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Ultra ?Low Energy Cycled Burst Spinal Cord Stimulation Yields Robust Outcomes in Pain, Function, and Affective Domains: A Subanalysis From Two Prospective, Multicenter, International Clinical Trials
DiscussionIntermittent cycling of burst SCS lowers the overall electric charge delivered to the spinal cord and preserves battery consumption, without compromising pain relief and associated symptoms. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 27, 2021 Category: Biotechnology Authors: Timothy Deer, Derron Wilson, David Schultz, Steven Falowski, Ed Tavel, Gregory Moore, Robert Heros, Denis Patterson, Marie Fahey, Robyn Capobianco, Magdalena Anitescu Tags: Clinical Research Source Type: research

Deep Brain Stimulation of Caudal Zona Incerta for Parkinson's Disease: One ?Year Follow?Up and Electric Field Simulations
ConclusionsBilateral cZi-DBS alleviates motor symptoms, especially tremor, and improves ADL and stigma in PD patients one year after surgery. Improvement maps may be a useful tool for visualizing the spread of the electric field. However, there was no clear-cut relation between anatomical location of the electric field and the degree of symptom relief. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 27, 2021 Category: Biotechnology Authors: Rasmus Stenmark Persson, Teresa Nordin, Gun ?Marie Hariz, Karin W�rdell, Lars Forsgren, Marwan Hariz, Patric Blomstedt Tags: Clinical Research Source Type: research

Deep Brain Stimulation of Caudal Zona Incerta for Parkinson's Disease: One ‐Year Follow‐Up and Electric Field Simulations
ConclusionsBilateral cZi-DBS alleviates motor symptoms, especially tremor, and improves ADL and stigma in PD patients one year after surgery. Improvement maps may be a useful tool for visualizing the spread of the electric field. However, there was no clear-cut relation between anatomical location of the electric field and the degree of symptom relief. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 27, 2021 Category: Biotechnology Authors: Rasmus Stenmark Persson, Teresa Nordin, Gun ‐Marie Hariz, Karin Wårdell, Lars Forsgren, Marwan Hariz, Patric Blomstedt Tags: Clinical Research Source Type: research

Wireless Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Trigeminal Pain: A Single Center Experience
ConclusionThe partially implantable sTNFS device seems to be safe, effective, and reliable. Compared to conventional devices, the equipment is not limited to the length of trial stimulation. Furthermore, the daily stimulation duration was much shorter compared to previous reports. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 27, 2021 Category: Biotechnology Authors: Mohammad Mehdi Hajiabadi, Martin Jakobs, Andreas Unterberg, Rezvan Ahmadi Tags: Clinical Research Source Type: research

Stability and Effect of Parkinsonian State on Deep Brain Stimulation Cortical Evoked Potentials
ConclusionsOur findings underscore the spatiotemporal specificity and relative stability of the DBS-CEP associated with different disease states and with therapeutic benefit. DBS-CEP may be a viable biomarker for therapeutic programming. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 27, 2021 Category: Biotechnology Authors: Brett A. Campbell, Hanbin Cho, Riley M. Faulhammer, Olivia Hogue, Jenny Peih ‐Chir Tsai, M. Shazam Hussain, Andre G. Machado, Kenneth B. Baker Tags: Basic Research Source Type: research

Single ?Center Retrospective Analysis of Device?Related Complications Related to Dorsal Root Ganglion Stimulation for Pain Relief in 31 Patients
ConclusionIn this study, we examine the various device-related complications associated with DRG stimulation requiring repeat surgery. High rates of hardware failure, revision surgery, and explantation of stimulators illustrate the need for hardware optimization to improve patient outcomes. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 26, 2021 Category: Biotechnology Authors: Kevin Hines, Vishal Swaminathan, Sara Thalheimer, Michael Kogan, Chengyuan Wu, Ashwini Sharan Tags: Clinical Research Source Type: research

