Composite Score Is a Better Reflection of Patient Response to Chronic Pain Therapy Compared With Pain Intensity Alone
ConclusionsOur study suggests that therapeutic response, similar to the chronic pain experience, is multidimensional. Careful consideration should be made to incorporate composite endpoints in future SCS clinical trials. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 27, 2020 Category: Biotechnology Authors: Julie G. Pilitsis, Marie Fahey, Amanda Custozzo, Krishnan Chakravarthy, Robyn Capobianco Tags: Clinical Research Source Type: research

Invasive Electrical Neuromodulation for the Treatment of Painful Diabetic Neuropathy: Systematic Review and Meta ‐Analysis
ConclusionEfficacious, lasting and safe surgical pain management options are available to diabetic patients suffering from PDN. Tonic ‐SCS is the established standard of treatment; however, other SCS paradigms and DRGS are emerging as promising treatments offering comparable pain benefits, but with few cases published to date. Randomized controlled trials are ongoing to assess their relative merits. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 26, 2020 Category: Biotechnology Authors: Ashley L. B. Raghu, Tariq Parker, Tipu Z. Aziz, Alexander L. Green, George Hadjipavlou, Rustam Rea, James J. FitzGerald Tags: Review Article Source Type: research

Improved Psychosocial and Functional Outcomes and Reduced Opioid Usage Following Burst Spinal Cord Stimulation
AbstractObjectiveBurst spinal cord stimulation (B ‐SCS) has been shown to reduce neuronal firing in the anterior cingulate cortex through selective modulation of the medial pain pathway tract. This pain pathway communicates the affective component of pain processing. The purpose of this study was to assess the effect of B‐SCS on psychosocial fu nctioning and its influence on pain and quality of life.Materials and MethodsEligible patients with chronic, intractable pain of the trunk, and/or lower limbs were enrolled. After a successful trial period, subjects received a permanent implant and returned for follow ‐up at 6...
Source: Neuromodulation: Technology at the Neural Interface - June 25, 2020 Category: Biotechnology Authors: Steven M. Falowski, Gregory A. Moore, Eric G. Cornidez, J. Kelby Hutcheson, Kenneth Candido, Isaac Pe ña, Bram Blomme, Robyn A. Capobianco Tags: Clinical Research Source Type: research

The Effect of Clinically Controllable Factors on Neural Activation During Dorsal Root Ganglion Stimulation
ConclusionsOur results suggest that DRGS applied with stimulation parameters within typical clinical ranges predominantly activates A β‐mechanoreceptors. In general, varying clinically controllable parameters affects the number of Aβ‐mechanoreceptors activated, although longer pulse widths can increase Aδ‐neuron activation. Our data support several Neuromodulation Appropriateness Consensus Committee guidelines on the clin ical implementation of DRGS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 24, 2020 Category: Biotechnology Authors: Robert D. Graham, Tim M. Bruns, Bo Duan, Scott F. Lempka Tags: Basic Research Source Type: research

Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review
ConclusionsThere is a highly variable response to different medical treatments in HT without randomized clinical trials available to dictate treatment decisions. A variety of medical and surgical treatment options can be considered for the management of HT. Collaborative reseach between different institutions and researchers are warranted and needed to improve our understanding of the pathophysiology and management of this condition. In this review, we propose a practical treatment algorithm for HT based on currently available evidence. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 24, 2020 Category: Biotechnology Authors: Kai ‐Liang Wang, Joshua K. Wong, Robert S. Eisinger, Samuel Carbunaru, Christine Smith, Wei Hu, Aparna Wagle Shukla, Christopher W. Hess, Michael S. Okun, Adolfo Ramirez‐Zamora Tags: Review Article Source Type: research

