The model of local axon homeostasis - explaining the role and regulation of microtubule bundles in axon maintenance and pathology
Axons are the slender, cable-like, up to meter-long projections of neurons that electrically wire our brains and bodies. In spite of their challenging morphology, they usually need to be maintained for an orga... (Source: Neural Development)
Source: Neural Development - November 9, 2019 Category: Neurology Authors: Ines Hahn, Andr é Voelzmann, Yu-Ting Liew, Beatriz Costa-Gomes and Andreas Prokop Tags: Review Source Type: research
sli is required for proper morphology and migration of sensory neurons in the Drosophila PNS
Neurons and glial cells coordinate with each other in many different aspects of nervous system development. Both types of cells are receiving multiple guidance cues to guide the neurons and glial cells to thei... (Source: Neural Development)
Source: Neural Development - October 24, 2019 Category: Neurology Authors: Madison Gonsior and Afshan Ismat Tags: Short Report Source Type: research
Commissural axon guidance in the developing spinal cord: from Cajal to the present day
During neuronal development, the formation of neural circuits requires developing axons to traverse a diverse cellular and molecular environment to establish synaptic contacts with the appropriate postsynaptic... (Source: Neural Development)
Source: Neural Development - September 12, 2019 Category: Neurology Authors: J. D. Comer, S. Alvarez, S. J. Butler and J. A. Kaltschmidt Tags: Review Source Type: research
Cellular properties of intrinsically photosensitive retinal ganglion cells during postnatal development
Melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs) respond directly to light and have been shown to mediate a broad variety of visual behaviors in adult animals. ipRGCs are als... (Source: Neural Development)
Source: Neural Development - August 30, 2019 Category: Neurology Authors: Jasmine A. Lucas and Tiffany M. Schmidt Tags: Research article Source Type: research
Novel GTF2I –PDGFRB and IKZF1–TYW1 fusions in pediatric leukemia with normal karyotype
Many cases of acute lymphoblastic leukemia (ALL) carry visible acquired chromosomal changes of pathogenetic, diagnostic, and prognostic importance. Nevertheless, from one-fourth to half of newly diagnosed ALL ... (Source: Neural Development)
Source: Neural Development - May 29, 2019 Category: Neurology Authors: Ioannis Panagopoulos, Marta Brunetti, Margrethe Stoltenberg, R ønnaug A. U. Strandabø, Julie Staurseth, Kristin Andersen, Ilyá Kostolomov, Tarjei S. Hveem, Susanne Lorenz, Tove Anita Nystad, Trond Flægstad, Francesca Micci and Sverre Heim Tags: Case report Source Type: research
NRAS and KRAS polymorphisms are not associated with hepatoblastoma susceptibility in Chinese children
Hepatoblastoma is the most common hepatic malignancy in children, accounting for approximately 80% of all childhood liver tumors. KRAS and NRAS, members of the RAS gene family, are closely linked to tumorigenesis... (Source: Neural Development)
Source: Neural Development - May 9, 2019 Category: Neurology Authors: Tianyou Yang, Yang Wen, Jiahao Li, Tianbao Tan, Jiliang Yang, Jing Pan, Chao Hu, Yuxiao Yao, Jiao Zhang, Yijuan Xin, Suhong Li, Huimin Xia, Jing He and Yan Zou Tags: Research Source Type: research
Development of a high resolution melting analysis assay for rapid identification of JAK2 V617F missense mutation and its validation
Myeloproliferative neoplasms (MPN) are heterogeneous diseases that classified by the presence of Philadelphia chromosome into Philadelphia chromosome negative (Ph-neg) and positive (Ph-pos) myeloproliferative ... (Source: Neural Development)
Source: Neural Development - April 30, 2019 Category: Neurology Authors: Alireza Moradabadi, Alireza Farsinejad, Behzad Khansarinejad and Ahamd Fatemi Tags: Research Source Type: research
Venetoclax with azacitidine targets refractory MDS but spares healthy hematopoiesis at tailored dose
Patients with Myelodysplastic Syndromes (MDS) and secondary Acute Myeloid Leukemia (sAML) have a very poor prognosis after failure of hypomethylating agents (HMA). Stem cell transplantation is the only effecti... (Source: Neural Development)
