Pax6 is required intrinsically by thalamic progenitors for the normal molecular patterning of thalamic neurons but not the growth and guidance of their axons
Conclusions:
Our results indicate that Pax6 is required by thalamic progenitors for the normal molecular patterning of the thalamic neurons that they generate but thalamic neurons do not need normal Pax6-dependent patterning to become competent to grow axons that can be guided appropriately. (Source: Neural Development)
Source: Neural Development - October 31, 2015 Category: Neurology Authors: James CleggZiwen LiMichael MolinekIsabel CaballeroMartine ManuelDavid Price Source Type: research
EphrinB2 sharpens lateral motor column division in the developing spinal cord
Conclusions:
Altogether, our study uncovered a novel cell autonomous role for ephrinB2 in LMC MN thus emphasizing the prevalent role of this ephrin member in maintaining cell population boundaries. (Source: Neural Development)
Source: Neural Development - October 26, 2015 Category: Neurology Authors: Maëva LuxeyJulien LaussuAlice Davy Source Type: research
An emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous system
The embryonic vertebrate neural tube is divided along its dorsoventral (DV) axis into eleven molecularly discrete progenitor domains. Each of these domains gives rise to distinct neuronal cell types; the ventral-most six domains contribute to motor circuits, while the five dorsal domains contribute to sensory circuits. Following the initial neurogenesis step, these domains also generate glial cell types—either astrocytes or oligodendrocytes. This DV pattern is initiated by two morphogens—Sonic Hedgehog released from notochord and floor plate and Bone Morphogenetic Protein produced in the roof plate—that act in concen...
Source: Neural Development - October 24, 2015 Category: Neurology Authors: Denise ZanninoCharles Sagerström Source Type: research
The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm
Conclusions:
Although stereotypic guidance of RGC axons at the vertebrate optic chiasm is controlled by multiple, redundant mechanisms, and despite the differences in ventral diencephalic tissue architecture, we identify a novel role for the LRR receptor Islr2 in ensuring proper axon navigation at the optic chiasm of both zebrafish and mouse. (Source: Neural Development)
Source: Neural Development - October 22, 2015 Category: Neurology Authors: Paolo PanzaAusten SitkoHans-Martin MaischeinIris KochMatthias FlötenmeyerGavin WrightKenji MandaiCarol MasonChristian Söllner Source Type: research
Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems
Conclusions:
The similarities in axon growth and guidance phenotypes caused by Rac1, Frizzled3, and Celsr3 loss-of-function mutations suggest a mechanistic connection between tissue polarity/planar cell polarity signaling and Rac1-dependent cytoskeletal regulation. (Source: Neural Development)
Source: Neural Development - September 23, 2015 Category: Neurology Authors: Zhong HuaFrancesco EmilianiJeremy Nathans Source Type: research
Developmental attenuation of N-methyl-D-aspartate receptor subunit expression by microRNAs
Conclusions:
miR-19a and miR-539, in collaboration with REST, serve to set the levels of GluN2A and GluN2B precisely during development. These miRNAs offer an entry point for interventions that affect plasticity and a novel approach to treat neurodegenerative diseases. (Source: Neural Development)
Source: Neural Development - September 17, 2015 Category: Neurology Authors: Caroline CorbelIsrael HernandezBian WuKenneth Kosik Source Type: research
Developmental remodeling of relay cells in the dorsal lateral geniculate nucleus in the absence of retinal input
Conclusions:
Retinal innervation plays an important trophic role in dLGN development. Additional support perhaps arising from non-retinal innervation and signaling is likely to contribute to the stabilization of their dendritic form and function. (Source: Neural Development)
Source: Neural Development - July 15, 2015 Category: Neurology Authors: Rana El-DanafThomas KraheEmily DilgerMartha BickfordMichael FoxWilliam Guido Source Type: research
Erratum to: Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones
No description available (Source: Neural Development)
Source: Neural Development - June 19, 2015 Category: Neurology Authors: Michael PiperAih LeeFrancisca van HorckHeather McNeillyTrina LuWilliam HarrisChristine Holt Source Type: research
Multi-site phosphorylation regulates NeuroD4 activity during primary neurogenesis: a conserved mechanism amongst proneural proteins
Conclusions:
