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Supraspinal Effects of Dorsal Root Ganglion Stimulation in Chronic Pain Patients
ConclusionOur results demonstrate increased low ‐frequency power spectral activity in chronic pain patients in the absence of stimulation which shifts toward higher frequency power spectrum activity in response to therapeutic DRGS. These cortical changes in response to DRGS provide support for the use of neuroimaging in the search for potential biomarkers of pain. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 11, 2021 Category: Biotechnology Authors: Tariq Parker, Yongzhi Huang, Ashley L. B. Raghu, James FitzGerald, Tipu Z. Aziz, Alexander L. Green Tags: Clinical Research Source Type: research

Inducing Cortical Plasticity to Manipulate and Consolidate Subjective Time Interval Production
ConclusionThese findings suggest that, while learned altered duration production decays over several hours, QPS over the right DLPFC enables the consolidation of newly learned duration production. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 8, 2021 Category: Biotechnology Authors: Motoyasu Honma, Shoko Saito, Takeshi Atsumi, Shin ‐ichi Tokushige, Satomi Inomata‐Terada, Atsuro Chiba, Yasuo Terao Tags: Basic Research Source Type: research

Feasibility of Spinal Cord Stimulation in Patients With Refractory Angina Pectoris and a Cardiac Implanted Electronic Device
ConclusionSpinal cord stimulation can be safely applied in patients with a CIED provided that the CIED is checked for interference during implantation, if mode switches of the SCS occurred and once yearly after implantation according to routine follow ‐up. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 6, 2021 Category: Biotechnology Authors: Fabienne E. Vervaat, Hans van Suijlekom, Inge Wijnbergen Tags: Clinical Research Source Type: research

Exploration of High and Low Frequency Options for Subperception Spinal Cord Stimulation Using Neural Dosing Parameter Relationships: The HALO Study
ConclusionsWe have derived an electric field configuration and, along with previous learnings in the kHz range, a set of neural dosing parameter relationships (10 –10,000 Hz), which enable the expansion of effective subperception SCS to low frequency and achieve major energy savings. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 5, 2021 Category: Biotechnology Authors: Jos é Paz‐Solís, Simon Thomson, Roshini Jain, Lilly Chen, Ismael Huertas, Que Doan Tags: Clinical Research Source Type: research

Long ‐Term Trigeminal Nerve Stimulation as a Treatment for Ocular Pain
ConclusionOur study suggests TNS is a safe, adjunctive treatment option in individuals with severe, chronic ocular pain. Individuals demonstrated gradual, continual improvement in pain symptoms over time within a multimodal approach. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 5, 2021 Category: Biotechnology Authors: Divy Mehra, Simran Mangwani ‐Mordani, Kelly Acuna, Jodi Hwang, Elizabeth Felix, Anat Galor Tags: Clinical Research Source Type: research

The Clinical Efficacy of High ‐Voltage Long‐Duration Pulsed Radiofrequency Treatment in Pudendal Neuralgia: A Retrospective Study
ConclusionsHigh ‐voltage long‐duration PRF provided significant short‐term (at least 12 weeks) pain relief to most patients with PN; it also improved subjective measures of depression and quality of life over the same duration of time. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 4, 2021 Category: Biotechnology Authors: Cheng ‐Long Wang, Tao Song Tags: Clinical Research Source Type: research

Conventional Dorsal Root Ganglion Stimulation in an Experimental Model of Painful Diabetic Peripheral Neuropathy: A Quantitative Immunocytochemical Analysis of Intracellular γ‐Aminobutyric Acid in Dorsal Root Ganglion Neurons
ConclusionCon ‐DRGS does not affect the average intracellular GABA immunofluorescence staining intensity in DRG sensory neurons of those animals which showed significant pain reduction. Similarly, no soma size related changes in intracellular GABA immunofluorescence were observed following Con‐DRGS. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - May 4, 2021 Category: Biotechnology Authors: Glenn Franken, Perla Douven, Jacques Debets, Elbert A.J. Joosten Tags: Basic Research Source Type: research

Sacral Neuromodulation in Patients With Neurogenic Lower Urinary Tract Dysfunction: A Multicenter Retrospective Study From China
ConclusionsIn conclusion, SNM is an effective and reliable method for treating NLUTD, especially in patients with urinary storage symptoms. Although not all of the symptoms in every patient can be resolve, SNM still might be a superior choice together with other treatment procedures. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 29, 2021 Category: Biotechnology Authors: Ifrah Masood, Qi Chen, Jiayi Li, Zhihui Xu, Xiaoqian Ying, Yiming Wang, Guoqing Chen, Limin Liao Tags: Clinical Research Source Type: research

