Use of Spinal Cord Stimulators in Patients With Pacemakers or Implantable Cardiac Defibrillators: A Review of Documented Accounts of Interference
ConclusionsInterference between cardiac devices and SCSs is a rare occurrence. As there are currently no published guidelines, devices should be interrogated on a case-by-case basis in the SCS trial period (if implanted after cardiac device), during permanent implantation, and during scheduled follow-up visits. Peri-operative testing should include increasing the SCS settings to maximally tolerated levels with cardiac device set at its maximum sensitivity. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 30, 2021 Category: Biotechnology Authors: Joshua Manuel Martens, Kenneth Fiala, Christopher Glover, Nicholas Zacharias, Alaa Abd ‐Elsayed Tags: Review Article Source Type: research

Ultra ‐Low Energy Cycled Burst Spinal Cord Stimulation Yields Robust Outcomes in Pain, Function, and Affective Domains: A Subanalysis From Two Prospective, Multicenter, International Clinical Trials
DiscussionIntermittent cycling of burst SCS lowers the overall electric charge delivered to the spinal cord and preserves battery consumption, without compromising pain relief and associated symptoms. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 28, 2021 Category: Biotechnology Authors: Timothy Deer, Derron Wilson, David Schultz, Steven Falowski, Ed Tavel, Gregory Moore, Robert Heros, Denis Patterson, Marie Fahey, Robyn Capobianco, Magdalena Anitescu Tags: Clinical Research Source Type: research

Deep Brain Stimulation of Caudal Zona Incerta for Parkinson's Disease: One ‐Year Follow‐Up and Electric Field Simulations
We report the one-year results of bilateral cZi-DBS in 15 patients with PD. Patients were evaluated on/off medication and stimulation using the Unified Parkinson's Disease Rating Scale (UPDRS). Main outcomes were changes in motor symptoms (UPDRS-III) and quality of life according to Parkinson's Disease Questionnaire-39 (PDQ-39). Secondary outcomes included efficacy profile according to sub-items of UPDRS-III, and simulation of the electric field distribution around the DBS lead using the finite element method. Simulations from all patients were transformed to one common magnetic resonance imaging template space for creatio...
Source: Neuromodulation: Technology at the Neural Interface - July 27, 2021 Category: Biotechnology Authors: Rasmus Stenmark Persson, Teresa Nordin, Gun ‐Marie Hariz, Karin Wårdell, Lars Forsgren, Marwan Hariz, Patric Blomstedt Tags: Clinical Research Source Type: research

Wireless Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Trigeminal Pain: A Single Center Experience
ConclusionThe partially implantable sTNFS device seems to be safe, effective, and reliable. Compared to conventional devices, the equipment is not limited to the length of trial stimulation. Furthermore, the daily stimulation duration was much shorter compared to previous reports. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 27, 2021 Category: Biotechnology Authors: Mohammad Mehdi Hajiabadi, Martin Jakobs, Andreas Unterberg, Rezvan Ahmadi Tags: Clinical Research Source Type: research

Stability and Effect of Parkinsonian State on Deep Brain Stimulation Cortical Evoked Potentials
AbstractObjectivesTo characterize and compare the stability of cortical potentials evoked by deep brain stimulation (DBS) of the subthalamic nucleus (STN) across the na ïve, parkinsonian, and pharmacologically treated parkinsonian states. To advance cortical potentials as possible biomarkers for DBS programming.Materials and MethodsSerial electrocorticographic (ECoG) recordings were made more than nine months from a single non-human primate instrumented with bilateral ECoG grids spanning anterior parietal to prefrontal cortex. Cortical evoked potentials (CEPs) were generated through time-lock averaging of the ECoG rec...
Source: Neuromodulation: Technology at the Neural Interface - July 27, 2021 Category: Biotechnology Authors: Brett A. Campbell, Hanbin Cho, Riley M. Faulhammer, Olivia Hogue, Jenny Peih ‐Chir Tsai, M. Shazam Hussain, Andre G. Machado, Kenneth B. Baker Tags: Basic Research Source Type: research

