Daily biofeedback to modulate heart rate oscillations affects structural volume in hippocampal subregions targeted by the locus coeruleus in older adults but not younger adults
Neurobiol Aging. 2023 Sep 1;132:85-99. doi: 10.1016/j.neurobiolaging.2023.08.010. Online ahead of print.ABSTRACTUsing data from a clinical trial, we tested the hypothesis that daily sessions modulating heart rate oscillations affect older adults' volume of a region-of-interest (ROI) comprised of adjacent hippocampal subregions with relatively strong locus coeruleus (LC) noradrenergic input. Younger and older adults were randomly assigned to one of two daily biofeedback practices for 5 weeks: (1) engage in slow-paced breathing to increase the amplitude of oscillations in heart rate at their breathing frequency (Osc+); (2) e...
Source: Neurobiology of Aging - September 28, 2023 Category: Geriatrics Authors: Hyun Joo Yoo Kaoru Nashiro Shubir Dutt Jungwon Min Christine Cho Julian F Thayer Paul Lehrer Catie Chang Mara Mather Source Type: research
Increased neural differentiation after a single session of aerobic exercise in older adults
Neurobiol Aging. 2023 Aug 28;132:67-84. doi: 10.1016/j.neurobiolaging.2023.08.008. Online ahead of print.ABSTRACTAging is associated with decreased cognitive function. One theory posits that this decline is in part due to multiple neural systems becoming dedifferentiated in older adults. Exercise is known to improve cognition in older adults, even after only a single session. We hypothesized that one mechanism of improvement is a redifferentiation of neural systems. We used a within-participant, cross-over design involving 2 sessions: either 30 minutes of aerobic exercise or 30 minutes of seated rest (n = 32; ages 55-81 ye...
Source: Neurobiology of Aging - September 24, 2023 Category: Geriatrics Authors: Jeremy Purcell Robert Wiley Junyeon Won Daniel Callow Lauren Weiss Alfonso Alfini Yi Wei J Carson Smith Source Type: research
Increased neural differentiation after a single session of aerobic exercise in older adults
Neurobiol Aging. 2023 Aug 28;132:67-84. doi: 10.1016/j.neurobiolaging.2023.08.008. Online ahead of print.ABSTRACTAging is associated with decreased cognitive function. One theory posits that this decline is in part due to multiple neural systems becoming dedifferentiated in older adults. Exercise is known to improve cognition in older adults, even after only a single session. We hypothesized that one mechanism of improvement is a redifferentiation of neural systems. We used a within-participant, cross-over design involving 2 sessions: either 30 minutes of aerobic exercise or 30 minutes of seated rest (n = 32; ages 55-81 ye...
Source: Neurobiology of Aging - September 24, 2023 Category: Geriatrics Authors: Jeremy Purcell Robert Wiley Junyeon Won Daniel Callow Lauren Weiss Alfonso Alfini Yi Wei J Carson Smith Source Type: research
Increased neural differentiation after a single session of aerobic exercise in older adults
Neurobiol Aging. 2023 Aug 28;132:67-84. doi: 10.1016/j.neurobiolaging.2023.08.008. Online ahead of print.ABSTRACTAging is associated with decreased cognitive function. One theory posits that this decline is in part due to multiple neural systems becoming dedifferentiated in older adults. Exercise is known to improve cognition in older adults, even after only a single session. We hypothesized that one mechanism of improvement is a redifferentiation of neural systems. We used a within-participant, cross-over design involving 2 sessions: either 30 minutes of aerobic exercise or 30 minutes of seated rest (n = 32; ages 55-81 ye...
