Midlife physical activity engagement is associated with later-life brain health
Neurobiol Aging. 2023 Nov 11;134:146-159. doi: 10.1016/j.neurobiolaging.2023.11.004. Online ahead of print.ABSTRACTThe relationship between midlife physical activity (PA), and cognition and brain health in later life is poorly understood with conflicting results from previous research. Investigating the contribution of midlife PA to later-life cognition and brain health in high-risk populations will propel the development of health guidance for those most in need. The current study examined the association between midlife PA engagement and later-life cognition, grey matter characteristics and resting-state functional conne...
Source: Neurobiology of Aging - December 13, 2023 Category: Geriatrics Authors: Meishan Ai Timothy P Morris Adri án Noriega de la Colina Nagashree Thovinakere Jennifer Tremblay-Mercier Sylvia Villeneuve Charles H Hillman Arthur F Kramer Maiya R Geddes PREVENT-AD Research Group Source Type: research
Neurite-based white matter alterations in MAPT mutation carriers: A multi-shell diffusion MRI study in the ALLFTD consortium
Neurobiol Aging. 2023 Dec 10;134:135-145. doi: 10.1016/j.neurobiolaging.2023.12.001. Online ahead of print.ABSTRACTWe assessed white matter (WM) integrity in MAPT mutation carriers (16 asymptomatic, 5 symptomatic) compared to 31 non-carrier family controls using diffusion tensor imaging (DTI) (fractional anisotropy; FA, mean diffusivity; MD) and neurite orientation dispersion and density imaging (NODDI) (neurite density index; NDI, orientation and dispersion index; ODI). Linear mixed-effects models accounting for age and family relatedness revealed alterations across DTI and NODDI metrics in all mutation carriers and in sy...
Source: Neurobiology of Aging - December 13, 2023 Category: Geriatrics Authors: Nick Corriveau-Lecavalier Nirubol Tosakulwong Timothy G Lesnick Angela J Fought Robert I Reid Christopher G Schwarz Matthew L Senjem Clifford R Jack David T Jones Prashanthi Vemuri Rosa Rademakers Eliana Marisa Ramos Daniel H Geschwind David S Knopman Hug Source Type: research
Midlife physical activity engagement is associated with later-life brain health
Neurobiol Aging. 2023 Nov 11;134:146-159. doi: 10.1016/j.neurobiolaging.2023.11.004. Online ahead of print.ABSTRACTThe relationship between midlife physical activity (PA), and cognition and brain health in later life is poorly understood with conflicting results from previous research. Investigating the contribution of midlife PA to later-life cognition and brain health in high-risk populations will propel the development of health guidance for those most in need. The current study examined the association between midlife PA engagement and later-life cognition, grey matter characteristics and resting-state functional conne...
Source: Neurobiology of Aging - December 13, 2023 Category: Geriatrics Authors: Meishan Ai Timothy P Morris Adri án Noriega de la Colina Nagashree Thovinakere Jennifer Tremblay-Mercier Sylvia Villeneuve Charles H Hillman Arthur F Kramer Maiya R Geddes PREVENT-AD Research Group Source Type: research
Does functional system segregation mediate the effects of lifestyle on cognition in older adults?
Neurobiol Aging. 2023 Nov 25;134:126-134. doi: 10.1016/j.neurobiolaging.2023.11.009. Online ahead of print.ABSTRACTHealthy aging is typically accompanied by cognitive decline. Previous work has shown that engaging in multiple, non-work activities during midlife can have a protective effect on cognition several decades later, rendering it less dependent on brain structural health; the definition of "cognitive reserve". Other work has shown that increasing age is associated with reduced segregation of large-scale brain functional networks. Here we tested the hypothesis that functional segregation (SyS) mediates this effect o...
Source: Neurobiology of Aging - December 9, 2023 Category: Geriatrics Authors: Petar P Raykov Ethan Knights None Cam-Can Richard N Henson Source Type: research
Does functional system segregation mediate the effects of lifestyle on cognition in older adults?
Neurobiol Aging. 2023 Nov 25;134:126-134. doi: 10.1016/j.neurobiolaging.2023.11.009. Online ahead of print.ABSTRACTHealthy aging is typically accompanied by cognitive decline. Previous work has shown that engaging in multiple, non-work activities during midlife can have a protective effect on cognition several decades later, rendering it less dependent on brain structural health; the definition of "cognitive reserve". Other work has shown that increasing age is associated with reduced segregation of large-scale brain functional networks. Here we tested the hypothesis that functional segregation (SyS) mediates this effect o...
Source: Neurobiology of Aging - December 9, 2023 Category: Geriatrics Authors: Petar P Raykov Ethan Knights None Cam-Can Richard N Henson Source Type: research
Does functional system segregation mediate the effects of lifestyle on cognition in older adults?
