Higher Preimplantation Opioid Doses Associated With Long ‐Term Spinal Cord Stimulation Failure in 211 Patients With Failed Back Surgery Syndrome
AbstractObjectiveSpinal cord stimulation (SCS) is an effective treatment in failed back surgery syndrome (FBSS). We studied the effect of preimplantation opioid use on SCS outcome and the effect of SCS on opioid use during a two ‐year follow‐up period.Materials and methodsThe study cohort included 211 consecutive FBSS patients who underwent an SCS trial from January 1997 to March 2014. Participants were divided into groups, which were as follows: 1) SCS trial only (n = 47), 2) successful SCS (implanted and in use throughout the two ‐year follow‐up period,n = 131), and 3) unsuccessful SCS (implanted but later explan...
Source: Neuromodulation: Technology at the Neural Interface - October 19, 2020 Category: Biotechnology Authors: Mette Nissen, Tiina ‐Mari Ikäheimo, Jukka Huttunen, Ville Leinonen, Henna‐Kaisa Jyrkkänen, Mikael von und zu Fraunberg Tags: Clinical Research Source Type: research

Long ‐Term Effects of Self‐Administered Transcranial Direct Current Stimulation in Episodic Migraine Prevention: Results of a Randomized Controlled Trial
ConclusionsThis study provides Class II evidence that self ‐administered anodal tDCS over the visual cortex in episodic migraine results in a significantly lower number of monthly migraine days. However, it has neither an immediate nor a long‐term effect. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - October 19, 2020 Category: Biotechnology Authors: Heiko Pohl, Marius Moisa, Hans ‐H. Jung, Kathrin Brenner, Jessica Aschmann, Franz Riederer, Christian C. Ruff, Jean Schoenen, Roger Luechinger, Lukas Widmer, Jens A. Petersen, Andreas R. Gantenbein, Peter S. Sandor, Lars Michels Tags: Basic Research Source Type: research

Treatment of Stage 3 COVID ‐19 With Transcutaneous Auricular Vagus Nerve Stimulation Drastically Reduces Interleukin‐6 Blood Levels: A Report on Two Cases
Neuromodulation: Technology at the Neural Interface, EarlyView. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - October 15, 2020 Category: Biotechnology Authors: Andr é P. Boezaart, Daniel A. Botha Tags: Clinical Letters (Case Reports and Technical Notes) Source Type: research

Short ‐Term Peripheral Nerve Stimulation Relieve Pain for Elder Herpes Zoster Ophthalmicus Patients: A Retrospective Study
AbstractObjectiveOphthalmic postherpetic neuralgia (PHN) is the final stage of herpes zoster (HZ) ophthalmicus and a severe refractory neuropathic pain, thus there is no curative treatment that could alleviate pain and reduce the incidence of ophthalmic PHN now. The purpose of this study is to evaluate therapeutic efficacy of short ‐term peripheral nerve stimulation (PNS) for elder patients with HZ ophthalmicus.Materials and MethodsWe performed a retrospective study from March 2015 to August 2019 in our pain department. All the HZ ophthalmicus patients underwent supraorbital nerve short ‐term PNS were included. The pat...
Source: Neuromodulation: Technology at the Neural Interface - October 15, 2020 Category: Biotechnology Authors: Cheng ‐fu Wan, Tao Song Tags: Clinical Research Source Type: research

Impact of Cardiac ‐Based Vagus Nerve Stimulation Closed‐Loop Stimulation on the Seizure Outcome of Patients With Generalized Epilepsy: A Prospective, Individual‐Control Study
AbstractObjectivesWe designed a prospective, individual ‐controlled study to evaluate the effect of cardiac‐based VNS (cbVNS) in a cohort of patients with generalized epilepsy (GE).Materials and MethodsTwenty patients were included. They were followed up for six  months under regular VNS (rVNS) and subsequently for six months during cbVNS. Stimulation parameters were 500 μsec, 30 Hz, and up to 2.5 mA. Seizure frequency was documented after two, four, and six months during the rVNS and cbVNS phases. Patients with at least 50% seizure frequency r eduction were considered respo...
Source: Neuromodulation: Technology at the Neural Interface - October 12, 2020 Category: Biotechnology Authors: Arthur Cukiert, Cristine Mella Cukiert, Pedro Paulo Mariani, Jose Augusto Burattini Tags: Clinical Research Source Type: research

