Sex modifies effects of imaging and CSF biomarkers on cognitive and functional outcomes: a study of Alzheimer's disease
Neurobiol Aging. 2023 Oct 20;133:67-77. doi: 10.1016/j.neurobiolaging.2023.10.002. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. Two of 3 patients with AD are biologically female; therefore, the biological underpinnings of this diagnosis disparity may inform interventions slowing the AD progression. To bridge this gap, we conducted analyses of 1078 male and female participants from the Alzheimer's Disease Neuroimaging Initiative to examine associations between levels of cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognit...
Source: Neurobiology of Aging - November 1, 2023 Category: Geriatrics Authors: Brian N Lee Junwen Wang Molly A Hall Dokyoon Kim Shana D Stites Li Shen Alzheimer ’s Disease Neuroimaging Initiative Source Type: research

Auditory robustness and resilience in the aging auditory system of the desert locust
Neurobiol Aging. 2023 Sep 23;133:39-50. doi: 10.1016/j.neurobiolaging.2023.09.009. Online ahead of print.ABSTRACTAfter overexposure to loud music, we experience a decrease in our ability to hear (robustness), which usually recovers (resilience). Here, we exploited the amenable auditory system of the desert locust, Schistocerca gregaria, to measure how robustness and resilience depend on age. We found that gene expression changes are dominated by age as opposed to noise exposure. We measured sound-evoked nerve activity for young and aged locusts directly, after 24 hours and 48 hours after noise exposure. We found that both ...
Source: Neurobiology of Aging - November 1, 2023 Category: Geriatrics Authors: Thomas T Austin Christian L Thomas Ben Warren Source Type: research

Contributions of hippocampal subfields and subregions to episodic memory performance in healthy cognitive aging
Neurobiol Aging. 2023 Oct 20;133:51-66. doi: 10.1016/j.neurobiolaging.2023.10.006. Online ahead of print.ABSTRACTIn the present study we investigated whether hippocampal subfield (cornu ammonis 1-3, dentate gyrus, and subiculum) and anteroposterior hippocampal subregion (head,body, and tail) volumes can predict episodic memory function using high-field high resolution structural magnetic resonance imaging (MRI). We recruited 126 healthy participants (18-85 years). MRI datasets were collected on a 4.7 T system. Participants were administered the Wechsler Memory Scale (WMS-IV) to evaluate episodic memory function. Structural...
Source: Neurobiology of Aging - November 1, 2023 Category: Geriatrics Authors: Nikolai Malykhin Wojciech Pietrasik Kim Ngan Hoang Yushan Huang Source Type: research

Sex modifies effects of imaging and CSF biomarkers on cognitive and functional outcomes: a study of Alzheimer's disease
Neurobiol Aging. 2023 Oct 20;133:67-77. doi: 10.1016/j.neurobiolaging.2023.10.002. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. Two of 3 patients with AD are biologically female; therefore, the biological underpinnings of this diagnosis disparity may inform interventions slowing the AD progression. To bridge this gap, we conducted analyses of 1078 male and female participants from the Alzheimer's Disease Neuroimaging Initiative to examine associations between levels of cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognit...
Source: Neurobiology of Aging - November 1, 2023 Category: Geriatrics Authors: Brian N Lee Junwen Wang Molly A Hall Dokyoon Kim Shana D Stites Li Shen Alzheimer ’s Disease Neuroimaging Initiative Source Type: research

Age-related hearing loss associated with differences in the neural correlates of feature binding in visual working memory
Neurobiol Aging. 2023 Sep 28;132:233-245. doi: 10.1016/j.neurobiolaging.2023.09.016. Online ahead of print.ABSTRACTThe underlying neural mechanisms underpinning the association between age-related hearing loss (ARHL) and dementia remain unclear. A limitation has been the lack of functional neuroimaging studies in ARHL cohorts to help clarify this relationship. In the present study, we investigated the neural correlates of feature binding in visual working memory with ARHL (controls = 14, mild HL = 21, and moderate or greater HL = 23). Participants completed a visual change detection task assessing feature binding while the...
Source: Neurobiology of Aging - October 22, 2023 Category: Geriatrics Authors: David G Loughrey Catherine Jordan Agustin Ibanez Mario A Parra Brian A Lawlor Richard B Reilly Source Type: research

