Long ‐Term Outcomes of Occipital Nerve Stimulation for New Daily Persistent Headache With Migrainous Features
ConclusionOur experience suggests that ONS is not effective in the treatment of NDPH with migrainous features even in centers with experience in treating chronic migraine with ONS. The difference in response rates of chronic migraine and NDPH with migrainous features supports the concept of a different pathophysiology to the two conditions. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 28, 2021 Category: Biotechnology Authors: Susie Lagrata, Sanjay Cheema, Laurence Watkins, Manjit Matharu Tags: Clinical Research Source Type: research

Impact of Cardiac ‐Based Vagus Nerve Stimulation Closed‐Loop Stimulation on the Seizure Outcome of Patients With Generalized Epilepsy: A Prospective, Individual‐Control Study
ConclusionsrVNS was effective in reducing seizure frequency in patients with generalized epilepsy, but activation of the cbVNS feature did not add significantly to rVNS efficacy. On the other hand, although not statistically significant, 40% of the patients showed some reduction in seizure frequency, which might prove useful at an individual level. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 28, 2021 Category: Biotechnology Authors: Arthur Cukiert, Cristine Mella Cukiert, Pedro Paulo Mariani, Jose Augusto Burattini Tags: Clinical Research Source Type: research

Reassessment of the Effect of Transcutaneous Auricular Vagus Nerve Stimulation Using a Novel Burst Paradigm on Cardiac Autonomic Function in Healthy Young Adults
ConclusionThe burst parameter could be used as an alternative strategy for regulating cardiac parasympathetic function by taVNS, which has the potential to be used as a complementary paradigm to traditional tonic taVNS for promoting clinical treatment efficacy. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 27, 2021 Category: Biotechnology Authors: Lin ‐Lin Shen, Jin‐Bo Sun, Xue‐Juan Yang, Hui Deng, Wei Qin, Meng‐Yu Du, Ling‐Xia Meng, Nan Li, Xiao‐Yu Guo, Wen‐Zhou Qiao, Wei‐Qi Yang, Peng Liu, Xiao Zeng Tags: Basic Research Source Type: research

Role of Microelectrode Recording in Deep Brain Stimulation of ?the Pedunculopontine Nucleus: A Physiological Study of Two Cases
ConclusionsEstimation of stimulation site within the PPN is possible by combining physiological guidance using MER and MRI findings. The PPN is a potential target for gait disturbances, although the efficacy of PPN DBS may depend on the location of the electrode and the stimulation parameters. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 26, 2021 Category: Biotechnology Authors: Takehiro Yako, Kazuo Kitazawa, Shigeaki Kobayashi, Shoji Yomo, Hiromasa Sato, Luke A. Johnson, Jerrold L. Vitek, Takao Hashimoto Tags: Clinical Research Source Type: research

Role of Microelectrode Recording in Deep Brain Stimulation of  the Pedunculopontine Nucleus: A Physiological Study of Two Cases
ConclusionsEstimation of stimulation site within the PPN is possible by combining physiological guidance using MER and MRI findings. The PPN is a potential target for gait disturbances, although the efficacy of PPN DBS may depend on the location of the electrode and the stimulation parameters. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 26, 2021 Category: Biotechnology Authors: Takehiro Yako, Kazuo Kitazawa, Shigeaki Kobayashi, Shoji Yomo, Hiromasa Sato, Luke A. Johnson, Jerrold L. Vitek, Takao Hashimoto Tags: Clinical Research Source Type: research

Cross ‐Country Differences in Pain Medication Before and After Spinal Cord Stimulation: A Pooled Analysis of Individual Patient Data From Two Prospective Studies in the United Kingdom and Belgium
ConclusionsOur combined analysis revealed differences in prescription practice in patients scheduled for SCS implantation between Belgium and United Kingdom. NSAIDs and neuropathic mood agents are more frequently used in the United Kingdom, presumably due to easier access to repeat prescriptions and over the counter medications. After three  months of SCS, a decrease in medication use is observed in both countries, with higher reductions in Belgium, presumably due to strict regulations concerning reimbursement criteria. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 25, 2021 Category: Biotechnology Authors: Lisa Goudman, Rui V. Duarte, Ann De Smedt, Sue Copley, Sam Eldabe, Maarten Moens Tags: Clinical Research Source Type: research

Cross ?Country Differences in Pain Medication Before and After Spinal Cord Stimulation: A Pooled Analysis of Individual Patient Data From Two Prospective Studies in the United Kingdom and Belgium
ConclusionsOur combined analysis revealed differences in prescription practice in patients scheduled for SCS implantation between Belgium and United Kingdom. NSAIDs and neuropathic mood agents are more frequently used in the United Kingdom, presumably due to easier access to repeat prescriptions and over the counter medications. After three ?months of SCS, a decrease in medication use is observed in both countries, with higher reductions in Belgium, presumably due to strict regulations concerning reimbursement criteria. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 24, 2021 Category: Biotechnology Authors: Lisa Goudman, Rui V. Duarte, Ann De Smedt, Sue Copley, Sam Eldabe, Maarten Moens Tags: Clinical Research Source Type: research

