Comparison of Outcomes of In-Centre Haemodialysis Patients between the 1st and 2nd COVID-19 Outbreak in England, Wales, and Northern Ireland: A UK Renal Registry Analysis
Conclusions: Risk of death of patients on ICHD treatment with COVID-19 remained unchanged between the first and second outbreaks. This highlights that this vulnerable patient group needs to be prioritized for interventions to prevent severe COVID-19, including vaccination, and the implementation of measures to reduce the risk of transmission alone is not sufficient.Nephron (Source: Nephron)
Source: Nephron - March 30, 2022 Category: Urology & Nephrology Source Type: research
Proceedings of the 11th Annual UAB-UCSD O ’Brien Center Symposium: Changing Paradigms in Acute Kidney Injury – From Mechanisms to Management
Nephron (Source: Nephron)
Source: Nephron - March 29, 2022 Category: Urology & Nephrology Source Type: research
Clinical Kidney Xenotransplantation: Major Progress but More Work Needs to Be Done
Nephron (Source: Nephron)
Source: Nephron - March 25, 2022 Category: Urology & Nephrology Source Type: research
Drug Testing for Chronic Kidney Disease and Diabetes in Animals versus Humans: A Comparative Analysis of Study Designs and Reporting Qualities
Conclusion: Bench-to-bedside translation in the domain of DKD suffers from major deficits in the design of experimental studies in view of the projected clinical trials as well as from significant deficits in the reporting quality in preclinical and clinical studies.Nephron (Source: Nephron)
Source: Nephron - March 23, 2022 Category: Urology & Nephrology Source Type: research
Hemolytic Uremic Syndrome Associated with Norovirus Gastroenteritis: Case Report and Literature Review
A previously healthy 3-year-old girl was admitted with fever, nonbloody diarrhea, vomiting for 3 days, and oliguria. Physical examination showed fatigue, pale appearance, hypertension, and mild periorbital edema. Laboratory examinations revealed anemia, thrombocytopenia, acute kidney injury, high LDH, and low haptoglobin levels. Urinalysis showed proteinuria and hematuria. Schistocytes and helmet cells were detected in the peripheral blood smear. There were no electrolyte imbalance and hypocomplementemia. Direct Coombs and viral panel were negative. Blood, urine, throat, and stool cultures were negative. Norovirus GII was ...
Source: Nephron - March 21, 2022 Category: Urology & Nephrology Source Type: research
Propofol Disrupts Clear Cell Renal Cell Carcinoma Tumorigenesis by Regulating circFBXW7/miR-942 Axis
Conclusion: Propofol suppressed the growth, migration, and invasion of ccRCC cells by regulating circFBXW7/miR-942 axis, suggesting a potential therapeutic strategy for the intervention of human ccRCC development.Nephron (Source: Nephron)
Source: Nephron - March 18, 2022 Category: Urology & Nephrology Source Type: research
Renal Involvement in Transthyretin Amyloidosis: The Double Presentation of Transthyretin Amyloidosis Deposition Disease
We describe 2 WT ATTR patients, 1 patient with c.424G#x3e;A (p.(Val142Ile)) mutation of the TTR gene, and 1 patient with Val30Met mutation of the TTR gene. In all patients, the biopsy showed the presence of amyloid deposits with different distribution (#1 pericapsular, #2 –3 vessels, #4 vessels, interstitium of medulla and cortex, and tubular basement membrane). The use of immunohistochemistry has enabled the identification of TTR, and identify the precursor protein. The possibility of kidney involvement in TTR amyloidosis should be taken into account in patients w ith renal impairment and unexplained cardiomyopathy and/...
Source: Nephron - March 18, 2022 Category: Urology & Nephrology Source Type: research
Kidney Health for All: Bridging the Gap in Kidney Health Education and Literacy
The high burden of kidney disease, global disparities in kidney care, and poor outcomes of kidney failure bring a concomitant growing burden to persons affected, their families, and carers, and the community at large. Health literacy is the degree to which persons and organizations have or equitably enable individuals to have the ability to find, understand, and use information and services to make informed health-related decisions and actions for themselves and others. Rather than viewing health literacy as a patient deficit, improving health literacy largely rests with health care providers communicating and educating ef...