Single ‐Center Retrospective Analysis of Device‐Related Complications Related to Dorsal Root Ganglion Stimulation for Pain Relief in 31 Patients
ConclusionIn this study, we examine the various device-related complications associated with DRG stimulation requiring repeat surgery. High rates of hardware failure, revision surgery, and explantation of stimulators illustrate the need for hardware optimization to improve patient outcomes. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 26, 2021 Category: Biotechnology Authors: Kevin Hines, Vishal Swaminathan, Sara Thalheimer, Michael Kogan, Chengyuan Wu, Ashwini Sharan Tags: Clinical Research Source Type: research

Functional Magnetic Resonance Imaging Signal Variability Is Associated With Neuromodulation in Fibromyalgia
ConclusionOur findings suggest that M1-tDCS might revert temporal variability of fMRI signals in the rACC/vmPFC and posterior insula linked to FM pain. Changes in neural variability would be part of the mechanisms underlying repetitive M1-tDCS analgesia in FM. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 26, 2021 Category: Biotechnology Authors: Manyoel Lim, Dajung J. Kim, Thiago D. Nascimento, Eric Ichesco, Chelsea Kaplan, Richard E. Harris, Alexandre F. DaSilva Tags: Clinical Research Source Type: research

A Clinical Feasibility Study of Spinal Evoked Compound Action Potential Estimation Methods
AbstractObjectivesSpinal cord stimulation (SCS) is a treatment for chronic neuropathic pain. Recently, SCS has been enhanced further with evoked compound action potential (ECAP) sensing. Characteristics of the ECAP, if appropriately isolated from concurrent stimulation artifact (SA), may be used to control, and aid in the programming of, SCS systems. Here, we characterize the sensitivity of the ECAP growth curve slope (S) to both neural response (|Sresp|) and SA contamination (|Sart|) for four spinal ECAP estimation methods with a novel performance measure (|Sresp/Sart|).Materials and MethodsWe collected a library of 112 E...
Source: Neuromodulation: Technology at the Neural Interface - July 23, 2021 Category: Biotechnology Authors: Krishnan Chakravarthy, James FitzGerald, Andrew Will, Karen Trutnau, Robert Corey, David Dinsmoor, Leonid Litvak Tags: Basic Research Source Type: research

Deep Brain Stimulation Reduces Conflict ‐Related Theta and Error‐Related Negativity in Patients With Obsessive–Compulsive Disorder
ConclusionALIC/NAc DBS diminished MFT and ERN, demonstrating modulation of the medial frontal performance monitoring system in OCD. Furthermore, our findings encourage further studies to explore the ERN as a potential predictor for clinical efficacy. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Authors: Elena Sildatke, Theo O. J. Gruendler, Markus Ullsperger, Till A. Dembek, Juan Carlos Baldermann, Sina Kohl, Veerle Visser ‐Vandewalle, Daniel Huys, Jens Kuhn, Thomas Schüller Tags: Basic Research Source Type: research

BDNF rs6265 Genotype Influences Outcomes of Pharmacotherapy and Subthalamic Nucleus Deep Brain Stimulation in Early ‐Stage Parkinson's Disease
ConclusionsGenotyping for the rs6265 polymorphism may be useful for predicting long-term response to drug therapy and counseling Parkinson's disease patients regarding whether to consider earlier subthalamic nucleus deep brain stimulation. Validation in a larger cohort of early-stage Parkinson's disease subjects is warranted. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Authors: Caryl E. Sortwell, Mallory L. Hacker, David Luke Fischer, Peter E. Konrad, Thomas L. Davis, Joseph S. Neimat, Lily Wang, Yanna Song, Zach R. Mattingly, Allyson Cole ‐Strauss, Jack W. Lipton, P. David Charles Tags: Clinical Research Source Type: research

Calendar of Events
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Tags: Professional Development Source Type: research

Table of Contents
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Tags: Issue Information – Table of Contents Source Type: research

Aims and Scope
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Tags: Issue Information – Aims and Scope Source Type: research

Editorial Board
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Tags: Issue Information – Editorial Board Source Type: research

