Data-driven analysis of regional brain metabolism in behavioral frontotemporal dementia and late-onset primary psychiatric diseases with frontal lobe syndrome: A PET/MRI study
Neurobiol Aging. 2024 Feb 3;137:47-54. doi: 10.1016/j.neurobiolaging.2024.01.015. Online ahead of print.ABSTRACTLate-onset primary psychiatric disease (PPD) and behavioral frontotemporal dementia (bvFTD) present with a similar frontal lobe syndrome. We compare brain glucose metabolism in bvFTD and late-onset PPD and investigate the metabolic correlates of cognitive and behavioral disturbances through FDG-PET/MRI. We studied 37 bvFTD and 20 late-onset PPD with a mean clinical follow-up of three years. At baseline evaluation, metabolism of the dorsolateral, ventrolateral, orbitofrontal regions and caudate could classify the ...
Source: Neurobiology of Aging - February 29, 2024 Category: Geriatrics Authors: Annachiara Cagnin Giorgio Pigato Ilaria Pettenuzzo Giovanni Zorzi Beatrice Roiter Maria Giulia Anglani Cinzia Buss è Stefano Mozzetta Carlo Gabelli Cristina Campi Diego Cecchin Source Type: research
Association of peripheral immunity and cerebral small vessel disease in older adults without dementia: A longitudinal study
This study explored the associations between peripheral immunity with cerebral small vessel diseases. Older adults without dementia from the Alzheimer's Disease Neuroimaging Initiative were investigated. Peripheral blood was obtained, and magnetic resonance imaging was performed to measure cerebral microbleeds (CMB), lacunar infarctions (LI), and white matter hyperintensities (WMH). Multivariable-adjusted regression models, linear mixed-effects models, and the Spearman correlations were used to evaluate the associations. At baseline, individuals with greater neutrophils (odds ratio [OR] =1.10, 95% confidence interval [CI] ...
Source: Neurobiology of Aging - February 29, 2024 Category: Geriatrics Authors: Chu-Yun Xiao Ya-Hui Ma Yong-Li Zhao Jia-Yao Liu Lan Tan Alzheimer ’s Disease Neuroimaging Initiative Source Type: research
Resting state electroencephalographic alpha rhythms are sensitive to Alzheimer's disease mild cognitive impairment progression at a 6-month follow-up
Neurobiol Aging. 2024 Feb 1;137:19-37. doi: 10.1016/j.neurobiolaging.2024.01.013. Online ahead of print.ABSTRACTAre posterior resting-state electroencephalographic (rsEEG) alpha rhythms sensitive to the Alzheimer's disease mild cognitive impairment (ADMCI) progression at a 6-month follow-up? Clinical, cerebrospinal, neuroimaging, and rsEEG datasets in 52 ADMCI and 60 Healthy old seniors (equivalent groups for demographic features) were available from an international archive (www.pdwaves.eu). The ADMCI patients were arbitrarily divided into two groups: REACTIVE and UNREACTIVE, based on the reduction (reactivity) in the pos...
Source: Neurobiology of Aging - February 25, 2024 Category: Geriatrics Authors: Claudio Babiloni Dharmendra Jakhar Federico Tucci Claudio Del Percio Susanna Lopez Andrea Soricelli Marco Salvatore Raffaele Ferri Valentina Catania Federico Massa Dario Arnaldi Francesco Fam à Bahar G üntekin G örsev Yener Fabrizio Stocchi Laura Vacca Source Type: research
Personality traits and cognitive reserve-High openness benefits cognition in the presence of age-related brain changes
Neurobiol Aging. 2024 Feb 22;137:38-46. doi: 10.1016/j.neurobiolaging.2024.02.009. Online ahead of print.ABSTRACTCognitive reserve explains differential susceptibility of cognitive performance to neuropathology. We investigated whether certain personality traits underlie cognitive reserve and are accordingly associated with better cognition and less cognitive decline in the presence of age-related brain changes. We included healthy adults aged 19-80 years for cross-sectional (N=399) and longitudinal (N=273, mean follow-up time=5 years, SD=0.7 years) analyses. Assessment of the BIG5 personality traits openness, conscientiou...
