Mutation of Kinesin-6 Kif20b causes defects in cortical neuron polarization and morphogenesis
How neurons change their cytoskeleton to adopt their complex polarized morphology is still not understood. Growing evidence suggests that proteins that help build microtubule structures during cell division ar... (Source: Neural Development)
Source: Neural Development - March 31, 2017 Category: Neurology Authors: Katrina C. McNeely, Timothy D. Cupp, Jessica Neville Little, Kerstin M. Janisch, Ayushma Shrestha and Noelle D. Dwyer Source Type: research
Lacking of palladin leads to multiple cellular events changes which contribute to NTD
The actin cytoskeleton-associated protein palladin plays an important role in cell motility, morphogenesis and adhesion. In mice, Palladin deficient embryos are lethal before embryonic day (E) 15.5, and exhibi... (Source: Neural Development)
Source: Neural Development - March 24, 2017 Category: Neurology Authors: Juan Tan, Xue-Jiao Chen, Chun-Ling Shen, Hong-Xin Zhang, Ling-Yun Tang, Shun-Yuan Lu, Wen-Ting Wu, Ying Kuang, Jian Fei and Zhu-Gang Wang Source Type: research
The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development
Formation of precise neuronal connections requires proper axon guidance. Microtubules (MTs) of the growth cone provide a critical driving force during navigation of the growing ends of axons. Pioneer MTs and t... (Source: Neural Development)
Source: Neural Development - February 15, 2017 Category: Neurology Authors: Burcu Erdogan, Garrett M. Cammarata, Eric J. Lee, Benjamin C. Pratt, Andrew F. Francl, Erin L. Rutherford and Laura Anne Lowery Source Type: research
Differential timing of neurogenesis underlies dorsal-ventral topographic projection of olfactory sensory neurons
The mammalian primary olfactory system has a spatially-ordered projection in which olfactory sensory neurons (OSNs) located in the dorsomedial (DM) and ventrolateral (VL) region of the olfactory epithelium (OE... (Source: Neural Development)
Source: Neural Development - February 13, 2017 Category: Neurology Authors: Eerdunfu, Naoki Ihara, Bao Ligao, Yuji Ikegaya and Haruki Takeuchi Source Type: research
The Hunchback temporal transcription factor establishes, but is not required to maintain, early-born neuronal identity
Drosophila and mammalian neural progenitors typically generate a diverse family of neurons in a stereotyped order. Neuronal diversity can be generated by the sequential expression of t... (Source: Neural Development)
Source: Neural Development - January 31, 2017 Category: Neurology Authors: Keiko Hirono, Minoree Kohwi, Matt Q. Clark, Ellie S. Heckscher and Chris Q. Doe Source Type: research
Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain
Neurons arise in very specific regions of the neural tube, controlled by components of the Notch signalling pathway, proneural genes, and other bHLH transcription factors. How these specific neuronal areas in ... (Source: Neural Development)
Source: Neural Development - December 7, 2016 Category: Neurology Authors: Michelle Ware, Houda Hamdi-Roz é, Julien Le Friec, Véronique David and Valérie Dupé Source Type: research
Akirin2 is essential for the formation of the cerebral cortex
The proper spatial and temporal regulation of dorsal telencephalic progenitor behavior is a prerequisite for the formation of the highly-organized, six-layered cerebral cortex. Premature differentiation of cel... (Source: Neural Development)
Source: Neural Development - November 21, 2016 Category: Neurology Authors: Peter J. Bosch, Leah C. Fuller, Carolyn M. Sleeth and Joshua A. Weiner Source Type: research
Oligodendrocyte development in the embryonic tuberal hypothalamus and the influence of Ascl1
Although the vast majority of cells in our brains are glia, we are only beginning to understand programs governing their development, especially within the embryonic hypothalamus. In mice, gliogenesis is a pro... (Source: Neural Development)
Source: Neural Development - November 18, 2016 Category: Neurology Authors: Candace M. Marsters, Jessica M. Rosin, Hayley F. Thornton, Shaghayegh Aslanpour, Natasha Klenin, Grey Wilkinson, Carol Schuurmans, Quentin J. Pittman and Deborah M. Kurrasch Source Type: research
Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord
Newborn neurons often migrate before undergoing final differentiation, extending neurites, and forming synaptic connections. Therefore, neuronal migration is crucial for establishing neural circuitry during de... (Source: Neural Development)
Source: Neural Development - October 26, 2016 Category: Neurology Authors: Harald J. Junge, Andrea R. Yung, Lisa V. Goodrich and Zhe Chen Source Type: research
Contralateral migration of oculomotor neurons is regulated by Slit/Robo signaling
Oculomotor neurons develop initially like typical motor neurons, projecting axons out of the ventral midbrain to their ipsilateral targets, the extraocular muscles. However, in all vertebrates, after the oculo... (Source: Neural Development)
Source: Neural Development - October 22, 2016 Category: Neurology Authors: Brielle Bjorke, Farnaz Shoja-Taheri, Minkyung Kim, G. Eric Robinson, Tatiana Fontelonga, Kyung-Tai Kim, Mi-Ryoung Song and Grant S. Mastick Source Type: research
Differential timing of granule cell production during cerebellum development underlies generation of the foliation pattern
The mouse cerebellum (Cb) has a remarkably complex foliated three-dimensional (3D) structure, but a stereotypical cytoarchitecture and local circuitry. Little is known of the cellular behaviors and genes that ... (Source: Neural Development)
Source: Neural Development - September 8, 2016 Category: Neurology Authors: Emilie Legu é, Jackie L. Gottshall, Edouard Jaumouillé, Alberto Roselló-Díez, Wei Shi, Luis Humberto Barraza, Senna Washington, Rachel L. Grant and Alexandra L. Joyner Source Type: research
Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons
Alterations in neurotransmitter phenotypes of specific neurons can cause imbalances in excitation and inhibition in the central nervous system (CNS), leading to diseases. Therefore, the correct specification a... (Source: Neural Development)
Source: Neural Development - August 23, 2016 Category: Neurology Authors: William C. Hilinski, Jonathan R. Bostrom, Samantha J. England, Jos é L. Juárez-Morales, Sarah de Jager, Olivier Armant, Jessica Legradi, Uwe Strähle, Brian A. Link and Katharine E. Lewis Source Type: research