Source: Neural Development - April 16, 2019 Category: Neurology Authors: Stefanie Jilg, Richard T. Hauch, Johanna Kauschinger, Lars Buschhorn, Timo O. Odinius, Veronika Dill, Catharina M üller-Thomas, Tobias Herold, Peter M. Prodinger, Burkhard Schmidt, Dirk Hempel, Florian Bassermann, Christian Peschel, Katharina S. Götze, Tags: Rapid communication Source Type: research
Multi-organ failure induced by Nivolumab in the context of allo-stem cell transplantation
Immune checkpoint inhibitors have radically changed the landscape of anti-tumor therapies in several malignancies. However the adverse events associated with immune checkpoint blockade in combination with othe... (Source: Neural Development)
Source: Neural Development - March 28, 2019 Category: Neurology Authors: Julie Charles, Diane Giovannini, Nicolas Terzi, Carole Schwebel, Nathalie Sturm, Dominique Masson, Marie-Th érèse Leccia, Jean-Yves Cahn, Olivier Manches, Claude-Eric Bulabois and Laurence Chaperot Tags: Case report Source Type: research
Timing the spinal cord development with neural progenitor cells losing their proliferative capacity: a theoretical analysis
In the developing neural tube in chicken and mammals, neural stem cells proliferate and differentiate according to a stereotyped spatiotemporal pattern. Several actors have been identified in the control of th... (Source: Neural Development)
Source: Neural Development - March 13, 2019 Category: Neurology Authors: Manon Aza ïs, Eric Agius, Stéphane Blanco, Angie Molina, Fabienne Pituello, Jean-Marc Tregan, Anaïs Vallet and Jacques Gautrais Tags: Short Report Source Type: research
Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse
Purkinje cells play a central role in establishing the cerebellar circuit. Accordingly, disrupting Purkinje cell development impairs cerebellar morphogenesis and motor function. In the Car8wdl mouse model of here... (Source: Neural Development)
Source: Neural Development - March 12, 2019 Category: Neurology Authors: Lauren N. Miterko, Joshua J. White, Tao Lin, Amanda M. Brown, Kevin J. O ’Donovan and Roy V. Sillitoe Tags: Research article Source Type: research
Zebrafish prdm12b acts independently of nkx6.1 repression to promote eng1b expression in the neural tube p1 domain
Functioning of the adult nervous system depends on the establishment of neural circuits during embryogenesis. In vertebrates, neurons that make up motor circuits form in distinct domains along the dorsoventral... (Source: Neural Development)
Source: Neural Development - February 27, 2019 Category: Neurology Authors: Ozge Yildiz, Gerald B. Downes and Charles G. Sagerstr öm Tags: Research article Source Type: research
Genetic deletion of genes in the cerebellar rhombic lip lineage can stimulate compensation through adaptive reprogramming of ventricular zone-derived progenitors
The cerebellum is a foliated posterior brain structure involved in coordination of motor movements and cognition. The cerebellum undergoes rapid growth postnataly due to Sonic Hedgehog (SHH) signaling-dependen... (Source: Neural Development)
Source: Neural Development - February 14, 2019 Category: Neurology Authors: Alexandre Wojcinski, Morgane Morabito, Andrew K. Lawton, Daniel N. Stephen and Alexandra L. Joyner Tags: Research article Source Type: research
TrkB expression and dependence divides gustatory neurons into three subpopulations
During development, gustatory (taste) neurons likely undergo numerous changes in morphology and expression prior to differentiation into maturity, but little is known this process or the factors that regulate ... (Source: Neural Development)
Source: Neural Development - January 28, 2019 Category: Neurology Authors: Jennifer Rios-Pilier and Robin F. Krimm Tags: Research article Source Type: research
An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development
Mammalian motor circuits display remarkable cellular diversity with hundreds of motor neuron (MN) subtypes innervating hundreds of different muscles. Extensive research on limb muscle-innervating MNs has begun... (Source: Neural Development)
Source: Neural Development - January 18, 2019 Category: Neurology Authors: Catarina Catela, Edgar Correa, Kailong Wen, Jihad Aburas, Laura Croci, G. Giacomo Consalez and Paschalis Kratsios Tags: Research article Source Type: research