Effects of Focal Radiation on [18F] ‐Fluoro‐D‐Glucose Positron Emission Tomography in the Brains of Miniature Pigs: Preliminary Findings on Local Metabolism
ConclusionFocal, noninvasive, and durable changes in brain activity can be induced without a magnetic resonance imaging (MRI)-visible lesion, a result that may be consistent with the occurrence of neuromodulation. This approach may provide new venues for the investigation of neuromodulatory treatments for disorders involving dysfunctional brain circuits. Postmortem pathological analysis is needed to elucidate whether there have been morphological changes not detected by MRI. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Authors: Chun ‐I Yeh, Mei‐Fang Cheng, Furen Xiao, Yi‐Chieh Chen, Chien‐Chu Liu, Hung‐Yi Chen, Ruoh‐Fang Yen, Yu‐Ten Ju, Yilin Chen, Mohan Bodduluri, Pin‐Huan Yu, Chau‐Hwa Chi, Ngot Swan Chong, Liang‐Hsiang Wu, John R. Adler Jr, M Tags: Basic Research Source Type: research

Offline Bi ‐Frontal Anodal Transcranial Direct Current Stimulation Decreases Total Sleep Time Without Disturbing Overnight Memory Consolidation
Conclusion(s)The application of tDCS can be considered safe regarding overnight memory consolidation and represents a promising treatment approach in conditions of decreased vigilance and arousal. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Authors: Lukas Frase, Friederike Jahn, Sulamith Tsodor, Lukas Krone, Peter Selhausen, Bernd Feige, Jonathan G. Maier, Hannah Piosczyk, Dieter Riemann, Michael A. Nitsche, Christoph Nissen Tags: Clinical Research Source Type: research

Brain ‐Derived Neurotrophic Factor Polymorphism Influences Response to Single‐Pulse Transcranial Magnetic Stimulation at Rest
ConclusionsThe findings should be further substantiated in larger-scale studies. If validated, intrinsic differences by BDNF polymorphism status could index response to TMS prior to implementing plasticity-inducing protocols. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Authors: Priyanka Shah ‐Basak, Denise Y. Harvey, Shreya Parchure, Olufunsho Faseyitan, Daniela Sacchetti, Ahmed Ahmed, Abdou Thiam, Falk W. Lohoff, Roy H. Hamilton Tags: Basic Research Source Type: research

Feasibility of Interferential and Pulsed Transcranial Electrical Stimulation for Neuromodulation at the Human Scale
ConclusionsEnhancing the spatiotemporal precision and penetrability of tES with interferential and intersectional strategies is possible at the human scale. However, IF-tACS or IS-tDCS will likely require spatial multiplexing with multiple simultaneous sources to counteract their reduced potency, compared to standard techniques, to maintain stimulation currents at tolerable levels. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Authors: Bryan Howell, Cameron C. McIntyre Tags: Basic Research Source Type: research

A Secondary Analysis on Effects of Theta Burst Transcranial Magnetic Stimulation to Reduce Anger in Veterans With Posttraumatic Stress Disorder
ConclusionsThis secondary analysis suggests that iTBS might reduce anger in veterans with PTSD. Future studies focused on more granular level anger outcomes and effects of number of stimulation sessions are needed. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Authors: Mascha van 't Wout ‐Frank, Mary Tracie Shea, David O. Sorensen, Christiana R. Faucher, Benjamin D. Greenberg, Noah S. Philip Tags: Basic Research Source Type: research

Combining Frontal Transcranial Direct Current Stimulation With Walking Rehabilitation to Enhance Mobility and Executive Function: A Pilot Clinical Trial
ConclusionsEighteen sessions of walking rehabilitation combined with tDCS is a feasible and safe intervention for older adults. Preliminary effects size data indicate a potential improvement in executive function by adding frontal tDCS to walking rehabilitation. This study justifies future larger clinical trials to better understand the benefits of combining tDCS with walking rehabilitation. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Authors: David J. Clark, Sudeshna A. Chatterjee, Jared W. Skinner, Paige E. Lysne, Chanoan Sumonthee, Samuel S. Wu, Ronald A. Cohen, Dorian K. Rose, Adam J. Woods Tags: Clinical Research Source Type: research

