Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline
Neurobiol Aging. 2024 Feb 5;136:125-132. doi: 10.1016/j.neurobiolaging.2024.02.001. Online ahead of print.ABSTRACTDopamine decline is suggested to underlie aging-related cognitive decline, but longitudinal examinations of this link are currently missing. We analyzed 5-year longitudinal data for a sample of healthy, older adults (baseline: n = 181, age: 64-68 years; 5-year follow-up: n = 129) who underwent positron emission tomography with 11C-raclopride to assess dopamine D2-like receptor (DRD2) availability, magnetic resonance imaging to evaluate structural brain measures, and cognitive tests. Health, lifestyle, and genet...
Source: Neurobiology of Aging - February 15, 2024 Category: Geriatrics Authors: Nina Karalija Goran Papenberg Jarkko Johansson Anders W åhlin Alireza Salami Micael Andersson Jan Axelsson Dmitry Kuznetsov Katrine Riklund Martin L övdén Ulman Lindenberger Lars B äckman Lars Nyberg Source Type: research
Longitudinal support for the correlative triad among aging, dopamine D2-like receptor loss, and memory decline
Neurobiol Aging. 2024 Feb 5;136:125-132. doi: 10.1016/j.neurobiolaging.2024.02.001. Online ahead of print.ABSTRACTDopamine decline is suggested to underlie aging-related cognitive decline, but longitudinal examinations of this link are currently missing. We analyzed 5-year longitudinal data for a sample of healthy, older adults (baseline: n = 181, age: 64-68 years; 5-year follow-up: n = 129) who underwent positron emission tomography with 11C-raclopride to assess dopamine D2-like receptor (DRD2) availability, magnetic resonance imaging to evaluate structural brain measures, and cognitive tests. Health, lifestyle, and genet...
Source: Neurobiology of Aging - February 15, 2024 Category: Geriatrics Authors: Nina Karalija Goran Papenberg Jarkko Johansson Anders W åhlin Alireza Salami Micael Andersson Jan Axelsson Dmitry Kuznetsov Katrine Riklund Martin L övdén Ulman Lindenberger Lars B äckman Lars Nyberg Source Type: research
Volume electron microscopy reveals age-related ultrastructural differences of globular bush cell axons in mouse central auditory system
Neurobiol Aging. 2024 Feb 6;136:111-124. doi: 10.1016/j.neurobiolaging.2024.01.016. Online ahead of print.ABSTRACTIn mammals, thick axonal calibers wrapped with heavy myelin sheaths are prevalent in the auditory nervous system. These features are crucial for fast traveling of nerve impulses with minimal attenuation required for sound signal transmission. In particular, the long-range projections from the cochlear nucleus - the axons of globular bush cells (GBCs) - to the medial nucleus of the trapezoid body (MNTB) are tonotopically organized. However, it remains controversial in gerbils and mice whether structural and func...
Source: Neurobiology of Aging - February 11, 2024 Category: Geriatrics Authors: Wen-Qing Huang Haibin Sheng Haoyu Wang Yumeng Qi Fangfang Wang Yunfeng Hua Source Type: research
Volume electron microscopy reveals age-related ultrastructural differences of globular bush cell axons in mouse central auditory system
Neurobiol Aging. 2024 Feb 6;136:111-124. doi: 10.1016/j.neurobiolaging.2024.01.016. Online ahead of print.ABSTRACTIn mammals, thick axonal calibers wrapped with heavy myelin sheaths are prevalent in the auditory nervous system. These features are crucial for fast traveling of nerve impulses with minimal attenuation required for sound signal transmission. In particular, the long-range projections from the cochlear nucleus - the axons of globular bush cells (GBCs) - to the medial nucleus of the trapezoid body (MNTB) are tonotopically organized. However, it remains controversial in gerbils and mice whether structural and func...
Source: Neurobiology of Aging - February 11, 2024 Category: Geriatrics Authors: Wen-Qing Huang Haibin Sheng Haoyu Wang Yumeng Qi Fangfang Wang Yunfeng Hua Source Type: research
Fornix fractional anisotropy mediates the association between Mediterranean diet adherence and memory four years later in older adults without dementia
Neurobiol Aging. 2024 Feb 2;136:99-110. doi: 10.1016/j.neurobiolaging.2024.01.012. Online ahead of print.ABSTRACTHere, we investigated whether fractional anisotropy (FA) of hippocampus-relevant white-matter tracts mediates the association between baseline Mediterranean diet adherence (MeDiAd) and verbal episodic memory over four years. Participants were healthy older adults with and without subjective cognitive decline and patients with amnestic mild cognitive impairment from the DELCODE cohort study (n = 376; age: 71.47 ± 6.09 years; 48.7 % female). MeDiAd and diffusion data were obtained at baseline. Verbal episodic mem...
