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Directional Deep Brain Stimulation for Parkinson's Disease: Results of an International Crossover Study With Randomized, Double ‐Blind Primary Endpoint
ConclusionDirectional stimulation yielded a wider TW compared to omnidirectional stimulation and was preferred by blinded subjects and clinicians. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 28, 2021 Category: Biotechnology Authors: Alfons Schnitzler, Pablo Mir, Matthew A. Brodsky, Leonard Verhagen, Sergiu Groppa, Ramiro Alvarez, Andrew Evans, Marta Blazquez, Sean Nagel, Julie G. Pilitsis, Monika P ötter‐Nerger, Winona Tse, Leonardo Almeida, Nestor Tomycz, Joohi Jime Tags: Clinical Research Source Type: research

A Systematic Review of the Safety and Tolerability of Theta Burst Stimulation in Children and Adolescents
ConclusionsTBS interventions in children may have similar safety, tolerability, and feasibility as compared to adults. However, long-term, follow-up studies of TBS are lacking. Future dose-ranging studies with systematic assessment of adverse events will be important in the translation of findings with TBS from adults to youth. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 27, 2021 Category: Biotechnology Authors: Rana Elmaghraby, Qi Sun, Can Ozger, Julia Shekunov, Magdalena Romanowicz, Paul E. Croarkin Tags: Review Article Source Type: research

The Impact of Subthalamic Deep Brain Stimulation on Restless Legs Syndrome in Parkinson's Disease
ConclusionDBS-STN provided relief of symptoms in most of the patients with PD and RLS. We found that RLS was associated with worse subjective sleep quality, more severe NMS, and complications of levodopa therapy. DBS-STN may have direct impact on RLS rather than related indirectly through post-surgery change in medications. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 26, 2021 Category: Biotechnology Authors: Jaros ław Dulski, Piotr Wąż, Agnieszka Konkel, Karol Grabowski, Witold Libionka, Michał Schinwelski, Emilia J. Sitek, Jarosław Sławek Tags: Clinical Research Source Type: research

Insights on the Potential Mechanisms of Action of Functional Electrical Stimulation Therapy in Combination With Task ‐Specific Training: A Scoping Review
ConclusionsThe results of this scoping review suggest that FEST  + TST can result in multiple effects on different elements of the neuromuscular system, while most research studies were focused on the muscle changes after FEST + TST. Despite the efficacy of the FEST + TST in the neurorehabilitation after CNS injury or disease, the results of this rev iew underline an important knowledge gap with regards to the actual mechanism of action of FEST + TST. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 25, 2021 Category: Biotechnology Authors: Julio Cesar Furlan, Maureen Pakosh, Beverley Catharine Craven, Milos Radomir Popovic Tags: Review Article Source Type: research

Deep Brain Stimulation Compared With Contingency Management for the Treatment of Cocaine Use Disorders: A Threshold and Cost ‐Effectiveness Analysis
ConclusionsWe find DBS would not be cost-effective in the short-term (one year) but may be cost-effective in longer timelines. Since DBS holds promise to potentially be a cost-effective treatment for CUDs, future randomized controlled trials should be performed to assess its efficacy. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 24, 2021 Category: Biotechnology Authors: Fiene Marie Kuijper, Uma V. Mahajan, Seul Ku, Daniel A. N. Barbosa, Sheila M. Alessi, Sherman C. Stein, Kyle M. Kampman, Brandon S. Bentzley, Casey H. Halpern Tags: Clinical Research Source Type: research

Effects of Medications and Subthalamic Nucleus ‐Deep Brain Stimulation on the Cutaneous Silent Period in Patients With Parkinson's Disease
ConclusionDifferent onset latencies and the duration of CSP between low- and high-strength stimuli support the hypotheses proposing two different reflex pathways. Despite being independent from the UPDRS-III, the CSP may be an electrophysiological indicator reflective of the changes in inhibitory activity to the spinal α-motoneuron in response to anti-PD medications and DBS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 21, 2021 Category: Biotechnology Authors: Eiichirou Urasaki, Yasushi Miyagi, Junji Kishimoto Tags: Clinical Research Source Type: research

Transcutaneous Electrical Stimulation for Neurogenic Bladder Dysfunction Following Spinal Cord Injury: Meta ‐Analysis of Randomized Controlled Trials
ConclusionsTENS may be an effective, safe intervention for neurogenic bladder dysfunction following SCI. Further studies are essential to confirm these results and more work is required to determine optimal stimulation parameters and duration of the treatment. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 20, 2021 Category: Biotechnology Authors: Sam Parittotokkaporn, Chris Varghese, Gregory O'Grady, Anna Lawrence, Darren Svirskis, Simon J. O'Carroll Tags: Review Article Source Type: research