Three ‐Year Outcomes After Dorsal Root Ganglion Stimulation in the Treatment of Neuropathic Pain After Peripheral Nerve Injury of Upper and Lower Extremities
AbstractObjectivesTraumatic peripheral nerve injuries (PNI) often result in severe neuropathic pain which typically becomes chronic, is recalcitrant to common analgesics, and is associated with sleep disturbances, anxiety, and depression. Pharmacological treatments proven to be effective against neuropathic pain are not well tolerated due to side effects. Neuromodulative interventions such as peripheral nerve or spinal cord stimulation have generated mixed results and may be limited by reduced somatotopic specificity. Dorsal root ganglion (DRG) stimulation may be more effective in this etiology.Materials and MethodsTwenty ...
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2020 Category: Biotechnology Authors: Michael Kretzschmar, Marco Reining, Marcus A. Schwarz Tags: Clinical Research Source Type: research

Deep Brain Stimulation of the Internal Pallidum in Lesch –Nyhan Syndrome: Clinical Outcomes and Connectivity Analysis
ConclusionCombined bilateral stimulation of the anteromedial and posteroventral GPi may be considered as an option for managing refractory dystonia and self ‐harm behavior in LNS patients. A multidisciplinary team‐based approach is essential for patient selection and management, to support children and families, to achieve functional improvement and alleviate the overall disease burden for patients and caregivers. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 23, 2020 Category: Biotechnology Authors: Kantharuby Tambirajoo, Luciano Furlanetti, Harutomo Hasegawa, Ahmed Raslan, Hortensia Gimeno, Jean ‐Pierre Lin, Richard Selway, Keyoumars Ashkan Tags: Clinical Research Source Type: research

Pelvic Floor Muscle Electromyography as a Guiding Tool During Lead Placement and (Re)Programming in Sacral Neuromodulation Patients: Validity, Reliability, and Feasibility of the Technique
ConclusionsMeasuring PFM contractions with EMG during placement and (re)programming of lead electrodes in SNM patients is valid, reliable, and feasible. Therefore, the use of PFM EMG motor responses could be considered as a tool to assist in these procedures. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 19, 2020 Category: Biotechnology Authors: Donald Vagan ée, Sigrid Van de Borne, Petra Voorham‐van der Zalm, Jeroen Voorham, Erik Fransen, Stefan De Wachter Tags: Clinical Research Source Type: research

Behavioral Survey of Effects of Pulsed Radiofrequency on Neuropathic and Nociceptive Pain in Rats: Treatment Profile and Device Implantation
ConclusionsPRF temporarily attenuates neuropathic and inflammatory pain. Bipolar PRF generates significant analgesia with a much lower electrical power than unipolar PRF. Meanwhile, the minor variant effects between PRF ‐DRG and PRF‐SN may indicate distinct mechanisms. The sustained‐analgesia by repetitive treatments suggests implantation technique could be a promising choice. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 17, 2020 Category: Biotechnology Authors: Ren ‐Yu Huang, Lawrence Poree, Kok‐Yuen Ho, Shih‐Ying Tsai, Yu‐Chen Liu, Ping‐Heng Tan, Yeong‐Ray Wen Tags: Basic Research Source Type: research

Calendar of Events
Neuromodulation: Technology at the Neural Interface, Volume 23, Issue 4, Page 550-551, June 2020. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 15, 2020 Category: Biotechnology Tags: Professional Development Source Type: research

Table of Contents
Neuromodulation: Technology at the Neural Interface, Volume 23, Issue 4, Page iii-vi, June 2020. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 15, 2020 Category: Biotechnology Tags: Issue Information – Table of Contents Source Type: research

Editorial Board
Neuromodulation: Technology at the Neural Interface, Volume 23, Issue 4, Page i-i, June 2020. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 15, 2020 Category: Biotechnology Tags: Issue Information – Editorial Board Source Type: research

Aims and Scope
Neuromodulation: Technology at the Neural Interface, Volume 23, Issue 4, Page ii-ii, June 2020. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 15, 2020 Category: Biotechnology Tags: Issue Information – Aims and Scope Source Type: research

Complications and Effects of Dorsal Root Ganglion Stimulation in the Treatment of Chronic Neuropathic Pain: A Nationwide Cohort Study in Denmark
ConclusionsThis study suggests a significant, clinically relevant effect of DRG stimulation on neuropathic pain, but also demonstrates substantial problems with maintenance and revision of currently available systems. Consequently, treatment with equipment marketed specifically for DRG stimulation is currently paused in Denmark. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 15, 2020 Category: Biotechnology Authors: Mattias Horan, Anne Helene Jacobsen, Christian Scherer, Christina Rosenlund, Helga Angela Gulisano, Morten S øe, Jens Christian Hedemann Sørensen, Kaare Meier, Morten Rune Blichfeldt‐Eckhardt Tags: Clinical Research Source Type: research

