Olfactory sensory axons target specific protoglomeruli in the olfactory bulb of zebrafish
The axons of Olfactory Sensory Neurons (OSNs) project to reproducible target locations within the Olfactory Bulb (OB), converting odorant experience into a spatial map of neural activity. We characterized the ... (Source: Neural Development)
Source: Neural Development - October 11, 2017 Category: Neurology Authors: Xin Shao, Vanisha Lakhina, Puneet Dang, Ryan P. Cheng, Christina L. Marcaccio and Jonathan A. Raper Tags: Research Source Type: research
Cell type-specific effects of p27KIP1 loss on retinal development
Cyclin-dependent kinase (CDK) inhibitors play an important role in regulating cell cycle progression, cell cycle exit and cell differentiation. p27KIP1 (p27), one of the major CDK inhibitors in the retina, has be... (Source: Neural Development)
Source: Neural Development - September 20, 2017 Category: Neurology Authors: Mariko Ogawa, Fuminori Saitoh, Norihiro Sudou, Fumi Sato and Hiroki Fujieda Tags: Research article Source Type: research
Prdm13 forms a feedback loop with Ptf1a and is required for glycinergic amacrine cell genesis in the Xenopus Retina
Amacrine interneurons that modulate synaptic plasticity between bipolar and ganglion cells constitute the most diverse cell type in the retina. Most are inhibitory neurons using either GABA or glycine as neuro... (Source: Neural Development)
Source: Neural Development - September 1, 2017 Category: Neurology Authors: Nathalie Bessodes, Karine Parain, Odile Bronchain, Eric J. Bellefroid and Muriel Perron Tags: Research article Source Type: research
Two Drosophila model neurons can regenerate axons from the stump or from a converted dendrite, with feedback between the two sites
After axon severing, neurons recover function by reinitiating axon outgrowth. New outgrowth often originates from the remaining axon stump. However, in many mammalian neurons, new axons initiate from a dendrit... (Source: Neural Development)
Source: Neural Development - August 17, 2017 Category: Neurology Authors: Kavitha S. Rao and Melissa M. Rolls Tags: Research Source Type: research
Septal contributions to olfactory bulb interneuron diversity in the embryonic mouse telencephalon: role of the homeobox gene Gsx2
Olfactory bulb (OB) interneurons are known to represent diverse neuronal subtypes, which are thought to originate from a number of telencephalic regions including the embryonic dorsal lateral ganglionic eminen... (Source: Neural Development)
Source: Neural Development - August 16, 2017 Category: Neurology Authors: Shenyue Qin, Stephanie M. Ware, Ronald R. Waclaw and Kenneth Campbell Tags: Research article Source Type: research
Neocortical Sox9+ radial glia generate glutamatergic neurons for all layers, but lack discernible evidence of early laminar fate restriction
Glutamatergic neurons in the cerebral cortex are derived from embryonic neural stem cells known as radial glial progenitors (RGPs). Early RGPs, present at the onset of cortical neurogenesis, are classically th... (Source: Neural Development)
Source: Neural Development - August 16, 2017 Category: Neurology Authors: E. S. Kaplan, K. A. Ramos-Laguna, A. B. Mihalas, R. A. M. Daza and R. F. Hevner Tags: Short report Source Type: research
Fate bias during neural regeneration adjusts dynamically without recapitulating developmental fate progression
Regeneration of neurons in the central nervous system is poor in humans. In other vertebrates neural regeneration does occur efficiently and involves reactivation of developmental processes. Within the neural ... (Source: Neural Development)
Source: Neural Development - July 13, 2017 Category: Neurology Authors: Jeremy Ng Chi Kei, Peter David Currie and Patricia Regina Jusuf Source Type: research
The emergence of mesencephalic trigeminal neurons
The cells of the mesencephalic trigeminal nucleus (MTN) are the proprioceptive sensory neurons that innervate the jaw closing muscles. These cells differentiate close to the two key signalling centres that inf... (Source: Neural Development)
Source: Neural Development - June 21, 2017 Category: Neurology Authors: Marcela Lipovsek, Julia Ledderose, Thomas Butts, Tanguy Lafont, Clemens Kiecker, Andrea Wizenmann and Anthony Graham Source Type: research
Eph/Ephrin Signaling Controls Progenitor Identities In The Ventral Spinal Cord
In the vertebrate spinal cord, motor neurons (MN) are generated in stereotypical numbers from a pool of dedicated progenitors (pMN) whose number depends on signals that control their specification but also the... (Source: Neural Development)
Source: Neural Development - June 8, 2017 Category: Neurology Authors: Julien Laussu, Christophe Audouard, Anthony Kischel, Poincyane Assis-Nascimento, Nathalie Escalas, Daniel J. Liebl, Cathy Soula and Alice Davy Source Type: research
Astroglial-mediated remodeling of the interhemispheric midline during telencephalic development is exclusive to eutherian mammals
The corpus callosum forms the major interhemispheric connection in the human brain and is unique to eutherian (or placental) mammals. The developmental events associated with the evolutionary emergence of this... (Source: Neural Development)
Source: Neural Development - May 30, 2017 Category: Neurology Authors: Ilan Gobius, Rodrigo Su árez, Laura Morcom, Annalisa Paolino, Timothy J. Edwards, Peter Kozulin and Linda J. Richards Source Type: research
Rp58 and p27kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex
During the development of the mammalian cerebral cortex, newborn postmitotic projection neurons are born from local neural stem cells and must undergo radial migration so as to position themselves appropriatel... (Source: Neural Development)
Source: Neural Development - May 15, 2017 Category: Neurology Authors: Olivier Cl ément, Isabel Anne Hemming, Ivan Enghian Gladwyn-Ng, Zhengdong Qu, Shan Shan Li, Michael Piper and Julian Ik-Tsen Heng Source Type: research
Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia
In developing tissues, cell polarity and tissue architecture play essential roles in the regulation of proliferation and differentiation. During cerebral cortical development, adherens junctions link highly po... (Source: Neural Development)
Source: Neural Development - May 8, 2017 Category: Neurology Authors: Jennifer Rakotomamonjy, Molly Brunner, Christoph J üschke, Keling Zang, Eric J. Huang, Louis F. Reichardt and Anjen Chenn Source Type: research
Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance
Sensory processing relies on projections from the thalamus to the neocortex being established during development. Information from different sensory modalities reaching the thalamus is segregated into speciali... (Source: Neural Development)
Source: Neural Development - April 24, 2017 Category: Neurology Authors: Manuela D. Mitsogiannis, Graham E. Little and Kevin J. Mitchell Source Type: research
