Age-related hearing loss associated with differences in the neural correlates of feature binding in visual working memory
Neurobiol Aging. 2023 Sep 28;132:233-245. doi: 10.1016/j.neurobiolaging.2023.09.016. Online ahead of print.ABSTRACTThe underlying neural mechanisms underpinning the association between age-related hearing loss (ARHL) and dementia remain unclear. A limitation has been the lack of functional neuroimaging studies in ARHL cohorts to help clarify this relationship. In the present study, we investigated the neural correlates of feature binding in visual working memory with ARHL (controls = 14, mild HL = 21, and moderate or greater HL = 23). Participants completed a visual change detection task assessing feature binding while the...
Source: Neurobiology of Aging - October 22, 2023 Category: Geriatrics Authors: David G Loughrey Catherine Jordan Agustin Ibanez Mario A Parra Brian A Lawlor Richard B Reilly Source Type: research
Effect of short-term androgen supplementation on cognitive performance in older male rhesus macaques
Neurobiol Aging. 2023 Sep 27;132:246-249. doi: 10.1016/j.neurobiolaging.2023.09.013. Online ahead of print.ABSTRACTOld male rhesus macaques often show cognitive impairment, and also have attenuated circulating levels of testosterone and dehydroepiandrosterone sulfate (DHEAS). However, it is unclear if these age-associated decreases in circulating androgen levels are casually related to mechanisms that support cognition. To test this possibility, old male rhesus macaques were given daily supplements of testosterone and DHEA for ∼7 months, using a paradigm designed to mimic the 24-hour circulating hormone patterns of young...
Source: Neurobiology of Aging - October 22, 2023 Category: Geriatrics Authors: Alison Ruth Weiss Henryk Francis Urbanski Source Type: research
Age-related hearing loss associated with differences in the neural correlates of feature binding in visual working memory
Neurobiol Aging. 2023 Sep 28;132:233-245. doi: 10.1016/j.neurobiolaging.2023.09.016. Online ahead of print.ABSTRACTThe underlying neural mechanisms underpinning the association between age-related hearing loss (ARHL) and dementia remain unclear. A limitation has been the lack of functional neuroimaging studies in ARHL cohorts to help clarify this relationship. In the present study, we investigated the neural correlates of feature binding in visual working memory with ARHL (controls = 14, mild HL = 21, and moderate or greater HL = 23). Participants completed a visual change detection task assessing feature binding while the...
Source: Neurobiology of Aging - October 22, 2023 Category: Geriatrics Authors: David G Loughrey Catherine Jordan Agustin Ibanez Mario A Parra Brian A Lawlor Richard B Reilly Source Type: research
Effect of short-term androgen supplementation on cognitive performance in older male rhesus macaques
Neurobiol Aging. 2023 Sep 27;132:246-249. doi: 10.1016/j.neurobiolaging.2023.09.013. Online ahead of print.ABSTRACTOld male rhesus macaques often show cognitive impairment, and also have attenuated circulating levels of testosterone and dehydroepiandrosterone sulfate (DHEAS). However, it is unclear if these age-associated decreases in circulating androgen levels are casually related to mechanisms that support cognition. To test this possibility, old male rhesus macaques were given daily supplements of testosterone and DHEA for ∼7 months, using a paradigm designed to mimic the 24-hour circulating hormone patterns of young...
Source: Neurobiology of Aging - October 22, 2023 Category: Geriatrics Authors: Alison Ruth Weiss Henryk Francis Urbanski Source Type: research
Age-related hearing loss associated with differences in the neural correlates of feature binding in visual working memory
Neurobiol Aging. 2023 Sep 28;132:233-245. doi: 10.1016/j.neurobiolaging.2023.09.016. Online ahead of print.ABSTRACTThe underlying neural mechanisms underpinning the association between age-related hearing loss (ARHL) and dementia remain unclear. A limitation has been the lack of functional neuroimaging studies in ARHL cohorts to help clarify this relationship. In the present study, we investigated the neural correlates of feature binding in visual working memory with ARHL (controls = 14, mild HL = 21, and moderate or greater HL = 23). Participants completed a visual change detection task assessing feature binding while the...