Source: Nephron - March 14, 2022 Category: Urology & Nephrology Source Type: research
The Proximal Tubule as the Pathogenic and Therapeutic Target in Acute Kidney Injury
Background: In 2004, the term acute kidney injury (AKI) was introduced with the intention of broadening our understanding of rapid declines in renal function and to replace the historical terms of acute renal failure and acute tubular necrosis (ATN). Despite this evolution in terminology, the mechanisms of AKI have stayed largely elusive with the pathophysiological concepts of ATN remaining the mainstay in our understanding of AKI.Summary: The proximal tubule (PT), having the highest mitochondrial content in the kidney and relying heavily on oxidative phosphorylation to generate ATP, is vulnerable to ischaemic insults and ...
Source: Nephron - March 10, 2022 Category: Urology & Nephrology Source Type: research
Detection of Acute Kidney Injury in Neonates after Cardiopulmonary Bypass
Cardiac surgery-associated acute kidney injury (CS-AKI) in neonates has been associated with poor outcomes. Early detection and intervention of acute kidney injury (AKI) are needed in order to mitigate some of these sequalae. Currently, serum creatinine (SCr) remains the gold standard for AKI diagnosis; however, changes are not seen until days after injury thus delaying the diagnosis. Serum creatinine in neonates varies based on multiple factors such as prematurity, the presence of maternal SCr and renal tubule immaturity. Acute kidney injury biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL), are useful...
Source: Nephron - February 25, 2022 Category: Urology & Nephrology Source Type: research
Effects of Body Weight Change on Development of Chronic Kidney Disease in Obese Metabolic Phenotypes
Conclusions: In the MHO phenotype, an increased BMI deteriorated CKD development, and a decreased BMI ameliorated CKD development in the MUNO phenotype.Nephron (Source: Nephron)
Source: Nephron - February 18, 2022 Category: Urology & Nephrology Source Type: research
Losartan Attenuates Atherosclerosis in Uremic Mice by Regulating Treg/Th17 Balance via Mediating PTEN/PI3K/Akt Pathway
Conclusion: Losartan attenuated UAAS in mice by regulating Treg/Th17 cells balance via mediating PTEN/PI3K/Akt pathway, providing possible therapeutic method for UAAS in clinical practice.Nephron (Source: Nephron)
Source: Nephron - February 17, 2022 Category: Urology & Nephrology Source Type: research
Evolution of Quality of Life in Chronic Kidney Disease Stage 4 –5 Patients Transitioning to Dialysis and Transplantation
Conclusion: QoL improved in KTRs in kidney disease-specific domains compared to patients initiating dialysis or those without RRT. Plasma albumin and lipids were associated with QoL over time.Nephron (Source: Nephron)
Source: Nephron - February 9, 2022 Category: Urology & Nephrology Source Type: research
Warfarin Use, Stroke, and Bleeding Risk among Pre-Existing Atrial Fibrillation US Veterans Transitioning to Dialysis
In this study, we validated risk scores for stroke and bleeding in this population and assessed risk of stroke and bleeding among warfarin users compared to nonusers.Methods: We utilized a cohort of 28,620 pre-dialysis US veterans transitioning to hemodialysis between October 2007 and March 2015. Incident rates for the risks of stroke and bleeding were ascertained based upon CHA2DS2-VASc or HAS-BLED scores, respectively. A propensity score-based competing risk analysis was used to assess risk of stroke and bleeding.Findings: The mean age of our cohort was 77 ± 9 years, and the median CHA2DS2-VASc and HAS-BLED scores were ...
Source: Nephron - February 4, 2022 Category: Urology & Nephrology Source Type: research
Superiority of Simplified Acute Physiologic Score II Compared with Acute Physiologic and Chronic Health Evaluation II and Sequential Organ Failure Assessment Scores for Predicting 48-Hour Mortality in Patients Receiving Continuous Kidney Replacement Therapy
Conclusions: The predictive performance of SAPS II for mortality within the first 48 h was superior to that of the APACHE II and SOFA scores in patients with acute kidney injury receiving CKRT.Nephron (Source: Nephron)
Source: Nephron - January 31, 2022 Category: Urology & Nephrology Source Type: research