Source: Neurobiology of Aging - February 25, 2024 Category: Geriatrics Authors: Annabell Coors Seonjoo Lee Christian Habeck Yaakov Stern Source Type: research
Resting state electroencephalographic alpha rhythms are sensitive to Alzheimer's disease mild cognitive impairment progression at a 6-month follow-up
Neurobiol Aging. 2024 Feb 1;137:19-37. doi: 10.1016/j.neurobiolaging.2024.01.013. Online ahead of print.ABSTRACTAre posterior resting-state electroencephalographic (rsEEG) alpha rhythms sensitive to the Alzheimer's disease mild cognitive impairment (ADMCI) progression at a 6-month follow-up? Clinical, cerebrospinal, neuroimaging, and rsEEG datasets in 52 ADMCI and 60 Healthy old seniors (equivalent groups for demographic features) were available from an international archive (www.pdwaves.eu). The ADMCI patients were arbitrarily divided into two groups: REACTIVE and UNREACTIVE, based on the reduction (reactivity) in the pos...
Source: Neurobiology of Aging - February 25, 2024 Category: Geriatrics Authors: Claudio Babiloni Dharmendra Jakhar Federico Tucci Claudio Del Percio Susanna Lopez Andrea Soricelli Marco Salvatore Raffaele Ferri Valentina Catania Federico Massa Dario Arnaldi Francesco Fam à Bahar G üntekin G örsev Yener Fabrizio Stocchi Laura Vacca Source Type: research
Personality traits and cognitive reserve-High openness benefits cognition in the presence of age-related brain changes
Neurobiol Aging. 2024 Feb 22;137:38-46. doi: 10.1016/j.neurobiolaging.2024.02.009. Online ahead of print.ABSTRACTCognitive reserve explains differential susceptibility of cognitive performance to neuropathology. We investigated whether certain personality traits underlie cognitive reserve and are accordingly associated with better cognition and less cognitive decline in the presence of age-related brain changes. We included healthy adults aged 19-80 years for cross-sectional (N=399) and longitudinal (N=273, mean follow-up time=5 years, SD=0.7 years) analyses. Assessment of the BIG5 personality traits openness, conscientiou...
Source: Neurobiology of Aging - February 25, 2024 Category: Geriatrics Authors: Annabell Coors Seonjoo Lee Christian Habeck Yaakov Stern Source Type: research
Resting state electroencephalographic alpha rhythms are sensitive to Alzheimer's disease mild cognitive impairment progression at a 6-month follow-up
Neurobiol Aging. 2024 Feb 1;137:19-37. doi: 10.1016/j.neurobiolaging.2024.01.013. Online ahead of print.ABSTRACTAre posterior resting-state electroencephalographic (rsEEG) alpha rhythms sensitive to the Alzheimer's disease mild cognitive impairment (ADMCI) progression at a 6-month follow-up? Clinical, cerebrospinal, neuroimaging, and rsEEG datasets in 52 ADMCI and 60 Healthy old seniors (equivalent groups for demographic features) were available from an international archive (www.pdwaves.eu). The ADMCI patients were arbitrarily divided into two groups: REACTIVE and UNREACTIVE, based on the reduction (reactivity) in the pos...
