Cytokine profiling in senescent and reactive astrocytes: A systematic review
Neurobiol Aging. 2024 Feb 27;138:28-35. doi: 10.1016/j.neurobiolaging.2024.02.012. Online ahead of print.ABSTRACTAstrocytes play an important role in neuroinflammation by producing proinflammatory molecules. In response to various stressful stimuli, astrocytes can become senescent or reactive, both are present in age-associated cognitive impairment and other neurodegenerative diseases, and contribute to neuroinflammation. However, there are no studies that compare the cytokines secreted by these types of astrocytes in the brain during aging. Hence, we aimed to broaden the picture of the secretory profiles and to differenti...
Source: Neurobiology of Aging - March 24, 2024 Category: Geriatrics Authors: Michel L ópez-Teros Adriana Alarc ón-Aguilar Alejandra Castillo-Arag ón Mina K önigsberg Armando Luna-L ópez Source Type: research
Childhood engagement in cognitively stimulating activities moderates relationships between brain structure and cognitive function in adulthood
Neurobiol Aging. 2024 Feb 23;138:36-44. doi: 10.1016/j.neurobiolaging.2024.02.010. Online ahead of print.ABSTRACTGreater engagement in cognitively stimulating activities (CSA) during adulthood has been shown to protect against neurocognitive decline, but no studies have investigated whether CSA during childhood protects against effects of brain changes on cognition later in life. The current study tested the moderating role of childhood CSA in the relationships between brain structure and cognitive performance during adulthood. At baseline (N=250) and 5-year follow-up (N=204) healthy adults aged 20-80 underwent MRI to asse...
Source: Neurobiology of Aging - March 24, 2024 Category: Geriatrics Authors: Alexandra M Gaynor Yunglin Gazes Caleb R Haynes Reshma S Babukutty Christian Habeck Yaakov Stern Yian Gu Source Type: research
Cytokine profiling in senescent and reactive astrocytes: A systematic review
Neurobiol Aging. 2024 Feb 27;138:28-35. doi: 10.1016/j.neurobiolaging.2024.02.012. Online ahead of print.ABSTRACTAstrocytes play an important role in neuroinflammation by producing proinflammatory molecules. In response to various stressful stimuli, astrocytes can become senescent or reactive, both are present in age-associated cognitive impairment and other neurodegenerative diseases, and contribute to neuroinflammation. However, there are no studies that compare the cytokines secreted by these types of astrocytes in the brain during aging. Hence, we aimed to broaden the picture of the secretory profiles and to differenti...
Source: Neurobiology of Aging - March 24, 2024 Category: Geriatrics Authors: Michel L ópez-Teros Adriana Alarc ón-Aguilar Alejandra Castillo-Arag ón Mina K önigsberg Armando Luna-L ópez Source Type: research
Childhood engagement in cognitively stimulating activities moderates relationships between brain structure and cognitive function in adulthood
Neurobiol Aging. 2024 Feb 23;138:36-44. doi: 10.1016/j.neurobiolaging.2024.02.010. Online ahead of print.ABSTRACTGreater engagement in cognitively stimulating activities (CSA) during adulthood has been shown to protect against neurocognitive decline, but no studies have investigated whether CSA during childhood protects against effects of brain changes on cognition later in life. The current study tested the moderating role of childhood CSA in the relationships between brain structure and cognitive performance during adulthood. At baseline (N=250) and 5-year follow-up (N=204) healthy adults aged 20-80 underwent MRI to asse...
Source: Neurobiology of Aging - March 24, 2024 Category: Geriatrics Authors: Alexandra M Gaynor Yunglin Gazes Caleb R Haynes Reshma S Babukutty Christian Habeck Yaakov Stern Yian Gu Source Type: research
Cytokine profiling in senescent and reactive astrocytes: A systematic review
Neurobiol Aging. 2024 Feb 27;138:28-35. doi: 10.1016/j.neurobiolaging.2024.02.012. Online ahead of print.ABSTRACTAstrocytes play an important role in neuroinflammation by producing proinflammatory molecules. In response to various stressful stimuli, astrocytes can become senescent or reactive, both are present in age-associated cognitive impairment and other neurodegenerative diseases, and contribute to neuroinflammation. However, there are no studies that compare the cytokines secreted by these types of astrocytes in the brain during aging. Hence, we aimed to broaden the picture of the secretory profiles and to differenti...
