The neurotrophin receptor p75 regulates gustatory axon branching and promotes innervation of the tongue during development
Conclusions:
p75 regulates gustatory neuron axon branching and tongue innervation patterns during taste system development. This function is likely accomplished independently of BDNF, NT4, and TrkB. In addition, p75 does not support the remaining neurons or taste buds in TrkB-/-mice. (Source: Neural Development)
Source: Neural Development - June 24, 2014 Category: Neurology Authors: Da FeiTao HuangRobin Krimm Source Type: research
Dynamic mechanisms of neuroligin-dependent presynaptic terminal assembly in living cortical neurons
Conclusions:
Together, our data support a model of synaptogenesis where presynaptic proteins are trapped at specific axonal sites, where they are stabilized by trans-synaptic adhesion signaling. (Source: Neural Development)
Source: Neural Development - May 29, 2014 Category: Neurology Authors: Luke BuryShasta Sabo Source Type: research
Genome-wide expression profile of the response to spinal cord injury in Xenopus laevis reveals extensive differences between regenerative and non-regenerative stages
Conclusions:
We identified differences in the timing of the transcriptional response and in the inventory of regulated transcripts and biological processes activated in response to spinal cord injury when comparing regenerative and non-regenerative stages. These genes and biological processes provide an entry point to understand why regeneration fails in mammals. Furthermore, our results introduce Xenopus laevis as a genetic model organism to study spinal cord regeneration. (Source: Neural Development)
Source: Neural Development - May 22, 2014 Category: Neurology Authors: Dasfne Lee-LiuMauricio MorenoLeonardo AlmonacidVíctor TapiaRosana MuñozJavier von MaréesMarcia GaeteFrancisco MeloJuan Larraín Source Type: research
Multiple conserved regulatory domains promote Fezf2 expression in the developing cerebral cortex
Conclusions:
These results provide insight into the regulatory logic controlling Fezf2 expression and further the understanding of how multiple non-coding regulatory domains can collaborate to control gene expression in vivo. (Source: Neural Development)
Source: Neural Development - March 12, 2014 Category: Neurology Authors: Matthew EcklerKathryn LarkinWilliam McKennaSol KatzmanChao GuoRobin RoqueAxel ViselJohn RubensteinBin Chen Source Type: research
Proper connectivity of Drosophila motion detector neurons requires Atonal function in progenitor cells
Conclusions:
Our findings reveal that a proneural gene is expressed in progenitors but is required for neurite development of their progeny neurons. This suggests that transcriptional programs initiated specifically in progenitors are necessary for subsequent neuronal morphogenesis. (Source: Neural Development)
Source: Neural Development - February 26, 2014 Category: Neurology Authors: Carlos OlivaChing-Man ChoiLaura NicolaiNatalia MoraNatalie De GeestBassem Hassan Source Type: research
Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in image-forming circuits
Conclusions:
Taken together, these data suggest that Isl2+ RGCs comprise a distinct class and support a role for Isl2 as an important component of a transcription factor code specifying functional visual circuits. Furthermore, this study describes a novel genetically-labeled mouse line that will be a valuable resource in future investigations of the molecular mechanisms of visual circuit formation. (Source: Neural Development)
Source: Neural Development - February 5, 2014 Category: Neurology Authors: Jason TriplettWei WeiCristina GonzalezNeal SweeneyAndrew HubermanMarla FellerDavid Feldheim Source Type: research
Developmental origins of diversity in cerebellar output nuclei
Conclusions:
Our results confirm the relationship between cell fate and a fine grain temporal patterning at the rhombic lip. This suggests that the lack of a cerebellar output to the dorsal thalamus of birds corresponds with a restricted expression of the LIM-homeodomain gene Lhx9 to earlier born rhombic lip cohorts when compared to mice. The evolution of cerebellar nucleus diversity in amniotes may hence reflect a heterochronic adaptation of gene expression with respect to the sequential production of rhombic lip derivatives resulting in altered axonal targeting. (Source: Neural Development)
Source: Neural Development - January 9, 2014 Category: Neurology Authors: Mary GreenRichard Wingate Source Type: research
Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development
Conclusions:
These data give essential advances into the early generation of neurons in the hypothalamus. We demonstrate that inhibition of Notch signalling during early development of the hypothalamus enhances expression of several new markers. These genes must be considered as important new targets of the Notch/proneural network. (Source: Neural Development)