Single ‐Center Retrospective Analysis of Device‐Related Complications Related to Dorsal Root Ganglion Stimulation for Pain Relief in 31 Patients
ConclusionIn this study, we examine the various device-related complications associated with DRG stimulation requiring repeat surgery. High rates of hardware failure, revision surgery, and explantation of stimulators illustrate the need for hardware optimization to improve patient outcomes. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 26, 2021 Category: Biotechnology Authors: Kevin Hines, Vishal Swaminathan, Sara Thalheimer, Michael Kogan, Chengyuan Wu, Ashwini Sharan Tags: Clinical Research Source Type: research

Functional Magnetic Resonance Imaging Signal Variability Is Associated With Neuromodulation in Fibromyalgia
ConclusionOur findings suggest that M1-tDCS might revert temporal variability of fMRI signals in the rACC/vmPFC and posterior insula linked to FM pain. Changes in neural variability would be part of the mechanisms underlying repetitive M1-tDCS analgesia in FM. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 26, 2021 Category: Biotechnology Authors: Manyoel Lim, Dajung J. Kim, Thiago D. Nascimento, Eric Ichesco, Chelsea Kaplan, Richard E. Harris, Alexandre F. DaSilva Tags: Clinical Research Source Type: research

A Clinical Feasibility Study of Spinal Evoked Compound Action Potential Estimation Methods
ConclusionsThis work represents the first comprehensive assessment of spinal ECAP estimation schemes. Understanding the clinically relevant sensitivities of these schemes is increasingly important, particularly with closed-loop SCS systems using ECAP as a feedback control variable where misclassification of artifact as neural signal may lead to suboptimal therapy adjustments. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 23, 2021 Category: Biotechnology Authors: Krishnan Chakravarthy, James FitzGerald, Andrew Will, Karen Trutnau, Robert Corey, David Dinsmoor, Leonid Litvak Tags: Basic Research Source Type: research

Deep Brain Stimulation Reduces Conflict ‐Related Theta and Error‐Related Negativity in Patients With Obsessive–Compulsive Disorder
ConclusionALIC/NAc DBS diminished MFT and ERN, demonstrating modulation of the medial frontal performance monitoring system in OCD. Furthermore, our findings encourage further studies to explore the ERN as a potential predictor for clinical efficacy. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Authors: Elena Sildatke, Theo O. J. Gruendler, Markus Ullsperger, Till A. Dembek, Juan Carlos Baldermann, Sina Kohl, Veerle Visser ‐Vandewalle, Daniel Huys, Jens Kuhn, Thomas Schüller Tags: Basic Research Source Type: research

Deep Brain Stimulation Reduces Conflict ?Related Theta and Error?Related Negativity in Patients With Obsessive�Compulsive Disorder
ConclusionALIC/NAc DBS diminished MFT and ERN, demonstrating modulation of the medial frontal performance monitoring system in OCD. Furthermore, our findings encourage further studies to explore the ERN as a potential predictor for clinical efficacy. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Authors: Elena Sildatke, Theo O. J. Gruendler, Markus Ullsperger, Till A. Dembek, Juan Carlos Baldermann, Sina Kohl, Veerle Visser ?Vandewalle, Daniel Huys, Jens Kuhn, Thomas Sch�ller Tags: Basic Research Source Type: research

BDNF rs6265 Genotype Influences Outcomes of Pharmacotherapy and Subthalamic Nucleus Deep Brain Stimulation in Early ‐Stage Parkinson's Disease
ConclusionsGenotyping for the rs6265 polymorphism may be useful for predicting long-term response to drug therapy and counseling Parkinson's disease patients regarding whether to consider earlier subthalamic nucleus deep brain stimulation. Validation in a larger cohort of early-stage Parkinson's disease subjects is warranted. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Authors: Caryl E. Sortwell, Mallory L. Hacker, David Luke Fischer, Peter E. Konrad, Thomas L. Davis, Joseph S. Neimat, Lily Wang, Yanna Song, Zach R. Mattingly, Allyson Cole ‐Strauss, Jack W. Lipton, P. David Charles Tags: Clinical Research Source Type: research

Calendar of Events
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Tags: Professional Development Source Type: research

Table of Contents
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Tags: Issue Information – Table of Contents Source Type: research

Aims and Scope
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 20, 2021 Category: Biotechnology Tags: Issue Information – Aims and Scope Source Type: research