Low-moderate dose whole-brain γ-ray irradiation modulates the expressions of glial fibrillary acidic protein and intercellular adhesion molecule-1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mouse model
Neurobiol Aging. 2023 Jun 29;132:175-184. doi: 10.1016/j.neurobiolaging.2023.06.015. Online ahead of print.ABSTRACTThe anti-inflammatory efficacy of radiation therapy (RT) with single fractions below 1.0 Gy has been demonstrated in Alzheimer's disease mouse models. As neuroinflammation is also a major pathological feature of Parkinson's disease (PD), RT may also be effective in PD treatment. Therefore, this study aimed to investigate the anti-inflammatory effect of low-moderate dose RT (LMDRT, 0.6 Gy/single dose, for 5 days) exposure in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 30 mg/kg, intraperitoneally, for ...
Source: Neurobiology of Aging - October 14, 2023 Category: Geriatrics Authors: Mijeong Park Jimin Ha Yuri Lee Hoon-Seong Choi Byoung Soo Kim Youn Kyoung Jeong Source Type: research
The role of gut-brain axis in a rotenone-induced rat model of Parkinson's disease
Neurobiol Aging. 2023 Jul 13;132:185-197. doi: 10.1016/j.neurobiolaging.2023.07.005. Online ahead of print.ABSTRACTParkinson's disease (PD) is a widespread neurodegenerative condition affecting millions globally. This investigation centered on the gut-brain axis in a rotenone-induced PD rat model. Researchers monitored behavioral shifts, histological modifications, neurodegeneration, and inflammation markers throughout the rats' bodies. Results revealed that rotenone-treated rats displayed reduced exploration (p = 0.004) and motor coordination (p < 0.001), accompanied by decreased Nissl staining and increased alpha-synu...
Source: Neurobiology of Aging - October 14, 2023 Category: Geriatrics Authors: J úlio César Claudino Dos Santos Concei ção da Silva Martins Rebouças Leandro Freitas Oliveira Fabrizio Dos Santos Cardoso Tyciane de Souza Nascimento Alfaete Vieira Oliveira Micael Porto Portela Lima Geanne Matos de Andrade Gerly Anne de Castro Brit Source Type: research
Protein retention in the endoplasmic reticulum rescues A β toxicity in Drosophila
Neurobiol Aging. 2023 Sep 21;132:154-174. doi: 10.1016/j.neurobiolaging.2023.09.008. Online ahead of print.ABSTRACTAmyloid β (Aβ) accumulation is a hallmark of Alzheimer's disease. In adult Drosophila brains, human Aβ overexpression harms climbing and lifespan. It's uncertain whether Aβ is intrinsically toxic or activates downstream neurodegeneration pathways. Our study uncovers a novel protective role against Aβ toxicity: intra-endoplasmic reticulum (ER) protein accumulation with a focus on laminin and collagen subunits. Despite high Aβ, laminin B1 (LanB1) overexpression robustly counters toxicity, suggesting a pote...
Source: Neurobiology of Aging - October 14, 2023 Category: Geriatrics Authors: James H Catterson Lucy Minkley Salom é Aspe Sebastian Judd-Mole Sofia Moura Miranda C Dyson Arjunan Rajasingam Nathaniel S Woodling Magda L Atilano Mumtaz Ahmad Claire S Durrant Tara L Spires-Jones Linda Partridge Source Type: research
Low-moderate dose whole-brain γ-ray irradiation modulates the expressions of glial fibrillary acidic protein and intercellular adhesion molecule-1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mouse model
Neurobiol Aging. 2023 Jun 29;132:175-184. doi: 10.1016/j.neurobiolaging.2023.06.015. Online ahead of print.ABSTRACTThe anti-inflammatory efficacy of radiation therapy (RT) with single fractions below 1.0 Gy has been demonstrated in Alzheimer's disease mouse models. As neuroinflammation is also a major pathological feature of Parkinson's disease (PD), RT may also be effective in PD treatment. Therefore, this study aimed to investigate the anti-inflammatory effect of low-moderate dose RT (LMDRT, 0.6 Gy/single dose, for 5 days) exposure in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 30 mg/kg, intraperitoneally, for ...
Source: Neurobiology of Aging - October 14, 2023 Category: Geriatrics Authors: Mijeong Park Jimin Ha Yuri Lee Hoon-Seong Choi Byoung Soo Kim Youn Kyoung Jeong Source Type: research
The role of gut-brain axis in a rotenone-induced rat model of Parkinson's disease
Neurobiol Aging. 2023 Jul 13;132:185-197. doi: 10.1016/j.neurobiolaging.2023.07.005. Online ahead of print.ABSTRACTParkinson's disease (PD) is a widespread neurodegenerative condition affecting millions globally. This investigation centered on the gut-brain axis in a rotenone-induced PD rat model. Researchers monitored behavioral shifts, histological modifications, neurodegeneration, and inflammation markers throughout the rats' bodies. Results revealed that rotenone-treated rats displayed reduced exploration (p = 0.004) and motor coordination (p < 0.001), accompanied by decreased Nissl staining and increased alpha-synu...
