Dorsoventral patterning of the Xenopus eye involves differential temporal changes in the response of optic stalk and retinal progenitors to Hh signalling
Conclusions:
Our results suggest the existence of two competence windows during which the Hh pathway differentially controls patterning of the eye region. In the first window, between the neural plate and the optic vesicle stages, Hh signalling exerts a global influence on eye dorsoventral polarity, contributing to the specification of optic stalk, ventral retina and dorsal retinal domains. In the second window, between optic vesicle and optic cup stages, this pathway plays a more limited role in the maintenance of the optic stalk domain. We speculate that this temporal regulation is important to coordinate dorsoventral pa...
Source: Neural Development - March 20, 2015 Category: Neurology Authors: Xiumei WangGiuseppe LupoRongqiao HeGiuseppina BarsacchiWilliam HarrisYing Liu Source Type: research
Reviewer Acknowledgement
Contributing reviewersThe editors of Neural Development would like to thank all the reviewers who have contributed to the journal in Volume 9 (2014). (Source: Neural Development)
Source: Neural Development - March 15, 2015 Category: Neurology Authors: Chris DoeWilliam HarrisKang ShenRachel Wong Source Type: research
Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones
Conclusions:
Taken together, our results show that while actin and microtubules are both crucial for cue-induced axonal protein synthesis, they serve distinct roles with F-actin being required for the initiation of translation and microtubules acting later at the elongation step. (Source: Neural Development)
Source: Neural Development - February 25, 2015 Category: Neurology Authors: Michael PiperAih LeeFrancisca van HorckHeather McNeillyTrina LuWilliam HarrisChristine Holt Source Type: research
Polycomb group genes are required to maintain a binary fate choice in the Drosophila eye
Conclusions:
We conclude that cells can use PcG genes specifically to maintain a subset of their binary fate choices. (Source: Neural Development)
Source: Neural Development - January 31, 2015 Category: Neurology Authors: Jennifer FinleyAdam MillerTory Herman Source Type: research
Quantitative differences in developmental profiles of spontaneous activity in cortical and hippocampal cultures
Conclusions:
Although cultured networks of hippocampal and cortical networks both generate spontaneous activity that changes over time, at any given time we can reliably detect differences in the activity patterns. We anticipate that this quantitative framework could have applications in many areas, including neurotoxicity testing and for characterising the phenotype of different mutant mice. All code and data relating to this report are freely available for others to use. (Source: Neural Development)
Source: Neural Development - January 28, 2015 Category: Neurology Authors: Paul CharlesworthEllese CotterillAndrew MortonSeth GrantStephen Eglen Source Type: research
Establishment of the neurogenic boundary of the mouse retina requires cooperation of SOX2 and WNT signaling
Conclusion:
We propose two distinct roles for SOX2 in the developing retina. Our findings suggest that SOX2 antagonizes the WNT pathway to maintain a neurogenic fate and, in contrast, regulates cycling of optic cup progenitors in a WNT-independent manner. Given that WNT signaling acting upstream of SOX2 has been implicated in the tumorigenicity of embryonic stem cell-derived retinal progenitor cells, our results distinguish the endogenous role of WNT signaling in early optic cup patterning and support a WNT-independent role for SOX2 in maintaining retinal progenitor cell proliferation. (Source: Neural Development)
Source: Neural Development - December 9, 2014 Category: Neurology Authors: Whitney HeavnerCynthia AndoniadouLarysa Pevny Source Type: research
Leading-process actomyosin coordinates organelle positioning and adhesion receptor dynamics in radially migrating cerebellar granule neurons
Conclusions:
We propose that actomyosin coordinates the overall polarity of migrating CGNs by controlling asymmetric organelle positioning and cell-cell contacts as these cells move along their glial guides. (Source: Neural Development)
Source: Neural Development - December 2, 2014 Category: Neurology Authors: Niraj TrivediJoseph RamahiMahmut KarakayaDanielle HowellRyan KerekesDavid Solecki Source Type: research
Eye-specific retinogeniculate segregation proceeds normally following disruption of patterned spontaneous retinal activity
Conclusions:
Our data demonstrate normal eye-specific retinogeniculate development despite significant abnormalities in patterned SRA. Comparing our current results with earlier studies suggests that defects in retinal wave size, absolute levels of SRA, correlations between RGC pairs, RGC burst frequency, high frequency RGC firing during bursts, and the number of spikes per RGC burst are each uncorrelated with abnormalities in eye-specific segregation in the dLGN. An increase in the fraction of asynchronous spikes occurring outside of bursts and waves correlates with eye-specific segregation defects in studies reported to ...