The Effects of Acute Transcranial Direct Current Stimulation on Attentional Bias in Pedophilic Disorder: A Preregistered Pilot Study
ConclusionsThese results suggest enhanced cognitive control in response to salient stimuli during active tDCS. Thus, to assist future studies on neuromodulation in PD, we provide suggestions for design improvement. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Authors: Patrizia Pezzoli, Anastasios Ziogas, Michael C. Seto, Natalia Jaworska, Andreas Mokros, Paul Fedoroff, Pekka Santtila Tags: Basic Research Source Type: research

Repetitive Transcranial Magnetic Stimulation With H ‐Coil Coupled With Cycling for Improving Lower Limb Motor Function After Stroke: An Exploratory Study
ConclusionsThis exploratory study suggests that bilateral HF-rTMS combined with cycling is safe and potentially effective in ameliorating paretic LE motor function and spasticity, rather than gait speed or endurance, in chronic stroke. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Authors: Raffaella Chieffo, Fabio Giatsidis, Roberto Santangelo, Uri Alyagon, Mauro Comola, Abraham Zangen, Giancarlo Comi, Letizia Leocani Tags: Clinical Research Source Type: research

Comparison of Paresthesia Mapping With Anatomic Placement in Burst Spinal Cord Stimulation: Long ‐Term Results of the Prospective, Multicenter, Randomized, Double‐Blind, Crossover CRISP Study
ConclusionsThis study demonstrated that equivalent clinical benefits could be achieved with burst SCS using either paresthesia mapping or anatomic landmark-based approaches for lead placement. Nonparesthesia-based approaches, such as anatomic landmark-based lead placement investigated here, have the potential to simplify implantation of SCS and improve current surgical practice. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Authors: Adnan Al ‐Kaisy, Ganesan Baranidharan, Haggai Sharon, Stefano Palmisani, David Pang, Onita Will, Samuel Wesley, Tracey Crowther, Karl Ward, Paul Castino, Adil Raza, Yagna J. Pathak, Filippo Agnesi, Thomas Yearwood Tags: Clinical Research Source Type: research

Investigating the Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Cortical Excitability in Healthy Males
ConclusionstaVNS did not affect cortical excitability measurements in the overall population in this study. However, taVNS has the potential to modulate specific markers of cortical excitability in participants who tolerate higher stimulation levels. These findings indicate the need for adequate stimulation protocols based on the recording of objective outcome parameters. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Authors: Ann Mertens, Sofie Carrette, Debby Klooster, Emma Lescrauwaet, Jean Delbeke, Wytse Jan Wadman, Evelien Carrette, Robrecht Raedt, Paul Boon, Kristl Vonck Tags: Clinical Research Source Type: research

Mechanisms Underlying Poststimulation Block Induced by High ‐Frequency Biphasic Stimulation
ConclusionThis study reveals two possible ionic mechanisms underlying post-HFBS block of axonal conduction. Understanding these mechanisms is important for improving clinical applications of HFBS block and for developing new nerve block methods employing HFBS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 19, 2021 Category: Biotechnology Authors: Yihua Zhong, Jicheng Wang, Jonathan Beckel, William C. de Groat, Changfeng Tai Tags: Basic Research Source Type: research

Paresthesia ‐Based Versus High‐Frequency Spinal Cord Stimulation: A Retrospective, Real‐World, Single‐Center Comparison
ConclusionsThis study adds further evidence to the published literature that successful long-term results can be achieved with SCS. Our retrospective analysis did not find a statistically significant difference in PR-PIPS between traditional stimulation and high-frequency stimulation in a variety of indications over an average follow-up of nearly two years. Notably, there were statistically significant differences in treatment indications and primary sites of pain between the two patient cohorts, and this should be considered when interpreting the results. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 17, 2021 Category: Biotechnology Authors: Jonathan M. Hagedorn, Joshua Romero, Chris Thuc Ha, Markus A. Bendel, Ryan S. D'Souza Tags: Clinical Research Source Type: research

Vagus Nerve Stimulation ‐Induced Pseudo‐Pheochromocytoma
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 16, 2021 Category: Biotechnology Authors: Camille Dutordoir, Alfred Meurs Tags: Clinical Letter Source Type: research