Brain ‐Derived Neurotrophic Factor Polymorphism Influences Response to Single‐Pulse Transcranial Magnetic Stimulation at Rest
ConclusionsThe findings should be further substantiated in larger ‐scale studies. If validated, intrinsic differences by BDNF polymorphism status could index response to TMS prior to implementing plasticity‐inducing protocols. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - October 9, 2020 Category: Biotechnology Authors: Priyanka Shah ‐Basak, Denise Y. Harvey, Shreya Parchure, Olufunsho Faseyitan, Daniela Sacchetti, Ahmed Ahmed, Abdou Thiam, Falk W. Lohoff, Roy H. Hamilton Tags: Basic Research Source Type: research

Anterior Cingulate Cortex in Addiction: New Insights for Neuromodulation
ConclusionFirst, we illustrate that the ACC serves as a central “hub” in addiction‐related neural networks of cognitive functions, including, but not limited to, decision‐making, cognitive inhibition, emotion, and motivation. Then, we summarize the literature targeting the ACC to treat SUDs via available neuromodulation approaches. Finally, we propose po tential directions to improve the effect of stimulating the ACC in SUD treatment. We emphasize that the ACC can be divided into at least four sub‐regions, which have distinctive functions and connections. Studies focusing on these sub‐regions may help t...
Source: Neuromodulation: Technology at the Neural Interface - October 9, 2020 Category: Biotechnology Authors: Yijie Zhao, Samantha N. Sallie, Hailun Cui, Ningning Zeng, Jiang Du, Tifei Yuan, Dianyou Li, Dirk De Ridder, Chencheng Zhang Tags: Review Article Source Type: research

Evaluation of the Efficacy of Musical Vibroacupuncture in Pain Relief: A Randomized Controlled Pilot Study
ConclusionsThese results suggest that MVA effectively increased pain tolerance and reduced pain intensity when compared with all groups, although not significant to the VA group. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - October 7, 2020 Category: Biotechnology Authors: Augusto Weber, Simon Busbridge, Ricardo Governo Tags: Study Protocol Source Type: research

Scope for Vagus Nerve Stimulation in Traumatic Brain Injury
Neuromodulation: Technology at the Neural Interface, EarlyView. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - October 4, 2020 Category: Biotechnology Authors: Ashwin Kumaria, Christos M. Tolias Tags: Letter to the Editor Source Type: research

Explantation Rates of High Frequency Spinal Cord Stimulation in Two Outpatient Clinics
ConclusionsRecently, high frequency SCS technology has been demonstrated as more effective in treatment of lower ‐ and leg‐pain, compared to conventional low frequency SCS, in a 12‐month randomized controlled trial (SENZA‐RCT). Longer term results have yet to be published. In this study, we found that the explantation rate was much higher than expected, based on the prior studies demonstrating its effi cacy. As the use of neuromodulation continues to grow, longitudinal data will be critical in understanding its long‐term effects on treated patients. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - October 4, 2020 Category: Biotechnology Authors: Victor C. Wang, Vickie Bounkousohn, Kara Fields, Clifford Bernstein, Richard M. Paicius, Christopher Gilligan Tags: Clinical Research Source Type: research

Multicenter Retrospective Analysis of Dorsal Root Ganglion Stimulator Placement Using Intraoperative Neuromonitoring in Asleep Patients During Early Periods of Adoption
ConclusionThis retrospective series demonstrates the utility and accuracy of IONM in not only confirming proper dorsal placement of a DRG electrode but also in maintaining a low adverse event profile. It further demonstrates that its utility in the real world with new users can be safe and accurate with an ease of integration. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - October 4, 2020 Category: Biotechnology Authors: Steven M. Falowski, Tim Deer, Goran Tubic, Pankaj Mehta Tags: Clinical Research Source Type: research

Utility of Deep Brain Stimulation Telemedicine for Patients With Movement Disorders During the COVID ‐19 Outbreak in China
ConclusionsDBS telemedicine could have a unique role to play in maintaining the delivery of DBS treatment and medical care to outpatients with movement disorders during the COVID ‐19 pandemic. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - October 1, 2020 Category: Biotechnology Authors: Chencheng Zhang, Kaiwen Zhu, Zhengyu Lin, Peng Huang, Yixin Pan, Bomin Sun, Dianyou Li Tags: Clinical Research Source Type: research

