Dpr10 and Nocte are required for Drosophila motor axon pathfinding
The paths axons travel to reach their targets and the subsequent synaptic connections they form are highly stereotyped. How cell surface proteins (CSPs) mediate these processes is not completely understood. The D... (Source: Neural Development)
Source: Neural Development - October 21, 2022 Category: Neurology Authors: Meike Lobb-Rabe, Katherine DeLong, Rio J. Salazar, Ruiling Zhang, Yupu Wang and Robert A. Carrillo Tags: Research Source Type: research
mRNAs encoding neurodevelopmental regulators have equal N6-methyladenosine stoichiometry in Drosophila neuroblasts and neurons
N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in metazoans and is particularly abundant in the central nervous system. The extent to which m6A is dynamically regulated and whether m6A.... (Source: Neural Development)
Source: Neural Development - October 15, 2022 Category: Neurology Authors: Josephine D. Sami, Robert C. Spitale and Michael D. Cleary Tags: Research Source Type: research
Single cell RNA-seq analysis reveals temporally-regulated and quiescence-regulated gene expression in Drosophila larval neuroblasts
The mechanisms that generate neural diversity during development remains largely unknown. Here, we use scRNA-seq methodology to discover new features of the Drosophila larval CNS across several key developmental ... (Source: Neural Development)
Source: Neural Development - August 24, 2022 Category: Neurology Authors: Noah Dillon, Ben Cocanougher, Chhavi Sood, Xin Yuan, Andrea B Kohn, Leonid L Moroz, Sarah E Siegrist, Marta Zlatic and Chris Q. Doe Tags: Research Source Type: research
A single-cell transcriptomic atlas of complete insect nervous systems across multiple life stages
Molecular profiles of neurons influence neural development and function but bridging the gap between genes, circuits, and behavior has been very difficult. Here we used single cell RNAseq to generate a complet... (Source: Neural Development)
Source: Neural Development - August 24, 2022 Category: Neurology Authors: Marc Corrales, Benjamin T. Cocanougher, Andrea B. Kohn, Jason D. Wittenbach, Xi S. Long, Andrew Lemire, Albert Cardona, Robert H. Singer, Leonid L. Moroz and Marta Zlatic Tags: Research Source Type: research
Early development of the cochlea of the common marmoset, a non-human primate model
Fine-tuned cochlear development is essential for hearing. Owing to the difficulty in using early human fetal samples, most of our knowledge regarding cochlear development has been obtained from rodents. Howeve... (Source: Neural Development)
Source: Neural Development - May 7, 2022 Category: Neurology Authors: Makoto Hosoya, Masato Fujioka, Junko Okahara, Sho Yoshimatsu, Hideyuki Okano and Hiroyuki Ozawa Tags: Research Source Type: research
DSCAM is differentially patterned along the optic axon pathway in the developing Xenopus visual system and guides axon termination at the target
The Xenopus retinotectal circuit is organized topographically, where the dorsal –ventral axis of the retina maps respectively on to the ventral-dorsal axis of the tectum; axons from the nasal-temporal axis of the ... (Source: Neural Development)
Source: Neural Development - April 15, 2022 Category: Neurology Authors: Rommel Andrew Santos, Rodrigo Del Rio Jr, Alexander Delfin Alvarez, Gabriela Romero, Brandon Zarate Vo and Susana Cohen-Cory Tags: Research Source Type: research
Correction to: Loss of Neuropilin2a/b or Sema3fa alters olfactory sensory axon dynamics and protoglomerular targeting
(Source: Neural Development)
Source: Neural Development - March 5, 2022 Category: Neurology Authors: Ryan P. Cheng, Puneet Dang, Alemji A. Taku, Yoon Ji Moon, Vi Pham, Xiaohe Sun, Ethan Zhao and Jonathan A. Raper Tags: Correction Source Type: research
Enhancer of trithorax/polycomb, Corto, regulates timing of hunchback gene relocation and competence in Drosophila neuroblasts
Neural progenitors produce diverse cells in a stereotyped birth order, but can specify each cell type for only a limited duration. In the Drosophila embryo, neuroblasts (neural progenitors) specify multiple, dist... (Source: Neural Development)