Neurobiol Aging. 2023 Nov 25;134:126-134. doi: 10.1016/j.neurobiolaging.2023.11.009. Online ahead of print.ABSTRACTHealthy aging is typically accompanied by cognitive decline. Previous work has shown that engaging in multiple, non-work activities during midlife can have a protective effect on cognition several decades later, rendering it less dependent on brain structural health; the definition of "cognitive reserve". Other work has shown that increasing age is associated with reduced segregation of large-scale brain functional networks. Here we tested the hypothesis that functional segregation (SyS) mediates this effect o...
Source: Neurobiology of Aging - December 9, 2023 Category: Geriatrics Authors: Petar P Raykov Ethan Knights None Cam-Can Richard N Henson Source Type: research
Does functional system segregation mediate the effects of lifestyle on cognition in older adults?
Neurobiol Aging. 2023 Nov 25;134:126-134. doi: 10.1016/j.neurobiolaging.2023.11.009. Online ahead of print.ABSTRACTHealthy aging is typically accompanied by cognitive decline. Previous work has shown that engaging in multiple, non-work activities during midlife can have a protective effect on cognition several decades later, rendering it less dependent on brain structural health; the definition of "cognitive reserve". Other work has shown that increasing age is associated with reduced segregation of large-scale brain functional networks. Here we tested the hypothesis that functional segregation (SyS) mediates this effect o...
Source: Neurobiology of Aging - December 9, 2023 Category: Geriatrics Authors: Petar P Raykov Ethan Knights None Cam-Can Richard N Henson Source Type: research
Disease trajectories in older adults with non-AD pathologic change and comparison with Alzheimer's disease pathophysiology: A longitudinal study
This study aimed to assess the long-term clinical and cognitive trajectories of individuals with non-AD pathologic change among older adults without dementia, comparing them to those with normal AD biomarkers and AD pathophysiology. Analyzing Alzheimer's Disease Neuroimaging Initiative data, we evaluated clinical outcomes and conversion risk longitudinally using mixed effects models and multivariate Cox proportional hazard models. We found that compared to individuals with A-T-N-, those with abnormal tauopathy or neurodegeneration biomarkers (A-T + N-, A-T-N + , and A-T + N + ) had a faster rate of cognitive decline and di...
Source: Neurobiology of Aging - December 6, 2023 Category: Geriatrics Authors: Jie-Qiong Li Jing-Hui Song John Suckling Yan-Jiang Wang Chuan-Tao Zuo Can Zhang Jing Gao Yu-Qiang Song An-Mu Xie Lan Tan Jin-Tai Yu Alzheimer ’s Disease Neuroimaging Initiative Source Type: research
Downregulation of KCNMA1 in mice accelerates auditory hair cells senescence via ferroptosis
In conclusion, these results revealed that KCNMA1 is associated with the aging process in auditory hair cells by regulating ferroptosis, which deepens our understanding of age-related hearing loss.PMID:38056217 | DOI:10.1016/j.neurobiolaging.2023.10.011 (Source: Neurobiology of Aging)
Source: Neurobiology of Aging - December 6, 2023 Category: Geriatrics Authors: Xiaomin Tang Haoyue Zhong Chenyu Xu Yuxuan Sun Yuxiang Lou Yi Zhao Yue Liang Xiaotao Guo Chunchen Pan Jiaqiang Sun Jingwu Sun Source Type: research
Disease trajectories in older adults with non-AD pathologic change and comparison with Alzheimer's disease pathophysiology: A longitudinal study
This study aimed to assess the long-term clinical and cognitive trajectories of individuals with non-AD pathologic change among older adults without dementia, comparing them to those with normal AD biomarkers and AD pathophysiology. Analyzing Alzheimer's Disease Neuroimaging Initiative data, we evaluated clinical outcomes and conversion risk longitudinally using mixed effects models and multivariate Cox proportional hazard models. We found that compared to individuals with A-T-N-, those with abnormal tauopathy or neurodegeneration biomarkers (A-T + N-, A-T-N + , and A-T + N + ) had a faster rate of cognitive decline and di...