Multi-site phosphorylation on serine/threonine-proline pairs is a widely conserved mechanism of limiting proneural protein activity, where it is the number of phosphorylated sites, rather than their location that determines protein activity. Hence, multi-site phosphorylation is very well suited to allow co-ordination of proneural protein activity with the cellular proline-directed kinase environment. (Source: Neural Development)
Source: Neural Development - June 18, 2015 Category: Neurology Authors: Laura HardwickAnna Philpott Source Type: research
Netrin-1 directs dendritic growth and connectivity of vertebrate central neurons in vivo
Conclusions:
These in vivo findings together with the patterns of expression of netrin and its receptors reveal an important role for netrin in the early growth and guidance of vertebrate central neuron dendritic arbors. Collectively, our studies indicate that netrin shapes both pre- and postsynaptic arbor morphology directly and in multiple ways at stages critical for functional visual system development. (Source: Neural Development)
Source: Neural Development - June 10, 2015 Category: Neurology Authors: Anastasia NagelSonya MarshakColleen ManittRommel SantosMarc PiercySarah MorteroNicole Shirkey-SonSusana Cohen-Cory Source Type: research
The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex
Conclusions:
Our data suggest that although MBD3/NuRD is not required for neural stem cell lineage commitment, it is required to repress inappropriate transcription in both progenitor cells and neurons to facilitate appropriate cell lineage choice and differentiation programmes. (Source: Neural Development)
Source: Neural Development - May 2, 2015 Category: Neurology Authors: Erin KnockJoão PereiraPatrick LombardAndrew DimondDonna LeafordFrederick LiveseyBrian Hendrich Source Type: research
Dynamic regulation of mRNA decay during neural development
Conclusions:
We found that differential mRNA decay contributes to the relative abundance of transcripts involved in cell-fate decisions, axonogenesis, and other critical events during Drosophila neural development. Neural-specific decay kinetics and the functional specificity of mRNA decay suggest the existence of a dynamic neurodevelopmental mRNA decay network. We found that Pumilio is one component of this network, revealing a novel function for this RNA-binding protein. (Source: Neural Development)
Source: Neural Development - April 21, 2015 Category: Neurology Authors: Dana BurowMaxine Umeh-GarciaMarie TrueCrystal BakhajDavid ArdellMichael Cleary Source Type: research
Formation of functional areas in the cerebral cortex is disrupted in a mouse model of autism spectrum disorder
Conclusions:
We demonstrate that interhemispheric connectivity and cortical area formation are altered in an age- and region-specific manner in BTBR mice, which may contribute to the behavioural deficits previously observed in this strain. Some of these developmental patterns of change are also present in human ASD patients, and elucidating the aetiology driving cortical changes in BTBR mice may therefore help to increase our understanding of this disorder. (Source: Neural Development)
Source: Neural Development - April 3, 2015 Category: Neurology Authors: Laura FenlonSha LiuIlan GobiusNyoman KurniawanSkyle MurphyRandal MoldrichLinda Richards Source Type: research
Subrepellent doses of Slit1 promote Netrin-1 chemotactic responses in subsets of axons
Conclusions:
Our study reveals that at subthreshold repulsive levels, Slit1 acts as a potent promoter of both Netrin-1 attractive and repulsive activities on distinct neuronal cell types, thereby opening novel perspectives on the role of combinations of cues in brain wiring. (Source: Neural Development)
Source: Neural Development - March 20, 2015 Category: Neurology Authors: Isabelle DupinLudmilla LokmaneMaxime DahanSonia GarelVincent Studer Source Type: research
Upregulation of the zebrafish Nogo-A homologue, Rtn4b, in retinal ganglion cells is functionally involved in axon regeneration
Conclusions:
Thus, Rtn4b is an important neuron-intrinsic component and required for the success of axon regeneration in the zebrafish visual system. The spontaneous lesion-induced upregulation of Rtn4b in fish correlates with an increase in ER, soma size, biosynthetic activity, and thus growth and predicts that mammalian neurons require the same upregulation in order to successfully regenerate RGC axons. (Source: Neural Development)
Source: Neural Development - March 20, 2015 Category: Neurology Authors: Cornelia WelteSarah EngelClaudia Stuermer Source Type: research
