Alzheimer's disease cortical morphological phenotypes are associated with TOMM40'523-APOE haplotypes
Neurobiol Aging. 2023 Sep 11;132:131-144. doi: 10.1016/j.neurobiolaging.2023.09.001. Online ahead of print.ABSTRACTBoth the APOE ε4 and TOMM40 rs10524523 ("523") genes have been associated with risk for Alzheimer's disease (AD) and neuroimaging biomarkers of AD. No studies have investigated the relationship of TOMM40'523-APOE ε4 on the structural complexity of the brain in AD individuals. We quantified brain morphology and multiple cortical attributes in individuals with mild cognitive impairment (MCI) and AD, then tested whether APOE ε4 or TOMM40 poly-T genotypes were related to AD morphological biomarkers in cognitive...
Source: Neurobiology of Aging - October 7, 2023 Category: Geriatrics Authors: Robyn A Honea Suzanne Hunt Rebecca J Lepping Eric D Vidoni Jill K Morris Amber Watts Elias Michaelis Jeffrey M Burns Russell H Swerdlow Source Type: research
Biological age and brain age in midlife: relationship to multimorbidity and mental health
Neurobiol Aging. 2023 Sep 11;132:145-153. doi: 10.1016/j.neurobiolaging.2023.09.003. Online ahead of print.ABSTRACTBiological age and brain age estimated using biological and neuroimaging measures have recently emerged as surrogate aging biomarkers shown to be predictive of diverse health outcomes. As aging underlies the development of many chronic conditions, surrogate aging biomarkers capture health at the whole person level, having the potential to improve our understanding of multimorbidity. Our study investigates whether elevated biological age and brain age are associated with an increased risk of multimorbidity usin...
Source: Neurobiology of Aging - October 7, 2023 Category: Geriatrics Authors: Fengqing Zhang Hansoo Chang Stacey M Schaefer Jiangtao Gou Source Type: research
Alzheimer's disease cortical morphological phenotypes are associated with TOMM40'523-APOE haplotypes
Neurobiol Aging. 2023 Sep 11;132:131-144. doi: 10.1016/j.neurobiolaging.2023.09.001. Online ahead of print.ABSTRACTBoth the APOE ε4 and TOMM40 rs10524523 ("523") genes have been associated with risk for Alzheimer's disease (AD) and neuroimaging biomarkers of AD. No studies have investigated the relationship of TOMM40'523-APOE ε4 on the structural complexity of the brain in AD individuals. We quantified brain morphology and multiple cortical attributes in individuals with mild cognitive impairment (MCI) and AD, then tested whether APOE ε4 or TOMM40 poly-T genotypes were related to AD morphological biomarkers in cognitive...
Source: Neurobiology of Aging - October 7, 2023 Category: Geriatrics Authors: Robyn A Honea Suzanne Hunt Rebecca J Lepping Eric D Vidoni Jill K Morris Amber Watts Elias Michaelis Jeffrey M Burns Russell H Swerdlow Source Type: research
Biological age and brain age in midlife: relationship to multimorbidity and mental health
Neurobiol Aging. 2023 Sep 11;132:145-153. doi: 10.1016/j.neurobiolaging.2023.09.003. Online ahead of print.ABSTRACTBiological age and brain age estimated using biological and neuroimaging measures have recently emerged as surrogate aging biomarkers shown to be predictive of diverse health outcomes. As aging underlies the development of many chronic conditions, surrogate aging biomarkers capture health at the whole person level, having the potential to improve our understanding of multimorbidity. Our study investigates whether elevated biological age and brain age are associated with an increased risk of multimorbidity usin...
Source: Neurobiology of Aging - October 7, 2023 Category: Geriatrics Authors: Fengqing Zhang Hansoo Chang Stacey M Schaefer Jiangtao Gou Source Type: research
Alzheimer's disease cortical morphological phenotypes are associated with TOMM40'523-APOE haplotypes
Neurobiol Aging. 2023 Sep 11;132:131-144. doi: 10.1016/j.neurobiolaging.2023.09.001. Online ahead of print.ABSTRACTBoth the APOE ε4 and TOMM40 rs10524523 ("523") genes have been associated with risk for Alzheimer's disease (AD) and neuroimaging biomarkers of AD. No studies have investigated the relationship of TOMM40'523-APOE ε4 on the structural complexity of the brain in AD individuals. We quantified brain morphology and multiple cortical attributes in individuals with mild cognitive impairment (MCI) and AD, then tested whether APOE ε4 or TOMM40 poly-T genotypes were related to AD morphological biomarkers in cognitive...