Source: Neurobiology of Aging - December 6, 2023 Category: Geriatrics Authors: Jie-Qiong Li Jing-Hui Song John Suckling Yan-Jiang Wang Chuan-Tao Zuo Can Zhang Jing Gao Yu-Qiang Song An-Mu Xie Lan Tan Jin-Tai Yu Alzheimer ’s Disease Neuroimaging Initiative Source Type: research
Downregulation of KCNMA1 in mice accelerates auditory hair cells senescence via ferroptosis
In conclusion, these results revealed that KCNMA1 is associated with the aging process in auditory hair cells by regulating ferroptosis, which deepens our understanding of age-related hearing loss.PMID:38056217 | DOI:10.1016/j.neurobiolaging.2023.10.011 (Source: Neurobiology of Aging)
Source: Neurobiology of Aging - December 6, 2023 Category: Geriatrics Authors: Xiaomin Tang Haoyue Zhong Chenyu Xu Yuxuan Sun Yuxiang Lou Yi Zhao Yue Liang Xiaotao Guo Chunchen Pan Jiaqiang Sun Jingwu Sun Source Type: research
Disease trajectories in older adults with non-AD pathologic change and comparison with Alzheimer's disease pathophysiology: A longitudinal study
This study aimed to assess the long-term clinical and cognitive trajectories of individuals with non-AD pathologic change among older adults without dementia, comparing them to those with normal AD biomarkers and AD pathophysiology. Analyzing Alzheimer's Disease Neuroimaging Initiative data, we evaluated clinical outcomes and conversion risk longitudinally using mixed effects models and multivariate Cox proportional hazard models. We found that compared to individuals with A-T-N-, those with abnormal tauopathy or neurodegeneration biomarkers (A-T + N-, A-T-N + , and A-T + N + ) had a faster rate of cognitive decline and di...
Source: Neurobiology of Aging - December 6, 2023 Category: Geriatrics Authors: Jie-Qiong Li Jing-Hui Song John Suckling Yan-Jiang Wang Chuan-Tao Zuo Can Zhang Jing Gao Yu-Qiang Song An-Mu Xie Lan Tan Jin-Tai Yu Alzheimer ’s Disease Neuroimaging Initiative Source Type: research
Downregulation of KCNMA1 in mice accelerates auditory hair cells senescence via ferroptosis
In conclusion, these results revealed that KCNMA1 is associated with the aging process in auditory hair cells by regulating ferroptosis, which deepens our understanding of age-related hearing loss.PMID:38056217 | DOI:10.1016/j.neurobiolaging.2023.10.011 (Source: Neurobiology of Aging)
Source: Neurobiology of Aging - December 6, 2023 Category: Geriatrics Authors: Xiaomin Tang Haoyue Zhong Chenyu Xu Yuxuan Sun Yuxiang Lou Yi Zhao Yue Liang Xiaotao Guo Chunchen Pan Jiaqiang Sun Jingwu Sun Source Type: research
Low-Grade systemic inflammation is associated with domain-specific cognitive performance and cognitive decline in older adults: Data from the TUDA study
Neurobiol Aging. 2023 Nov 28;134:94-105. doi: 10.1016/j.neurobiolaging.2023.11.008. Online ahead of print.ABSTRACTStudies examining the relationships between chronic inflammation, cognitive function and cognitive decline in older adults have yielded conflicting results. In a large cohort of older adults free from established dementia (n = 3270; 73.1 ± 7.9 years; 68.4% female), we evaluated the cross-sectional and longitudinal relationships between serum cytokines (IL-6, IL-10, TNF-α) and both global and domain-specific cognitive performance (Repeatable Battery for Assessment of Neuropsychological Status [RBANS]). Higher ...
Source: Neurobiology of Aging - December 3, 2023 Category: Geriatrics Authors: Adam H Dyer Helene McNulty Aoife Caffrey Shane Gordon Eamon Laird Leane Hoey Catherine F Hughes Mary Ward J J Strain Maurice O'Kane Fergal Tracey Anne M Molloy Conal Cunningham Kevin McCarroll Source Type: research
Low-Grade systemic inflammation is associated with domain-specific cognitive performance and cognitive decline in older adults: Data from the TUDA study
Neurobiol Aging. 2023 Nov 28;134:94-105. doi: 10.1016/j.neurobiolaging.2023.11.008. Online ahead of print.ABSTRACTStudies examining the relationships between chronic inflammation, cognitive function and cognitive decline in older adults have yielded conflicting results. In a large cohort of older adults free from established dementia (n = 3270; 73.1 ± 7.9 years; 68.4% female), we evaluated the cross-sectional and longitudinal relationships between serum cytokines (IL-6, IL-10, TNF-α) and both global and domain-specific cognitive performance (Repeatable Battery for Assessment of Neuropsychological Status [RBANS]). Higher ...
Source: Neurobiology of Aging - December 3, 2023 Category: Geriatrics Authors: Adam H Dyer Helene McNulty Aoife Caffrey Shane Gordon Eamon Laird Leane Hoey Catherine F Hughes Mary Ward J J Strain Maurice O'Kane Fergal Tracey Anne M Molloy Conal Cunningham Kevin McCarroll Source Type: research
