusionsThe experimental results show that control performance and tracking ability of the joint reference trajectory are improved by using the simultaneous modulation of PW, amplitude, and frequency. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Vahab Nekoukar Tags: Basic Research Source Type: research

Spatial Filtering of Electroencephalography Reduces Artifacts and Enhances Signals Related to Spinal Cord Stimulation (SCS)
ConclusionsEEG spectral analysis combined with spatial filtering allows for a spatially and temporally specific assessment of SCS-related, neuromodulatory EEG activity, and may help to disentangle therapeutic and side effects of SCS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Lars Buentjen, Petya Vicheva, BS Chander, Sophie ‐Antoinette Beccard, Christopher Coutts, Elena Azañón, Max‐Philipp Stenner, Matthias Deliano Tags: Basic Research Source Type: research

Evaluation of the Efficacy of Musical Vibroacupuncture in Pain Relief: A Randomized Controlled Pilot Study
ConclusionsThese results suggest that MVA effectively increased pain tolerance and reduced pain intensity when compared with all groups, although not significant to the VA group. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Augusto Weber, Simon Busbridge, Ricardo Governo Tags: Study Protocol Source Type: research

Response to “Investigating the Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Cortical Excitability in Healthy Males”
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - November 16, 2021 Category: Biotechnology Authors: Minghui Gu, Jiang Xu Tags: Letter to the Editor Source Type: research

Response to: “Single‐Center Retrospective Analysis of Device‐Related Complications Related to Dorsal Root Ganglion Stimulation for Pain Relief in 31 Patients”
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - November 8, 2021 Category: Biotechnology Authors: Kenneth B. Chapman, Noud van Helmond Tags: Letter to the Editor Source Type: research

Potential Value of Electroacupuncture in Alleviating COVID ‐19 by Stimulating Acupuncture Point
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - October 27, 2021 Category: Biotechnology Authors: Xianqiang Yu Tags: Letter to the Editor Source Type: research

Calendar of Events
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - October 22, 2021 Category: Biotechnology Tags: Professional Development Source Type: research

Table of Contents
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - October 22, 2021 Category: Biotechnology Tags: Issue Information – Table of Contents Source Type: research

Aims and Scope
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - October 22, 2021 Category: Biotechnology Tags: Issue Information – Aims and Scope Source Type: research

Editorial Board
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - October 22, 2021 Category: Biotechnology Tags: Issue Information – Editorial Board Source Type: research

Response to: “Wireless Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Trigeminal Pain: A Single Center Experience”
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - October 22, 2021 Category: Biotechnology Authors: Tom Theys Tags: Letter to the Editor Source Type: research

Response to Letter to the Editor Regarding: “Deep Brain Stimulation for Alzheimer's Disease: Tackling Circuit Dysfunction”
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - October 22, 2021 Category: Biotechnology Authors: Jordan Lam, Darrin J. Lee Tags: Letter to the Editor Source Type: research

Response to: “Deep Brain Stimulation for Alzheimer's Disease: Tackling Circuit Dysfunction”
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - October 22, 2021 Category: Biotechnology Authors: Ashwin Kumaria, Christos M. Tolias Tags: Letter to the Editor Source Type: research

Isotopic Scintigraphy in Intrathecal Drug Delivery Failure: A Single ‐Institution Case Series
ConclusionsTwenty-two abnormalities were identified in 21 examinations, with these abnormalities consisting of leakage (n = 7), spinal catheter obstruction (n = 7), and cerebrospinal fluid flow obstruction (n = 8). Interventions (n = 19) confirmed the cause of ITDD failure. A false-positive finding at follow-up (n = 1) and a false-negative finding (n = 1) were encountered. Sensitivity was 95% (20/21) and the specificity 93% (14/15). A significant difference (p 
Source: Neuromodulation: Technology at the Neural Interface - October 22, 2021 Category: Biotechnology Authors: Elmar M. Delhaas, Dani ëlle M.E. Assema, Alida C. Fröberg, Ben G.J.C. Zwezerijnen, Biswadjiet S. Harhangi, Sander P.G. Frankema, Frank J.P.M. Huygen, Aad Lugt Tags: Clinical Research Source Type: research