Source: Neurobiology of Aging - October 14, 2023 Category: Geriatrics Authors: J úlio César Claudino Dos Santos Concei ção da Silva Martins Rebouças Leandro Freitas Oliveira Fabrizio Dos Santos Cardoso Tyciane de Souza Nascimento Alfaete Vieira Oliveira Micael Porto Portela Lima Geanne Matos de Andrade Gerly Anne de Castro Brit Source Type: research
Protein retention in the endoplasmic reticulum rescues A β toxicity in Drosophila
Neurobiol Aging. 2023 Sep 21;132:154-174. doi: 10.1016/j.neurobiolaging.2023.09.008. Online ahead of print.ABSTRACTAmyloid β (Aβ) accumulation is a hallmark of Alzheimer's disease. In adult Drosophila brains, human Aβ overexpression harms climbing and lifespan. It's uncertain whether Aβ is intrinsically toxic or activates downstream neurodegeneration pathways. Our study uncovers a novel protective role against Aβ toxicity: intra-endoplasmic reticulum (ER) protein accumulation with a focus on laminin and collagen subunits. Despite high Aβ, laminin B1 (LanB1) overexpression robustly counters toxicity, suggesting a pote...
Source: Neurobiology of Aging - October 14, 2023 Category: Geriatrics Authors: James H Catterson Lucy Minkley Salom é Aspe Sebastian Judd-Mole Sofia Moura Miranda C Dyson Arjunan Rajasingam Nathaniel S Woodling Magda L Atilano Mumtaz Ahmad Claire S Durrant Tara L Spires-Jones Linda Partridge Source Type: research
Low-moderate dose whole-brain γ-ray irradiation modulates the expressions of glial fibrillary acidic protein and intercellular adhesion molecule-1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mouse model
Neurobiol Aging. 2023 Jun 29;132:175-184. doi: 10.1016/j.neurobiolaging.2023.06.015. Online ahead of print.ABSTRACTThe anti-inflammatory efficacy of radiation therapy (RT) with single fractions below 1.0 Gy has been demonstrated in Alzheimer's disease mouse models. As neuroinflammation is also a major pathological feature of Parkinson's disease (PD), RT may also be effective in PD treatment. Therefore, this study aimed to investigate the anti-inflammatory effect of low-moderate dose RT (LMDRT, 0.6 Gy/single dose, for 5 days) exposure in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 30 mg/kg, intraperitoneally, for ...
Source: Neurobiology of Aging - October 14, 2023 Category: Geriatrics Authors: Mijeong Park Jimin Ha Yuri Lee Hoon-Seong Choi Byoung Soo Kim Youn Kyoung Jeong Source Type: research
The role of gut-brain axis in a rotenone-induced rat model of Parkinson's disease
Neurobiol Aging. 2023 Jul 13;132:185-197. doi: 10.1016/j.neurobiolaging.2023.07.005. Online ahead of print.ABSTRACTParkinson's disease (PD) is a widespread neurodegenerative condition affecting millions globally. This investigation centered on the gut-brain axis in a rotenone-induced PD rat model. Researchers monitored behavioral shifts, histological modifications, neurodegeneration, and inflammation markers throughout the rats' bodies. Results revealed that rotenone-treated rats displayed reduced exploration (p = 0.004) and motor coordination (p < 0.001), accompanied by decreased Nissl staining and increased alpha-synu...
Source: Neurobiology of Aging - October 14, 2023 Category: Geriatrics Authors: J úlio César Claudino Dos Santos Concei ção da Silva Martins Rebouças Leandro Freitas Oliveira Fabrizio Dos Santos Cardoso Tyciane de Souza Nascimento Alfaete Vieira Oliveira Micael Porto Portela Lima Geanne Matos de Andrade Gerly Anne de Castro Brit Source Type: research
The (hyper)excitable brain: what can a ubiquitous TMS measure reveal about cognitive aging?
Neurobiol Aging. 2023 Sep 20:S0197-4580(23)00227-0. doi: 10.1016/j.neurobiolaging.2023.09.007. Online ahead of print.NO ABSTRACTPMID:37827912 | DOI:10.1016/j.neurobiolaging.2023.09.007 (Source: Neurobiology of Aging)
Source: Neurobiology of Aging - October 12, 2023 Category: Geriatrics Authors: Mark H Sundman Bernadette Elise Avila De Vault Allison Yu-Chin Chen Lalitha Madhavan Andrew J Fuglevand Ying-Hui Chou Source Type: research
The (hyper)excitable brain: what can a ubiquitous TMS measure reveal about cognitive aging?