Risk Factors and Survival Analysis of Spinal Cord Stimulator Explantation
ConclusionsIn a cohort of SCS patients from multiple institutions, this study demonstrates that explantation for noninfectious reasons is more likely in younger patients, tobacco users, and those with certain psychiatric conditions. With an estimated 10% of patients opting to have their devices removed within 5  years of implantation, refining the ability of clinicians to predict who will see benefit from SCS treatment remains necessary. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - June 3, 2020 Category: Biotechnology Authors: Mark C. Dougherty, Royce W. Woodroffe, Saul Wilson, George T. Gillies, Matthew A. Howard, Ryan M. Carnahan Tags: Clinical Research Source Type: research

Subthalamic Nucleus Deep Brain Stimulation in Primary Meige Syndrome: A 1 ‐Year Follow‐Up Study
AbstractObjectiveTo investigate the efficacy of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in patients with Meige syndrome.Materials and MethodsFifteen consecutive patients who underwent STN ‐DBS at the Peking University People's Hospital between September 2017 and June 2018 were included in this study. The Burke–Fahn–Marsden Dystonia Rating Scale (BFMDRS) movement score and the BFMDRS disability score were obtained prior to surgery, and at specific time points after surgery. Pati ents' sleep status was also assessed before and after surgery.ResultsThe BFMDRS movement scores decreased fr...
Source: Neuromodulation: Technology at the Neural Interface - June 1, 2020 Category: Biotechnology Authors: Jia Ouyang, Qingpei Hao, Runze Zhu, Guangyong Wu, Hu Ding, Dongliang Wang, Ruen Liu Tags: Clinical Research Source Type: research

Effects and Mechanisms of Transcutaneous Electrical Acustimulation on Postoperative Recovery After Elective Cesarean Section
AbstractObjectivesTo explore the effects and mechanisms of transcutaneous electrical acustimulation (TEA) on postoperative recovery after cesarean section (CS).Materials and MethodsA total of 108 women who underwent CS were randomized to receive TEA or sham ‐TEA. Four hours after CS, electrogastrogram (EGG) and electrocardiogram (ECG) were recorded for 30 min to assess gastric slow waves and autonomic functions, respectively. TEA at ST36 or sham‐TEA at non‐acupoints was performed for one hour right after recording ECG and EGG and then twice d aily from postoperative days (POD) 1 to 3. In the morning of ...
Source: Neuromodulation: Technology at the Neural Interface - May 29, 2020 Category: Biotechnology Authors: Miaomiao Li, Feng Xu, Minjie Liu, Yinfang Li, Jingfei Zheng, Ying Zhu, Lin Lin, Jiande Chen Tags: Clinical Research Source Type: research

Initiation of Intrathecal Drug Delivery Dramatically Reduces Systemic Opioid Use in Patients With Advanced Cancer
AbstractObjectivesPain is common in cancer, affecting more than 70% of patients with advanced disease. Intrathecal drug delivery systems (IDDS) are a well ‐established treatment for patients with refractory cancer pain, improving pain control and reducing associated side effects. To date, details of systemic opioid use before and after IDDS implant have not been reported.Materials and MethodsWe conducted a retrospective review of patients at Huntsman Cancer Institute ‐University of Utah treated with IDDS for cancer pain from May 2014 to May 2018. Oral, transdermal, and parenteral opioid use before IDDS implant was comp...
Source: Neuromodulation: Technology at the Neural Interface - May 27, 2020 Category: Biotechnology Authors: Jill E. Sindt, Daniel W. Odell, Andrew P. Dalley, Shane E. Brogan Tags: Clinical Research Source Type: research