Healthy Volunteers Immediately Adapt to Submental Stimulation During Swallowing
AbstractObjectivesTranscutaneous stimulation above and below the hyoid is used to assist patients with swallowing disorders (dysphagia) but has shown different effects. Previously, infrahyoid transcutaneous stimulation lowered the hyoid and larynx resisting swallowing movement while suprahyoid stimulation had no effects on hyolaryngeal movement either at rest or during swallowing. More recently, large submental electrodes, covering the submental region, are used for swallowing therapy in combination with resistance therapy. To gain insight into the effects of these electrodes on movement during swallowing, we studied healt...
Source: Neuromodulation: Technology at the Neural Interface - September 30, 2021 Category: Biotechnology Authors: Mohammed F. Safi, Sandra Martin, Lincoln Gray, Christy L. Ludlow Tags: Clinical Research Source Type: research

Heart Rate Variability Features as Predictors of Intermittent Theta ‐Burst Stimulation Response in Posttraumatic Stress Disorder
ConclusionsOur findings indicate that autonomic activity is a potential low-cost and technically simple predictive biomarker of iTBS response in PTSD. Less autonomic dysfunction was associated with superior clinical improvements with iTBS. Future studies might consider HRV acquisition during iTBS, as well as prospective testing of these findings in patients with elevated hyperarousal. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 27, 2021 Category: Biotechnology Authors: Camila Cosmo, Antonia V. Seligowski, Emily M. Aiken, Mascha van't Wout ‐Frank, Noah S. Philip Tags: Clinical Research Source Type: research

Five ‐Session Dual‐Transcranial Direct Current Stimulation With Task‐Specific Training Does Not Improve Gait and Lower Limb Performance Over Training Alone in Subacute Stroke: A Pilot Randomized Controlled Trial
ConclusionThe combined intervention showed no benefit over training alone in improving gait variables and lower-limb performance. However, some performances were saturated at some point, as moderate to high function participants were recruited in the present study. Future studies should consider recruiting participants with more varied motor impairment levels and may need to determine the optimal stimulation protocols and parameters to improve gait and lower-limb performance. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 21, 2021 Category: Biotechnology Authors: Benchaporn Aneksan, Montawan Sawatdipan, Sunee Bovonsunthonchai, Jarugool Tretriluxana, Roongtiwa Vachalathiti, Paradee Auvichayapat, Anuchai Pheungphrarattanatrai, Pagamas Piriyaprasarth, Wanalee Klomjai Tags: Clinical Research Source Type: research

Sacral Neuromodulation Changes Pelvic Floor Activity in Overactive Bladder Patients —Possible New Insights in Mechanism of Action: A Pilot Study
AbstractObjectivesTo evaluate if electrodiagnostic tools can advance the understanding in the effect of sacral neuromodulation (SNM) on pelvic floor activity, more specifically if SNM induces changes in pelvic floor muscle (PFM) contraction.Materials and MethodsSingle tertiary center, prospective study (October 2017 –May 2018) including patients with overactive bladder syndrome undergoing SNM. Electromyography of the PFM was recorded using the Multiple Array Probe Leiden. The procedure consisted of consecutive stimulations of the lead electrodes with increasing intensity (1–3, 5, 7, 10 V). Recordings were ...
Source: Neuromodulation: Technology at the Neural Interface - September 21, 2021 Category: Biotechnology Authors: Jeroen Voorham, Donald Vagan ée, Petra Voorham‐van der Zalm, Guus Lycklama à Nijeholt, Hein Putter, Stefan De Wachter Tags: Clinical Research Source Type: research

Cognitive Outcome After Deep Brain Stimulation for Refractory Obsessive –Compulsive Disorder: A Systematic Review
ConclusionAlthough individual studies generally do not report cognitive deterioration after DBS for OCD, the variability of study designs and the multitude of cognitive measures used, precluded a meta-analysis to confirm its safety, and recognition of a cognitive pattern through which the efficacy of DBS for OCD might be explained. In future, prospective studies should preferably include a standardized neuropsychological assessment battery specifically addressing executive functioning and have a longer-term follow-up in order to demonstrate the cognitive safety of the procedure. Such prospective and more uniform data colle...
Source: Neuromodulation: Technology at the Neural Interface - September 21, 2021 Category: Biotechnology Authors: Tim A. M. Bouwens van der Vlis, Annelien Duits, M égan M. G. H. Veerdonk, Anne E. P. Mulders, Koen R. J. Schruers, Yasin Temel, Linda Ackermans, Albert F. G. Leentjens Tags: Review Article Source Type: research