Source: Neurobiology of Aging - October 7, 2023 Category: Geriatrics Authors: Robyn A Honea Suzanne Hunt Rebecca J Lepping Eric D Vidoni Jill K Morris Amber Watts Elias Michaelis Jeffrey M Burns Russell H Swerdlow Source Type: research
Biological age and brain age in midlife: relationship to multimorbidity and mental health
Neurobiol Aging. 2023 Sep 11;132:145-153. doi: 10.1016/j.neurobiolaging.2023.09.003. Online ahead of print.ABSTRACTBiological age and brain age estimated using biological and neuroimaging measures have recently emerged as surrogate aging biomarkers shown to be predictive of diverse health outcomes. As aging underlies the development of many chronic conditions, surrogate aging biomarkers capture health at the whole person level, having the potential to improve our understanding of multimorbidity. Our study investigates whether elevated biological age and brain age are associated with an increased risk of multimorbidity usin...
Source: Neurobiology of Aging - October 7, 2023 Category: Geriatrics Authors: Fengqing Zhang Hansoo Chang Stacey M Schaefer Jiangtao Gou Source Type: research
Longitudinal trajectories of basal forebrain volume in normal aging and Alzheimer's disease
This study investigated the nature and magnitude of volume loss in the BF, over an extended period, in 516 older adults who completed Aβ-PET and serial magnetic resonance imaging scans. Individuals were grouped at baseline according to the presence of cognitive impairment (CU, CI) and Aβ status (Aβ-, Aβ+). Longitudinal volumetric changes in the BF and hippocampus were assessed across groups. The results indicated that high Aβ levels correlated with faster volume loss in the BF and hippocampus, and the effect of Aβ varied within BF subregions. Compared to CU Aβ+ individuals, Aβ-related loss among CI Aβ+ adults was ...
Source: Neurobiology of Aging - October 6, 2023 Category: Geriatrics Authors: Ying Xia Paul Maruff Vincent Dor é Pierrick Bourgeat Simon M Laws Christopher Fowler Stephanie R Rainey-Smith Ralph N Martins Victor L Villemagne Christopher C Rowe Colin L Masters Elizabeth J Coulson Jurgen Fripp Source Type: research
Longitudinal trajectories of basal forebrain volume in normal aging and Alzheimer's disease
This study investigated the nature and magnitude of volume loss in the BF, over an extended period, in 516 older adults who completed Aβ-PET and serial magnetic resonance imaging scans. Individuals were grouped at baseline according to the presence of cognitive impairment (CU, CI) and Aβ status (Aβ-, Aβ+). Longitudinal volumetric changes in the BF and hippocampus were assessed across groups. The results indicated that high Aβ levels correlated with faster volume loss in the BF and hippocampus, and the effect of Aβ varied within BF subregions. Compared to CU Aβ+ individuals, Aβ-related loss among CI Aβ+ adults was ...
Source: Neurobiology of Aging - October 6, 2023 Category: Geriatrics Authors: Ying Xia Paul Maruff Vincent Dor é Pierrick Bourgeat Simon M Laws Christopher Fowler Stephanie R Rainey-Smith Ralph N Martins Victor L Villemagne Christopher C Rowe Colin L Masters Elizabeth J Coulson Jurgen Fripp Source Type: research
Integrated multi-omics analysis of brain aging in female nonhuman primates reveals altered signaling pathways relevant to age-related disorders
Neurobiol Aging. 2023 Aug 29;132:109-119. doi: 10.1016/j.neurobiolaging.2023.08.009. Online ahead of print.ABSTRACTThe prefrontal cortex (PFC) has been implicated as a key brain region responsible for age-related cognitive decline. Little is known about aging-related molecular changes in PFC that may mediate these effects. To date, no studies have used untargeted discovery methods with integrated analyses to determine PFC molecular changes in healthy female primates. We quantified PFC changes associated with healthy aging in female baboons by integrating multiple omics data types (transcriptomics, proteomics, metabolomics)...
Source: Neurobiology of Aging - October 5, 2023 Category: Geriatrics Authors: Laura A Cox Sobha Puppala Jeannie Chan Kip D Zimmerman Zeeshan Hamid Isaac Ampong Hillary F Huber Ge Li Avinash Y L Jadhav Benlian Wang Cun Li Mark G Baxter Carol Shively Geoffrey D Clarke Thomas C Register Peter W Nathanielsz Michael Olivier Source Type: research
Integrated multi-omics analysis of brain aging in female nonhuman primates reveals altered signaling pathways relevant to age-related disorders
Neurobiol Aging. 2023 Aug 29;132:109-119. doi: 10.1016/j.neurobiolaging.2023.08.009. Online ahead of print.ABSTRACTThe prefrontal cortex (PFC) has been implicated as a key brain region responsible for age-related cognitive decline. Little is known about aging-related molecular changes in PFC that may mediate these effects. To date, no studies have used untargeted discovery methods with integrated analyses to determine PFC molecular changes in healthy female primates. We quantified PFC changes associated with healthy aging in female baboons by integrating multiple omics data types (transcriptomics, proteomics, metabolomics)...
