Preventive effect of propolis on cognitive decline in Alzheimer's disease model mice
Neurobiol Aging. 2024 Mar 13;139:20-29. doi: 10.1016/j.neurobiolaging.2024.03.002. Online ahead of print.ABSTRACTBrazilian green propolis (propolis) is a chemically complex resinous substance that is a potentially viable therapeutic agent for Alzheimer's disease. Herein, propolis induced a transient increase in intracellular Ca2+ concentration ([Ca2+]i) in Neuro-2A cells; moreover, propolis-induced [Ca2+]i elevations were suppressed prior to 24-h pretreatment with amyloid-β. To reveal the effect of [Ca2+]i elevation on impaired cognition, we performed memory-related behavioral tasks in APP-KI mice relative to WT mice at 4...
Source: Neurobiology of Aging - April 7, 2024 Category: Geriatrics Authors: Ryo Inagaki Tohru Yamakuni Takashi Saito Takaomi C Saido Shigeki Moriguchi Source Type: research
Preventive effect of propolis on cognitive decline in Alzheimer's disease model mice
Neurobiol Aging. 2024 Mar 13;139:20-29. doi: 10.1016/j.neurobiolaging.2024.03.002. Online ahead of print.ABSTRACTBrazilian green propolis (propolis) is a chemically complex resinous substance that is a potentially viable therapeutic agent for Alzheimer's disease. Herein, propolis induced a transient increase in intracellular Ca2+ concentration ([Ca2+]i) in Neuro-2A cells; moreover, propolis-induced [Ca2+]i elevations were suppressed prior to 24-h pretreatment with amyloid-β. To reveal the effect of [Ca2+]i elevation on impaired cognition, we performed memory-related behavioral tasks in APP-KI mice relative to WT mice at 4...
Source: Neurobiology of Aging - April 7, 2024 Category: Geriatrics Authors: Ryo Inagaki Tohru Yamakuni Takashi Saito Takaomi C Saido Shigeki Moriguchi Source Type: research
Preventive effect of propolis on cognitive decline in Alzheimer's disease model mice
Neurobiol Aging. 2024 Mar 13;139:20-29. doi: 10.1016/j.neurobiolaging.2024.03.002. Online ahead of print.ABSTRACTBrazilian green propolis (propolis) is a chemically complex resinous substance that is a potentially viable therapeutic agent for Alzheimer's disease. Herein, propolis induced a transient increase in intracellular Ca2+ concentration ([Ca2+]i) in Neuro-2A cells; moreover, propolis-induced [Ca2+]i elevations were suppressed prior to 24-h pretreatment with amyloid-β. To reveal the effect of [Ca2+]i elevation on impaired cognition, we performed memory-related behavioral tasks in APP-KI mice relative to WT mice at 4...
Source: Neurobiology of Aging - April 7, 2024 Category: Geriatrics Authors: Ryo Inagaki Tohru Yamakuni Takashi Saito Takaomi C Saido Shigeki Moriguchi Source Type: research
Apolipoprotein E and Alzheimer's disease pathology in African American older adults
Neurobiol Aging. 2024 Mar 30;139:11-19. doi: 10.1016/j.neurobiolaging.2024.03.005. Online ahead of print.ABSTRACTThe apolipoprotein-E4 (APOE*4) and apolipoprotein-E2 (APOE*2) alleles are more common in African American versus non-Hispanic white populations, but relationships of both alleles with Alzheimer's disease (AD) pathology among African American individuals are unclear. We measured APOE allele and β-amyloid (Aβ) and tau using blood samples and positron emission tomography (PET) images, respectively. Individual regression models tested associations of each APOE allele with Aβ or tau PET overall, stratified by raci...
Source: Neurobiology of Aging - April 6, 2024 Category: Geriatrics Authors: Sarah K Royse Beth E Snitz Ashley V Hill Alexandria C Reese Rebecca E Roush M Ilyas Kamboh Marnie Bertolet Anum Saeed Brian J Lopresti Victor L Villemagne Oscar L Lopez Steven E Reis James T Becker Ann D Cohen Source Type: research
Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden
We examined whether older adults, and APOE4 carriers specifically, with diminished CVR would exhibit higher WMH burden. Independently living older adults (N = 125, mean age = 69.2 years; SD = 7.6; 31.2% male) free of dementia or clinical stroke underwent brain MRI to quantify cerebral perfusion during CVR to hypercapnia and hypocapnia and determine WMH volume. Adjusting for age, sex and intracranial volume, hierarchical regression analysis revealed a significant association between whole brain CVR to hypercapnia and WMH overall [B = -.02, 95% CI (-.04, -.008), p =.003] and in APOE4 carriers [B = -.03, 95% CI (-.06, -.009),...