Clinical Effect Analysis of Spinal Cord Electrical Stimulator Implantation for Diabetic Foot
AbstractObjectiveTo investigate the clinical effect of spinal cord electrical stimulator implantation in the treatment of diabetic foot (DF).Materials and MethodsWe recruited 19 patients with DF who were admitted to Shengjing Hospital of China Medical University between January 2018 and May 2020. All the patients were treated with spinal cord electrical stimulator implantation. Skin temperature, degree of pain, quality of life (QOL) score, limb (toe) preservation, and nerve conduction velocity of the patients were compared pre- and postoperatively.ResultsThe diameter and peak velocity of multisegment arteries in the lower ...
Source: Neuromodulation: Technology at the Neural Interface - July 16, 2021 Category: Biotechnology Authors: Peng ‐Bo Zhou, Min Bao Tags: Clinical Research Source Type: research

Device ‐Related Complications of Sacral Neuromodulation and Weight Loss: Is the Patient Caught in a Crossfire?
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 16, 2021 Category: Biotechnology Authors: Tariq F. Al ‐Shaiji Tags: Letter to the Editor Source Type: research

Reprogramming Sacral Neuromodulation for Sub ‐Optimal Outcomes: Evidence and Recommendations for Clinical Practice
ConclusionsReprogramming aims to further improve patient symptoms or ensure a comfortable delivery of the therapy. Initial changes of electrode configuration and adjustment of stimulation parameters can be performed at home to avoid unnecessary hospital visits. A logical and stepwise approach to reprogramming can improve the outcome of therapy and restore patient satisfaction. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 15, 2021 Category: Biotechnology Authors: Thomas C. Dudding, Paul A. Lehur, Michael S ørensen, Stefan Engelberg, Maria Paola Bertapelle, Emmanuel Chartier‐Kastler, Karel Everaert, Philip Van Kerrebroeck, Charles H. Knowles, Lilli Lundby, Klaus E. Matzel, Arantxa Muñoz‐Duyos, Mon Tags: Review Article Source Type: research

Brain ‐Derived Neurotrophic Factor Gene Polymorphism Predicts Response to Continuous Theta Burst Stimulation in Chronic Stroke Patients
ConclusionsOur findings strongly suggest that BDNF genotype differentially affects neuroplastic responses to TMS in individuals with chronic stroke. This provides novel insight into potential sources of variability in cTBS response in patients, which has important implications for optimizing the utility of this neuromodulation approach. Incorporating BDNF polymorphism genetic screening to stratify patients prior to use of cTBS as a neuromodulatory technique in therapy or research may optimize response rates. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 13, 2021 Category: Biotechnology Authors: Shreya Parchure, Denise Y. Harvey, Priyanka P. Shah ‐Basak, Laura DeLoretta, Rachel Wurzman, Daniela Sacchetti, Olufunsho Faseyitan, Falk W. Lohoff, Roy H. Hamilton Tags: Basic Research Source Type: research

Short ‐Term Outcomes of a High‐Volume, Low‐Concentration Bolus Starting Dose Technique With Ziconotide: A Case Series
ConclusionsThe HVLC-B starting regimen was effective and well tolerated in this short-term study of patients with chronic spine pain. More studies are needed to better elucidate long-term outcomes in larger patient populations. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 12, 2021 Category: Biotechnology Authors: David Lindley Tags: Clinical Research Source Type: research

Durability of the Therapeutic Effect of Restorative Neurostimulation for Refractory Chronic Low Back Pain
We report the four-year outcomes of this trial.Materials and MethodsReActiv8-A is a prospective, single-arm trial performed at nine sites in the United  Kingdom, Belgium, and Australia. Eligible patients had disabling CLBP (low back pain Numeric Rating Scale [NRS] ≥6; Oswestry Disability Index [ODI] ≥25), no indications for spine surgery or spinal cord stimulation, and failed conventional management including at least physical therapy and med ications for low back pain. Fourteen days postimplantation, stimulation parameters were programmed to elicit strong, smooth contractions of the multifidus, and participan...
Source: Neuromodulation: Technology at the Neural Interface - July 10, 2021 Category: Biotechnology Authors: Bruce Mitchell, Kristiaan Deckers, Kris De Smedt, Marc Russo, Peter Georgius, Matthew Green, Ashish Gulve, Jean ‐Pierre Buyten, Iris Smet, Vivek Mehta, Ganesan Baranidharan, James Rathmell, Chris Gilligan, Ben Goss, Sam Eldabe Tags: Clinical Research Source Type: research

