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Response to “Negative Results Call for More Delicate Experimental Design in Cortical Excitability Change of taVNS Intervention”
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Ann Mertens, Kristl Vonck Tags: Letter to the Editor Source Type: research

A Prospective, Multicenter Study to Assess the Safety and Efficacy of Translingual Neurostimulation Plus Physical Therapy for the Treatment of a Chronic Balance Deficit Due to Mild ‐to‐Moderate Traumatic Brain Injury
ConclusionsSignificant improvements in balance and gait, in addition to headaches, sleep quality, and fall frequency, were observed with TLNS plus targeted PT; in participants who had a chronic balance deficit following an mmTBI and had plateaued on prior conventional physiotherapy. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Alain Ptito, Linda Papa, Kenton Gregory, Robert L. Folmer, William C. Walker, Vivek Prabhakaran, Rima Wardini, Kim Skinner, Michael Yochelson Tags: Clinical Research Source Type: research

Behavioral Survey of Effects of Pulsed Radiofrequency on Neuropathic and Nociceptive Pain in Rats: Treatment Profile and Device Implantation
ConclusionsPRF temporarily attenuates neuropathic and inflammatory pain. Bipolar PRF generates significant analgesia with a much lower electrical power than unipolar PRF. Meanwhile, the minor variant effects between PRF-DRG and PRF-SN may indicate distinct mechanisms. The sustained-analgesia by repetitive treatments suggests implantation technique could be a promising choice. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Ren ‐Yu Huang, Lawrence Poree, Kok‐Yuen Ho, Shih‐Ying Tsai, Yu‐Chen Liu, Ping‐Heng Tan, Yeong‐Ray Wen Tags: Basic Research Source Type: research

Annual Number of Spinal Cord Stimulation Procedures Performed in the State of Florida During 2018: Implications for Establishing Neuromodulation Centers of Excellence
ConclusionsFew physicians performing spinal cord stimulation procedures in the state of Florida in 2018 would have been considered as "high volume. ” Although volume is only one among many criteria used to designate centers of excellence for other procedures, the potential impact on physician practice and patient access to care should be considered if a specific minimum number of annual cases by physician is to be established. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Richard H. Epstein, Franklin Dexter, Edward M. Podgorski, Amy C. S. Pearson Tags: Clinical Research Source Type: research

Conscious Sedation Using Dexmedetomidine During Surgical Paddle Lead Placement Improves Outcome in Spinal Cord Stimulation: A Case Series of 25 Consecutive Patients
ConclusionsImplantation of spinal cord stimulation electrodes through a surgical laminectomy using dexmedetomidine is a safe and feasible procedure with adequate comfort for patient and surgeon. This way of working increases the optimal position of the electrode resulting in the most convenient stimulation pattern and avoiding revisions. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Dimitri J. Vanhauwaert, Tim Couvreur, Anneleen Vandebroek, Olivier De Coster, Karel Hanssens Tags: Case Series Source Type: research

Accuracy of Electrode Position in Sphenopalatine Ganglion Stimulation in Correlation With Clinical Efficacy
ConclusionThere was no significant correlation regarding aberrations of lead position from the planned position with clinical outcome. However, this study might be underpowered to detect such a correlation. The closest electrode contact to the vidian canal was in the stimulation area in all but one patient in the final programming. This indicates that, overall, the lead location does play a crucial role in SPG stimulation for cluster headache. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Guilherme S. Piedade, Jan Vesper, Rahel Hoyer, Thomas Klenzner, Philipp J. Slotty Tags: Clinical Research Source Type: research

Input –Output Functions in Human Heads Obtained With Cochlear Implant and Transcranial Electric Stimulation
ConclusionThese results provide a novel objective measure of electric stimulation in the human head, which can help to optimize stimulation parameters that improve neural excitation of deep structures by reducing the influence of current spread.Conflict of InterestThe authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Phillip Tran, Matthew L. Richardson, Fan ‐Gang Zeng Tags: Basic Research Source Type: research

Tissue Temperature Increases by a 10 kHz Spinal Cord Stimulation System: Phantom and Bioheat Model
ConclusionsHeating of spinal tissues by this 10 kHz SCS system theoretically increases quickly with stimulation level and load impedance, while dampened by IPG pulse bandwidth and voltage compliance limitations. If validated in vivo as a mechanism of kHz SCS, bioheat models informed by IPG limitations allow prediction and optimization of temperature changes. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Adantchede L. Zannou, Niranjan Khadka, Mohamad FallahRad, Dennis Q. Truong, Brian H. Kopell, Marom Bikson Tags: Basic Research Source Type: research

Localization of the Sphenopalatine Ganglion Within the Pterygopalatine Fossa on Computed Tomography Angiography —A Potential Role in the Setting of Sphenopalatine Ganglion Microstimulator Implantation
ConclusionsSince localization of SPG on CTAs is feasible and reproducible, it has future clinical potential to aid placement, optimal positioning and individualized programming of the electrode array. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Loizos Siakallis, Steve E. J. Connor Tags: Clinical Research Source Type: research

Implantable Pulse Generator Site May Be Associated With Spinal Cord Stimulation Revision Surgeries
ConclusionAlthough this study found a significant association between IPG site and revision surgeries, the effect of IPG site was not found to be predictive. The IPG site likely influences whether a patient will require revision surgery, but further investigation is required to establish this association. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Shyle H. Mehta, Christian M. Hoelscher, Ashwini D. Sharan, Sara Thalheimer, Chengyuan Wu Tags: Clinical Research Source Type: research

Pulsed Radiofrequency Neuromodulation Contributes to Activation of Platelet ‐Rich Plasma in In Vitro Conditions
ConclusionsWe confirmed that PRF may activate PRP without additional platelet activators. So, a combination of both methods PRF and PRP application may provide a more effective opportunity for tissue regeneration in dentistry, surgery, dermatology, or in orthopedics. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Anna Michno, Zbigniew Kirkor, Ewelina Gojtowska, Marek Suchorzewski, Irmina Śmietańska, Bartosz Baścik Tags: Basic Research Source Type: research

Control of Functional Electrical Stimulation Systems Using Simultaneous Pulse Width, Amplitude, and Frequency Modulations
ConclusionsThe experimental results show that control performance and tracking ability of the joint reference trajectory are improved by using the simultaneous modulation of PW, amplitude, and frequency. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Vahab Nekoukar Tags: Basic Research Source Type: research

Spatial Filtering of Electroencephalography Reduces Artifacts and Enhances Signals Related to Spinal Cord Stimulation (SCS)
ConclusionsEEG spectral analysis combined with spatial filtering allows for a spatially and temporally specific assessment of SCS-related, neuromodulatory EEG activity, and may help to disentangle therapeutic and side effects of SCS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Lars Buentjen, Petya Vicheva, BS Chander, Sophie ‐Antoinette Beccard, Christopher Coutts, Elena Azañón, Max‐Philipp Stenner, Matthias Deliano Tags: Basic Research Source Type: research

Evaluation of the Efficacy of Musical Vibroacupuncture in Pain Relief: A Randomized Controlled Pilot Study
ConclusionsThese results suggest that MVA effectively increased pain tolerance and reduced pain intensity when compared with all groups, although not significant to the VA group. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - December 15, 2021 Category: Biotechnology Authors: Augusto Weber, Simon Busbridge, Ricardo Governo Tags: Study Protocol Source Type: research

Response to “Investigating the Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Cortical Excitability in Healthy Males”
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - November 16, 2021 Category: Biotechnology Authors: Minghui Gu, Jiang Xu Tags: Letter to the Editor Source Type: research