The Relationship between Timing of Pretransplant Kidney Biopsy, Graft Loss, and Survival in Kidney Transplantation: An Italian Cohort Study
Conclusion: Performing preimplantation kidney biopsy during the recovery, prior to the aortic cross-clamping, may be a strategy to reduce CIT and improve transplant outcomes.Nephron (Source: Nephron)
Source: Nephron - October 27, 2021 Category: Urology & Nephrology Source Type: research
Unexpected Participation of Intercalated Cells in Renal Inflammation and Acute Kidney Injury
Epithelial cells constitute the 1st line of defense against pathogens, and their participation in innate immunity is rapidly emerging. In this mini-review, we discuss the noncanonical role of renal intercalated cells (ICs) in pathogen defense and in the initiation of sterile inflammation. This last function has strong implications in the onset of acute kidney injury (AKI), a potentially fatal medical complication that is seen in hospitalized patients. AKI is associated with inflammation, and it is often diagnosed only after the kidneys have suffered significant and often irreversible damage. While examining the regulation ...
Source: Nephron - October 15, 2021 Category: Urology & Nephrology Source Type: research
Ataxia Telangiectasia and Rad3-Related Activation by DNA Damage Mitigates Maladaptive Repair after Acute Kidney Injury
DNA damage is an important consequence of injury to the proximal tubule. The proximal tubule cell responds to this damage by mounting a DNA damage response (DDR). Two protein kinases, ataxia-telangiectasia mutated (ATM) or ataxia telangiectasia and Rad3-related (ATR), play an important role in this DDR. If efficient, the DDR can lead to repair of the DNA, cell renewal, and return to a healthy state. In many cases, however, especially in the setting of baseline kidney injury, there is incomplete repair. In human chronic kidney disease (CKD) and in human kidney organoids exposed to acute injury, there is increased evidence o...
Source: Nephron - October 14, 2021 Category: Urology & Nephrology Source Type: research
The Impact of Chronic Kidney Disease on Outcomes of Patients with COVID-19 Admitted to the Intensive Care Unit
This study provides important new data demonstrating differences in clinical presentation in patients with KFRT and ND-CKD with COVID-19. Alhough patients with severe CKD had higher mortality than those without CKD, approximately half survived after 28 days, demonstrating that patients with COVID-19 and severe CKD can benefit from ICU care. The markedly lower use of emerging COVID-19 treatments in patients with severe CKD highlights the need to include these patients in clinical trials of new COVID-19 therapies and for clinicians to ensure equal access to care in patients with severe CKD and COVID-19.Nephron (Source: Nephron)
Source: Nephron - October 11, 2021 Category: Urology & Nephrology Source Type: research
Low Creatininuria due to Hyponatremia Is Reversible in Many Patients
Conclusion: Chronic hyponatremia (#x3e;1 month) is associated with a decrease in solute output (or intake) and in creatinine excretion. In many patients, these abnormalities are reversible in the long term.Nephron (Source: Nephron)
Source: Nephron - September 28, 2021 Category: Urology & Nephrology Source Type: research
Comment on “Which Patients with Obesity Are at Risk for Renal Disease?”
Nephron (Source: Nephron)
Source: Nephron - September 21, 2021 Category: Urology & Nephrology Source Type: research
Interferon- γ-Induced Myeloid-Derived Suppressor Cells Aggravate Kidney Ischemia-Reperfusion Injury by Regulating Innate Immune Cells
Conclusions: Herein, we successfully developed a protocol wherein MDSCs were differentiated in vitro through combination GM-CSF/IFN- γ treatment. When these MDSCs were subsequently adoptively transferred into a murine model of renal IRI, they aggravated kidney damage, likely owing to the differentiation of M-MDSCs into deleterious macrophages and DCs.Nephron (Source: Nephron)
Source: Nephron - September 21, 2021 Category: Urology & Nephrology Source Type: research
Drug-Induced Kidney Injury Caused by Osimertinib: Report of a Rare Case
We report a patient with NSCLC who presented with acute kidney injury associated with biopsy-proven acute tubular injury during osimertinib treatment and whose renal function recovered after reducing the osimertinib dose. A 61-year-old male smoker complained of dyspnoea on exertion for 1 month before his visit to the medical centre. He was diagnosed with lung adenocarcinoma of the left lower lobe (cT4N3M1a, stage IVA) and was positive for anEGFR mutation (exon 19 deletion). Osimertinib was initiated at 80 mg/day. At treatment initiation, the patient ’s serum creatinine level was 0.64 mg/dL, with microscopic haematuria; b...