Comparison of Two Different Pulsed Radiofrequency Modes for Prevention of Postherpetic Neuralgia in Elderly Patients with Acute/Subacute Trigeminal Herpes Zoster
ConclusionHL-PRF neuromodulation of the gasserian ganglion appears to be more effective than S-PRF for preventing PHN in the elderly.Clinical Trial RegistrationChiCTR2000038775. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 19, 2021 Category: Biotechnology Authors: Cheng ‐Fu Wan, Tao Song Tags: Clinical Research Source Type: research

Implantable Peripheral Nerve Stimulation for Trigeminal Neuropathic Pain: A Systematic Review and Meta ‐Analysis
ConclusionPeripheral nerve stimulation may be a promising approach in the management of trigeminal neuropathic pain, especially for patients intractable to conventional therapy. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 19, 2021 Category: Biotechnology Authors: Yuncheng Ni, Liuqing Yang, Rui Han, Gangwen Guo, Shitong Huang, Lili Weng, Xun Wang, Zhenxing Li, Dong Huang, Rong Hu, Haocheng Zhou Tags: Review Article Source Type: research

Effectiveness of Low ‐Frequency Pallidal Deep Brain Stimulation at 65 Hz in Tourette Syndrome
ConclusionsThe results of this study indicated that low-frequency DBS represents an effective and practical treatment for refractory TS with comparable efficacy to high-frequency DBS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 18, 2021 Category: Biotechnology Authors: Fengqiao Sun, Xiaohua Zhang, Sheng Dong, Yuqing Zhang, Jiping Li, Yunpeng Wang, Jin Zhu Tags: Clinical Research Source Type: research

Model ‐Based Optimization of Spinal Cord Stimulation for Inspiratory Muscle Activation
ConclusionsOur computational modeling and experimental results support the potential advantages of a lead design with longer contacts and larger edge ‐to‐edge contact spacing to maximize inspiratory muscle activation during HF‐SCS at the T2 spinal level. While these results need to be further validated in future studies, we believe that the results of this study will help improve the efficacy of HF‐SCS technologies for inspiratory muscle pacing. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 14, 2021 Category: Biotechnology Authors: Hans J. Zander, Krzysztof E. Kowalski, Anthony F. DiMarco, Scott F. Lempka Tags: Basic Research Source Type: research

The Link Between Spinal Cord Stimulation and the Parasympathetic Nervous System in Patients With Failed Back Surgery Syndrome
ConclusionsParameters that are regulated by the sympathetic nervous system were not significantly different between SCS on and off states, leading to the hypothesis that SCS is capable of restoring the dysregulation of the autonomic nervous system by primarily increasing the activity of the parasympathetic system, in patients with FBSS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 14, 2021 Category: Biotechnology Authors: Lisa Goudman, Ann De Smedt, Fr édéric Louis, Virginie Stalmans, Bengt Linderoth, Philippe Rigoard, Maarten Moens Tags: Clinical Research Source Type: research

Effectiveness of Microcurrent Stimulation in Preserving Retinal Function of Blind Leading Retinal Degeneration and Optic Neuropathy: A Systematic Review
ConclusionsES treatment has promising therapeutic effects on RP and optic neuropathy. More large ‐scale RCT studies should be conducted to elucidate the potential of ES, especially on AMD, RAO, and glaucoma. A comparison of the effects by different ES methods in the same disease populations is still lacking. Parameters of the electric current and sensitive detection method should be optimized for the evaluation of ES treatment effects in future studies. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 13, 2021 Category: Biotechnology Authors: Jinfeng Liu, Kelvin Tong, Youhong Lin, Vincent W. H. Lee, Kwok Fai So, Kendrick Co Shih, Jimmy S. M. Lai, Kin Chiu Tags: Review Article Source Type: research

Exploring Patient Perceptions of Noninvasive Brain Stimulation: A Systematic Review
ConclusionThe findings from this review suggest that rTMS is well accepted as a therapeutic treatment among psychiatric populations, providing support for its clinical utility. Future work is needed to determine if similar findings exist for other conditions (e.g., chronic pain) and for other therapeutic forms of brain stimulation (e.g., tDCS). (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 12, 2021 Category: Biotechnology Authors: Georgia Stillianesis, Rocco Cavaleri, Clarice Y. Tang, Simon J. Summers Tags: Review Article Source Type: research

Low Rate of Intrathecal Baclofen Pump Catheter ‐Related Complications: Long‐Term Study in Over 100 Adult Patients Associated With Reinforced Catheter
ConclusionsReported CRCs have been high for ITB pump systems. Ours is the first large cohort, long ‐term study of CRCs related to reinforced catheters; additionally, our low CRC rate compares favorably to previously published data. Thus, implantation of reinforced catheters may be associated with a low CRC rate. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 11, 2021 Category: Biotechnology Authors: Christina N. Feller, Ahmed J. Awad, Mary Elizabeth S. Nelson, Nicholas Ketchum, Peter A. Pahapill Tags: Clinical Research Source Type: research