Intrathecal Drug Delivery for the Treatment of Cancer ‐Associated Chronic Pain in Children
ConclusionsThere exist children with cancer whose pain is refractory to the standard approaches and may benefit from IT drug delivery. The existing data, although limited and of low tier evidence, suggest that IT drug delivery has been effective in the pediatric cancer population. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 15, 2021 Category: Biotechnology Authors: Meaghan Kenfield, Nicholas Zacharias, Alaa Abd ‐Elsayed Tags: Review Article Source Type: research

Thalamic Deep Brain Stimulation May Improve Restless Legs Syndrome in Patients With Essential Tremor
ConclusionsWe report for the first time improvement of RLS in patients with ET after bilateral thalamic DBS. Although many ET patients with nonrechargeable DBS systems switch off their stimulator at night to conserve battery life, those with RLS may potentially benefit from keeping their stimulator ON at night to relieve their RLS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 14, 2021 Category: Biotechnology Authors: Virgilio Gerald H. Evidente, Danica H. Evidente, Francisco A. Ponce, Maris H. Evidente, Margaret Lambert, Robin Garrett Tags: Clinical Research Source Type: research

Cortical, Spinal, Sacral, and Peripheral Neuromodulations as Therapeutic Approaches for the Treatment of Lower Urinary Tract Symptoms in Multiple Sclerosis Patients: A Review
DiscussionPTNS and SNM seem to be effective and safe therapeutic options for treating lower urinary tract symptoms in MS patients principally in case of overactive bladder (OAB) symptoms. Similarly, also SCS and TMS have been shown to be effective, despite the very limited number of patients and the small number of studies found in the literature. Interestingly, these techniques are effective even in patients who do not respond well to conservative therapies, such as anticholinergics. Furthermore, given their safety and efficacy, stimulations such as PTNS could be considered as a first-line treatment for OAB in MS patients...
Source: Neuromodulation: Technology at the Neural Interface - September 9, 2021 Category: Biotechnology Authors: Martina Pericolini, Gabriel Miget, Claire Hentzen, Enrico Finazzi Agr ò, Camille Chesnel, Philippe Lagnau, Rebecca Haddad, Matthieu Grasland, Gerard Amarenco Tags: Review Article Source Type: research

Factors Contributing to Spinal Cord Stimulation Outcomes for Chronic Pain
ConclusionsPatient outcome was associated with diagnosis, postimplantation falls, and device manufacturer. Further investigation is recommended to confirm associations through prospective studies that can more accurately quantify patient outcome over longer periods. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 8, 2021 Category: Biotechnology Authors: Dakota T. Graham, Margaret Lambert, Zaman Mirzadeh, Francisco A. Ponce Tags: Clinical Research Source Type: research

The Intraoperative Microlesion Effect Positively Correlates With the Short ‐Term Clinical Effect of Deep Brain Stimulation in Parkinson's Disease
The objective of this study was to determine the correlation between the intraoperative MLE and the clinical effect of DBS.Materials and MethodsThirty Parkinson's disease (PD) patients with Movement Disorder Society (MDS) Unified Parkinson's Disease Rating Scale (UPDRS) part III (MDS-UPDRS III) scores during bilateral STN-DBS implantation were included in this retrospective study. MDS-UPDRS III subscores (resting tremor, rigidity, and bradykinesia) of the contralateral upper extremity were used. During surgery, these subscores were assessed directly before and after insertion of the electrode. Also, these subscores were de...
Source: Neuromodulation: Technology at the Neural Interface - September 8, 2021 Category: Biotechnology Authors: St èfan F. Lange, Naomi I. Kremer, Teus van Laar, Fiete Lange, T. Elien Steendam‐Oldekamp, D. L. Marinus Oterdoom, Anthony R. Absalom, J. Marc C. van Dijk, Gea Drost Tags: Clinical Research Source Type: research

A Case Series of Neuropsychological Outcome After Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Refractory Obsessive –Compulsive Disorder
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 7, 2021 Category: Biotechnology Authors: Tim A. M. Bouwens van der Vlis, Annelien A. Duits Tags: Clinical Letter Source Type: research