Source: Neurobiology of Aging - September 24, 2023 Category: Geriatrics Authors: Jeremy Purcell Robert Wiley Junyeon Won Daniel Callow Lauren Weiss Alfonso Alfini Yi Wei J Carson Smith Source Type: research
Increased neural differentiation after a single session of aerobic exercise in older adults
Neurobiol Aging. 2023 Aug 28;132:67-84. doi: 10.1016/j.neurobiolaging.2023.08.008. Online ahead of print.ABSTRACTAging is associated with decreased cognitive function. One theory posits that this decline is in part due to multiple neural systems becoming dedifferentiated in older adults. Exercise is known to improve cognition in older adults, even after only a single session. We hypothesized that one mechanism of improvement is a redifferentiation of neural systems. We used a within-participant, cross-over design involving 2 sessions: either 30 minutes of aerobic exercise or 30 minutes of seated rest (n = 32; ages 55-81 ye...
Source: Neurobiology of Aging - September 24, 2023 Category: Geriatrics Authors: Jeremy Purcell Robert Wiley Junyeon Won Daniel Callow Lauren Weiss Alfonso Alfini Yi Wei J Carson Smith Source Type: research
Comorbid amyloid with cerebrovascular disease in domain-specific cognitive and neuropsychiatric disturbances: a cross-sectional memory clinic study
Neurobiol Aging. 2023 Aug 19;132:47-55. doi: 10.1016/j.neurobiolaging.2023.08.005. Online ahead of print.ABSTRACTDementia is a multifactorial disorder that is likely influenced by both Alzheimer's disease (AD) and vascular pathologies. We evaluated domain-specific cognitive and neuropsychiatric dysfunction using a two-neuroimaging biomarker construct (beta-amyloid [Aβ] and cerebrovascular disease [CeVD]). We analyzed data from 216 memory clinic participants (mean age = 75.9 ± 6.9; 56.5% female) with neuropsychological and neuropsychiatric assessments, 3T-MRI, and Aβ-PET imaging. Structural equation modeling showed that ...
Source: Neurobiology of Aging - September 20, 2023 Category: Geriatrics Authors: Cheuk Ni Kan Xuhua Huang Liwen Zhang Saima Hilal Anthonin Reilhac Tomotaka Tanaka Narayanaswamy Venketasubramanian Christopher Chen Xin Xu Source Type: research
White matter hyperintensity load mediates the relationship between age and cognition
Neurobiol Aging. 2023 Aug 25;132:56-66. doi: 10.1016/j.neurobiolaging.2023.08.007. Online ahead of print.ABSTRACTTo elucidate the relationship between age and cognitive decline, it is important to consider structural brain changes such as white matter hyperintensities (WMHs), which are common in older age and may affect behavior. Therefore, we aimed to investigate if WMH load is a mediator of the relationship between age and cognitive decline. Healthy participants (N = 166, 20-80 years) completed the Montreal Cognitive Assessment (MoCA). WMHs were manually delineated on FLAIR scans. Mediation analysis was conducted to dete...
Source: Neurobiology of Aging - September 20, 2023 Category: Geriatrics Authors: Natalie Busby Sarah Wilson Janina Wilmskoetter Roger Newman-Norlund Sara Sayers Sarah Newman-Norlund Rebecca Roth Chris Rorden Julius Fridriksson Leonardo Bonilha Source Type: research
Comorbid amyloid with cerebrovascular disease in domain-specific cognitive and neuropsychiatric disturbances: a cross-sectional memory clinic study
Neurobiol Aging. 2023 Aug 19;132:47-55. doi: 10.1016/j.neurobiolaging.2023.08.005. Online ahead of print.ABSTRACTDementia is a multifactorial disorder that is likely influenced by both Alzheimer's disease (AD) and vascular pathologies. We evaluated domain-specific cognitive and neuropsychiatric dysfunction using a two-neuroimaging biomarker construct (beta-amyloid [Aβ] and cerebrovascular disease [CeVD]). We analyzed data from 216 memory clinic participants (mean age = 75.9 ± 6.9; 56.5% female) with neuropsychological and neuropsychiatric assessments, 3T-MRI, and Aβ-PET imaging. Structural equation modeling showed that ...