Source: Neurobiology of Aging - February 10, 2024 Category: Geriatrics Authors: Adriana L Ruiz-Rizzo Kathrin Finke Jessica S Damoiseaux Claudia Bartels Katharina Buerger Nicoleta Carmen Cosma Peter Dechent Laura Dobisch Michael Ewers Klaus Fliessbach Ingo Frommann Wenzel Glanz Doreen Goerss Stefan Hetzer Enise I Incesoy Daniel Janowi Source Type: research
Vascular risk burden is a key player in the early progression of Alzheimer's disease
Neurobiol Aging. 2024 Jan 10;136:88-98. doi: 10.1016/j.neurobiolaging.2023.12.008. Online ahead of print.ABSTRACTUnderstanding whether vascular risk factors (VRFs) synergistically potentiate Alzheimer's disease (AD) progression is important in the context of emerging treatments for preclinical AD. In a group of 503 cognitively unimpaired individuals, we tested whether VRF burden interacts with AD pathophysiology to accelerate neurodegeneration and cognitive decline. Baseline VRF burden was calculated considering medical data and AD pathophysiology was assessed based on cerebrospinal fluid (CSF) amyloid-β1-42 (Aβ1-42) and...
Source: Neurobiology of Aging - February 9, 2024 Category: Geriatrics Authors: Jo ão Pedro Ferrari-Souza Wagner S Brum Lucas A Hauschild Lucas U Da Ros P âmela C L Ferreira Bruna Bellaver Douglas T Leffa Andrei Bieger C écile Tissot Firoza Z Lussier Marco Ant ônio De Bastiani Guilherme Povala Andr éa L Benedet Joseph Therriault Source Type: research
The spatial distribution of coupling between tau and neurodegeneration in amyloid- β positive mild cognitive impairment
This study aimed to evaluate the extent of spatial coupling between tau and neurodegeneration (atrophy) and its relation to Aβ positivity in mild cognitive impairment (MCI). Data from 409 participants were included (95 cognitively normal controls, 158 Aβ positive (Aβ+) MCI, and 156 Aβ negative (Aβ-) MCI). Florbetapir PET, Flortaucipir PET, and structural MRI were used as biomarkers for Aβ, tau and atrophy, respectively. Individual correlation matrices for tau load and atrophy were used to layer a multilayer network, with separate layers for tau and atrophy. A measure of coupling between corresponding regions of inter...
Source: Neurobiology of Aging - February 8, 2024 Category: Geriatrics Authors: Belfin Robinson Shankar Bhamidi Eran Dayan Alzheimer's Disease Neuroimaging Initiative Source Type: research
Electrophysiological alterations during action semantic processing in Parkinson's disease
Neurobiol Aging. 2024 Jan 10;136:78-87. doi: 10.1016/j.neurobiolaging.2024.01.001. Online ahead of print.ABSTRACTAssessments of action semantics consistently reveal markers of Parkinson's disease (PD). However, neurophysiological signatures of the domain remain under-examined in this population, especially under conditions that allow patients to process stimuli without stringent time constraints. Here we assessed event-related potentials and time-frequency modulations in healthy individuals (HPs) and PD patients during a delayed-response semantic judgment task involving related and unrelated action-picture pairs. Both grou...
Source: Neurobiology of Aging - February 8, 2024 Category: Geriatrics Authors: Mariano N D íaz Rivera Luc ía Amoruso Yamile Bocanegra Jazmin X Su árez Leonardo Moreno Edinson Mu ñoz Agustina Birba Adolfo M Garc ía Source Type: research
Contributions of mouse genetic strain background to age-related phenotypes in physically active HET3 mice
Neurobiol Aging. 2024 Jan 30;136:58-69. doi: 10.1016/j.neurobiolaging.2024.01.010. Online ahead of print.ABSTRACTWe assessed aging hallmarks in skin, muscle, and adipose in the genetically diverse HET3 mouse, and generated a broad dataset comparing these to individual animal diagnostic SNPs from the 4 founding inbred strains of the HET3 line. For middle- and old-aged HET3 mice, we provided running wheel exercise to ensure our observations were not purely representative of sedentary animals, but age-related phenotypes were not improved with running wheel activity. Adipose tissue fibrosis, peripheral neuropathy, and loss of ...
Source: Neurobiology of Aging - February 7, 2024 Category: Geriatrics Authors: Jake W Willows Zahra Alshahal Naeemah M Story Michele J Alves Pablo Vidal Hallie Harris Rochelle Rodrigo Kristin I Stanford Juan Peng Peter C Reifsnyder David E Harrison W David Arnold Kristy L Townsend Source Type: research
Atypical paroxysmal slow cortical activity in healthy adults: Relationship to age and cognitive performance
Neurobiol Aging. 2024 Jan 26;136:44-57. doi: 10.1016/j.neurobiolaging.2024.01.009. Online ahead of print.ABSTRACTParoxysmal patterns of slow cortical activity have been detected in EEG recordings from individuals with age-related neuropathology and have been shown to be correlated with cognitive dysfunction and blood-brain barrier disruption in these participants. The prevalence of these events in healthy participants, however, has not been studied. In this work, we inspect MEG recordings from 623 healthy participants from the Cam-CAN dataset for the presence of paroxysmal slow wave events (PSWEs). PSWEs were detected in a...
