In vivo functional analysis of Drosophila Robo1 immunoglobulin-like domains
In animals with bilateral symmetry, midline crossing of axons in the developing central nervous system is regulated by Slit ligands and their neuronal Roundabout (Robo) receptors. Multiple structural domains a... (Source: Neural Development)
Source: Neural Development - August 18, 2016 Category: Neurology Authors: Marie C. Reichert, Haley E. Brown and Timothy A. Evans Source Type: research
Fragile X mental retardation protein knockdown in the developing Xenopus tadpole optic tectum results in enhanced feedforward inhibition and behavioral deficits
Fragile X Syndrome is the leading monogenetic cause of autism and most common form of intellectual disability. Previous studies have implicated changes in dendritic spine architecture as the primary result of ... (Source: Neural Development)
Source: Neural Development - August 8, 2016 Category: Neurology Authors: Torrey L. S. Truszkowski, Eric J. James, Mashfiq Hasan, Tyler J. Wishard, Zhenyu Liu, Kara G. Pratt, Hollis T. Cline and Carlos D. Aizenman Source Type: research
Dual leucine zipper kinase regulates expression of axon guidance genes in mouse neuronal cells
Recent genetic studies in model organisms, such as Drosophila, C. elegans and mice, have highlighted a critical role for dual leucine zipper kinase (DLK) in neural development and axonal responses to injury. Howe... (Source: Neural Development)
Source: Neural Development - July 28, 2016 Category: Neurology Authors: Andr éanne Blondeau, Jean-François Lucier, Dominick Matteau, Lauralyne Dumont, Sébastien Rodrigue, Pierre-Étienne Jacques and Richard Blouin Source Type: research
Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei
Neurons in the hypothalamus function to regulate the state of the animal during both learned and innate behaviors, and alterations in hypothalamic development may contribute to pathological conditions such as ... (Source: Neural Development)
Source: Neural Development - May 21, 2016 Category: Neurology Authors: Katie Sokolowski, Tuyen Tran, Shigeyuki Esumi, Yasmin Kamal, Livio Oboti, Julieta Lischinsky, Meredith Goodrich, Andrew Lam, Margaret Carter, Yasushi Nakagawa and Joshua G. Corbin Source Type: research
The role of heparan sulfate deficiency in autistic phenotype: potential involvement of Slit/Robo/srGAPs-mediated dendritic spine formation
Autism Spectrum Disorders (ASD) are the second most common developmental cause of disability in the United States. ASDs are accompanied with substantial economic and emotional cost. The brains of ASD patients ... (Source: Neural Development)
Source: Neural Development - April 18, 2016 Category: Neurology Authors: Christine Pérez, Darrell Sawmiller and Jun Tan Source Type: research
Characterization of primary cilia during the differentiation of retinal ganglion cells in the zebrafish
Retinal ganglion cell (RGC) differentiation in vivo is a highly stereotyped process, likely resulting from the interaction of cell type-specific transcription factors and tissue-derived signaling factors. The ... (Source: Neural Development)
Source: Neural Development - April 6, 2016 Category: Neurology Authors: Paola Lepanto, Camila Davison, Gabriela Casanova, Jose L. Badano and Flavio R. Zolessi Source Type: research
Expression and functional analysis of the Wnt/beta-catenin induced mir-135a-2 locus in embryonic forebrain development
Brain size and patterning are dependent on dosage-sensitive morphogen signaling pathways – yet how these pathways are calibrated remains enigmatic. Recent studies point to a new role for microRNAs in tempering... (Source: Neural Development)
Source: Neural Development - April 5, 2016 Category: Neurology Authors: Giuliana Caronia-Brown, Angela Anderegg and Rajeshwar Awatramani Source Type: research
The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration
During development, a coordinated and integrated series of events must be accomplished in order to generate functional neural circuits. Axons must navigate toward target cells, build synaptic connections, and ... (Source: Neural Development)
Source: Neural Development - March 23, 2016 Category: Neurology Authors: Brock Grill, Rodney K. Murphey and Melissa A. Borgen Source Type: research
Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons
The development of neural circuits within the embryonic cerebral cortex relies on the timely production of neurons, their positioning within the embryonic cerebral cortex as well as their terminal differentiat... (Source: Neural Development)
Source: Neural Development - March 11, 2016 Category: Neurology Authors: Ivan Gladwyn-Ng, Lieven Huang, Linh Ngo, Shan Shan Li, Zhengdong Qu, Hannah Kate Vanyai, Hayley Daniella Cullen, John Michael Davis and Julian Ik-Tsen Heng Source Type: research
Reviewer acknowledgement
The editors of Neural Development would like to thank all the reviewers who have contributed to the journal in Volume 10 (2015). (Source: Neural Development)
Source: Neural Development - March 8, 2016 Category: Neurology Authors: Chris Q. Doe, William Harris, Kang Shen and Rachel Wong Source Type: research
Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2-independent mechanism
For neurons to function correctly in neuronal circuitry they must utilize appropriate neurotransmitters. However, even though neurotransmitter specificity is one of the most important and defining properties o... (Source: Neural Development)
Source: Neural Development - February 19, 2016 Category: Neurology Authors: José L. Juárez-Morales, Claus J. Schulte, Sofia A. Pezoa, Grace K. Vallejo, William C. Hilinski, Samantha J. England, Sarah de Jager and Katharine E. Lewis Source Type: research
Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation
Nerve growth factor (NGF) is the prototypical target-derived neurotrophic factor required for sympathetic neuron survival and for the growth and ramification of sympathetic axons within most but not all sympat... (Source: Neural Development)
Source: Neural Development - February 15, 2016 Category: Neurology Authors: Gerard W. O’Keeffe, Humberto Gutierrez, Laura Howard, Christopher W. Laurie, Catarina Osorio, Núria Gavaldà, Sean L. Wyatt and Alun M. Davies Source Type: research
Identification of molecular signatures specific for distinct cranial sensory ganglia in the developing chick
The cranial sensory ganglia represent populations of neurons with distinct functions, or sensory modalities. The production of individual ganglia from distinct neurogenic placodes with different developmental ... (Source: Neural Development)
Source: Neural Development - January 27, 2016 Category: Neurology Authors: Cedric Patthey, Harry Clifford, Wilfried Haerty, Chris P. Ponting, Sebastian M. Shimeld and Jo Begbie Source Type: research
Charcot-Marie-Tooth 2b associated Rab7 mutations cause axon growth and guidance defects during vertebrate sensory neuron development
Charcot-Marie-Tooth2b (CMT2b) is an axonal form of a human neurodegenerative disease that preferentially affects sensory neurons. CMT2b is dominantly inherited and is characterized by unusually early onset, pr... (Source: Neural Development)
Source: Neural Development - January 20, 2016 Category: Neurology Authors: Olga Y. Ponomareva, Kevin W. Eliceiri and Mary C. Halloran Source Type: research
Microtubule-associated protein 1b is required for shaping the neural tube
Shaping of the neural tube, the precursor of the brain and spinal cord, involves narrowing and elongation of the neural tissue, concomitantly with other morphogenetic changes that contribue to this process. In... (Source: Neural Development)
Source: Neural Development - January 18, 2016 Category: Neurology Authors: Pradeepa Jayachandran, Valerie N. Olmo, Stephanie P. Sanchez, Rebecca J. McFarland, Eudorah Vital, Jonathan M. Werner, Elim Hong, Neus Sanchez-Alberola, Aleksey Molodstov and Rachel M. Brewster Source Type: research