Electrically Evoked Compound Action Potentials in Spinal Cord Stimulation: Implications for Preclinical Research Models
ConclusionsThis is the first evidence demonstrating the feasibility of recording ECAPs from the rat spinal cord, which may be more useful in determining parameters of SCS in preclinical SCS models than MTs. Thus, this approach may allow for the development of a novel model of SCS in rats with chronic pain that will translate better between animals and humans. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 5, 2021 Category: Biotechnology Authors: Birte Elisabeth Dietz, Dave Mugan, Quoc Chi Vuong, Ilona Obara Tags: Basic Research Source Type: research

Neuromodulation in Beta ‐Band Power Between Movement Execution and Inhibition in the Human Hippocampus
AbstractIntroductionThe hippocampus is thought to be involved in movement, but its precise role in movement execution and inhibition has not been well studied. Previous work with direct neural recordings has found beta-band (13 –30 Hz) modulation in both movement execution and inhibition throughout the motor system, but the role of beta-band modulation in the hippocampus during movement inhibition is not well understood. Here, we perform a Go/No-Go reaching task in ten patients with medically refractory epilepsy to stud y human hippocampal beta-power changes during movement.Materials and MethodsTen epilepsy pati...
Source: Neuromodulation: Technology at the Neural Interface - July 5, 2021 Category: Biotechnology Authors: Roberto Martin Campo ‐Vera, Austin M. Tang, Angad S. Gogia, Kuang‐Hsuan Chen, Rinu Sebastian, Zachary D. Gilbert, George Nune, Charles Y. Liu, Spencer Kellis, Brian Lee Tags: Clinical Research Source Type: research

Incidence and Risk Factors for Spinal Cord Stimulator Lead Migration With or Without Loss of Efficacy: A Retrospective Review of 91 Consecutive Thoracic Lead Implants
ConclusionsIn the subacute postoperative period after SCS implant, the majority of SCS leads migrated caudally with an average of two lead contacts. Knowledge of this expected migration and risk factors can better inform implanting physicians intraoperatively when deciding final lead placement location. The finding of high likelihood of caudal lead migration in the subacute postoperative period brings the need for a well-designed prospective study to the forefront of our field. This will allow implanting providers to make well-informed decisions for intraoperative lead placement. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 3, 2021 Category: Biotechnology Authors: Marissa L. Dombovy ‐Johnson, Ryan S. D'Souza, Chris Thuc Ha, Jonathan M. Hagedorn Tags: Clinical Research Source Type: research

Impulse Configuration in Hypoglossal Nerve Stimulation in Obstructive Sleep Apnea: The Effect of Modifying Pulse Width and Frequency
AbstractObjectivesHypoglossal nerve stimulation is an effective treatment option for obstructive sleep apnea (OSA) in positive airway pressure therapy failure. Nonetheless, data regarding the functional effect of modifying stimulation parameters within each electrode configuration are limited.Materials and MethodsIn a retrospective study of 76 patients with 12  months or more follow-up, functional tongue protrusion thresholds were compared for pulse width and frequency configurations of 90 μsec 33 Hz vs 120 μsec 40 Hz. The number of tolerated voltage amplitude steps between sensation, f...
Source: Neuromodulation: Technology at the Neural Interface - July 2, 2021 Category: Biotechnology Authors: Armin Steffen, Stephanie Jeschke, Ryan J. Soose, Katrin Hasselbacher, Inke R. K önig Tags: Clinical Research Source Type: research