Patient ‐Administered Transcutaneous Electrical Nerve Stimulation for Postoperative Pain Control After Laparoscopic Cholecystectomy: A Randomized, Sham‐Controlled Feasibility Trial
ConclusionsPatient ‐administered TENS is safe and acceptable. Future studies may use sub‐sensory TENS as a proxy sham control to more reliably blind patients. A larger, double‐blinded RCT employing these techniques is now needed to determine the analgesic efficacy of TENS in an enhanced recovery setting, and its potential to reduce opiate usage. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 30, 2020 Category: Biotechnology Authors: William Xu, Chris Varghese, Cameron I. Wells, Ian P. Bissett, Gregory O'Grady Tags: Clinical Research Source Type: research

The Effects of Acute Transcranial Direct Current Stimulation on Attentional Bias in Pedophilic Disorder: A Preregistered Pilot Study
ConclusionsThese results suggest enhanced cognitive control in response to salient stimuli during active tDCS. Thus, to assist future studies on neuromodulation in PD, we provide suggestions for design improvement. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 30, 2020 Category: Biotechnology Authors: Patrizia Pezzoli, Anastasios Ziogas, Michael C. Seto, Natalia Jaworska, Andreas Mokros, Paul Fedoroff, Pekka Santtila Tags: Basic Research Source Type: research

Response to Letter to the Editor Regarding “Complications and Effects of Dorsal Root Ganglion Stimulation in the Treatment of Chronic Neuropathic Pain: A Nationwide Cohort Study in Denmark”
Neuromodulation: Technology at the Neural Interface, EarlyView. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 29, 2020 Category: Biotechnology Authors: Mattias Horan, Morten Rune Blichfeldt ‐Eckhardt Tags: Letter to the Editor Source Type: research

Long ‐Term Outcomes of Occipital Nerve Stimulation for New Daily Persistent Headache With Migrainous Features
ConclusionOur experience suggests that ONS is not effective in the treatment of NDPH with migrainous features even in centers with experience in treating chronic migraine with ONS. The difference in response rates of chronic migraine and NDPH with migrainous features supports the concept of a different pathophysiology to the two conditions. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 29, 2020 Category: Biotechnology Authors: Susie Lagrata, Sanjay Cheema, Laurence Watkins, Manjit Matharu Tags: Case Series Source Type: research

Spatial Filtering of Electroencephalography Reduces Artifacts and Enhances Signals Related to Spinal Cord Stimulation (SCS)
ConclusionsEEG spectral analysis combined with spatial filtering allows for a spatially and temporally specific assessment of SCS ‐related, neuromodulatory EEG activity, and may help to disentangle therapeutic and side effects of SCS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 23, 2020 Category: Biotechnology Authors: Lars Buentjen, Petya Vicheva, BS Chander, Sophie ‐Antoinette Beccard, Christopher Coutts, Elena Azañón, Max‐Philipp Stenner, Matthias Deliano Tags: Basic Research Source Type: research

Experiences From the Patient Perspective on Spinal Cord Stimulation for Failed Back Surgery Syndrome: A Qualitatively Driven Mixed Method Analysis
ConclusionMultiple QoL ‐ and psychosocial‐related themes are related to SCS‐outcomes. In order to improve SCS‐outcomes for both short‐ and long‐term, these themes should be implemented as a multidimensional approach, both prior to implantation as during follow‐up. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 22, 2020 Category: Biotechnology Authors: Richard L. Witkam, Erkan Kurt, Robert van Dongen, Inge Arnts, Monique A.H. Steegers, Kris C.P. Vissers, Dylan J.H.A. Henssen, Yvonne Engels Tags: Clinical Research Source Type: research

Response to Letter to the Editor Regarding: “Localization of the Sphenopalatine Ganglion Within the Pterygopalatine Fossa on Computed Tomography Angiography—A Potential Role in the Setting of Sphenopalatine Ganglion Microstimulator Implantation”
Neuromodulation: Technology at the Neural Interface, EarlyView. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 22, 2020 Category: Biotechnology Authors: Loizos Siakallis, Steve E. J. Connor Tags: Letter to the Editor Source Type: research