Anesthetic Considerations and Perioperative Management of Sacral Neuromodulators: Literature Review and Initial Recommendations
ConclusionsAvailable information on management in a variety of periprocedural settings is summarized. However, there are areas that lack satisfactory information, which are highlighted throughout the article. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 14, 2020 Category: Biotechnology Authors: Alaa Abd ‐Elsayed, Christopher Mitry, Jonathan Mitry, Weston Nadherny Tags: Review Article Source Type: research

The Use of Non ‐invasive Vagus Nerve Stimulation to Treat Respiratory Symptoms Associated With COVID‐19: A Theoretical Hypothesis and Early Clinical Experience
ConclusionsPreliminary observations and a strong scientific foundation suggest that nVNS might provide clinical benefits in patients with COVID ‐19 via multiple mechanisms. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 12, 2020 Category: Biotechnology Authors: Peter Staats, Georgios Giannakopoulos, Justyna Blake, Eric Liebler, Robert M. Levy Tags: Clinical Research Source Type: research

Offline Bi ‐Frontal Anodal Transcranial Direct Current Stimulation Decreases Total Sleep Time Without Disturbing Overnight Memory Consolidation
Conclusion(s)The application of tDCS can be considered safe regarding overnight memory consolidation and represents a promising treatment approach in conditions of decreased vigilance and arousal. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 11, 2020 Category: Biotechnology Authors: Lukas Frase, Friederike Jahn, Sulamith Tsodor, Lukas Krone, Peter Selhausen, Bernd Feige, Jonathan G. Maier, Hannah Piosczyk, Dieter Riemann, Michael A. Nitsche, Christoph Nissen Tags: Clinical Research Source Type: research

A Custom Made Electrode Construct and Reliable Implantation Method That Allows for Long ‐Term Bilateral Deep Brain Stimulation in Mice
ConclusionThe DBS electrode construct and implantation method described can be used for long ‐term DBS studies to further investigate the mechanisms underlying DBS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 8, 2020 Category: Biotechnology Authors: Sylvana Pol, Yasin Temel, Ali Jahanshahi Tags: Basic Research Source Type: research

Localization of the Sphenopalatine Ganglion Within the Pterygopalatine Fossa on Computed Tomography Angiography —A Potential Role in the Setting of Sphenopalatine Ganglion Microstimulator Implantation
ConclusionsSince localization of SPG on CTAs is feasible and reproducible, it has future clinical potential to aid placement, optimal positioning and individualized programming of the electrode array. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 7, 2020 Category: Biotechnology Authors: Loizos Siakallis, Steve E. J. Connor Tags: Clinical Research Source Type: research

Transcutaneous Electrical Acustimulation Improves Gastrointestinal Disturbances Induced by Transcatheter Arterial Chemoembolization in Patients With Liver Cancers
This study was designed to evaluate effects and mechanisms of noninvasive TEA on GI symptoms in patients treated with TACE.Materials and MethodsSeventy ‐four patients with liver cancers (eighteen female; age 63.4 ± 1.1 years) scheduled for TACE were randomized to TEA (n = 37) or sham ‐TEA (n = 37). TEA was performed via acupoints, ST36 and PC6 using parameters previously optimized for GI motility (1  h, bid) from the postoperative day 0 (POD0) to POD2. Sham‐TEA was performed using the same parameters via non‐acupoints. Symptom questionnaires were completed daily. The electrogastro...
Source: Neuromodulation: Technology at the Neural Interface - May 6, 2020 Category: Biotechnology Authors: Ying Zhu, Xianpeng Li, Jibo Ma, Wenyi Xu, Miaomiao Li, Yaoyao Gong, Bo Zhang, Ying Chen, Sun Chao, Qingcheng Xu, Lin Lin, Jiande D.Z. Chen Tags: Clinical Research Source Type: research