Source: Neurobiology of Aging - February 25, 2024 Category: Geriatrics Authors: Claudio Babiloni Dharmendra Jakhar Federico Tucci Claudio Del Percio Susanna Lopez Andrea Soricelli Marco Salvatore Raffaele Ferri Valentina Catania Federico Massa Dario Arnaldi Francesco Fam à Bahar G üntekin G örsev Yener Fabrizio Stocchi Laura Vacca Source Type: research
Personality traits and cognitive reserve-High openness benefits cognition in the presence of age-related brain changes
Neurobiol Aging. 2024 Feb 22;137:38-46. doi: 10.1016/j.neurobiolaging.2024.02.009. Online ahead of print.ABSTRACTCognitive reserve explains differential susceptibility of cognitive performance to neuropathology. We investigated whether certain personality traits underlie cognitive reserve and are accordingly associated with better cognition and less cognitive decline in the presence of age-related brain changes. We included healthy adults aged 19-80 years for cross-sectional (N=399) and longitudinal (N=273, mean follow-up time=5 years, SD=0.7 years) analyses. Assessment of the BIG5 personality traits openness, conscientiou...
Source: Neurobiology of Aging - February 25, 2024 Category: Geriatrics Authors: Annabell Coors Seonjoo Lee Christian Habeck Yaakov Stern Source Type: research
Resting state electroencephalographic alpha rhythms are sensitive to Alzheimer's disease mild cognitive impairment progression at a 6-month follow-up
Neurobiol Aging. 2024 Feb 1;137:19-37. doi: 10.1016/j.neurobiolaging.2024.01.013. Online ahead of print.ABSTRACTAre posterior resting-state electroencephalographic (rsEEG) alpha rhythms sensitive to the Alzheimer's disease mild cognitive impairment (ADMCI) progression at a 6-month follow-up? Clinical, cerebrospinal, neuroimaging, and rsEEG datasets in 52 ADMCI and 60 Healthy old seniors (equivalent groups for demographic features) were available from an international archive (www.pdwaves.eu). The ADMCI patients were arbitrarily divided into two groups: REACTIVE and UNREACTIVE, based on the reduction (reactivity) in the pos...
Source: Neurobiology of Aging - February 25, 2024 Category: Geriatrics Authors: Claudio Babiloni Dharmendra Jakhar Federico Tucci Claudio Del Percio Susanna Lopez Andrea Soricelli Marco Salvatore Raffaele Ferri Valentina Catania Federico Massa Dario Arnaldi Francesco Fam à Bahar G üntekin G örsev Yener Fabrizio Stocchi Laura Vacca Source Type: research
Personality traits and cognitive reserve-High openness benefits cognition in the presence of age-related brain changes
Neurobiol Aging. 2024 Feb 22;137:38-46. doi: 10.1016/j.neurobiolaging.2024.02.009. Online ahead of print.ABSTRACTCognitive reserve explains differential susceptibility of cognitive performance to neuropathology. We investigated whether certain personality traits underlie cognitive reserve and are accordingly associated with better cognition and less cognitive decline in the presence of age-related brain changes. We included healthy adults aged 19-80 years for cross-sectional (N=399) and longitudinal (N=273, mean follow-up time=5 years, SD=0.7 years) analyses. Assessment of the BIG5 personality traits openness, conscientiou...
Source: Neurobiology of Aging - February 25, 2024 Category: Geriatrics Authors: Annabell Coors Seonjoo Lee Christian Habeck Yaakov Stern Source Type: research
Associations of brain morphology with cortical proteins of cognitive resilience
This study examines the extent to which these proteins are associated with the brain structures of cognitive resilience in decedents from the Religious Orders Study and Memory and Aging Project. Six proteins were associated with brain morphometric characteristics related to higher resilience (i.e., larger anterior and medial temporal lobe volumes), and five were associated with morphometric characteristics related to lower resilience (i.e., enlarged ventricles). Two synaptic proteins, RPH3A and CPLX1, remained inversely associated with the lower resilience signature, after further controlling for 10 neuropathologic indices...