Stimulation ‐Induced Dyskinesia After Subthalamic Nucleus Deep Brain Stimulation in Patients With Meige Syndrome
This study attempts to explore possible causes of SID.Materials and MethodsRetrospectively collected clinical data on 32 patients who underwent STN ‐DBS between October 2016 and April 2019 were analyzed. Clinical outcomes were assessed pre‐ and post‐surgery, using the Burke–Fahn–Marsden dystonia rating scale (BFMDRS). Patients were divided into a dyskinesia group and a non‐dyskinesia group, according to whether or not they experienc ed persistent SID during follow‐up. The coordinates of the active contacts were calculated from post‐operative computerized tomography or magnetic resonance imaging, usi...
Source: Neuromodulation: Technology at the Neural Interface - September 21, 2020 Category: Biotechnology Authors: Ning Wang, Kailiang Wang, Qiao Wang, Shiying Fan, Zonghui Fu, Feng Zhang, Lin Wang, Fangang Meng Tags: Clinical Research Source Type: research

Response to Letter to the Editor Regarding: “The Use of Non‐Invasive Vagus Nerve Stimulation to Treat Respiratory Symptoms Associated With COVID‐19: A Theoretical Hypothesis and Early Clinical Experience”
Neuromodulation: Technology at the Neural Interface, EarlyView. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 20, 2020 Category: Biotechnology Authors: Peter S. Staats, Robert Levy Tags: Letter to the Editor Source Type: research

The Unmet Need for Intrathecal Drug Delivery Pumps for the Treatment of Cancer Pain in England: An Assessment of the Hospital Episode Statistics Database
ConclusionsWe observed a substantial gap between the need and provision of ITDD for patients with refractory cancer pain in England despite the recommendation for the use of ITDD for this patient population. In addition, we present suggestions for improvement of access to and provision of ITDD in England. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 17, 2020 Category: Biotechnology Authors: Rui V. Duarte, Alicia Sale, Pallav Desai, Theresa Marshall, Sam Eldabe Tags: Clinical Research Source Type: research

Isotopic Scintigraphy in Intrathecal Drug Delivery Failure: A Single ‐Institution Case Series
ConclusionsTwenty ‐two abnormalities were identified in 21 examinations, with these abnormalities consisting of leakage (n = 7), spinal catheter obstruction (n = 7), and cerebrospinal fluid flow obstruction (n = 8). Interventions (n = 19) confirmed the cause of ITDD failure. A false ‐positive finding at follow‐up (n = 1) and a false ‐negative finding (n = 1) were encountered. Sensitivity was 95% (20/21) and the specificity 93% (14/15). A significant difference (p 
Source: Neuromodulation: Technology at the Neural Interface - September 17, 2020 Category: Biotechnology Authors: Elmar M. Delhaas, Dani ëlle M.E. van Assema, Alida C. Fröberg, Ben G.J.C. Zwezerijnen, Biswadjiet S. Harhangi, Sander P.G. Frankema, Frank J.P.M. Huygen, Aad van der Lugt Tags: Case Series Source Type: research

Using Lower Amplitudes to Maintain Effective High Dose Spinal Cord Stimulation Therapy (SCS Dosing Pilot Study)
ConclusionThe qualified study patients defined an implanted population reporting good pain relief and satisfaction using HD SCS therapy at baseline. The majority of these patients were able to maintain therapy satisfaction and pain relief (70% and 63.3%, respectively) with 20% perception threshold amplitude. Amplitudes below perception threshold could potentially maintain effective SCS therapy with HD stimulation in a subset of patients. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 17, 2020 Category: Biotechnology Authors: Amr O. El ‐Naggar, Christopher L. Reis, John A. Hatheway, Todd E. Schmidt, Tristan C. Pico, Mahendra R. Sanapati, Alaa Abd‐Elsayed, Amit S. Patel, Aaron Calodney, Lisa Johanek, Ye Tan, Sheryl McCammon Tags: Clinical Research Source Type: research