Patient Satisfaction Following Intrathecal Targeted Drug Delivery for Benign Chronic Pain: Results of a Single ‐Center Survey Study
ObjectivesTargeted Drug Delivery (TDD) is commonly used for the management of patients with intractable pain. Past studies have proven efficacy in pain relief and reduction in opioid use and cost ‐effectiveness in long‐term pain management. There are few studies investigating satisfaction among patients with implanted pain pumps that are managed with targeted intrathecal medications.Material and MethodsPatients in a single medical practice implanted with pain pumps for relief of intractable pain were identified and extracted from the electronic health record (EHR). Six hundred and ten active TDD patients were identifie...
Source: Neuromodulation: Technology at the Neural Interface - May 6, 2020 Category: Biotechnology Authors: David M. Schultz, Vwaire Orhurhu, Faizan Khan, Jonathan M. Hagedorn, Alaa Abd ‐Elsayed Tags: Clinical Research Source Type: research

Correlations Between Family History of Psychiatric Illnesses and Outcomes of Spinal Cord Stimulation
ConclusionsSubjects with PFH may experience less improvement in disability following SCS as compared to subjects without PFH. They may take longer to achieve the same outcomes, including pain relief and decrease in pain rumination. Our findings show that improvements in the PFH cohort are equivalent to that of the no PFH cohort on all measures except ODI at 12 ‐month follow‐up. Thus obtaining a detailed PFH prior to performing SCS is important in order to implement pre‐operative coping training for PFH patients, rather than exclusion from SCS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 5, 2020 Category: Biotechnology Authors: Breanna L. Sheldon, Olga Khazen, Paul J. Feustel, Guy Gechtman, Gavril Rosoklija, Shrey Patel, Marisa DiMarzio, Cheyanne Bridger, Rachel Dentinger, Julia Slyer, Julie G. Pilitsis Tags: Clinical Research Source Type: research

Use of Functional Magnetic Resonance Imaging to Assess How Motor Phenotypes of Parkinson's Disease Respond to Deep Brain Stimulation
BackgroundDeep brain stimulation (DBS) is a well ‐accepted treatment of Parkinson's disease (PD). Motor phenotypes include tremor‐dominant (TD), akinesia‐rigidity (AR), and postural instability gait disorder (PIGD). The mechanism of action in how DBS modulates motor symptom relief remains unknown.ObjectiveBlood oxygen level ‐dependent (BOLD) functional magnetic resonance imaging (fMRI) was used to determine whether the functional activity varies in response to DBS depending on PD phenotypes.Materials and MethodsSubjects underwent an fMRI scan with DBS cycling ON and OFF. The effects of DBS cycling on BOLD activatio...
Source: Neuromodulation: Technology at the Neural Interface - May 5, 2020 Category: Biotechnology Authors: Marisa DiMarzio, Radhika Madhavan, Suresh Joel, Ileana Hancu, Eric Fiveland, Julia Prusik, Michael Gillogly, Tanweer Rashid, Jacquelyn MacDonell, Jeffrey Ashe, Ilknur Telkes, Paul Feustel, Michael D Staudt, Damian S. Shin, Jennifer Durphy, Tags: Clinical Research Source Type: research

The Impact of Fluoroscopy During Percutaneous Nerve Evaluation on Subsequent Implantation of a Sacral Neuromodulator Among Women With Pelvic Floor Disorders: A Randomized, Noninferiority Trial
ConclusionsPNE performed without fluoroscopy is noninferior to PNE with fluoroscopy use for the outcome of SNM device implantation within three months among women undergoing therapy for PFDs. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 4, 2020 Category: Biotechnology Authors: Ankita Gupta, Casey Kinman, Deslyn T.G. Hobson, Kate V. Meriwether, Jeremy T. Gaskins, Md. Nazir Uddin, J. Ryan Stewart, Sean L. Francis Tags: Clinical Research Source Type: research

A Case Report of Reticular Telangiectatic Erythema Following Intrathecal Drug Delivery System Reservoir Replacement
Neuromodulation: Technology at the Neural Interface, EarlyView. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 4, 2020 Category: Biotechnology Authors: Logan Kinch, Lynn Kohan Tags: Letter to the Editor Source Type: research

Managing intrathecal drug delivery devices in a global pandemic
Neuromodulation: Technology at the Neural Interface, Accepted Article. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 2, 2020 Category: Biotechnology Authors: Philip Kim, Timothy Deer Tags: Letter to the Editor Source Type: research