Systematic Literature Review of Spinal Cord Stimulation in Patients With Chronic Back Pain Without Prior Spine Surgery
ConclusionFindings suggest that SCS is a promising, safe, minimally invasive, and reversible alternative option for managing chronic back pain in patients who have not undergone spinal surgery. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 19, 2021 Category: Biotechnology Authors: Jan M. Eckermann, Julie G. Pilitsis, Christopher Vannaboutathong, Belinda J. Wagner, Rose Province ‐Azalde, Markus A. Bendel Tags: Review Article Source Type: research

Local Field Potential ‐Based Programming: A Proof‐of‐Concept Pilot Study
ConclusionsThe approach presented in this pilot proof-of-concept study may inform and streamline the DBS programming for conditions requiring clinicians and patients to wait weeks before appreciating any clinical benefit. Prospective studies on larger samples of patients are warranted. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 18, 2021 Category: Biotechnology Authors: Alfonso Fasano, Carolina Gorodetsky, Darcia Paul, J ürgen Germann, Aaron Loh, Han Yan, Peter L. Carlen, Sara Breitbart, Andres M. Lozano, George M. Ibrahim, Suneil K. Kalia Tags: Clinical Research Source Type: research

Efficacy of Transcutaneous Electrical Nerve Stimulation and Interferential Current on Tactile Acuity of Individuals With Nonspecific Chronic Low Back Pain
ConclusionsTENS increases the tactile acuity of individuals with NSCLBP, whereas IFC demonstrated no significant change in tactile acuity. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 18, 2021 Category: Biotechnology Authors: Bosede Abidemi Tella, Saturday Nicholas Oghumu, Caleb Ademola Omuwa Gbiri Tags: Clinical Research Source Type: research

Local Field Potential ?Based Programming: A Proof?of?Concept Pilot Study
ConclusionsThe approach presented in this pilot proof-of-concept study may inform and streamline the DBS programming for conditions requiring clinicians and patients to wait weeks before appreciating any clinical benefit. Prospective studies on larger samples of patients are warranted. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 18, 2021 Category: Biotechnology Authors: Alfonso Fasano, Carolina Gorodetsky, Darcia Paul, J rgen Germann, Aaron Loh, Han Yan, Peter L. Carlen, Sara Breitbart, Andres M. Lozano, George M. Ibrahim, Suneil K. Kalia Tags: Clinical Research Source Type: research

Combining Trauma Script Exposure With rTMS to Reduce Symptoms of Post ?Traumatic Stress Disorder: Randomized Controlled Trial
ConclusionWe found no evidence of difference in clinical improvement or remission rates between the 110% HF and 70% LF stimulation. These findings may reflect the importance of exposure procedure and that larger number of participants is needed. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 17, 2021 Category: Biotechnology Authors: Sarah Thierr e, Marie Raulin?Briot, Marc Legrand, Amlie Le Gouge, Alexis Vancappel, Andrei?Cristian Tudorache, Bruno Brizard, David Clarys, Agns Caille, Wissam El?Hage Tags: Clinical Research Source Type: research

Combining Trauma Script Exposure With rTMS to Reduce Symptoms of Post ‐Traumatic Stress Disorder: Randomized Controlled Trial
ConclusionWe found no evidence of difference in clinical improvement or remission rates between the 110% HF and 70% LF stimulation. These findings may reflect the importance of exposure procedure and that larger number of participants is needed. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 17, 2021 Category: Biotechnology Authors: Sarah Thierr ée, Marie Raulin‐Briot, Marc Legrand, Amélie Le Gouge, Alexis Vancappel, Andrei‐Cristian Tudorache, Bruno Brizard, David Clarys, Agnès Caille, Wissam El‐Hage Tags: Clinical Research Source Type: research

Short ‐ and Long‐Term Response of Vagus Nerve Stimulation Therapy in Drug‐Resistant Epilepsy: A Systematic Review and Meta‐Analysis
ConclusionsThe estimating of efficacy and tolerability, using data from the existing literature, indicated VNS therapy is a safe and effective treatment option for patients with DRE. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 15, 2021 Category: Biotechnology Authors: Hongliang Mao, Yonghao Chen, Qintao Ge, Lei Ye, Hongwei Cheng Tags: Review Article Source Type: research

Short ? and Long?Term Response of Vagus Nerve Stimulation Therapy in Drug?Resistant Epilepsy: A Systematic Review and Meta?Analysis
ConclusionsThe estimating of efficacy and tolerability, using data from the existing literature, indicated VNS therapy is a safe and effective treatment option for patients with DRE. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - August 14, 2021 Category: Biotechnology Authors: Hongliang Mao, Yonghao Chen, Qintao Ge, Lei Ye, Hongwei Cheng Tags: Review Article Source Type: research