Source: Neurobiology of Aging - October 22, 2023 Category: Geriatrics Authors: David G Loughrey Catherine Jordan Agustin Ibanez Mario A Parra Brian A Lawlor Richard B Reilly Source Type: research
Effect of short-term androgen supplementation on cognitive performance in older male rhesus macaques
Neurobiol Aging. 2023 Sep 27;132:246-249. doi: 10.1016/j.neurobiolaging.2023.09.013. Online ahead of print.ABSTRACTOld male rhesus macaques often show cognitive impairment, and also have attenuated circulating levels of testosterone and dehydroepiandrosterone sulfate (DHEAS). However, it is unclear if these age-associated decreases in circulating androgen levels are casually related to mechanisms that support cognition. To test this possibility, old male rhesus macaques were given daily supplements of testosterone and DHEA for ∼7 months, using a paradigm designed to mimic the 24-hour circulating hormone patterns of young...
Source: Neurobiology of Aging - October 22, 2023 Category: Geriatrics Authors: Alison Ruth Weiss Henryk Francis Urbanski Source Type: research
Early treatment with an M1 and sigma-1 receptor agonist prevents cognitive decline in a transgenic rat model displaying Alzheimer-like amyloid pathology
Neurobiol Aging. 2023 Sep 26;132:220-232. doi: 10.1016/j.neurobiolaging.2023.09.010. Online ahead of print.ABSTRACTThe application of the selective allosteric M1 muscarinic and sigma-1 receptor agonist, AF710B (aka ANAVEX3-71), has shown to attenuate Alzheimer's disease-like hallmarks in McGill-R-Thy1-APP transgenic rats when administered at advanced pathological stages. It remains unknown whether preventive treatment strategies applying this compound may be equally effective. We tested whether daily oral administration of AF710B (10 µg/kg) in 7-month-old, preplaque, McGill-R-Thy1-APP rats for 7 months, followed by a 4-we...
Source: Neurobiology of Aging - October 21, 2023 Category: Geriatrics Authors: Chiara Orciani Sonia Do Carmo Morgan K Foret Helene Hall Quentin Bonomo Agustina Lavagna Chunwei Huang A Claudio Cuello Source Type: research
Degeneration of cholinergic white matter pathways and nucleus basalis of Meynert in individuals with objective subtle cognitive impairment
Neurobiol Aging. 2023 Sep 25;132:198-208. doi: 10.1016/j.neurobiolaging.2023.09.011. Online ahead of print.ABSTRACTWe evaluated alterations in the nucleus basalis of Meynert (NBM) volume and integrity of cholinergic white matter pathways in objective subtle cognitive impairment (Obj-SCI) individuals. NBM segmentation and cholinergic pathways tracking were conducted at baseline, 12-, 24-, and 48-month follow-ups in 41 Obj-SCI individuals and 61 healthy controls (HC). The baseline and 4-year rate of change in NBM volume and cholinergic pathways mean diffusivity were compared. Associations between cholinergic index changes an...
Source: Neurobiology of Aging - October 18, 2023 Category: Geriatrics Authors: Tiantian Qiu Hui Hong Qingze Zeng Xiao Luo Xiaohan Wang Xiaopei Xu Fei Xie Xiaodong Li Kaicheng Li Peiyu Huang Shouping Dai Minming Zhang Alzheimer's Disease Neuroimaging Initiative Source Type: research
Association of APOE- ε4 and GAP-43-related presynaptic loss with β-amyloid, tau, neurodegeneration, and cognitive decline
Neurobiol Aging. 2023 Sep 23;132:209-219. doi: 10.1016/j.neurobiolaging.2023.09.012. Online ahead of print.ABSTRACTApolipoprotein E-ε4 (APOE-ε4) carriers had elevated cerebrospinal fluid (CSF) presynaptic protein growth-associated protein-43 (GAP-43), but the underlying mechanism is not fully understood. We investigated how the APOE-ε4 genotype affects the baseline and longitudinal changes in CSF GAP-43 and their associations with β-amyloid positron emission tomography (Aβ PET), CSF phosphorylated tau 181 (p-Tau181), neurodegeneration, and cognitive decline. Compared to APOE-ε4 non-carriers, APOE-ε4 carriers had hig...