A Secondary Analysis on Effects of Theta Burst Transcranial Magnetic Stimulation to Reduce Anger in Veterans With Posttraumatic Stress Disorder
ConclusionsThis secondary analysis suggests that iTBS might reduce anger in veterans with PTSD. Future studies focused on more granular level anger outcomes and effects of number of stimulation sessions are needed. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 16, 2020 Category: Biotechnology Authors: Mascha van 't Wout ‐Frank, Mary Tracie Shea, David O. Sorensen, Christiana R. Faucher, Benjamin D. Greenberg, Noah S. Philip Tags: Basic Research Source Type: research

Health ‐Related Quality of Life Associated With Pain Health States in Spinal Cord Stimulation for Chronic Neuropathic Pain
AbstractObjectivesA substantial proportion of patients have recently reported pain reduction levels of ≥80% following treatment with Evoked Compound Action Potential (ECAP) spinal cord stimulation (SCS). The additional health‐related quality of life (HRQoL) utility gain that can be achieved in this patient group is unclear. The aim of this study is to quantify the HRQoL utility values seen in a r emission health state (defined as ≥80% pain reduction) and contrast with more traditional health states of
Source: Neuromodulation: Technology at the Neural Interface - September 16, 2020 Category: Biotechnology Authors: Rui V. Duarte, Nicole Soliday, Angela Leitner, Rod S. Taylor Tags: Clinical Research Source Type: research

Outcomes Associated With Infection of Chronic Pain Spinal Implantable Electronic Devices: Insights From a Nationwide Inpatient Sample Study
ConclusionsThe complications of CPSIED infection were higher among patients that did not undergo device removal. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 13, 2020 Category: Biotechnology Authors: Vasudha Goel, Varun Kumar, Shivani N. Agrawal, Amol M. Patwardhan, Mohab Ibrahim, Daniel C. DeSimone, Eellan Sivanesan, Ratan K. Banik, Hariharan Shankar Tags: Clinical Research Source Type: research

Neuromodulation With Burst and Tonic Stimulation Decreases Opioid Consumption: A Post Hoc Analysis of the Success Using Neuromodulation With BURST (SUNBURST) Randomized Controlled Trial
AbstractObjectiveThe SUNBURST study was a prospective, multicenter, randomized crossover trial of a single device delivering burst and tonic spinal cord stimulation (SCS) for chronic trunk and/or limb pain. We performed apost hoc analysis of opioid consumption at baseline and after device implantation.Materials and MethodsAfter implantation, 100 patients were randomized to one mode (tonic or burst) for 12  weeks, and the other mode for the subsequent 12 weeks. After the crossover period (24 weeks), patients chose their preferred mode and were assessed for one year. We analyzed 69 patients who took opio...
Source: Neuromodulation: Technology at the Neural Interface - September 13, 2020 Category: Biotechnology Authors: Ryan S. D'Souza, Natalie Strand Tags: Clinical Research Source Type: research

1.2 kHz High ‐Frequency Stimulation as a Rescue Therapy in Patients With Chronic Pain Refractory to Conventional Spinal Cord Stimulation
AbstractObjectivesWe aimed to investigate the efficacy of new subperception stimulation paradigms including 1.2  kHz‐high‐frequency stimulation (HFS) and advanced‐HFS field‐shaping algorithm (dorsal horn HFS [DHHFS]) in refractory cases which initially benefited from conventional spinal cord stimulation (SCS) and lost the effect throughout time.Materials and MethodsIn the context of a rescue ‐therapy, patients underwent externalization of the implanted SCS‐leads and were tested with multiple combinations of new SCS paradigms. Pain intensity was analyzed using the numeric rating scale (NRS), and data were...
Source: Neuromodulation: Technology at the Neural Interface - September 13, 2020 Category: Biotechnology Authors: Pablo Andrade, Petra Heiden, Veerle Visser ‐Vandewalle, Georgios Matis Tags: Clinical Research Source Type: research

Pain Catastrophizing Does Not Predict Spinal Cord Stimulation Outcomes: A Cohort Study of 259 Patients With Long ‐Term Follow‐Up
ConclusionThis study did not demonstrate any associations between baseline PCS scores and SCS outcomes. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 13, 2020 Category: Biotechnology Authors: Dennis M øgeltoft Poulsen, Jens Christian Hedemann Sørensen, Morten Rune Blichfeldt‐Eckhardt, Helga Angela Gulisano, Anne Lene Høst Knudsen, Lone Nikolajsen, Kaare Meier Tags: Clinical Research Source Type: research