Source: Neurobiology of Aging - April 5, 2024 Category: Geriatrics Authors: Arunima Kapoor Shubir Dutt John Paul M Alitin Isabel J Sible Anisa Marshall Fatemah Shenasa Allison C Engstrom Aim ée Gaubert Xingfeng Shao David Robert Bradford Kathleen Rodgers Mara Mather Danny J J Wang Daniel A Nation Source Type: research
Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden
We examined whether older adults, and APOE4 carriers specifically, with diminished CVR would exhibit higher WMH burden. Independently living older adults (N = 125, mean age = 69.2 years; SD = 7.6; 31.2% male) free of dementia or clinical stroke underwent brain MRI to quantify cerebral perfusion during CVR to hypercapnia and hypocapnia and determine WMH volume. Adjusting for age, sex and intracranial volume, hierarchical regression analysis revealed a significant association between whole brain CVR to hypercapnia and WMH overall [B = -.02, 95% CI (-.04, -.008), p =.003] and in APOE4 carriers [B = -.03, 95% CI (-.06, -.009),...
Source: Neurobiology of Aging - April 5, 2024 Category: Geriatrics Authors: Arunima Kapoor Shubir Dutt John Paul M Alitin Isabel J Sible Anisa Marshall Fatemah Shenasa Allison C Engstrom Aim ée Gaubert Xingfeng Shao David Robert Bradford Kathleen Rodgers Mara Mather Danny J J Wang Daniel A Nation Source Type: research
Alterations in gamma frequency oscillations correlate with cortical tau deposition in Alzheimer's disease
Neurobiol Aging. 2024 Mar 30;139:1-4. doi: 10.1016/j.neurobiolaging.2024.03.008. Online ahead of print.ABSTRACTWe assessed the relationship of gamma oscillations with tau deposition in Alzheimer's disease (AD) and other cognitive diseases, as both are altered during the disease course and relate to neurodegeneration. We retrospectively analyzed data from 7 AD, tau positive patients and 9 tau negative patients, who underwent cerebral amyloid PET and tau PET, and EEG within 12 months. Relative gamma power was higher in tau positive (AD) patients than in tau negative patients (p < .05). In tau positive AD patients, tau bur...
Source: Neurobiology of Aging - April 4, 2024 Category: Geriatrics Authors: Umberto Nencha Isotta Rigoni Federica Ribaldi Daniele Altomare Margitta Seeck Valentina Garibotto Serge Vulli émoz Giovanni B Frisoni Source Type: research
Alterations in gamma frequency oscillations correlate with cortical tau deposition in Alzheimer's disease
Neurobiol Aging. 2024 Mar 30;139:1-4. doi: 10.1016/j.neurobiolaging.2024.03.008. Online ahead of print.ABSTRACTWe assessed the relationship of gamma oscillations with tau deposition in Alzheimer's disease (AD) and other cognitive diseases, as both are altered during the disease course and relate to neurodegeneration. We retrospectively analyzed data from 7 AD, tau positive patients and 9 tau negative patients, who underwent cerebral amyloid PET and tau PET, and EEG within 12 months. Relative gamma power was higher in tau positive (AD) patients than in tau negative patients (p < .05). In tau positive AD patients, tau bur...