Source: Neurobiology of Aging - October 18, 2023 Category: Geriatrics Authors: Guoyu Lan Jing Du Xuhui Chen Qingyong Wang Alzheimer ’s Disease Neuroimaging Initiative Ying Han Tengfei Guo Source Type: research
Degeneration of cholinergic white matter pathways and nucleus basalis of Meynert in individuals with objective subtle cognitive impairment
Neurobiol Aging. 2023 Sep 25;132:198-208. doi: 10.1016/j.neurobiolaging.2023.09.011. Online ahead of print.ABSTRACTWe evaluated alterations in the nucleus basalis of Meynert (NBM) volume and integrity of cholinergic white matter pathways in objective subtle cognitive impairment (Obj-SCI) individuals. NBM segmentation and cholinergic pathways tracking were conducted at baseline, 12-, 24-, and 48-month follow-ups in 41 Obj-SCI individuals and 61 healthy controls (HC). The baseline and 4-year rate of change in NBM volume and cholinergic pathways mean diffusivity were compared. Associations between cholinergic index changes an...
Source: Neurobiology of Aging - October 18, 2023 Category: Geriatrics Authors: Tiantian Qiu Hui Hong Qingze Zeng Xiao Luo Xiaohan Wang Xiaopei Xu Fei Xie Xiaodong Li Kaicheng Li Peiyu Huang Shouping Dai Minming Zhang Alzheimer's Disease Neuroimaging Initiative Source Type: research
Association of APOE- ε4 and GAP-43-related presynaptic loss with β-amyloid, tau, neurodegeneration, and cognitive decline
Neurobiol Aging. 2023 Sep 23;132:209-219. doi: 10.1016/j.neurobiolaging.2023.09.012. Online ahead of print.ABSTRACTApolipoprotein E-ε4 (APOE-ε4) carriers had elevated cerebrospinal fluid (CSF) presynaptic protein growth-associated protein-43 (GAP-43), but the underlying mechanism is not fully understood. We investigated how the APOE-ε4 genotype affects the baseline and longitudinal changes in CSF GAP-43 and their associations with β-amyloid positron emission tomography (Aβ PET), CSF phosphorylated tau 181 (p-Tau181), neurodegeneration, and cognitive decline. Compared to APOE-ε4 non-carriers, APOE-ε4 carriers had hig...
Source: Neurobiology of Aging - October 18, 2023 Category: Geriatrics Authors: Guoyu Lan Jing Du Xuhui Chen Qingyong Wang Alzheimer ’s Disease Neuroimaging Initiative Ying Han Tengfei Guo Source Type: research
Degeneration of cholinergic white matter pathways and nucleus basalis of Meynert in individuals with objective subtle cognitive impairment
Neurobiol Aging. 2023 Sep 25;132:198-208. doi: 10.1016/j.neurobiolaging.2023.09.011. Online ahead of print.ABSTRACTWe evaluated alterations in the nucleus basalis of Meynert (NBM) volume and integrity of cholinergic white matter pathways in objective subtle cognitive impairment (Obj-SCI) individuals. NBM segmentation and cholinergic pathways tracking were conducted at baseline, 12-, 24-, and 48-month follow-ups in 41 Obj-SCI individuals and 61 healthy controls (HC). The baseline and 4-year rate of change in NBM volume and cholinergic pathways mean diffusivity were compared. Associations between cholinergic index changes an...