Dorsal Root Ganglion Stimulation for Chronic Postoperative Pain Following Thoracic Surgery: A Pilot Study
ConclusionsOur preliminary results show that DRG ‐S is an effective therapy for PTPS after thoracic surgery. In addition, thoracic paravertebral blocks performed prior to DRG‐S correlated with a positive outcome with treatment. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 8, 2020 Category: Biotechnology Authors: Giuliano Lo Bianco, Alfonso Papa, Giuseppe Gazzerro, Marco Rispoli, Dario Tammaro, Maria Teresa Di Dato, Federica Vernuccio, Michael Schatman Tags: Clinical Research Source Type: research

Transgrade Dorsal Root Ganglion Stimulation as a Salvage Technique for Three Different Anatomical Barriers: A Case Series
ConclusionBarriers to anterograde foraminal access including previous implantation, previous instrumentation, and epidural adhesions may prevent DRGS placement in certain indicated patients. This can be especially challenging in patients who have failed other neuromodulation options like dorsal column stimulation. Our case series demonstrated that the transgrade technique can be successfully used in these cases to increase access to DRGS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 8, 2020 Category: Biotechnology Authors: Gregory Lawson Smith, Erika A. Petersen, Christopher Paul, Johnathan H. Goree Tags: Case Series Source Type: research

Accuracy of Electrode Position in Sphenopalatine Ganglion Stimulation in Correlation With Clinical Efficacy
ConclusionThere was no significant correlation regarding aberrations of lead position from the planned position with clinical outcome. However, this study might be underpowered to detect such a correlation. The closest electrode contact to the vidian canal was in the stimulation area in all but one patient in the final programming. This indicates that, overall, the lead location does play a crucial role in SPG stimulation for cluster headache. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 7, 2020 Category: Biotechnology Authors: Guilherme S. Piedade, Jan Vesper, Rahel Hoyer, Thomas Klenzner, Philipp J. Slotty Tags: Clinical Research Source Type: research

Response to “Complications and Effects of Dorsal Root Ganglion Stimulation in the Treatment of Chronic Neuropathic Pain: A Nationwide Cohort Study in Denmark”
Neuromodulation: Technology at the Neural Interface, EarlyView. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 5, 2020 Category: Biotechnology Authors: Timothy Lubenow, Harold Nijhuis Tags: Letter to the Editor Source Type: research

Response to “Localization of the Sphenopalatine Ganglion Within the Pterygopalatine Fossa on Computed Tomography Angiography—A Potential Role in the Setting of Sphenopalatine Ganglion Microstimulator Implantation”
Neuromodulation: Technology at the Neural Interface, EarlyView. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 3, 2020 Category: Biotechnology Authors: Kantharuby Tambirajoo, Keyoumars Ashkan Tags: Letter to the Editor Source Type: research

Effects of Subthalamic Deep Brain Stimulation With Different Frequencies in a Parkinsonian Rat Model
In this study, diffusion tensor imaging (DTI) was used to detect parameter changes in different regions of rat brains after DBS, and rat exercise capacity and brain tissue immunohistochemistry were evaluated.Materials and MethodsThe 6 ‐hydroxydopamine‐induced hemi‐parkinsonian rat models were made and divided into four groups: a control group, sham group, low‐frequency group, and high‐frequency group. Low‐frequency (30 Hz) and high‐frequency (130 Hz) DBS were given to the STN in rats. First, an open‐field experime nt was used to evaluate changes in exercise performance. Then, the DTI was used to measure par...
Source: Neuromodulation: Technology at the Neural Interface - September 3, 2020 Category: Biotechnology Authors: Zhimin Li, Yi Guo, Xinjie Bao, Jianfeng Lei, Zhiwei Shen, Xin Wang, Luming Li, Yongning Li, Renzhi Wang Tags: Basic Research Source Type: research

