Update on Lupus Nephritis: Looking for a New Vision
Lupus nephritis (LN) is one of the most common manifestations of systemic lupus erythematosus (SLE), affecting approximately 40% of patients with lupus. It represents a major risk factor for morbidity and mortality, and 10% of patients with LN will develop end-stage kidney disease (ESKD). Therefore, there are a number of areas for improvement in the field of LN such as the search for new clinical biomarkers with a more accurate correlation with lupus activity and the redefinition of the histological classification into different subgroups in order to guide a personalized treatment. Although the role of protocol repeat kidn...
Source: Nephron - November 4, 2020 Category: Urology & Nephrology Source Type: research
Peritubular Capillary Oxygen Consumption in Sepsis-Induced AKI: Multi-Parametric Photoacoustic Microscopy
Understanding and measuring parameters responsible for the pathogenesis of sepsis-induced AKI (SI-AKI) is critical in developing therapies. Blood flow to the kidney is heterogeneous, partly due to the existence of dynamic networks of capillaries in various regions, responding differentially to oxygen demand in cortex versus medulla. High energy demand regions, especially the outer medulla, are susceptible to hypoxia and subject to damage during SI-AKI. Proximal tubule epithelial cells in the cortex and the outer medulla can also undergo metabolic reprogramming during SI-AKI to maintain basal physiological status and to avo...
Source: Nephron - November 4, 2020 Category: Urology & Nephrology Source Type: research
Proceedings of the 10th Annual UAB-UCSD O ’Brien Center Symposium: Changing Paradigms in Acute Kidney Injury: From Mechanisms to Management
Nephron (Source: Nephron)
Source: Nephron - November 2, 2020 Category: Urology & Nephrology Source Type: research
Regenerative Role of Stem Cell-Derived Extracellular Vesicles in Acute Kidney Injury
Acute kidney injury (AKI) is a frequent complication of hospital admission and worsens short- and long-term patients ’ prognosis. Currently, AKI treatment remains supportive and no therapy has proven significant benefit in clinical trials. Stem cells (SCs) are a promising therapeutic option, but their translation to the clinical setting is limited by the risk of rejection or aberrant differentiation. Numerous st udies have shown how SC effects are mediated by paracrine factors such as extracellular vesicles (EVs). In this review, we describe the preclinical evidence about EV efficacy in acute tubular and glomerular injur...
Source: Nephron - October 30, 2020 Category: Urology & Nephrology Source Type: research
The Effects of Chronic Dialysis on Physical Status, Quality of Life, and Arterial Stiffness: A Longitudinal Study in Prevalent Dialysis Patients
Conclusion: We observed no statistically significant changes in functional outcomes during a 2-year follow-up period, but a significant increase was observed for arterial stiffness. These results might suggest that after a certain period in time, a relatively stable course is present in functional outcomes, but an ongoing deterioration in arterial stiffness occurs, which might increase the risk of cardiovascular disease and all-cause mortality in these patients.Nephron (Source: Nephron)
Source: Nephron - October 27, 2020 Category: Urology & Nephrology Source Type: research