Source: Neural Development - December 23, 2013 Category: Neurology Authors: Leslie RatiéMichelle WareFrédérique Barloy-HublerHélène RoméIsabelle GicquelChristèle DubourgVéronique DavidValérie Dupé Source Type: research
Interneurons in the mouse visual thalamus maintain a high degree of retinal convergence throughout postnatal development
Conclusions:
The lack of pruning onto interneurons suggests that the activity-dependent refinement of retinal connections in dLGN is cell-type specific. The high degree of retinal convergence onto interneurons may be necessary for these cells to provide both widespread and local forms of inhibition in dLGN. (Source: Neural Development)
Source: Neural Development - December 21, 2013 Category: Neurology Authors: Tania SeabrookThomas KraheGubbi GovindaiahWilliam Guido Source Type: research
Brain on the stage - Spotlight on nervous system development in zebrafish: EMBO practical course, KIT, Sept. 2013
During the EMBO course 'Imaging of Neural Development in Zebrafish', held on September 9-15th 2013, researchers from different backgrounds shared their latest results, ideas and practical expertise on zebrafish as a model to address open questions regarding nervous system development. (Source: Neural Development)
Source: Neural Development - December 19, 2013 Category: Neurology Authors: Steffen ScholppLucia PoggiMihaela ¿igman Source Type: research
Growth cone-specific functions of XMAP215 in restricting microtubule dynamics and promoting axonal outgrowth
Conclusions:
Collectively, our findings reveal unexpected functions for XMAP215 in axon outgrowth and growth cone MT dynamics. Not only does XMAP215 balance actomyosin-mediated axon retraction, but it also affects growth cone MT translocation rates and MT trajectory colinearity, all of which depend on regulated linkages to F-actin. Thus, our analysis suggests that XMAP215 functions as more than a simple MT polymerase, and that in both axon and growth cone, XMAP215 contributes to the coupling between MTs and F-actin. This indicates that the function and regulation of XMAP215 may be significantly more complicated than previo...
Source: Neural Development - December 1, 2013 Category: Neurology Authors: Laura LoweryAlina StoutAnna FarisLiya DingMichelle BairdMichael DavidsonGaudenz DanuserDavid Van Vactor Source Type: research
Acute inactivation of the serine-threonine kinase Stk25 disrupts neuronal migration
Conclusions:
Loss of Stk25 function early in development likely leads to functional compensation for its roles in neuronal development. Stk25 regulates neuronal positioning, possibly as part of the LKB1-STRAD-Stk25-GM130 pathway that was previously shown to be important for neuronal polarization. (Source: Neural Development)
Source: Neural Development - November 13, 2013 Category: Neurology Authors: Tohru MatsukiJianhua ChenBrian Howell Source Type: research
Neurosensory development and cell fate determination in the human cochlea
Conclusions:
Our study provides new insights into the fetal development of the human cochlea, contributing to our understanding of deafness and to the development of new therapeutic strategies to restore hearing. (Source: Neural Development)
Source: Neural Development - October 16, 2013 Category: Neurology Authors: Heiko LocherJohan FrijnsLiesbeth van IperenJohn de GrootMargriet HuismanSusana Chuva de Sousa Lopes Source Type: research
The ventral habenulae of zebrafish develop in prosomere 2 dependent on Tcf7l2 function
Conclusions:
We show in vivo that dorsal and ventral habenulae develop in different regions of prosomere 2. In the process of ventral habenula formation, functional tcf7l2 gene activity is required and in its absence, ventral habenular neurons do not develop. Influenced by signals from parapineal cells, dorsal habenular neurons differentiate at a time at which ventral habenular cells are still on their way towards their final destination. Thus, our finding may provide a simple explanation as to why only neuronal populations of the dorsal habenulae differ in size across brain hemispheres. (Source: Neural Development)
Source: Neural Development - September 25, 2013 Category: Neurology Authors: Carlo BerettaNicolas DrossPeter BankheadMatthias Carl Source Type: research
The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons
Conclusions:
We introduce N4BP3 as a novel molecular element for the correct branching of neurites in developing neurons and propose a central role for an N4BP3-Nedd4 complex in neurite branching and circuit formation. (Source: Neural Development)
Source: Neural Development - September 17, 2013 Category: Neurology Authors: Michael SchmeisserSusanne KühlMichael SchoenNathalie BethTobias WeisAndreas GrabruckerMichael KühlTobias Boeckers Source Type: research