Biomarker Optimization of Spinal Cord Stimulation Therapies
ConclusionsEfforts to identify one or more biomarkers are well underway with some preliminary evidence supporting their efficacy. This has far ‐reaching implications, including improved outcomes, fewer adverse events, harmonization of treatment and individuals, performance gains, and cost savings. We anticipate that novel biomarkers will be used widely to manage chronic pain. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 2, 2020 Category: Biotechnology Authors: Sean J. Nagel, Jason Hsieh, Andre G. Machado, Leonardo A. Frizon, Matthew A. Howard, George T. Gillies, Saul Wilson Tags: Review Article Source Type: research

A Review of the Evidence and Current Applications of Portable Translingual Neurostimulation Technology
ConclusionsTLNS is a promising treatment modality for various chronic neurological conditions that are often refractory to conventional therapy. However, TLNS technology remains largely investigational as high ‐quality RCTs are still required to elucidate efficacy, optimal dosages, necessary treatment durations, and treatment durability. Further research to develop an appropriate control group is needed for scientifically valid comparisons of TLNS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 2, 2020 Category: Biotechnology Authors: Dion Diep, Andrew C. L. Lam, Gordon Ko Tags: Review Article Source Type: research

Characterizing Complications of Intracranial Responsive Neurostimulation Devices for Epilepsy Through a Retrospective Analysis of the Federal MAUDE Database
ConclusionsFuture research endeavors should attempt to optimize the implantable device for preventing infections. The data of complications provided by this review will also aid physicians in providing the most accurate informed consent for patients when deciding to undergo implantation with the responsive neurostimulation system. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - September 1, 2020 Category: Biotechnology Authors: Tyler Xavier Giles, Josiah Bennet, Courtney Elizabeth Stone, Julian Lassiter Gendreau, Mickey Abraham, Antonios Mammis Tags: Clinical Research Source Type: research

Vagally Mediated Heart Rate Variability Is Associated With Executive Function Changes in Patients With Treatment ‐Resistant Depression Following Magnetic Seizure Therapy
ConclusionsSince this is an open ‐label trial, the influence of the placebo effect cannot be excluded. However, our results suggest that baseline RMSSD may be a state‐biomarker of depression and executive function impairment. Additionally, while baseline vagally mediated resting cardiac activity did not predict the outcome of d epression, it may mediate executive function improvements following MST. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 31, 2020 Category: Biotechnology Authors: Yoshihiro Noda, Yuliya Knyahnytska, Reza Zomorrodi, Jonathan Downar, Tarek K. Rajji, Zafiris J. Daskalakis, Daniel M. Blumberger Tags: Clinical Research Source Type: research

How Should we Use Multicolumn Spinal Cord Stimulation to Optimize Back Pain Spatial Neural Targeting? A Prospective, Multicenter, Randomized, Double ‐Blind, Controlled Trial (ESTIMET Study)
AbstractBackgroundRecent studies have highlighted multicolumn spinal cord stimulation (SCS) efficacy, hypothesizing that optimized spatial neural targeting provided by new ‐generation SCS lead design or its multicolumn programming abilities could represent an opportunity to better address chronic back pain (BP).ObjectiveTo compare multicolumn vs. monocolumn programming on clinical outcomes of refractory postoperative chronic BP patients implanted with SCS using multicolumn surgical lead.Materials and MethodsTwelve centers included 115 patients in a multicenter, randomized, double ‐blind, controlled trial. After randomi...
Source: Neuromodulation: Technology at the Neural Interface - August 30, 2020 Category: Biotechnology Authors: Philippe Rigoard, Maxime Billot, Pierre Ingrand, Isabelle Durand ‐Zaleski, Manuel Roulaud, Philippe Peruzzi, Phong Dam Hieu, Jimmy Voirin, Sylvie Raoul, Philippe Page, Marie‐Christine Djian, Denys Fontaine, Michel Lantéri‐Minet, Serge Tags: Clinical Research Source Type: research

A Review of Neuromodulation for Treatment of Complex Regional Pain Syndrome in Pediatric Patients and Novel Use of Dorsal Root Ganglion Stimulation in an Adolescent Patient With 30 ‐Month Follow‐Up
ConclusionsDRG stimulation has been shown to significantly alter the symptomatology in patients with CRPS. This case suggests that DRG stimulation may be as effective for the treatment of refractory CRPS in pediatric patients as in adults. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 27, 2020 Category: Biotechnology Authors: Heather Pinckard ‐Dover, Angela Palmer, Erika A. Petersen Tags: Review Article Source Type: research