A Prospective, Multicenter Study to Assess the Safety and Efficacy of Translingual Neurostimulation Plus Physical Therapy for the Treatment of a Chronic Balance Deficit Due to Mild ‐to‐Moderate Traumatic Brain Injury
This study was designed to assess the safety and efficacy of TLNS plus targeted physical therapy (PT) in people with a chronic balance deficit after mild ‐to‐moderate traumatic brain injury (mmTBI).Materials and MethodsThis international, multicenter, randomized study enrolled 122 participants with a chronic balance deficit who had undergone PT following an mmTBI and had plateaued in recovery. Randomized participants received PT plus either high ‐frequency pulse (HFP;n = 59) or low ‐frequency pulse (LFP;n = 63) TLNS. The primary efficacy and safety endpoints were the proportion of sensory organization test (SOT) re...
Source: Neuromodulation: Technology at the Neural Interface - April 29, 2020 Category: Biotechnology Authors: Alain Ptito, Linda Papa, Kenton Gregory, Robert L. Folmer, William C. Walker, Vivek Prabhakaran, Rima Wardini, Kim Skinner, Michael Yochelson Tags: Clinical Research Source Type: research

Evaluation of Fixed Intrathecal Bupivacaine Infusion Doses in the Oncologic Population
ConclusionsFor oncological patients, our data and experience support the initiation of intrathecal bupivacaine at the following doses: 5 mg/day for catheter tips in the cervical spine, 8 mg/day for catheter tips at T1 –4, and 10 mg/day for catheter tips at T5–8. Given the higher likelihood of adverse effects in catheters at T9‐12 and the lumbar spine, we start at 8 mg/day with close follow‐up of the patient. Initiating these doses allow our patients to safely reach adequate analgesia faster, with a shorte r hospitalization and quicker return to anti‐cancer therapy. (Source: Neuromodulation: Technology at ...
Source: Neuromodulation: Technology at the Neural Interface - April 28, 2020 Category: Biotechnology Authors: Grant H. Chen, Matthew A. Spiegel, Yan C. Magram, Ehtesham Baig, Keith Clement, Ilya Laufer, Amitabh Gulati Tags: Clinical Research Source Type: research

Use of non ‐invasive vagus nerve stimulation to treat respiratory symptoms associated with COVID‐19: A theoretical hypothesis and early clinical experience
ConclusionsPreliminary observations and a strong scientific foundation suggest that nVNS might provide clinical benefits in patients with COVID ‐19 via multiple mechanisms. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 27, 2020 Category: Biotechnology Authors: Peter Staats, Georgios Giannakopoulos, Justyna Blake, Eric Liebler, Robert M. Levy Tags: Clinical Research Source Type: research

Calendar of Events
Neuromodulation: Technology at the Neural Interface, Volume 23, Issue 3, Page 409-410, April 2020. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 27, 2020 Category: Biotechnology Tags: Professional Development Source Type: research

Table of Contents
Neuromodulation: Technology at the Neural Interface, Volume 23, Issue 3, Page iii-vi, April 2020. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 27, 2020 Category: Biotechnology Tags: Issue Information – Table of Contents Source Type: research

Editorial Board
Neuromodulation: Technology at the Neural Interface, Volume 23, Issue 3, Page i-i, April 2020. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 27, 2020 Category: Biotechnology Tags: Issue Information – Editorial Board Source Type: research

Aims and Scope
Neuromodulation: Technology at the Neural Interface, Volume 23, Issue 3, Page ii-ii, April 2020. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 27, 2020 Category: Biotechnology Tags: Issue Information – Aims and Scope Source Type: research

Abstracts from the North American Neuromodulation Society's 23rd Annual Meeting, Las Vegas, NV, USA
Neuromodulation: Technology at the Neural Interface, Volume 23, Issue 3, Page e1-e325, April 2020. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 27, 2020 Category: Biotechnology Tags: Abstracts Source Type: research

