Grey matter volume and CSF biomarkers predict neuropsychological subtypes of MCI
Neurobiol Aging. 2023 Jul 12;131:196-208. doi: 10.1016/j.neurobiolaging.2023.07.006. Online ahead of print.ABSTRACTThere is increasing evidence of different subtypes of individuals with mild cognitive impairment (MCI). An important line of research is whether neuropsychologically-defined subtypes have distinct patterns of neurodegeneration and cerebrospinal fluid (CSF) biomarker composition. In our study, we demonstrated that MCI participants of the ADNI database (N = 640) can be discriminated into 3 coherent neuropsychological subgroups. Our clustering approach revealed amnestic MCI, mixed MCI, and cluster-derived normal ...
Source: Neurobiology of Aging - September 9, 2023 Category: Geriatrics Authors: Jeremy Lefort-Besnard Mikael Naveau Nicolas Delcroix Leslie Marion Decker Fabien Cignetti Alzheimer ’s Disease Neuroimaging Initiative Source Type: research
An Alzheimer's disease risk variant in TTC3 modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neurons
Neurobiol Aging. 2023 Jul 17;131:182-195. doi: 10.1016/j.neurobiolaging.2023.07.007. Online ahead of print.ABSTRACTA missense variant in the tetratricopeptide repeat domain 3 (TTC3) gene (rs377155188, p.S1038C, NM_003316.4:c 0.3113C>G) was found to segregate with disease in a multigenerational family with late-onset Alzheimer's disease. This variant was introduced into induced pluripotent stem cells (iPSCs) derived from a cognitively intact individual using CRISPR genome editing, and the resulting isogenic pair of iPSC lines was differentiated into cortical neurons. Transcriptome analysis showed an enrichment for genes ...
Source: Neurobiology of Aging - September 7, 2023 Category: Geriatrics Authors: Holly N Cukier Carolina L Duarte Mayra J Laverde-Paz Shaina A Simon Derek J Van Booven Amanda T Miyares Patrice L Whitehead Kara L Hamilton-Nelson Larry D Adams Regina M Carney Michael L Cuccaro Jeffery M Vance Margaret A Pericak-Vance Anthony J Griswold Source Type: research
An Alzheimer's disease risk variant in TTC3 modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neurons
Neurobiol Aging. 2023 Jul 17;131:182-195. doi: 10.1016/j.neurobiolaging.2023.07.007. Online ahead of print.ABSTRACTA missense variant in the tetratricopeptide repeat domain 3 (TTC3) gene (rs377155188, p.S1038C, NM_003316.4:c 0.3113C>G) was found to segregate with disease in a multigenerational family with late-onset Alzheimer's disease. This variant was introduced into induced pluripotent stem cells (iPSCs) derived from a cognitively intact individual using CRISPR genome editing, and the resulting isogenic pair of iPSC lines was differentiated into cortical neurons. Transcriptome analysis showed an enrichment for genes ...
Source: Neurobiology of Aging - September 7, 2023 Category: Geriatrics Authors: Holly N Cukier Carolina L Duarte Mayra J Laverde-Paz Shaina A Simon Derek J Van Booven Amanda T Miyares Patrice L Whitehead Kara L Hamilton-Nelson Larry D Adams Regina M Carney Michael L Cuccaro Jeffery M Vance Margaret A Pericak-Vance Anthony J Griswold Source Type: research
Dissociating effects of aging and genetic risk of sporadic Alzheimer's disease on path integration
Neurobiol Aging. 2023 Jul 29;131:170-181. doi: 10.1016/j.neurobiolaging.2023.07.025. Online ahead of print.ABSTRACTPath integration is a spatial navigation ability that requires the integration of information derived from self-motion cues and stable landmarks, when available, to return to a previous location. Path integration declines with age and Alzheimer's disease (AD). Here, we sought to separate the effects of age and AD risk on path integration, with and without a landmark. Overall, 279 people participated, aged between 18 and 80 years old. Advanced age impaired the appropriate use of a landmark. Older participants f...
Source: Neurobiology of Aging - September 6, 2023 Category: Geriatrics Authors: Lise Colmant Anne Bierbrauer Youssef Bellaali Lukas Kunz Jasper Van Dongen Kristel Sleegers Nikolai Axmacher Philippe Lef èvre Bernard Hanseeuw Source Type: research
Dissociating effects of aging and genetic risk of sporadic Alzheimer's disease on path integration
Neurobiol Aging. 2023 Jul 29;131:170-181. doi: 10.1016/j.neurobiolaging.2023.07.025. Online ahead of print.ABSTRACTPath integration is a spatial navigation ability that requires the integration of information derived from self-motion cues and stable landmarks, when available, to return to a previous location. Path integration declines with age and Alzheimer's disease (AD). Here, we sought to separate the effects of age and AD risk on path integration, with and without a landmark. Overall, 279 people participated, aged between 18 and 80 years old. Advanced age impaired the appropriate use of a landmark. Older participants f...
Source: Neurobiology of Aging - September 6, 2023 Category: Geriatrics Authors: Lise Colmant Anne Bierbrauer Youssef Bellaali Lukas Kunz Jasper Van Dongen Kristel Sleegers Nikolai Axmacher Philippe Lef èvre Bernard Hanseeuw Source Type: research