Source: Neurobiology of Aging - March 24, 2024 Category: Geriatrics Authors: Michel L ópez-Teros Adriana Alarc ón-Aguilar Alejandra Castillo-Arag ón Mina K önigsberg Armando Luna-L ópez Source Type: research
Childhood engagement in cognitively stimulating activities moderates relationships between brain structure and cognitive function in adulthood
Neurobiol Aging. 2024 Feb 23;138:36-44. doi: 10.1016/j.neurobiolaging.2024.02.010. Online ahead of print.ABSTRACTGreater engagement in cognitively stimulating activities (CSA) during adulthood has been shown to protect against neurocognitive decline, but no studies have investigated whether CSA during childhood protects against effects of brain changes on cognition later in life. The current study tested the moderating role of childhood CSA in the relationships between brain structure and cognitive performance during adulthood. At baseline (N=250) and 5-year follow-up (N=204) healthy adults aged 20-80 underwent MRI to asse...
Source: Neurobiology of Aging - March 24, 2024 Category: Geriatrics Authors: Alexandra M Gaynor Yunglin Gazes Caleb R Haynes Reshma S Babukutty Christian Habeck Yaakov Stern Yian Gu Source Type: research
Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive impairment
Neurobiol Aging. 2024 Feb 16;138:19-27. doi: 10.1016/j.neurobiolaging.2024.02.006. Online ahead of print.ABSTRACTMild Behavioral Impairment (MBI) leverages later-life emergent and persistent neuropsychiatric symptoms (NPS) to identify a high-risk group for incident dementia. Phosphorylated tau (p-tau) is a hallmark biological manifestation of Alzheimer disease (AD). We investigated associations between MBI and tau accumulation in early-stage AD cortical regions. In 442 Alzheimer's Disease Neuroimaging Initiative participants with normal cognition or mild cognitive impairment, MBI status was determined alongside correspondi...
Source: Neurobiology of Aging - March 15, 2024 Category: Geriatrics Authors: James Naude Meng Wang Rebeca Leon Eric Smith Zahinoor Ismail Source Type: research
Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive impairment
Neurobiol Aging. 2024 Feb 16;138:19-27. doi: 10.1016/j.neurobiolaging.2024.02.006. Online ahead of print.ABSTRACTMild Behavioral Impairment (MBI) leverages later-life emergent and persistent neuropsychiatric symptoms (NPS) to identify a high-risk group for incident dementia. Phosphorylated tau (p-tau) is a hallmark biological manifestation of Alzheimer disease (AD). We investigated associations between MBI and tau accumulation in early-stage AD cortical regions. In 442 Alzheimer's Disease Neuroimaging Initiative participants with normal cognition or mild cognitive impairment, MBI status was determined alongside correspondi...
Source: Neurobiology of Aging - March 15, 2024 Category: Geriatrics Authors: James Naude Meng Wang Rebeca Leon Eric Smith Zahinoor Ismail Source Type: research
Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive impairment
Neurobiol Aging. 2024 Feb 16;138:19-27. doi: 10.1016/j.neurobiolaging.2024.02.006. Online ahead of print.ABSTRACTMild Behavioral Impairment (MBI) leverages later-life emergent and persistent neuropsychiatric symptoms (NPS) to identify a high-risk group for incident dementia. Phosphorylated tau (p-tau) is a hallmark biological manifestation of Alzheimer disease (AD). We investigated associations between MBI and tau accumulation in early-stage AD cortical regions. In 442 Alzheimer's Disease Neuroimaging Initiative participants with normal cognition or mild cognitive impairment, MBI status was determined alongside correspondi...
Source: Neurobiology of Aging - March 15, 2024 Category: Geriatrics Authors: James Naude Meng Wang Rebeca Leon Eric Smith Zahinoor Ismail Source Type: research
Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive impairment
Neurobiol Aging. 2024 Feb 16;138:19-27. doi: 10.1016/j.neurobiolaging.2024.02.006. Online ahead of print.ABSTRACTMild Behavioral Impairment (MBI) leverages later-life emergent and persistent neuropsychiatric symptoms (NPS) to identify a high-risk group for incident dementia. Phosphorylated tau (p-tau) is a hallmark biological manifestation of Alzheimer disease (AD). We investigated associations between MBI and tau accumulation in early-stage AD cortical regions. In 442 Alzheimer's Disease Neuroimaging Initiative participants with normal cognition or mild cognitive impairment, MBI status was determined alongside correspondi...