Calendar of Events
Neuromodulation: Technology at the Neural Interface, Volume 23, Issue 6, Page 890-892, August 2020. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 23, 2020 Category: Biotechnology Tags: Professional Development Source Type: research

Table of Contents
Neuromodulation: Technology at the Neural Interface, Volume 23, Issue 6, Page iii-vi, August 2020. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 23, 2020 Category: Biotechnology Tags: Issue Information – Table of Contents Source Type: research

Editorial Board
Neuromodulation: Technology at the Neural Interface, Volume 23, Issue 6, Page i-i, August 2020. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 23, 2020 Category: Biotechnology Tags: Issue Information – Editorial Board Source Type: research

Aims and Scope
Neuromodulation: Technology at the Neural Interface, Volume 23, Issue 6, Page ii-ii, August 2020. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 23, 2020 Category: Biotechnology Tags: Issue Information – Aims and Scope Source Type: research

Frequency of Automatic Stimulations in Responsive Vagal Nerve Stimulation in Patients With Refractory Epilepsy
AbstractBackgroundIn vagal nerve stimulation (VNS) therapy, the release of VNS model 106 (AspireSR) allowed for responsive VNS (rVNS). rVNS utilizes a cardiac ‐based seizure detection algorithm to detect seizure‐induced tachycardia to trigger additional stimulation. There are some studies suggesting clinical benefits of rVNS over traditional VNS, but the performance and significance of autostimulation mode in clinical practice are poorly understood.ObjectivesTo assess the effect of initiation of rVNS therapy and altered stimulation settings on the number of daily stimulations and energy consumption in VNS therapy and t...
Source: Neuromodulation: Technology at the Neural Interface - August 23, 2020 Category: Biotechnology Authors: Toni Kulju, Joonas Haapasalo, Ryan Verner, Maxine Dibu é‐Adjei, Kai Lehtimäki, Sirpa Rainesalo, Jukka Peltola Tags: Clinical Research Source Type: research

Stimulation Parameters for Sacral Neuromodulation on Lower Urinary Tract and Bowel Dysfunction –Related Clinical Outcome: A Systematic Review
ConclusionThe results of our systematic review indicate that stimulation parameters may improve efficacy of SNM in treatment of both urinary tract dysfunction and bowel dysfunction. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 23, 2020 Category: Biotechnology Authors: Roman Assmann, Perla Douven, Jos Kleijnen, Gommert A. van Koeveringe, Elbert A. Joosten, Jarno Melenhorst, Stephanie O. Breukink Tags: Review Article Source Type: research

Sacral Neuromodulation for Lower Urinary Tract and Bowel Dysfunction in Animal Models: A Systematic Review With Focus on Stimulation Parameter Selection
ConclusionsThe results of this systematic review indicate that SNM has a positive therapeutic effect on lower urinary tract and bowel dysfunction. Using low ‐frequency‐SNM, high‐frequency‐SNM, bilateral SNM, and higher pulse widths showed beneficial effects on storage and evacuation dysfunction in animal studies. An increased variability of stimulation parameters may serve as a basis for future improvement of the effect of SNM in patients suffer ing from urinary tract or bowel dysfunction. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 17, 2020 Category: Biotechnology Authors: Perla Douven, Roman Assmann, Stephanie O. Breukink, Jarno Melenhorst, Jos Kleijnen, Elbert A. Joosten, Gommert A. van Koeveringe Tags: Review Article Source Type: research

A Comprehensive Practice Guideline for Magnetic Resonance Imaging Compatibility in Implanted Neuromodulation Devices
ConclusionsThis is the first comprehensive guideline with regards to various devices in the market and MRI compatibility from the American Society of Pain and Neuroscience. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 17, 2020 Category: Biotechnology Authors: Dawood Sayed, Krishnan Chakravarthy, Kasra Amirdelfan, Hemant Kalia, Kathleen Meacham, Prasad Shirvalkar, Steven Falowski, Erika Petersen, Jonathan M. Hagedorn, Jason Pope, John Leever, the ASPN MRI Compatibility Working Group, Timothy Deer Tags: Review Article Source Type: research