Source: Neurobiology of Aging - April 4, 2024 Category: Geriatrics Authors: Umberto Nencha Isotta Rigoni Federica Ribaldi Daniele Altomare Margitta Seeck Valentina Garibotto Serge Vulli émoz Giovanni B Frisoni Source Type: research
APOE- ε4 is not associated with pure-tone hearing thresholds, visual acuity or cognition, cross-sectionally or over 3 years of follow up in the Canadian Longitudinal Study on Aging
CONCLUSION: APOE-ε4 allele count does not appear to be a common cause of sensory-cognitive associations in this large cohort.PMID:38547662 | DOI:10.1016/j.neurobiolaging.2024.01.006 (Source: Neurobiology of Aging)
Source: Neurobiology of Aging - March 28, 2024 Category: Geriatrics Authors: Paul Mick Rasel Kabir Malshi Karunatilake M Kathleen Pichora-Fuller Terry-Lyn Young Yuri Sosero Ziv Gan-Or Walter Wittich Natalie A Phillips Source Type: research
APOE- ε4 is not associated with pure-tone hearing thresholds, visual acuity or cognition, cross-sectionally or over 3 years of follow up in the Canadian Longitudinal Study on Aging
CONCLUSION: APOE-ε4 allele count does not appear to be a common cause of sensory-cognitive associations in this large cohort.PMID:38547662 | DOI:10.1016/j.neurobiolaging.2024.01.006 (Source: Neurobiology of Aging)
Source: Neurobiology of Aging - March 28, 2024 Category: Geriatrics Authors: Paul Mick Rasel Kabir Malshi Karunatilake M Kathleen Pichora-Fuller Terry-Lyn Young Yuri Sosero Ziv Gan-Or Walter Wittich Natalie A Phillips Source Type: research
APOE- ε4 is not associated with pure-tone hearing thresholds, visual acuity or cognition, cross-sectionally or over 3 years of follow up in the Canadian Longitudinal Study on Aging
CONCLUSION: APOE-ε4 allele count does not appear to be a common cause of sensory-cognitive associations in this large cohort.PMID:38547662 | DOI:10.1016/j.neurobiolaging.2024.01.006 (Source: Neurobiology of Aging)
Source: Neurobiology of Aging - March 28, 2024 Category: Geriatrics Authors: Paul Mick Rasel Kabir Malshi Karunatilake M Kathleen Pichora-Fuller Terry-Lyn Young Yuri Sosero Ziv Gan-Or Walter Wittich Natalie A Phillips Source Type: research
APOE- ε4 is not associated with pure-tone hearing thresholds, visual acuity or cognition, cross-sectionally or over 3 years of follow up in the Canadian Longitudinal Study on Aging
CONCLUSION: APOE-ε4 allele count does not appear to be a common cause of sensory-cognitive associations in this large cohort.PMID:38547662 | DOI:10.1016/j.neurobiolaging.2024.01.006 (Source: Neurobiology of Aging)
Source: Neurobiology of Aging - March 28, 2024 Category: Geriatrics Authors: Paul Mick Rasel Kabir Malshi Karunatilake M Kathleen Pichora-Fuller Terry-Lyn Young Yuri Sosero Ziv Gan-Or Walter Wittich Natalie A Phillips Source Type: research
APOE- ε4 is not associated with pure-tone hearing thresholds, visual acuity or cognition, cross-sectionally or over 3 years of follow up in the Canadian Longitudinal Study on Aging
CONCLUSION: APOE-ε4 allele count does not appear to be a common cause of sensory-cognitive associations in this large cohort.PMID:38547662 | DOI:10.1016/j.neurobiolaging.2024.01.006 (Source: Neurobiology of Aging)
Source: Neurobiology of Aging - March 28, 2024 Category: Geriatrics Authors: Paul Mick Rasel Kabir Malshi Karunatilake M Kathleen Pichora-Fuller Terry-Lyn Young Yuri Sosero Ziv Gan-Or Walter Wittich Natalie A Phillips Source Type: research
APOE- ε4 is not associated with pure-tone hearing thresholds, visual acuity or cognition, cross-sectionally or over 3 years of follow up in the Canadian Longitudinal Study on Aging
CONCLUSION: APOE-ε4 allele count does not appear to be a common cause of sensory-cognitive associations in this large cohort.PMID:38547662 | DOI:10.1016/j.neurobiolaging.2024.01.006 (Source: Neurobiology of Aging)
Source: Neurobiology of Aging - March 28, 2024 Category: Geriatrics Authors: Paul Mick Rasel Kabir Malshi Karunatilake M Kathleen Pichora-Fuller Terry-Lyn Young Yuri Sosero Ziv Gan-Or Walter Wittich Natalie A Phillips Source Type: research
Associations between multidomain modifiable dementia risk factors with AD biomarkers and cognition in middle-aged and older adults
This study aimed to determine associations between modifiable dementia risk factors (MDRF), across domains mood symptomatology, lifestyle behaviors, cardiovascular conditions, cognitive/social engagement, sleep disorders/symptomatology, with cognition, beta-amyloid (Aβ) and tau, and brain volume. Middle-aged/older adults (n=82) enrolled in a sub-study of the Healthy Brain Project completed self-report questionnaires and a neuropsychological battery. Cerebrospinal fluid levels of Aβ 1-42, total tau (t-tau), and phosphorylated tau (p-tau181) (Roche Elecsys), and MRI markers of hippocampal volume and total brain volume were...
Source: Neurobiology of Aging - March 27, 2024 Category: Geriatrics Authors: Lisa Bransby Nawaf Yassi Emily Rosenich Rachel Buckley Qiao-Xin Li Paul Maruff Matthew Pase Yen Ying Lim Source Type: research