Effect of short-term androgen supplementation on cognitive performance in older male rhesus macaques
Neurobiol Aging. 2023 Sep 27;132:246-249. doi: 10.1016/j.neurobiolaging.2023.09.013. Online ahead of print.ABSTRACTOld male rhesus macaques often show cognitive impairment, and also have attenuated circulating levels of testosterone and dehydroepiandrosterone sulfate (DHEAS). However, it is unclear if these age-associated decreases in circulating androgen levels are casually related to mechanisms that support cognition. To test this possibility, old male rhesus macaques were given daily supplements of testosterone and DHEA for ∼7 months, using a paradigm designed to mimic the 24-hour circulating hormone patterns of young...
Source: Neurobiology of Aging - October 22, 2023 Category: Geriatrics Authors: Alison Ruth Weiss Henryk Francis Urbanski Source Type: research

Age-related hearing loss associated with differences in the neural correlates of feature binding in visual working memory
Neurobiol Aging. 2023 Sep 28;132:233-245. doi: 10.1016/j.neurobiolaging.2023.09.016. Online ahead of print.ABSTRACTThe underlying neural mechanisms underpinning the association between age-related hearing loss (ARHL) and dementia remain unclear. A limitation has been the lack of functional neuroimaging studies in ARHL cohorts to help clarify this relationship. In the present study, we investigated the neural correlates of feature binding in visual working memory with ARHL (controls = 14, mild HL = 21, and moderate or greater HL = 23). Participants completed a visual change detection task assessing feature binding while the...
Source: Neurobiology of Aging - October 22, 2023 Category: Geriatrics Authors: David G Loughrey Catherine Jordan Agustin Ibanez Mario A Parra Brian A Lawlor Richard B Reilly Source Type: research

Effect of short-term androgen supplementation on cognitive performance in older male rhesus macaques
Neurobiol Aging. 2023 Sep 27;132:246-249. doi: 10.1016/j.neurobiolaging.2023.09.013. Online ahead of print.ABSTRACTOld male rhesus macaques often show cognitive impairment, and also have attenuated circulating levels of testosterone and dehydroepiandrosterone sulfate (DHEAS). However, it is unclear if these age-associated decreases in circulating androgen levels are casually related to mechanisms that support cognition. To test this possibility, old male rhesus macaques were given daily supplements of testosterone and DHEA for ∼7 months, using a paradigm designed to mimic the 24-hour circulating hormone patterns of young...
Source: Neurobiology of Aging - October 22, 2023 Category: Geriatrics Authors: Alison Ruth Weiss Henryk Francis Urbanski Source Type: research

Age-related hearing loss associated with differences in the neural correlates of feature binding in visual working memory
Neurobiol Aging. 2023 Sep 28;132:233-245. doi: 10.1016/j.neurobiolaging.2023.09.016. Online ahead of print.ABSTRACTThe underlying neural mechanisms underpinning the association between age-related hearing loss (ARHL) and dementia remain unclear. A limitation has been the lack of functional neuroimaging studies in ARHL cohorts to help clarify this relationship. In the present study, we investigated the neural correlates of feature binding in visual working memory with ARHL (controls = 14, mild HL = 21, and moderate or greater HL = 23). Participants completed a visual change detection task assessing feature binding while the...
Source: Neurobiology of Aging - October 22, 2023 Category: Geriatrics Authors: David G Loughrey Catherine Jordan Agustin Ibanez Mario A Parra Brian A Lawlor Richard B Reilly Source Type: research

Effect of short-term androgen supplementation on cognitive performance in older male rhesus macaques
Neurobiol Aging. 2023 Sep 27;132:246-249. doi: 10.1016/j.neurobiolaging.2023.09.013. Online ahead of print.ABSTRACTOld male rhesus macaques often show cognitive impairment, and also have attenuated circulating levels of testosterone and dehydroepiandrosterone sulfate (DHEAS). However, it is unclear if these age-associated decreases in circulating androgen levels are casually related to mechanisms that support cognition. To test this possibility, old male rhesus macaques were given daily supplements of testosterone and DHEA for ∼7 months, using a paradigm designed to mimic the 24-hour circulating hormone patterns of young...
Source: Neurobiology of Aging - October 22, 2023 Category: Geriatrics Authors: Alison Ruth Weiss Henryk Francis Urbanski Source Type: research