Source: Neurobiology of Aging - February 23, 2024 Category: Geriatrics Authors: Victoria N Poole Abdur R Ridwan Konstantinos Arfanakis Robert J Dawe Nicholas T Seyfried Philip L De Jager Julie A Schneider Sue E Leurgans Lei Yu David A Bennett Source Type: research
Age-related differences in perception and coding of attractive odorants in mice
Neurobiol Aging. 2024 Feb 15;137:8-18. doi: 10.1016/j.neurobiolaging.2024.02.003. Online ahead of print.ABSTRACTHedonic perception deeply changes with aging, significantly impacting health and quality of life in elderly. In young adult mice, an odor hedonic signature is represented along the antero-posterior axis of olfactory bulb, and transferred to the olfactory tubercle and ventral tegmental area, promoting approach behavior. Here, we show that while the perception of unattractive odorants was unchanged in older mice (22 months), the appreciation of some but not all attractive odorants declined. Neural activity in the o...
Source: Neurobiology of Aging - February 23, 2024 Category: Geriatrics Authors: Laura Chalen çon Ma ëllie Midroit Anna Athanassi Marc Thevenet Marine Breton J érémy Forest Marion Richard Anne Didier Nathalie Mandairon Source Type: research
Associations of brain morphology with cortical proteins of cognitive resilience
This study examines the extent to which these proteins are associated with the brain structures of cognitive resilience in decedents from the Religious Orders Study and Memory and Aging Project. Six proteins were associated with brain morphometric characteristics related to higher resilience (i.e., larger anterior and medial temporal lobe volumes), and five were associated with morphometric characteristics related to lower resilience (i.e., enlarged ventricles). Two synaptic proteins, RPH3A and CPLX1, remained inversely associated with the lower resilience signature, after further controlling for 10 neuropathologic indices...
Source: Neurobiology of Aging - February 23, 2024 Category: Geriatrics Authors: Victoria N Poole Abdur R Ridwan Konstantinos Arfanakis Robert J Dawe Nicholas T Seyfried Philip L De Jager Julie A Schneider Sue E Leurgans Lei Yu David A Bennett Source Type: research
Age-related differences in perception and coding of attractive odorants in mice
Neurobiol Aging. 2024 Feb 15;137:8-18. doi: 10.1016/j.neurobiolaging.2024.02.003. Online ahead of print.ABSTRACTHedonic perception deeply changes with aging, significantly impacting health and quality of life in elderly. In young adult mice, an odor hedonic signature is represented along the antero-posterior axis of olfactory bulb, and transferred to the olfactory tubercle and ventral tegmental area, promoting approach behavior. Here, we show that while the perception of unattractive odorants was unchanged in older mice (22 months), the appreciation of some but not all attractive odorants declined. Neural activity in the o...
Source: Neurobiology of Aging - February 23, 2024 Category: Geriatrics Authors: Laura Chalen çon Ma ëllie Midroit Anna Athanassi Marc Thevenet Marine Breton J érémy Forest Marion Richard Anne Didier Nathalie Mandairon Source Type: research
CRYAB plays a role in terminating the presence of pro-inflammatory macrophages in the older, injured mouse peripheral nervous system
Neurobiol Aging. 2024 Jan;133:1-15. doi: 10.1016/j.neurobiolaging.2023.10.004. Epub 2023 Oct 16.ABSTRACTEvidence indicates that dysfunction of older Schwann cells and macrophages contributes to poor regeneration of more mature peripheral nervous system (PNS) neurons after damage. Since the underlying molecular factors are largely unknown, we investigated if CRYAB, a small heat shock protein that is expressed by Schwann cells and axons and whose expression declines with age, impacts prominent deficits in the injured, older PNS including down-regulation of cholesterol biosynthesis enzyme genes, Schwann cell dysfunction, and ...
Source: Neurobiology of Aging - February 21, 2024 Category: Geriatrics Authors: Kathleen Margaret Hagen Paul Gordon Ariana Frederick Alexandra Louise Palmer Pariya Edalat Yohan Ricci Zonta Lucas Scott Melissa Flancia Jacqueline Kelsey Reid Matthew Joel Shalina Sheryl Ousman Source Type: research