First Evaluation Switching From Ropivacaine to Highly Concentrated Bupivacaine in Intrathecal Mixtures for Cancer Pain
AbstractBackgroundIntrathecal drug delivery is widely used for intractable cancer pain treatment. A combination of drugs with morphine and bupivacaine is recommended in first line therapy. In France, we use ropivacaine 10  mg/mL instead of bupivacaine 5 mg/mL, the only concentration available. Bupivacaine 40 mg/mL has been available in France only since July 2020 under temporary authorization of use.ObjectivesThe main objective of the study was to evaluate the safety, efficacy by pain assessment, to analyze drug dosage changes, to report adverse events (AEs) and conversion ratios switching from ropivacaine...
Source: Neuromodulation: Technology at the Neural Interface - June 29, 2021 Category: Biotechnology Authors: Florent Bienfait, Sabrina Jubier ‐Hamon, Valérie Seegers, Yves‐Marie Pluchon, Nathalie Lebrec, Virginie Jaoul, François Boré, Thierry Delorme, Julien Robert, Martine Bellanger, Jérémy Sorrieul, Denis Dupoiron Tags: Clinical Research Source Type: research

Transcutaneous Auricular Vagus Nerve Stimulation Combined With Slow Breathing: Speculations on Potential Applications and Technical Considerations
ConclusionsCombining taVNS with slow breathing seems to be a promising hybrid neurostimulation and behavioral intervention. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Authors: Miko łaj Tytus Szulczewski Tags: Review Article Source Type: research

A Review of Neuromodulation for Treatment of Complex Regional Pain Syndrome in Pediatric Patients and Novel Use of Dorsal Root Ganglion Stimulation in an Adolescent Patient With 30 ‐Month Follow‐Up
ConclusionsDRG stimulation has been shown to significantly alter the symptomatology in patients with CRPS. This case suggests that DRG stimulation may be as effective for the treatment of refractory CRPS in pediatric patients as in adults. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Authors: Heather Pinckard ‐Dover, Angela Palmer, Erika A. Petersen Tags: Review Article Source Type: research

The Pathways and Processes Underlying Spinal Transmission of Low Back Pain: Observations From Dorsal Root Ganglion Stimulation Treatment
BackgroundDorsal root ganglion stimulation (DRG-S) is a novel approach to treat chronic pain. Lead placement at L2 has been reported to be an effective treatment for axial low back pain (LBP) primarily of discogenic etiology. We have recently shown, in a diverse cohort including cases of multilevel instrumentation following extensive prior back surgeries, that DRG-S lead placement at T12 is another promising target. Local effects at the T12 DRG, alone, are insufficient to explain these results.Materials and MethodsWe performed a literature review to explore the mechanisms of LBP relief with T12 DRG-S.FindingsBranches of in...
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Authors: Kenneth B. Chapman, Pauline S. Groenen, Kris C. Vissers, Noud Helmond, Michael D. Stanton ‐Hicks Tags: Review Article Source Type: research

Calendar of Events
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Tags: Professional Development Source Type: research

Table of Contents
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Tags: Issue Information – Table of Contents Source Type: research

Aims and Scope
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Tags: Issue Information – Aims and Scope Source Type: research

Editorial Board
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Tags: Issue Information – Editorial Board Source Type: research

Dr. Jan Holsheimer 1941 –2021
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Authors: Mathieu W.P.M. Lenders, Kuan H. Kho, Cecile C. Vos, Andr é Elands Tags: Obituary Source Type: research

Abstracts from the North American Neuromodulation Society's 2021 Virtual Meeting, January 15 –16, 2021
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Tags: Abstracts Source Type: research

Dorsal Root Ganglion Stimulation for Post ‐Lyme Disease Chronic Peripheral Neuropathic Pain
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Authors: Jay Karri, Brian Bruel Tags: Letter to the Editor Source Type: research

Remembrances for a Departed Colleague, Friend, and Mentor: Jan Holsheimer, PhD
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Tags: Letter to the Editor Source Type: research

Response to: “Adverse Events and Complications Associated With Intrathecal Drug Delivery Systems: Insights From the Manufacturer and User Facility Device Experience (MAUDE) Database”
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2021 Category: Biotechnology Authors: David Schultz, Alaa Abd ‐Elsayed Tags: Letter to the Editor Source Type: research