Neurobiol Aging. 2023 Sep 20:S0197-4580(23)00227-0. doi: 10.1016/j.neurobiolaging.2023.09.007. Online ahead of print.NO ABSTRACTPMID:37827912 | DOI:10.1016/j.neurobiolaging.2023.09.007 (Source: Neurobiology of Aging)
Source: Neurobiology of Aging - October 12, 2023 Category: Geriatrics Authors: Mark H Sundman Bernadette Elise Avila De Vault Allison Yu-Chin Chen Lalitha Madhavan Andrew J Fuglevand Ying-Hui Chou Source Type: research
The (hyper)excitable brain: what can a ubiquitous TMS measure reveal about cognitive aging?
Neurobiol Aging. 2023 Sep 20:S0197-4580(23)00227-0. doi: 10.1016/j.neurobiolaging.2023.09.007. Online ahead of print.NO ABSTRACTPMID:37827912 | DOI:10.1016/j.neurobiolaging.2023.09.007 (Source: Neurobiology of Aging)
Source: Neurobiology of Aging - October 12, 2023 Category: Geriatrics Authors: Mark H Sundman Bernadette Elise Avila De Vault Allison Yu-Chin Chen Lalitha Madhavan Andrew J Fuglevand Ying-Hui Chou Source Type: research
Alzheimer's disease cortical morphological phenotypes are associated with TOMM40'523-APOE haplotypes
Neurobiol Aging. 2023 Sep 11;132:131-144. doi: 10.1016/j.neurobiolaging.2023.09.001. Online ahead of print.ABSTRACTBoth the APOE ε4 and TOMM40 rs10524523 ("523") genes have been associated with risk for Alzheimer's disease (AD) and neuroimaging biomarkers of AD. No studies have investigated the relationship of TOMM40'523-APOE ε4 on the structural complexity of the brain in AD individuals. We quantified brain morphology and multiple cortical attributes in individuals with mild cognitive impairment (MCI) and AD, then tested whether APOE ε4 or TOMM40 poly-T genotypes were related to AD morphological biomarkers in cognitive...
Source: Neurobiology of Aging - October 7, 2023 Category: Geriatrics Authors: Robyn A Honea Suzanne Hunt Rebecca J Lepping Eric D Vidoni Jill K Morris Amber Watts Elias Michaelis Jeffrey M Burns Russell H Swerdlow Source Type: research
Biological age and brain age in midlife: relationship to multimorbidity and mental health
Neurobiol Aging. 2023 Sep 11;132:145-153. doi: 10.1016/j.neurobiolaging.2023.09.003. Online ahead of print.ABSTRACTBiological age and brain age estimated using biological and neuroimaging measures have recently emerged as surrogate aging biomarkers shown to be predictive of diverse health outcomes. As aging underlies the development of many chronic conditions, surrogate aging biomarkers capture health at the whole person level, having the potential to improve our understanding of multimorbidity. Our study investigates whether elevated biological age and brain age are associated with an increased risk of multimorbidity usin...
Source: Neurobiology of Aging - October 7, 2023 Category: Geriatrics Authors: Fengqing Zhang Hansoo Chang Stacey M Schaefer Jiangtao Gou Source Type: research
Alzheimer's disease cortical morphological phenotypes are associated with TOMM40'523-APOE haplotypes
Neurobiol Aging. 2023 Sep 11;132:131-144. doi: 10.1016/j.neurobiolaging.2023.09.001. Online ahead of print.ABSTRACTBoth the APOE ε4 and TOMM40 rs10524523 ("523") genes have been associated with risk for Alzheimer's disease (AD) and neuroimaging biomarkers of AD. No studies have investigated the relationship of TOMM40'523-APOE ε4 on the structural complexity of the brain in AD individuals. We quantified brain morphology and multiple cortical attributes in individuals with mild cognitive impairment (MCI) and AD, then tested whether APOE ε4 or TOMM40 poly-T genotypes were related to AD morphological biomarkers in cognitive...
Source: Neurobiology of Aging - October 7, 2023 Category: Geriatrics Authors: Robyn A Honea Suzanne Hunt Rebecca J Lepping Eric D Vidoni Jill K Morris Amber Watts Elias Michaelis Jeffrey M Burns Russell H Swerdlow Source Type: research
Biological age and brain age in midlife: relationship to multimorbidity and mental health
Neurobiol Aging. 2023 Sep 11;132:145-153. doi: 10.1016/j.neurobiolaging.2023.09.003. Online ahead of print.ABSTRACTBiological age and brain age estimated using biological and neuroimaging measures have recently emerged as surrogate aging biomarkers shown to be predictive of diverse health outcomes. As aging underlies the development of many chronic conditions, surrogate aging biomarkers capture health at the whole person level, having the potential to improve our understanding of multimorbidity. Our study investigates whether elevated biological age and brain age are associated with an increased risk of multimorbidity usin...
Source: Neurobiology of Aging - October 7, 2023 Category: Geriatrics Authors: Fengqing Zhang Hansoo Chang Stacey M Schaefer Jiangtao Gou Source Type: research