Resource Use and Cost of Subcutaneous Nerve Stimulation Versus Optimized Medical Management in Patients With Failed Back Surgery Syndrome: An Analysis of the SubQStim Study
ConclusionsSubcutaneous nerve field stimulation has the potential to offset the initial costs of the device by reducing analgesic medication and the number of healthcare visits in FBSS patients, alongside potential gains in health ‐related quality of life. There remains uncertainty in long‐term costs and cost‐effectiveness of stimulation and longer‐term follow‐up analyses are needed. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 27, 2021 Category: Biotechnology Authors: Colin Green, Sam S. Eldabe, Rod S. Taylor, Mehdi Zahra, Simon Eggington Tags: Clinical Research Source Type: research

Practice Trends of Neuromodulation Therapies for Pain and Spasticity in India
ConclusionThe younger generation of pain practitioners in India is becoming more aware and convinced about the role of neuromodulation to alleviate severe pain and suffering. An all ‐round approach combining improved training, awareness at various levels, more flexible options of newer technology and reimbursement approval can positively influence its use. This can be achieved with the collective efforts of physicians, insurers, industry, and focused academic activities of cl inical societies. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 26, 2021 Category: Biotechnology Authors: Preeti P. Doshi, Marc Russo, Paresh K. Doshi Tags: Clinical Research Source Type: research

Auricular Vagal Nerve Stimulation Improves Constipation by Enhancing Colon Motility via the Central ‐Vagal Efferent Pathway in Opioid‐Induced Constipated Rats
ConclusionsaVNS improves OIC by enhancing colon motility and restoring enteric neural functions mediated via the central and vagal efferent pathway. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 22, 2021 Category: Biotechnology Authors: Yiling Zhang, Tao Lu, Yan Meng, Alimujiang Maisiyiti, Yan Dong, Shiying Li, Yan Chen, Jieyun Yin, Jiande D.Z. Chen Tags: Basic Research Source Type: research

Occipital Nerve Stimulation for Refractory Chronic Cluster Headache: A Cost ‐Effectiveness Study
ConclusionConsidering the burden of rCCH and the efficacy and safety of ONS, the demonstration that ONS is dominant should help its diffusion, validation, and reimbursement by health authorities in this severely disabled population. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 22, 2021 Category: Biotechnology Authors: Julie Bulsei, Aur élie Leplus, Anne Donnet, Jean Regis, Christian Lucas, Nadia Buisset, Sylvie Raoul, Evelyne Guegan‐Massardier, Stéphane Derrey, Bechir Jarraya, Dominique Valade, Caroline Roos, Christelle Creach, Stéphan Chabardes, Pie Tags: Clinical Research Source Type: research

Intestinal Perforation: A Very Rare Complication in Intrathecal Baclofen Therapy
(Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 21, 2021 Category: Biotechnology Authors: Thomas Decramer, Tom Theys Tags: Clinical Letters Source Type: research

Correct Sciatic Nerve Management to Apply Ultrasound ‐Guided Percutaneous Neuromodulation in Patients With Chronic Low Back Pain: A Pilot Study
ConclusionsThe choice of an anatomical location of application of the US ‐guided PNM on the sciatic nerve by the physiotherapist does not influence the improvement of pain, ROM, balance, and function in patients with chronic LBP. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 20, 2021 Category: Biotechnology Authors: Roberto San ‐Emeterio‐Iglesias, Francisco Minaya‐Muñoz, Carlos Romero‐Morales, Blanca De‐la‐Cruz‐Torres Tags: Clinical Research Source Type: research

Identification of Deep Brain Stimulation Targets for Neuropathic Pain After Spinal Cord Injury Using Localized Increases in White Matter Fiber Cross ‐Section
ConclusionsAltogether, we identified neuroarchitectural changes associated with NP in the SCI cohort and implemented a novel, evidence ‐driven target selection approach for DBS to guide future research in neuromodulation treatment of NP after SCI. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - April 19, 2021 Category: Biotechnology Authors: Shana R. Black, Andrew Janson, Mark Mahan, Jeffrey Anderson, Christopher R. Butson Tags: Clinical Research Source Type: research