Source: Neurobiology of Aging - March 15, 2024 Category: Geriatrics Authors: James Naude Meng Wang Rebeca Leon Eric Smith Zahinoor Ismail Source Type: research
Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive impairment
Neurobiol Aging. 2024 Feb 16;138:19-27. doi: 10.1016/j.neurobiolaging.2024.02.006. Online ahead of print.ABSTRACTMild Behavioral Impairment (MBI) leverages later-life emergent and persistent neuropsychiatric symptoms (NPS) to identify a high-risk group for incident dementia. Phosphorylated tau (p-tau) is a hallmark biological manifestation of Alzheimer disease (AD). We investigated associations between MBI and tau accumulation in early-stage AD cortical regions. In 442 Alzheimer's Disease Neuroimaging Initiative participants with normal cognition or mild cognitive impairment, MBI status was determined alongside correspondi...
Source: Neurobiology of Aging - March 15, 2024 Category: Geriatrics Authors: James Naude Meng Wang Rebeca Leon Eric Smith Zahinoor Ismail Source Type: research
Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive impairment
Neurobiol Aging. 2024 Feb 16;138:19-27. doi: 10.1016/j.neurobiolaging.2024.02.006. Online ahead of print.ABSTRACTMild Behavioral Impairment (MBI) leverages later-life emergent and persistent neuropsychiatric symptoms (NPS) to identify a high-risk group for incident dementia. Phosphorylated tau (p-tau) is a hallmark biological manifestation of Alzheimer disease (AD). We investigated associations between MBI and tau accumulation in early-stage AD cortical regions. In 442 Alzheimer's Disease Neuroimaging Initiative participants with normal cognition or mild cognitive impairment, MBI status was determined alongside correspondi...
Source: Neurobiology of Aging - March 15, 2024 Category: Geriatrics Authors: James Naude Meng Wang Rebeca Leon Eric Smith Zahinoor Ismail Source Type: research
Tau-PET in early cortical Alzheimer brain regions in relation to mild behavioral impairment in older adults with either normal cognition or mild cognitive impairment
Neurobiol Aging. 2024 Feb 16;138:19-27. doi: 10.1016/j.neurobiolaging.2024.02.006. Online ahead of print.ABSTRACTMild Behavioral Impairment (MBI) leverages later-life emergent and persistent neuropsychiatric symptoms (NPS) to identify a high-risk group for incident dementia. Phosphorylated tau (p-tau) is a hallmark biological manifestation of Alzheimer disease (AD). We investigated associations between MBI and tau accumulation in early-stage AD cortical regions. In 442 Alzheimer's Disease Neuroimaging Initiative participants with normal cognition or mild cognitive impairment, MBI status was determined alongside correspondi...
Source: Neurobiology of Aging - March 15, 2024 Category: Geriatrics Authors: James Naude Meng Wang Rebeca Leon Eric Smith Zahinoor Ismail Source Type: research
Psychosis in Alzheimer's disease is associated with specific changes in brain MRI volume, cognition and neuropathology
In conclusion, psychosis in ADNC with and without LB has clinical value and associates with subgroup patterns of neuropathology, cognition and regional atrophy.PMID:38471417 | DOI:10.1016/j.neurobiolaging.2024.02.013 (Source: Neurobiology of Aging)
Source: Neurobiology of Aging - March 12, 2024 Category: Geriatrics Authors: Francisco C Almeida Tiago Jesus Ana Coelho Miguel Quintas-Neves Kathryn Gauthreaux Merilee A Teylan Charles N Mock Walter A Kukull John F Crary Tiago Gil Oliveira Source Type: research
Psychosis in Alzheimer's disease is associated with specific changes in brain MRI volume, cognition and neuropathology
In conclusion, psychosis in ADNC with and without LB has clinical value and associates with subgroup patterns of neuropathology, cognition and regional atrophy.PMID:38471417 | DOI:10.1016/j.neurobiolaging.2024.02.013 (Source: Neurobiology of Aging)
Source: Neurobiology of Aging - March 12, 2024 Category: Geriatrics Authors: Francisco C Almeida Tiago Jesus Ana Coelho Miguel Quintas-Neves Kathryn Gauthreaux Merilee A Teylan Charles N Mock Walter A Kukull John F Crary Tiago Gil Oliveira Source Type: research