The Pathways and Processes Underlying Spinal Transmission of Low Back Pain: Observations From Dorsal Root Ganglion Stimulation Treatment
BackgroundDorsal root ganglion stimulation (DRG ‐S) is a novel approach to treat chronic pain. Lead placement at L2 has been reported to be an effective treatment for axial low back pain (LBP) primarily of discogenic etiology. We have recently shown, in a diverse cohort including cases of multilevel instrumentation following extensive prior bac k surgeries, that DRG‐S lead placement at T12 is another promising target. Local effects at the T12 DRG, alone, are insufficient to explain these results.Materials and MethodsWe performed a literature review to explore the mechanisms of LBP relief with T12 DRG ‐S.FindingsBranc...
Source: Neuromodulation: Technology at the Neural Interface - April 23, 2020 Category: Biotechnology Authors: Kenneth B. Chapman, Pauline S. Groenen, Kris C. Vissers, Noud van Helmond, Michael D. Stanton ‐Hicks Tags: Review Article Source Type: research

Interdisciplinary Laparoscopic Implantation of Neuromodulation Leads to the Sacral Plexus for Therapy of Chronic Pelvic Pain and Neurogenic Bladder Dysfunctions
ObjectiveThe aim of this study was to report on the use of laparoscopic implantation of leads on the branches of the sacral plexus for neuromodulation in the treatment of chronic pelvic pain (CPP) in a multidisciplinary setting with the help of electrophysiological neuromonitoring.Materials and MethodsBetween 2012 and 2019, six female patients complaining of chronic pain and bladder and bowel dysfunctions underwent laparoscopic exposure and nerve identification with the help of electrophysiological neuromonitoring. A lead was placed laparoscopically in direct contact with the affected nerve. Pain intensity (numerous rankin...
Source: Neuromodulation: Technology at the Neural Interface - April 22, 2020 Category: Biotechnology Authors: Malgorzata Kolodziej, Eberhard Uhl, Frank Schwarm, Jasmin Nagl, Rainer Sch ürg, Ivo Meinhold‐Heerlein, Hans‐Rudolf Tinneberg Tags: Basic Research Source Type: research

Development of an Educational Curriculum for Spinal Cord Stimulation
ConclusionA multidisciplinary task force of the NANS education committee developed a SCS training curriculum that defines ACGME milestones for basic learners, advanced learners, and practitioners. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 13, 2020 Category: Biotechnology Authors: Alaa Abd ‐Elsayed, Rany Abdallah, Steven Falowski, Gassan Chaiban, Adam Burkey, Konstantin Slavin, Maged Aziz, Ahmed M. Raslan Tags: Review Article Source Type: research

A Prospective Analysis of the Use of Intraoperative Neuromonitoring for Mapping the S1 Dorsal Root Ganglion Location to Determine Ideal Lead Positioning and Predict Postoperative Programming
ConclusionsThis prospective analysis further demonstrates the utility and accuracy of IONM. The use of DRG IONM is reliable for confirming dorsal placement along the S1 DRG, mapping its position, and guiding postoperative programming. The S1 DRG is located at the border of the foramen and canal in most, but not all cases. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 13, 2020 Category: Biotechnology Authors: Steven M. Falowski Tags: Clinical Research Source Type: research

Electroacupuncture Ameliorates Gastric Hypersensitivity via Adrenergic Pathway in a Rat Model of Functional Dyspepsia
ConclusionsEA ameliorates gastric hypersensitivity in IA ‐treated rats and the effect may be related to the improved sympathovagal balance and the decrease of stress hormones. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 13, 2020 Category: Biotechnology Authors: Xiaojun Ouyang, Shiying Li, Jingzhu Zhou, Jiande DZ Chen Tags: Basic Research Source Type: research

The Effect of Unilateral Subthalamic Nucleus Deep Brain Stimulation on Contralateral Subthalamic Nucleus Local Field Potentials
ConclusionsUnilateral STN DBS suppresses contralateral STN beta LFP. This indicates that unilateral STN DBS modulates bilateral basal ganglia networks. It remains unclear whether this mechanism accounts for the ipsilateral motor improvements. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 12, 2020 Category: Biotechnology Authors: Harutomo Hasegawa, Petra Fischer, Huiling Tan, Alek Pogosyan, Michael Samuel, Peter Brown, Keyoumars Ashkan Tags: Clinical Research Source Type: research