Age-related hearing loss associated with differences in the neural correlates of feature binding in visual working memory
Neurobiol Aging. 2023 Sep 28;132:233-245. doi: 10.1016/j.neurobiolaging.2023.09.016. Online ahead of print.ABSTRACTThe underlying neural mechanisms underpinning the association between age-related hearing loss (ARHL) and dementia remain unclear. A limitation has been the lack of functional neuroimaging studies in ARHL cohorts to help clarify this relationship. In the present study, we investigated the neural correlates of feature binding in visual working memory with ARHL (controls = 14, mild HL = 21, and moderate or greater HL = 23). Participants completed a visual change detection task assessing feature binding while the...
Source: Neurobiology of Aging - October 22, 2023 Category: Geriatrics Authors: David G Loughrey Catherine Jordan Agustin Ibanez Mario A Parra Brian A Lawlor Richard B Reilly Source Type: research

Effect of short-term androgen supplementation on cognitive performance in older male rhesus macaques
Neurobiol Aging. 2023 Sep 27;132:246-249. doi: 10.1016/j.neurobiolaging.2023.09.013. Online ahead of print.ABSTRACTOld male rhesus macaques often show cognitive impairment, and also have attenuated circulating levels of testosterone and dehydroepiandrosterone sulfate (DHEAS). However, it is unclear if these age-associated decreases in circulating androgen levels are casually related to mechanisms that support cognition. To test this possibility, old male rhesus macaques were given daily supplements of testosterone and DHEA for ∼7 months, using a paradigm designed to mimic the 24-hour circulating hormone patterns of young...
Source: Neurobiology of Aging - October 22, 2023 Category: Geriatrics Authors: Alison Ruth Weiss Henryk Francis Urbanski Source Type: research

Age-related hearing loss associated with differences in the neural correlates of feature binding in visual working memory
Neurobiol Aging. 2023 Sep 28;132:233-245. doi: 10.1016/j.neurobiolaging.2023.09.016. Online ahead of print.ABSTRACTThe underlying neural mechanisms underpinning the association between age-related hearing loss (ARHL) and dementia remain unclear. A limitation has been the lack of functional neuroimaging studies in ARHL cohorts to help clarify this relationship. In the present study, we investigated the neural correlates of feature binding in visual working memory with ARHL (controls = 14, mild HL = 21, and moderate or greater HL = 23). Participants completed a visual change detection task assessing feature binding while the...
Source: Neurobiology of Aging - October 22, 2023 Category: Geriatrics Authors: David G Loughrey Catherine Jordan Agustin Ibanez Mario A Parra Brian A Lawlor Richard B Reilly Source Type: research

Effect of short-term androgen supplementation on cognitive performance in older male rhesus macaques
Neurobiol Aging. 2023 Sep 27;132:246-249. doi: 10.1016/j.neurobiolaging.2023.09.013. Online ahead of print.ABSTRACTOld male rhesus macaques often show cognitive impairment, and also have attenuated circulating levels of testosterone and dehydroepiandrosterone sulfate (DHEAS). However, it is unclear if these age-associated decreases in circulating androgen levels are casually related to mechanisms that support cognition. To test this possibility, old male rhesus macaques were given daily supplements of testosterone and DHEA for ∼7 months, using a paradigm designed to mimic the 24-hour circulating hormone patterns of young...
Source: Neurobiology of Aging - October 22, 2023 Category: Geriatrics Authors: Alison Ruth Weiss Henryk Francis Urbanski Source Type: research

Age-related hearing loss associated with differences in the neural correlates of feature binding in visual working memory
Neurobiol Aging. 2023 Sep 28;132:233-245. doi: 10.1016/j.neurobiolaging.2023.09.016. Online ahead of print.ABSTRACTThe underlying neural mechanisms underpinning the association between age-related hearing loss (ARHL) and dementia remain unclear. A limitation has been the lack of functional neuroimaging studies in ARHL cohorts to help clarify this relationship. In the present study, we investigated the neural correlates of feature binding in visual working memory with ARHL (controls = 14, mild HL = 21, and moderate or greater HL = 23). Participants completed a visual change detection task assessing feature binding while the...
Source: Neurobiology of Aging - October 22, 2023 Category: Geriatrics Authors: David G Loughrey Catherine Jordan Agustin Ibanez Mario A Parra Brian A Lawlor Richard B Reilly Source Type: research