A Rare Case of Anchor Fracture Manifesting with New ‐Onset Neuropathic Pain after Spinal Cord Stimulator Implantation
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 7, 2021 Category: Biotechnology Authors: Ryan S. D'Souza, Christine L. Hunt Tags: Clinical Letter Source Type: research

Effects of High ‐Voltage Pulsed Radiofrequency on the Ultrastructure and Nav1.7 Level of the Dorsal Root Ganglion in Rats With Spared Nerve Injury
AbstractObjectivesTo investigate the analgesic effect of high-voltage pulsed radiofrequency (HV-PRF) on the dorsal root ganglion (DRG) for neuropathic pain induced by spared nerve injury (SNI) in rats, especially the influence of this treatment on the DRG ultrastructure and voltage-gated sodium channel 1.7 (Nav1.7) level in the DRG.Materials and MethodsOne hundred fifty adult male Sprague-Dawley rats were randomly divided into five groups: Sham, SNI, Free-PRF, standard-voltage PRF (SV-PRF), and HV-PRF. The 45V-PRF and 85V-PRF procedures applied to the left L5 DRG were performed in SV-PRF group and the HV-PRF group respecti...
Source: Neuromodulation: Technology at the Neural Interface - September 6, 2021 Category: Biotechnology Authors: Zhisen Dai, Xueru Xu, Yanqin Chen, Chun Lin, Fan Lin, Rongguo Liu Tags: Basic Research Source Type: research

A Comprehensive Review of Vagus Nerve Stimulation for Depression
ConclusionsThe mood effects of VNS were discovered from clinical trials investigating the use of VNS for reducing seizures in epileptic patients. Since then, VNS has gone on to be FDA approved for depression. The field of VNS is growing, and as noninvasive VNS quickly advances, it is important to consider a historical perspective to develop future brain stimulation therapies. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 6, 2021 Category: Biotechnology Authors: Christopher W. Austelle, Georgia H. O'Leary, Sean Thompson, Elise Gruber, Alex Kahn, Andrew J. Manett, Baron Short, Bashar W. Badran Tags: Review Article Source Type: research

Pulsed Electromagnetic Fields: A Novel Attractive Therapeutic Opportunity for Neuroprotection After Acute Cerebral Ischemia
ConclusionsAltogether, these data demonstrate the efficacy of PEMFs against several mechanisms underlying ischemic damage and suggest that PEMFs might represent a novel noninvasive adjunctive treatment for acute ischemic stroke, providing neuroprotection and reducing functional deficits following ischemia. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 5, 2021 Category: Biotechnology Authors: Fioravante Capone, Simona Salati, Fabrizio Vincenzi, Micaela Liberti, Giorgio Aicardi, Francesca Apollonio, Katia Varani, Ruggero Cadossi, Vincenzo Di Lazzaro Tags: Review Article Source Type: research

Low Intensity Focused Ultrasound Increases Duration of Anti ‐Nociceptive Responses in Female Common Peroneal Nerve Injury Rats
AbstractObjectiveChronic pain affects 7% –10% of Americans, occurs more frequently and severely in females, and available treatments have been shown to have less efficacy in female patients. Preclinical models addressing sex-specific treatment differences in the treatment of chronic pain have been limited. Here we examine the sex-specifi c effects of low intensity focused ultrasound (liFUS) in a modified sciatic nerve injury (SNI) model.Materials and MethodsA modified SNI performed by ligating the common peroneal nerve (CPN) was used to measure sensory, behavioral pain responses, and nerve conduction studies in femal...
Source: Neuromodulation: Technology at the Neural Interface - September 3, 2021 Category: Biotechnology Authors: Andrea Liss, Abigail Hellman, Vraj J. Patel, Teresa Maietta, Kanakaharini Byraju, Rachel Trowbridge, Jenica Acheta, Drishti Panse, Adithya Srikanthan, Paul Neubauer, Clif Burdette, Goutam Ghoshal, Emery Williams, Jiang Qian, Julie G. Pilitsi Tags: Basic Research Source Type: research

Calendar of Events
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 28, 2021 Category: Biotechnology Tags: Professional Development Source Type: research

Table of Contents
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 28, 2021 Category: Biotechnology Tags: Issue Information – Table of Contents Source Type: research