Postoperative Infections Associated With Prolonged Spinal Cord Stimulation Trial Duration (PROMISE RCT)
IntroductionIn the PROMISE study, a multinational randomized controlled trial (RCT) of the effectiveness of spinal cord stimulation (SCS) with multicolumn surgical leads as a treatment of low back pain, clinicians followed their usual practice. An early, unplanned safety analysis revealed that the infection rate in Belgium (5/23), where trial duration was a median 21.5  days, was significantly higher than the 1/64 rate observed in the other study countries (median 5.8 days,p 10  days was 24.1% vs. 1.4% for subjects trialed ≤10 days (p 
Source: Neuromodulation: Technology at the Neural Interface - April 8, 2020 Category: Biotechnology Authors: Richard North, Mehul J. Desai, Johan Vangeneugden, Christian Raftopoulos, Tony Van Havenbergh, Marc Deruytter, Jean ‐Michel Remacle, Jane Shipley, Ye Tan, Mary Jo Johnson, Carine Van den Abeele, Philippe Rigoard, on behalf of the PROMISE St Tags: Clinical Research Source Type: research

Effects of Focal Radiation on [18F] ‐Fluoro‐D‐Glucose Positron Emission Tomography in the Brains of Miniature Pigs: Preliminary Findings on Local Metabolism
ConclusionFocal, noninvasive, and durable changes in brain activity can be induced without a magnetic resonance imaging (MRI) ‐visible lesion, a result that may be consistent with the occurrence of neuromodulation. This approach may provide new venues for the investigation of neuromodulatory treatments for disorders involving dysfunctional brain circuits. Postmortem pathological analysis is needed to elucidate whether th ere have been morphological changes not detected by MRI. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 8, 2020 Category: Biotechnology Authors: Chun ‐I Yeh, Mei‐Fang Cheng, Furen Xiao, Yi‐Chieh Chen, Chien‐Chu Liu, Hung‐Yi Chen, Ruoh‐Fang Yen, Yu‐Ten Ju, Yilin Chen, Mohan Bodduluri, Pin‐Huan Yu, Chau‐Hwa Chi, Ngot Swan Chong, Liang‐Hsiang Wu, John R. Adler Jr, M Tags: Basic Research Source Type: research

Moving Beyond a Pain Intensity Reporting: The Value of Goal Identification in Neuromodulation
Neuromodulation: Technology at the Neural Interface, EarlyView. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 8, 2020 Category: Biotechnology Authors: Lisa Goudman, Maarten Moens Tags: Letter to the Editor Source Type: research

Catheter Access Port (Computed Tomography) Myelography in Intrathecal Drug Delivery Troubleshooting: A Case Series of 70 Procedures
ConclusionsCAP ‐CT myelography with 2D/3D reconstructions is an essential step in the diagnostic algorithm for cases involving ITDD failure. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 8, 2020 Category: Biotechnology Authors: Elmar M. Delhaas, Biswadjiet S. Harhangi, Sander P.G. Frankema, Frank J.P.M. Huygen, Aad van der Lugt Tags: Case Series Source Type: research

An Anatomical Study of the Foramen Ovale for Neuromodulation of Trigeminal Neuropathic Pain
ConclusionsThis study provides a novel means of approaching the FO via transoral gingival buccal access. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 3, 2020 Category: Biotechnology Authors: Ki ‐Hyun Cho, Hirsh A. Shah, Tyler Schimmoeller, Andre G. Machado, Francis A. Papay Tags: Basic Research Source Type: research

Wireless Spinal Cord Stimulation Technology for the Treatment of Neuropathic Pain: A Single ‐Center Experience
ConclusionsMinimal invasive implantation of wireless SCS systems was feasible and safe. The device offered a broader range of stimulation paradigms compared to conventional SCS devices, an allowed for a prolonged testing phase and continuous adjustment of SCS programs. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - March 31, 2020 Category: Biotechnology Authors: Rezvan Ahmadi, Mohammad Mehdi Hajiabadi, Andreas Unterberg, Christiane Geist, Benito Campos Tags: Clinical Research Source Type: research