Source: Neurobiology of Aging - February 3, 2024 Category: Geriatrics Authors: Lindsey Power Alon Friedman Timothy Bardouille Source Type: research
A blood biomarker of the pace of aging is associated with brain structure: replication across three cohorts
Neurobiol Aging. 2024 Jan 24;136:23-33. doi: 10.1016/j.neurobiolaging.2024.01.008. Online ahead of print.ABSTRACTBiological aging is the correlated decline of multi-organ system integrity central to the etiology of many age-related diseases. A novel epigenetic measure of biological aging, DunedinPACE, is associated with cognitive dysfunction, incident dementia, and mortality. Here, we tested for associations between DunedinPACE and structural MRI phenotypes in three datasets spanning midlife to advanced age: the Dunedin Study (age=45 years), the Framingham Heart Study Offspring Cohort (mean age=63 years), and the Alzheimer...
Source: Neurobiology of Aging - February 1, 2024 Category: Geriatrics Authors: Ethan T Whitman Calen P Ryan Wickliffe C Abraham Angela Addae David L Corcoran Maxwell L Elliott Sean Hogan David Ireland Ross Keenan Annchen R Knodt Tracy R Melzer Richie Poulton Sandhya Ramrakha Karen Sugden Benjamin S Williams Jiayi Zhou Ahmad R Hariri Source Type: research
Empirically derived formulae for calculation of age- and region-related levels of iron, copper and zinc in the adult C57BL/6 mouse brain
We report the effects of age (range: 3 to 18 months) on regional copper, iron and zinc levels in the brain of the C57BL/6 mouse, a widely used inbred strain with a permissive background allowing maximal expression of mutations in models that recapitulate these disorders. We present formulae that can be used to determine regional brain metal concentrations in the C57BL/6 mouse at any age in the range of three to eighteen months of life. Copper levels in the C57BL/6 mouse adult brain were highest in the striatum and cerebellum and increased with age, excepting the cortex and hippocampus. Regional iron levels increased linear...
Source: Neurobiology of Aging - February 1, 2024 Category: Geriatrics Authors: E Suryana B D Rowlands D P Bishop D I Finkelstein K L Double Source Type: research
Age-related similarities and differences in cognitive and neural processing revealed by task-related microstate analysis
Neurobiol Aging. 2024 Jan 20;136:9-22. doi: 10.1016/j.neurobiolaging.2024.01.007. Online ahead of print.ABSTRACTWe explored neural processing differences associated with aging across four cognitive functions. In addition to ERP analysis, we included task-related microstate analyses, which identified stable states of neural activity across the scalp over time, to explore whole-head neural activation differences. Younger and older adults (YA, OA) completed face perception (N170), word-pair judgment (N400), visual oddball (P3), and flanker (ERN) tasks. Age-related effects differed across tasks. Despite age-related delayed lat...
Source: Neurobiology of Aging - January 29, 2024 Category: Geriatrics Authors: Chandlyr M Denaro Catherine L Reed Jasmin Joshi Astrid Petropoulos Anjali Thapar Alan A Hartley Source Type: research
Perivascular space burden interacts with APOE- ε4 status on cognition in older adults
Neurobiol Aging. 2024 Jan 22;136:1-8. doi: 10.1016/j.neurobiolaging.2024.01.002. Online ahead of print.ABSTRACTEnlarged perivascular spaces (ePVS) may adversely affect cognition. Little is known about how basal ganglia ePVS interact with apolipoprotein (APOE)-ε4 status. Vanderbilt Memory and Aging Project participants (n = 326, 73 ± 7, 59% male) underwent 3 T brain MRI at baseline to assess ePVS and longitudinal neuropsychological assessments. The interaction between ePVS volume and APOE-ε4 carrier status was related to baseline outcomes using ordinary least squares regressions and longitudinal cognition using linear mi...
Source: Neurobiology of Aging - January 27, 2024 Category: Geriatrics Authors: Marissa A Gogniat Omair A Khan Corey W Bown Dandan Liu Kimberly R Pechman L Taylor Davis Katherine A Gifford Bennett A Landman Timothy J Hohman Angela L Jefferson Source Type: research
Impact of white matter hyperintensities on structural connectivity and cognition in cognitively intact ADNI participants
Neurobiol Aging. 2024 Mar;135:79-90. doi: 10.1016/j.neurobiolaging.2023.10.012. Epub 2023 Dec 12.ABSTRACTWe used indirect brain mapping with virtual lesion tractography to test the hypothesis that the extent of white matter tract disconnection due to white matter hyperintensities (WMH) is associated with corresponding tract-specific cognitive performance decrements. To estimate tract disconnection, WMH masks were extracted from FLAIR MRI data of 481 cognitively intact participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI) and used as regions of avoidance for fiber tracking in diffusion MRI data from 50 heal...
Source: Neurobiology of Aging - January 23, 2024 Category: Geriatrics Authors: Mohammad Taghvaei Dawn J Mechanic-Hamilton Shokufeh Sadaghiani Banafsheh Shakibajahromi Sudipto Dolui Sandhitsu Das Christopher Brown William Tackett Pulkit Khandelwal Philip Cook Russell T Shinohara Paul Yushkevich Danielle S Bassett David A Wolk John A Source Type: research