Source: Neurobiology of Aging - October 5, 2023 Category: Geriatrics Authors: Laura A Cox Sobha Puppala Jeannie Chan Kip D Zimmerman Zeeshan Hamid Isaac Ampong Hillary F Huber Ge Li Avinash Y L Jadhav Benlian Wang Cun Li Mark G Baxter Carol Shively Geoffrey D Clarke Thomas C Register Peter W Nathanielsz Michael Olivier Source Type: research
Association of white matter hyperintensity accumulation with domain-specific cognitive decline: a population-based cohort study
Neurobiol Aging. 2023 Sep 4;132:100-108. doi: 10.1016/j.neurobiolaging.2023.08.011. Online ahead of print.ABSTRACTWe investigated the association of load and accumulation of white matter hyperintensities (WMHs) with rate of cognitive decline. This population-based study included 510 dementia-free people (age ≥60 years) who had repeated measures of global and regional (lobar, deep, periventricular) WMHs up to 6 years (from 2001-2003 to 2007-2010) and repeated measures of cognitive function (episodic memory, semantic memory, category fluency, letter fluency, executive function, perceptual speed) up to 15 years (from 2001-2...
Source: Neurobiology of Aging - September 30, 2023 Category: Geriatrics Authors: Yuanjing Li Gr égoria Kalpouzos Lars B äckman Chengxuan Qiu Erika J Laukka Source Type: research
Association of white matter hyperintensity accumulation with domain-specific cognitive decline: a population-based cohort study
Neurobiol Aging. 2023 Sep 4;132:100-108. doi: 10.1016/j.neurobiolaging.2023.08.011. Online ahead of print.ABSTRACTWe investigated the association of load and accumulation of white matter hyperintensities (WMHs) with rate of cognitive decline. This population-based study included 510 dementia-free people (age ≥60 years) who had repeated measures of global and regional (lobar, deep, periventricular) WMHs up to 6 years (from 2001-2003 to 2007-2010) and repeated measures of cognitive function (episodic memory, semantic memory, category fluency, letter fluency, executive function, perceptual speed) up to 15 years (from 2001-2...
Source: Neurobiology of Aging - September 30, 2023 Category: Geriatrics Authors: Yuanjing Li Gr égoria Kalpouzos Lars B äckman Chengxuan Qiu Erika J Laukka Source Type: research
Association of white matter hyperintensity accumulation with domain-specific cognitive decline: a population-based cohort study
Neurobiol Aging. 2023 Sep 4;132:100-108. doi: 10.1016/j.neurobiolaging.2023.08.011. Online ahead of print.ABSTRACTWe investigated the association of load and accumulation of white matter hyperintensities (WMHs) with rate of cognitive decline. This population-based study included 510 dementia-free people (age ≥60 years) who had repeated measures of global and regional (lobar, deep, periventricular) WMHs up to 6 years (from 2001-2003 to 2007-2010) and repeated measures of cognitive function (episodic memory, semantic memory, category fluency, letter fluency, executive function, perceptual speed) up to 15 years (from 2001-2...
Source: Neurobiology of Aging - September 30, 2023 Category: Geriatrics Authors: Yuanjing Li Gr égoria Kalpouzos Lars B äckman Chengxuan Qiu Erika J Laukka Source Type: research
Association of white matter hyperintensity accumulation with domain-specific cognitive decline: a population-based cohort study
Neurobiol Aging. 2023 Sep 4;132:100-108. doi: 10.1016/j.neurobiolaging.2023.08.011. Online ahead of print.ABSTRACTWe investigated the association of load and accumulation of white matter hyperintensities (WMHs) with rate of cognitive decline. This population-based study included 510 dementia-free people (age ≥60 years) who had repeated measures of global and regional (lobar, deep, periventricular) WMHs up to 6 years (from 2001-2003 to 2007-2010) and repeated measures of cognitive function (episodic memory, semantic memory, category fluency, letter fluency, executive function, perceptual speed) up to 15 years (from 2001-2...
Source: Neurobiology of Aging - September 30, 2023 Category: Geriatrics Authors: Yuanjing Li Gr égoria Kalpouzos Lars B äckman Chengxuan Qiu Erika J Laukka Source Type: research
Daily biofeedback to modulate heart rate oscillations affects structural volume in hippocampal subregions targeted by the locus coeruleus in older adults but not younger adults
Neurobiol Aging. 2023 Sep 1;132:85-99. doi: 10.1016/j.neurobiolaging.2023.08.010. Online ahead of print.ABSTRACTUsing data from a clinical trial, we tested the hypothesis that daily sessions modulating heart rate oscillations affect older adults' volume of a region-of-interest (ROI) comprised of adjacent hippocampal subregions with relatively strong locus coeruleus (LC) noradrenergic input. Younger and older adults were randomly assigned to one of two daily biofeedback practices for 5 weeks: (1) engage in slow-paced breathing to increase the amplitude of oscillations in heart rate at their breathing frequency (Osc+); (2) e...
Source: Neurobiology of Aging - September 28, 2023 Category: Geriatrics Authors: Hyun Joo Yoo Kaoru Nashiro Shubir Dutt Jungwon Min Christine Cho Julian F Thayer Paul Lehrer Catie Chang Mara Mather Source Type: research
