The role of astrocyte ‐mediated plasticity in neural circuit development and function
Neuronal networks are capable of undergoing rapid structural and functional changes called plasticity, which are essential for shaping circuit function during nervous system development. These changes range fr... (Source: Neural Development)
Source: Neural Development - January 7, 2021 Category: Neurology Authors: Nelson A. Perez-Catalan, Chris Q. Doe and Sarah D. Ackerman Tags: Review Source Type: research
Precise levels of nectin-3 are required for proper synapse formation in postnatal visual cortex
Developing cortical neurons express a tightly choreographed sequence of cytoskeletal and transmembrane proteins to form and strengthen specific synaptic connections during circuit formation. Nectin-3 is a cell... (Source: Neural Development)
Source: Neural Development - November 7, 2020 Category: Neurology Authors: Johanna Tomorsky, Philip R. L. Parker, Chris Q. Doe and Cristopher M. Niell Tags: Research article Source Type: research
Individual neuronal subtypes control initial myelin sheath growth and stabilization
In the developing central nervous system, pre-myelinating oligodendrocytes sample candidate nerve axons by extending and retracting process extensions. Some contacts stabilize, leading to the initiation of axo... (Source: Neural Development)
Source: Neural Development - September 28, 2020 Category: Neurology Authors: Heather N. Nelson, Anthony J. Treichel, Erin N. Eggum, Madeline R. Martell, Amanda J. Kaiser, Allie G. Trudel, James R. Gronseth, Samantha T. Maas, Silas Bergen and Jacob H. Hines Tags: Research article Source Type: research
The SLC36 transporter Pathetic is required for neural stem cell proliferation and for brain growth under nutrition restriction
Drosophila neuroblasts (NBs) are neural stem cells whose maintenance relies on Notch activity. NBs proliferate throughout larval stages to generate a large number of adult neurons. Their proliferation is protecte... (Source: Neural Development)
Source: Neural Development - August 2, 2020 Category: Neurology Authors: Shiyun Feng, Evanthia Zacharioudaki, Kat Millen and Sarah J. Bray Tags: Research article Source Type: research
Synapse development and maturation at the drosophila neuromuscular junction
Synapses are the sites of neuron-to-neuron communication and form the basis of the neural circuits that underlie all animal cognition and behavior. Chemical synapses are specialized asymmetric junctions betwee... (Source: Neural Development)
Source: Neural Development - August 2, 2020 Category: Neurology Authors: Vivian T. Chou, Seth A. Johnson and David Van Vactor Tags: Review Source Type: research
A novel temporal identity window generates alternating Eve+/Nkx6+ motor neuron subtypes in a single progenitor lineage
Spatial patterning specifies neural progenitor identity, with further diversity generated by temporal patterning within individual progenitor lineages. In vertebrates, these mechanisms generate “cardinal class... (Source: Neural Development)
Source: Neural Development - July 28, 2020 Category: Neurology Authors: Austin Seroka, Rita M. Yazejian, Sen-Lin Lai and Chris Q. Doe Tags: Research article Source Type: research
Association between rare variants in specific functional pathways and human neural tube defects multiple subphenotypes
Neural tube defects (NTDs) are failure of neural tube closure, which includes multiple central nervous system phenotypes. More than 300 mouse mutant strains exhibits NTDs phenotypes and give us some clues to e... (Source: Neural Development)
Source: Neural Development - July 10, 2020 Category: Neurology Authors: Jizhen Zou, Fang Wang, Xueyan Yang, Hongyan Wang, Lee Niswander, Ting Zhang and Huili Li Tags: Research article Source Type: research
The first quarter of the C-terminal domain of Abelson regulates the WAVE regulatory complex and Enabled in axon guidance
Abelson tyrosine kinase (Abl) plays a key role in axon guidance in linking guidance receptors to actin dynamics. The long C-terminal domain (CTD) of Drosophila Abl is important for this role, and previous work... (Source: Neural Development)
Source: Neural Development - May 2, 2020 Category: Neurology Authors: Han Sian Joshua Cheong, Mark Nona, Samantha Barbara Guerra and Mark Francis VanBerkum Tags: Research article Source Type: research
Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease
Huwe1 is a highly conserved member of the HECT E3 ubiquitin ligase family. Here, we explore the growing importance of Huwe1 in nervous system development, function and disease. We discuss extensive progress ma... (Source: Neural Development)
Source: Neural Development - April 26, 2020 Category: Neurology Authors: Andrew C. Giles and Brock Grill Tags: Review Source Type: research
Cis-regulatory analysis of Onecut1 expression in fate-restricted retinal progenitor cells
The vertebrate retina consists of six major classes of neuronal cells. During development, these cells are generated from a pool of multipotent retinal progenitor cells (RPCs) that express the gene Vsx2. Fate-... (Source: Neural Development)
Source: Neural Development - March 19, 2020 Category: Neurology Authors: Sruti Patoori, Nathalie Jean-Charles, Ariana Gopal, Sacha Sulaiman, Sneha Gopal, Brian Wang, Benjamin Souferi and Mark M. Emerson Tags: Research article Source Type: research
Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life
Leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1) regulates stem cell quiescence. As a marker, it identifies stem cells in multiple organs of the mouse. We had detected Lrig1 expression in cultured I... (Source: Neural Development)
Source: Neural Development - March 17, 2020 Category: Neurology Authors: Hyung-song Nam and Mario R. Capecchi Tags: Research article Source Type: research
Drosophila enabled promotes synapse morphogenesis and regulates active zone form and function
Recent studies of synapse form and function highlight the importance of the actin cytoskeleton in regulating multiple aspects of morphogenesis, neurotransmission, and neural plasticity. The conserved actin-ass... (Source: Neural Development)
Source: Neural Development - March 17, 2020 Category: Neurology Authors: Elizabeth M. McNeill, Cheryl Thompson, Brett Berke, Vivian T. Chou, Jannette Rusch, April Duckworth, Jamin DeProto, Alicia Taylor, Julie Gates, Frank Gertler, Haig Keshishian and David Van Vactor Tags: Research article Source Type: research
An inducible Cre mouse line to sparsely target nervous system cells, including Remak Schwann cells
Nerves of the peripheral nervous system contain two classes of Schwann cells: myelinating Schwann cells that ensheath large caliber axons and generate the myelin sheath, and Remak Schwann cells that surround s... (Source: Neural Development)
Source: Neural Development - February 20, 2020 Category: Neurology Authors: Darshan Sapkota and Joseph D. Dougherty Tags: Short Report Source Type: research
Evaluating the effectiveness of anti-Nogo treatment in spinal cord injuries
As humans, we cannot regenerate axons within the central nervous system (CNS), therefore, making any damage to it permanent. This leads to the loss of sensory and motor function below the site of injury and ca... (Source: Neural Development)
Source: Neural Development - January 9, 2020 Category: Neurology Authors: Raihan Mohammed, Kaesi Opara, Rahul Lall, Utkarsh Ojha and Jinpo Xiang Tags: Review Source Type: research
Microglia in the developing retina
Microglia are increasingly shown to be key players in neuron development and synapse connectivity. However, the underlying mechanisms by which microglia regulate neuron function remain poorly understood in par... (Source: Neural Development)
Source: Neural Development - December 30, 2019 Category: Neurology Authors: Fenge Li, Danye Jiang and Melanie A. Samuel Tags: Review Source Type: research