Source: Neurobiology of Aging - October 18, 2023 Category: Geriatrics Authors: Tiantian Qiu Hui Hong Qingze Zeng Xiao Luo Xiaohan Wang Xiaopei Xu Fei Xie Xiaodong Li Kaicheng Li Peiyu Huang Shouping Dai Minming Zhang Alzheimer's Disease Neuroimaging Initiative Source Type: research
Association of APOE- ε4 and GAP-43-related presynaptic loss with β-amyloid, tau, neurodegeneration, and cognitive decline
Neurobiol Aging. 2023 Sep 23;132:209-219. doi: 10.1016/j.neurobiolaging.2023.09.012. Online ahead of print.ABSTRACTApolipoprotein E-ε4 (APOE-ε4) carriers had elevated cerebrospinal fluid (CSF) presynaptic protein growth-associated protein-43 (GAP-43), but the underlying mechanism is not fully understood. We investigated how the APOE-ε4 genotype affects the baseline and longitudinal changes in CSF GAP-43 and their associations with β-amyloid positron emission tomography (Aβ PET), CSF phosphorylated tau 181 (p-Tau181), neurodegeneration, and cognitive decline. Compared to APOE-ε4 non-carriers, APOE-ε4 carriers had hig...
Source: Neurobiology of Aging - October 18, 2023 Category: Geriatrics Authors: Guoyu Lan Jing Du Xuhui Chen Qingyong Wang Alzheimer ’s Disease Neuroimaging Initiative Ying Han Tengfei Guo Source Type: research
Protein retention in the endoplasmic reticulum rescues A β toxicity in Drosophila
Neurobiol Aging. 2023 Sep 21;132:154-174. doi: 10.1016/j.neurobiolaging.2023.09.008. Online ahead of print.ABSTRACTAmyloid β (Aβ) accumulation is a hallmark of Alzheimer's disease. In adult Drosophila brains, human Aβ overexpression harms climbing and lifespan. It's uncertain whether Aβ is intrinsically toxic or activates downstream neurodegeneration pathways. Our study uncovers a novel protective role against Aβ toxicity: intra-endoplasmic reticulum (ER) protein accumulation with a focus on laminin and collagen subunits. Despite high Aβ, laminin B1 (LanB1) overexpression robustly counters toxicity, suggesting a pote...
Source: Neurobiology of Aging - October 14, 2023 Category: Geriatrics Authors: James H Catterson Lucy Minkley Salom é Aspe Sebastian Judd-Mole Sofia Moura Miranda C Dyson Arjunan Rajasingam Nathaniel S Woodling Magda L Atilano Mumtaz Ahmad Claire S Durrant Tara L Spires-Jones Linda Partridge Source Type: research
Low-moderate dose whole-brain γ-ray irradiation modulates the expressions of glial fibrillary acidic protein and intercellular adhesion molecule-1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mouse model
Neurobiol Aging. 2023 Jun 29;132:175-184. doi: 10.1016/j.neurobiolaging.2023.06.015. Online ahead of print.ABSTRACTThe anti-inflammatory efficacy of radiation therapy (RT) with single fractions below 1.0 Gy has been demonstrated in Alzheimer's disease mouse models. As neuroinflammation is also a major pathological feature of Parkinson's disease (PD), RT may also be effective in PD treatment. Therefore, this study aimed to investigate the anti-inflammatory effect of low-moderate dose RT (LMDRT, 0.6 Gy/single dose, for 5 days) exposure in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 30 mg/kg, intraperitoneally, for ...
Source: Neurobiology of Aging - October 14, 2023 Category: Geriatrics Authors: Mijeong Park Jimin Ha Yuri Lee Hoon-Seong Choi Byoung Soo Kim Youn Kyoung Jeong Source Type: research