Source: Neural Development - November 7, 2014 Category: Neurology Authors: Colenso SpeerChao SunLauren LietsBen StaffordBarbara ChapmanHwai-Jong Cheng Source Type: research
Neuropilins define distinct populations of neural crest cells
Conclusions:
Taken together, our results demonstrate that Nrp1 and Nrp2 are expressed in different populations of NCCs, and that Nrp2-expressing NCCs are strongly biased towards a sensory fate. In the trunk, Nrp2-expressing NCCs specifically give rise to sensory ganglia, whereas Nrp1-expressing NCCs likely give rise to both sensory and sympathetic ganglia. Our findings therefore suggest that neuropilins play an essential role in coordinating NCC migration with fate specification. (Source: Neural Development)
Source: Neural Development - November 3, 2014 Category: Neurology Authors: Rachael LumbSophie WiszniakSamuela KabbaraMichaela SchererNatasha HarveyQuenten Schwarz Source Type: research
E-proteins orchestrate the progression of neural stem cell differentiation in the postnatal forebrain
Conclusions:
In contrast to former concepts, suggesting ubiquitous expression and subsidiary function for E-proteins to foster postnatal neurogenesis, this work unveils E-proteins as being active players in the orchestration of postnatal SVZ neurogenesis. (Source: Neural Development)
Source: Neural Development - October 29, 2014 Category: Neurology Authors: Bruno FischerKasum AzimAnahí Hurtado-ChongSandra RamelliMaría FernándezOlivier Raineteau Source Type: research
Axon-Schwann cell interactions during peripheral nerve regeneration in zebrafish larvae
Conclusion:
The accessibility of the pLL nerve and the availability of transgenic lines that label this structure and their synaptic targets provides an outstanding in vivo model to study the different events associated with axonal extension, target reinnervation, and the complex cellular interactions between glial cells and injured axons during nerve regeneration. (Source: Neural Development)
Source: Neural Development - October 17, 2014 Category: Neurology Authors: Maria CeciCamila Mardones-KrsulovicMario SánchezLeonardo ValdiviaMiguel Allende Source Type: research
Dbx1b defines the dorsal habenular progenitor domain in the zebrafish epithalamus
Conclusions:
We provide clear evidence in support of dbx1b marking the progenitor populations that give rise to the dorsal habenulae. In addition, the expression of dbx1b in the dorsal diencephalon is tightly controlled by FGF signaling. (Source: Neural Development)
Source: Neural Development - September 12, 2014 Category: Neurology Authors: Benjamin DeanBegum ErdoganJoshua GamseShu-Yu Wu Source Type: research
Optix defines a neuroepithelial compartment in the optic lobe of the Drosophila brain
Conclusion:
We propose that the optic lobe is compartmentalised by expression of Optix and Vsx1. Our findings provide insight into the spatial patterning of a complex region of the brain, and suggest an evolutionarily conserved principle of visual system development. (Source: Neural Development)
Source: Neural Development - July 29, 2014 Category: Neurology Authors: Katrina GoldAndrea Brand Source Type: research
Pioneer midbrain longitudinal axons navigate using a balance of Netrin attraction and Slit repulsion
Conclusions:
These results support a mechanism in which longitudinal trajectories are positioned by a push-pull balance between opposing Netrin and Slit signals. Our evidence suggests that longitudinal axons respond directly and simultaneously to both attractants and repellents, and that the combined signals constrain axons to grow longitudinally. (Source: Neural Development)
Source: Neural Development - July 24, 2014 Category: Neurology Authors: Minkyung KimW FarmerBrielle BjorkeSamuel McMahonPierre FabreFrédéric CharronGrant Mastick Source Type: research
Nuclei-specific differences in nerve terminal distribution, morphology, and development in mouse visual thalamus
Conclusions:
Taken together, these results reveal nuclei-specific differences in nerve terminal composition, distribution, and morphology in mouse visual thalamus. These results raise intriguing questions about the different functions of these nuclei in processing light-derived information, as well as differences in the mechanisms that underlie their unique, nuclei-specific development. (Source: Neural Development)
Source: Neural Development - July 10, 2014 Category: Neurology Authors: Sarah HammerGabriela CarrilloGubbi GovindaiahAboozar MonavarfeshaniJoseph BircherJianmin SuWilliam GuidoMichael Fox Source Type: research
