Degeneration of saccular hair cells caused by MITF gene mutation
Waardenburg syndrome (WS) is the consequence of an inherited autosomal dominant mutation which causes the early degeneration of intermediate cells of cochlear stria vascularis (SV) and profound hearing loss. P... (Source: Neural Development)
Source: Neural Development - January 11, 2019 Category: Neurology Authors: Yi Du, Li-li Ren, Qing-qing Jiang, Xing-jian Liu, Fei Ji, Yue Zhang, Shuo-long Yuan, Zi-Ming Wu, Wei-Wei Guo and Shi-Ming Yang Tags: Research article Source Type: research
The absence of retinal input disrupts the development of cholinergic brainstem projections in the mouse dorsal lateral geniculate nucleus
The dorsal lateral geniculate nucleus (dLGN) of the mouse has become a model system for understanding thalamic circuit assembly. While the development of retinal projections to dLGN has been a topic of extensi... (Source: Neural Development)
Source: Neural Development - December 12, 2018 Category: Neurology Authors: Guela Sokhadze, Tania A. Seabrook and William Guido Tags: Research article Source Type: research
Identification and characterization of early photoreceptor cis-regulatory elements and their relation to Onecut1
Cone and rod photoreceptors are two of the primary cell types affected in human retinal disease. Potential strategies to combat these diseases are the use of gene therapy to rescue compromised photoreceptors o... (Source: Neural Development)
Source: Neural Development - November 22, 2018 Category: Neurology Authors: Nathalie Jean-Charles, Diego F. Buenaventura and Mark M. Emerson Tags: Research article Source Type: research
Dynamic Notch signalling regulates neural stem cell state progression in the Drosophila optic lobe
Neural stem cells generate all of the neurons and glial cells in the central nervous system, both during development and in the adult to maintain homeostasis. In the Drosophila optic lobe, neuroepithelial cells p... (Source: Neural Development)
Source: Neural Development - November 22, 2018 Category: Neurology Authors: Esteban G. Contreras, Boris Egger, Katrina S. Gold and Andrea H. Brand Tags: Research article Source Type: research
Different Fgfs have distinct roles in regulating neurogenesis after spinal cord injury in zebrafish
Despite conserved developmental processes and organization of the vertebrate central nervous system, only some vertebrates including zebrafish can efficiently regenerate neural damage including after spinal co... (Source: Neural Development)
Source: Neural Development - November 17, 2018 Category: Neurology Authors: Yona Goldshmit, Jean Kitty K. Y. Tang, Ashley L. Siegel, Phong D. Nguyen, Jan Kaslin, Peter D. Currie and Patricia R. Jusuf Tags: Research article Source Type: research
Live imaging of developing mouse retinal slices
Ex vivo, whole-mount explant culture of the rodent retina has proved to be a valuable approach for studying retinal development. In a limited number of recent studies, this method has been coupled to live fluo... (Source: Neural Development)
Source: Neural Development - September 15, 2018 Category: Neurology Authors: Anthony P. Barrasso, Shang Wang, Xuefei Tong, Audrey E. Christiansen, Irina V. Larina and Ross A. Poch é Tags: Methodology Source Type: research
DSCAM differentially modulates pre- and postsynaptic structural and functional central connectivity during visual system wiring
Proper patterning of dendritic and axonal arbors is a critical step in the formation of functional neuronal circuits. Developing circuits rely on an array of molecular cues to shape arbor morphology, but the u... (Source: Neural Development)
Source: Neural Development - September 15, 2018 Category: Neurology Authors: Rommel A. Santos, Ariel J. C. Fuertes, Ginger Short, Kevin C. Donohue, Hanjuan Shao, Julian Quintanilla, Parinaz Malakzadeh and Susana Cohen-Cory Tags: Research article Source Type: research
Genomic analysis of transcriptional networks directing progression of cell states during MGE development