Source: Neurobiology of Aging - September 20, 2023 Category: Geriatrics Authors: Cheuk Ni Kan Xuhua Huang Liwen Zhang Saima Hilal Anthonin Reilhac Tomotaka Tanaka Narayanaswamy Venketasubramanian Christopher Chen Xin Xu Source Type: research
White matter hyperintensity load mediates the relationship between age and cognition
Neurobiol Aging. 2023 Aug 25;132:56-66. doi: 10.1016/j.neurobiolaging.2023.08.007. Online ahead of print.ABSTRACTTo elucidate the relationship between age and cognitive decline, it is important to consider structural brain changes such as white matter hyperintensities (WMHs), which are common in older age and may affect behavior. Therefore, we aimed to investigate if WMH load is a mediator of the relationship between age and cognitive decline. Healthy participants (N = 166, 20-80 years) completed the Montreal Cognitive Assessment (MoCA). WMHs were manually delineated on FLAIR scans. Mediation analysis was conducted to dete...
Source: Neurobiology of Aging - September 20, 2023 Category: Geriatrics Authors: Natalie Busby Sarah Wilson Janina Wilmskoetter Roger Newman-Norlund Sara Sayers Sarah Newman-Norlund Rebecca Roth Chris Rorden Julius Fridriksson Leonardo Bonilha Source Type: research
Comorbid amyloid with cerebrovascular disease in domain-specific cognitive and neuropsychiatric disturbances: a cross-sectional memory clinic study
Neurobiol Aging. 2023 Aug 19;132:47-55. doi: 10.1016/j.neurobiolaging.2023.08.005. Online ahead of print.ABSTRACTDementia is a multifactorial disorder that is likely influenced by both Alzheimer's disease (AD) and vascular pathologies. We evaluated domain-specific cognitive and neuropsychiatric dysfunction using a two-neuroimaging biomarker construct (beta-amyloid [Aβ] and cerebrovascular disease [CeVD]). We analyzed data from 216 memory clinic participants (mean age = 75.9 ± 6.9; 56.5% female) with neuropsychological and neuropsychiatric assessments, 3T-MRI, and Aβ-PET imaging. Structural equation modeling showed that ...
Source: Neurobiology of Aging - September 20, 2023 Category: Geriatrics Authors: Cheuk Ni Kan Xuhua Huang Liwen Zhang Saima Hilal Anthonin Reilhac Tomotaka Tanaka Narayanaswamy Venketasubramanian Christopher Chen Xin Xu Source Type: research
White matter hyperintensity load mediates the relationship between age and cognition
Neurobiol Aging. 2023 Aug 25;132:56-66. doi: 10.1016/j.neurobiolaging.2023.08.007. Online ahead of print.ABSTRACTTo elucidate the relationship between age and cognitive decline, it is important to consider structural brain changes such as white matter hyperintensities (WMHs), which are common in older age and may affect behavior. Therefore, we aimed to investigate if WMH load is a mediator of the relationship between age and cognitive decline. Healthy participants (N = 166, 20-80 years) completed the Montreal Cognitive Assessment (MoCA). WMHs were manually delineated on FLAIR scans. Mediation analysis was conducted to dete...
Source: Neurobiology of Aging - September 20, 2023 Category: Geriatrics Authors: Natalie Busby Sarah Wilson Janina Wilmskoetter Roger Newman-Norlund Sara Sayers Sarah Newman-Norlund Rebecca Roth Chris Rorden Julius Fridriksson Leonardo Bonilha Source Type: research
Comorbid amyloid with cerebrovascular disease in domain-specific cognitive and neuropsychiatric disturbances: a cross-sectional memory clinic study
Neurobiol Aging. 2023 Aug 19;132:47-55. doi: 10.1016/j.neurobiolaging.2023.08.005. Online ahead of print.ABSTRACTDementia is a multifactorial disorder that is likely influenced by both Alzheimer's disease (AD) and vascular pathologies. We evaluated domain-specific cognitive and neuropsychiatric dysfunction using a two-neuroimaging biomarker construct (beta-amyloid [Aβ] and cerebrovascular disease [CeVD]). We analyzed data from 216 memory clinic participants (mean age = 75.9 ± 6.9; 56.5% female) with neuropsychological and neuropsychiatric assessments, 3T-MRI, and Aβ-PET imaging. Structural equation modeling showed that ...