Source: Neural Development - February 17, 2022 Category: Neurology Authors: Terry L. Hafer, Sofiya Patra, Daiki Tagami and Minoree Kohwi Tags: Research Source Type: research
A subpopulation of astrocyte progenitors defined by Sonic hedgehog signaling
The molecular signaling pathway, Sonic hedgehog (Shh), is critical for the proper development of the central nervous system. The requirement for Shh signaling in neuronal and oligodendrocyte development in the... (Source: Neural Development)
Source: Neural Development - January 14, 2022 Category: Neurology Authors: Ellen C. Gingrich, Kendra Case and A. Denise R. Garcia Tags: Research article Source Type: research
Loss of Neuropilin2a/b or Sema3fa alters olfactory sensory axon dynamics and protoglomerular targeting
Olfactory Sensory Neuron (OSN) axons project from the zebrafish olfactory epithelium to reproducible intermediate target locations in the olfactory bulb called protoglomeruli at early stages in development. Tw... (Source: Neural Development)
Source: Neural Development - January 3, 2022 Category: Neurology Authors: Ryan P. Cheng, Puneet Dang, Alemji A. Taku, Yoon Ji Moon, Vi Pham, Xiaohe Sun, Ethan Zhao and Jonathan A. Raper Tags: Research article Source Type: research
The oligodendrocyte-enriched orphan G protein-coupled receptor Gpr62 is dispensable for central nervous system myelination
Myelination is a highly regulated process in the vertebrate central nervous system (CNS) whereby oligodendrocytes wrap axons with multiple layers of insulating myelin in order to allow rapid electrical conduct... (Source: Neural Development)
Source: Neural Development - November 29, 2021 Category: Neurology Authors: Curtis M. Hay, Stacey Jackson, Stanislaw Mitew, Daniel J. Scott, Matthias Koenning, AeSoon L. Bensen, Helena Bujalka, Trevor J. Kilpatrick and Ben Emery Tags: Research article Source Type: research
Genetic interplay between transcription factor Pou4f1/Brn3a and neurotrophin receptor Ret in retinal ganglion cell type specification
While the transcriptional code governing retinal ganglion cell (RGC) type specification begins to be understood, its interplay with neurotrophic signaling is largely unexplored. In mice, the transcription fact... (Source: Neural Development)
Source: Neural Development - September 21, 2021 Category: Neurology Authors: Vladimir Vladimirovich Muzyka and Tudor Constantin Badea Tags: Research article Source Type: research
Neuronal Dystroglycan regulates postnatal development of CCK/cannabinoid receptor-1 interneurons
The development of functional neural circuits requires the precise formation of synaptic connections between diverse neuronal populations. The molecular pathways that allow GABAergic interneuron subtypes in th... (Source: Neural Development)
Source: Neural Development - August 6, 2021 Category: Neurology Authors: Daniel S. Miller and Kevin M. Wright Tags: Research article Source Type: research
A two-step actin polymerization mechanism drives dendrite branching
Dendrite morphogenesis plays an essential role in establishing the connectivity and receptive fields of neurons during the development of the nervous system. To generate the diverse morphologies of branched de... (Source: Neural Development)
Source: Neural Development - July 19, 2021 Category: Neurology Authors: Rebecca Shi, Daniel A. Kramer, Baoyu Chen and Kang Shen Tags: Research article Source Type: research
Cellular response to spinal cord injury in regenerative and non-regenerative stages in Xenopus laevis
The efficient regenerative abilities at larvae stages followed by a non-regenerative response after metamorphosis in froglets makes Xenopus an ideal model organism to understand the cellular responses leading to ... (Source: Neural Development)
Source: Neural Development - February 2, 2021 Category: Neurology Authors: Gabriela Edwards-Faret, Karina Gonz ález-Pinto, Arantxa Cebrián-Silla, Johany Peñailillo, José Manuel García-Verdugo and Juan Larraín Tags: Research article Source Type: research