Source: Nephron - September 17, 2021 Category: Urology & Nephrology Source Type: research
Limitations of SARC-F as a Screening Tool for Sarcopenia in Patients on Hemodialysis
Conclusion: The SARC-F alone is an inadequate screening tool for sarcopenia in patients undergoing hemodialysis. It should be used in combination with objective assessment measures, rather than as a first-step screening tool, to diagnose sarcopenia.Nephron (Source: Nephron)
Source: Nephron - September 14, 2021 Category: Urology & Nephrology Source Type: research
A Case of a 49-Year-Old Man with Nonclassical Fabry Disease Diagnosed by Renal Biopsy
Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by mutations in the galactosidase A (GLA) gene that result in deficiency of α-GLA activity, leading to major organ failure and premature mortality. According to different disease courses, FD can be divided into classical and nonclassical phenotypes. The nonclassical FD phenotype is always absent of characteristic symptoms, which makes identifying it challenging. This artic le presents a 49-year-old man with a 10-year history of proteinuria and decreased glomerular filtration rate. An electrocardiogram showed a complete right bundle branch block and ab...
Source: Nephron - September 14, 2021 Category: Urology & Nephrology Source Type: research
XCL1 Aggravates Diabetic Nephropathy-Mediated Renal Glomerular Endothelial Cell Apoptosis and Inflammatory Response via Regulating p53/Nuclear Factor-Kappa B Pathway
Conclusions: Our findings in this work provided the mechanistic insights into the effects of XCL1 on the modulation of DN development, illustrating that XCL1 might serve as an essential prognostic indicator and therapeutic target for DN progression.Nephron (Source: Nephron)
Source: Nephron - September 9, 2021 Category: Urology & Nephrology Source Type: research
Pregnancy in Women with Atypical Hemolytic Uremic Syndrome
Conclusions: Our results show that in women with aHUS, even on dialysis or with a kidney graft, pregnancy is possible with careful monitoring for aHUS flares and prematurity. Prophylactic or therapeutic eculizumab offers disease control with low-risk of fetal abnormalities.Nephron (Source: Nephron)
Source: Nephron - September 7, 2021 Category: Urology & Nephrology Source Type: research
Disparate Information Provided by Pulse Wave Velocity versus Other Measures of Aortic Compliance in End-Stage Renal Disease
Conclusion: In the absence of differences in PWV, higher aortic pulse pressure and characteristic impedance, and lower ratio of stroke index to aortic pulse pressure, suggest reduced aortic compliance and impaired left ventricular function in CKD patients. A lower subendocardial viability ratio predisposes the CKD patients to impaired cardiac oxygen supply versus hypertensive patients and nonmedicated controls.Nephron (Source: Nephron)
Source: Nephron - September 6, 2021 Category: Urology & Nephrology Source Type: research
The Landscape and Potential Regulatory Mechanism of Lysine 2-Hydroxyisobutyrylation of Protein in End-Stage Renal Disease
Conclusion: In this study, we found thatKhib-modified proteins correlated with the occurrence and progression of ESRD.Nephron (Source: Nephron)
Source: Nephron - September 3, 2021 Category: Urology & Nephrology Source Type: research
Impact of Shielding and First Dose of COVID-19 Vaccination in Kidney Transplant Recipients
Nephron (Source: Nephron)
Source: Nephron - September 2, 2021 Category: Urology & Nephrology Source Type: research