Source: Neurobiology of Aging - September 20, 2023 Category: Geriatrics Authors: Cheuk Ni Kan Xuhua Huang Liwen Zhang Saima Hilal Anthonin Reilhac Tomotaka Tanaka Narayanaswamy Venketasubramanian Christopher Chen Xin Xu Source Type: research
White matter hyperintensity load mediates the relationship between age and cognition
Neurobiol Aging. 2023 Aug 25;132:56-66. doi: 10.1016/j.neurobiolaging.2023.08.007. Online ahead of print.ABSTRACTTo elucidate the relationship between age and cognitive decline, it is important to consider structural brain changes such as white matter hyperintensities (WMHs), which are common in older age and may affect behavior. Therefore, we aimed to investigate if WMH load is a mediator of the relationship between age and cognitive decline. Healthy participants (N = 166, 20-80 years) completed the Montreal Cognitive Assessment (MoCA). WMHs were manually delineated on FLAIR scans. Mediation analysis was conducted to dete...
Source: Neurobiology of Aging - September 20, 2023 Category: Geriatrics Authors: Natalie Busby Sarah Wilson Janina Wilmskoetter Roger Newman-Norlund Sara Sayers Sarah Newman-Norlund Rebecca Roth Chris Rorden Julius Fridriksson Leonardo Bonilha Source Type: research
Gamma connectivity predicts response to intermittent theta burst stimulation in Alzheimer's disease: a randomized controlled trial
Neurobiol Aging. 2023 Aug 22;132:13-23. doi: 10.1016/j.neurobiolaging.2023.08.006. Online ahead of print.ABSTRACTThere is growing evidence that neural network dysfunction is a likely proximate cause of cognitive impairment in Alzheimer's disease and may represent a promising therapeutic target. Here, we investigated whether a course of intermittent theta burst stimulation (iTBS) could modulate functional connectivity and cognition in mild to moderate Alzheimer's. In a double-blind parallel randomized sham-controlled trial, 58 participants were randomized to either active or sham iTBS. Stimulation was applied to the left do...
Source: Neurobiology of Aging - September 17, 2023 Category: Geriatrics Authors: Kate E Hoy Melanie R L Emonson Neil W Bailey Caitlyn Rogers Hannah Coyle Freya Stockman Paul B Fitzgerald Source Type: research
Multimodal imaging of microstructural cerebral alterations and loss of synaptic density in Alzheimer's disease
Neurobiol Aging. 2023 Aug 9;132:24-35. doi: 10.1016/j.neurobiolaging.2023.08.001. Online ahead of print.ABSTRACTMultiple neuropathological events are involved in Alzheimer's disease (AD). The current study investigated the concurrence of neurodegeneration, increased iron content, atrophy, and demyelination in AD. Quantitative multiparameter magnetic resonance imaging (MRI) maps providing neuroimaging biomarkers for myelination and iron content along with synaptic density measurements using [18F] UCB-H PET were acquired in 24 AD and 19 Healthy controls (19 males). The whole brain voxel-wise group comparison revealed demyeli...
Source: Neurobiology of Aging - September 17, 2023 Category: Geriatrics Authors: Soodeh Moallemian Eric Salmon Mohamed Ali Bahri Nikita Beliy Emma Delhaye Evelyne Balteau Christian Degueldre Christophe Phillips Christine Bastin Source Type: research