Homeodomain (HD) transcription factor (TF) NKX2 –1 critical for the regional specification of the medial ganglionic eminence (MGE) as well as promoting the GABAergic and cholinergic neuron fates via the inducti... (Source: Neural Development)
Source: Neural Development - September 14, 2018 Category: Neurology Authors: Magnus Sandberg, Leila Taher, Jianxin Hu, Brian L. Black, Alex S. Nord and John L. R. Rubenstein Tags: Research article Source Type: research
Sympathetic tales: subdivisons of the autonomic nervous system and the impact of developmental studies
Remarkable progress in a range of biomedical disciplines has promoted the understanding of the cellular components of the autonomic nervous system and their differentiation during development to a critical lev... (Source: Neural Development)
Source: Neural Development - September 13, 2018 Category: Neurology Authors: Uwe Ernsberger and Hermann Rohrer Tags: Review Source Type: research
Ensheathing cells utilize dynamic tiling of neuronal somas in development and injury as early as neuronal differentiation
Glial cell ensheathment of specific components of neuronal circuits is essential for nervous system function. Although ensheathment of axonal segments of differentiated neurons has been investigated, ensheathm... (Source: Neural Development)
Source: Neural Development - August 18, 2018 Category: Neurology Authors: Evan L. Nichols, Lauren A. Green and Cody J. Smith Tags: Research article Source Type: research
Identification and characterization of mushroom body neurons that regulate fat storage in Drosophila
In an earlier study, we identified two neuronal populations, c673a and Fru-GAL4, that regulate fat storage in fruit flies. Both populations partially overlap with a structure in the insect brain known as the m... (Source: Neural Development)
Source: Neural Development - August 13, 2018 Category: Neurology Authors: Bader Al-Anzi and Kai Zinn Tags: Research article Source Type: research
Mutations in dock1 disrupt early Schwann cell development
In the peripheral nervous system (PNS), specialized glial cells called Schwann cells produce myelin, a lipid-rich insulating sheath that surrounds axons and promotes rapid action potential propagation. During ... (Source: Neural Development)
Source: Neural Development - August 8, 2018 Category: Neurology Authors: Rebecca L. Cunningham, Amy L. Herbert, Breanne L. Harty, Sarah D. Ackerman and Kelly R. Monk Tags: Research article Source Type: research
Does experience provide a permissive or instructive influence on the development of direction selectivity in visual cortex?
In principle, the development of sensory receptive fields in cortex could arise from experience-independent mechanisms that have been acquired through evolution, or through an online analysis of the sensory ex... (Source: Neural Development)
Source: Neural Development - July 12, 2018 Category: Neurology Authors: Arani Roy, Ian K. Christie, Gina M. Escobar, Jason J. Osik, Marjena Popovi ć, Neil J. Ritter, Andrea K. Stacy, Shen Wang, Jozsef Fiser, Paul Miller and Stephen D. Van Hooser Tags: Review Source Type: research
Structural aspects of plasticity in the nervous system of Drosophila
Neurons extend and retract dynamically their neurites during development to form complex morphologies and to reach out to their appropriate synaptic partners. Their capacity to undergo structural rearrangement... (Source: Neural Development)
Source: Neural Development - July 1, 2018 Category: Neurology Authors: Atsushi Sugie, Giovanni Marchetti and Gaia Tavosanis Tags: Review Source Type: research
Postnatal developmental dynamics of cell type specification genes in Brn3a/Pou4f1 Retinal Ganglion Cells
About 20 –30 distinct Retinal Ganglion Cell (RGC) types transmit visual information from the retina to the brain. The developmental mechanisms by which RGCs are specified are still largely unknown. Brn3a is a m... (Source: Neural Development)
Source: Neural Development - June 29, 2018 Category: Neurology Authors: Vladimir Vladimirovich Muzyka, Matthew Brooks and Tudor Constantin Badea Tags: Research article Source Type: research
