Dismal Prognosis of Acute Allergic Tubulointerstitial Nephritis in Patients with AA Amyloidosis
Conclusion: In contrary to the patients without AA amyloidosis, patients with AA amyloidosis have extremely high risk of permanent renal failure in case of development of aTIN. Great caution should be exercised in prescribing drugs that are associated with aTIN, in patients with AA amyloidosis.Nephron (Source: Nephron)
Source: Nephron - December 1, 2021 Category: Urology & Nephrology Source Type: research
Thermoneutral Regulation and Acute Injury: Implications for Acute Kidney Injury
Acute kidney injury (AKI) has demonstrated sex differences as illustrated in clinical and preclinical studies. In most cases, females show a significant resistance to AKI as manifested by renal indicators of injury, and thus much of the literature is derived from studies exclusively in males. Thermoneutral housing alters sex differences in acute injury of the liver, but has not been studied in the kidney. Thermoneutrality, the ambient temperature at which additional energy is not needed to maintain core body temperature, is regulated by mechanisms residing in mitochondria. Importantly, mitochondrial function plays an impor...
Source: Nephron - November 25, 2021 Category: Urology & Nephrology Source Type: research
Autopsy Findings of Heterozygous Fabry Disease with the Severe Phenotype: A Case Report
Fabry disease (FD) is an inherited X-linked lysosomal storage disorder, with hemizygous males being more severely affected than heterozygous females. Herein, we report a rare case of FD in a heterozygous female with a severe phenotype. The patient had obesity and hyperlipidemia and had her first cerebral infarction at the age of 33 years. She underwent renal biopsy and was diagnosed with FD with morphological features of focal segmental glomerulosclerosis nephropathy at the age of 34 years. Her leukocyte alpha-galactosidase A activity was 2.3 Agal/U (normal: #x3e;20 Agal/U), and genetic analysis revealed the presence of th...
Source: Nephron - November 22, 2021 Category: Urology & Nephrology Source Type: research
Thrombotic Microangiopathy Triggered by COVID-19: Case Reports
In this study, we present 3 TMA cases with severe kidney injury triggered by SARS-CoV-2. In the absence of other TMA causes, we diagnosed the atypical hemolytic uremic syndrome, triggered by SARS-CoV-2 due to abnormal complement activation. Because of both coagulation factors activation, and the high level of D-dimer in patients with COVID-19, it is crucial to differentiate disseminated intravascular coagulation from TMA. The use of anticomplement therapies such as eculizumab should be considered in refractory cases of progressive COVID-19. Controlled clinical trials are required before a definitive statement can be made.N...
Source: Nephron - November 22, 2021 Category: Urology & Nephrology Source Type: research
The Prevalence of Mesangial Electron-Dense Deposits in PLA2R-Positive Membranous Nephropathy
Conclusion: PLA2R-negative cases were not more likely to have mesangial deposits than PLA2R-positive cases. Mesangial deposits should not be used as an indicator of secondary MN.Nephron (Source: Nephron)
Source: Nephron - November 19, 2021 Category: Urology & Nephrology Source Type: research
The Prognostic Importance of Serum Sodium for Mortality among Critically Ill Patients Requiring Continuous Renal Replacement Therapy
Conclusion: Before CRRT initiation, hypernatremia and during CRRT, hypo- and hypernatremia were associated with increased mortality.Nephron (Source: Nephron)
Source: Nephron - November 18, 2021 Category: Urology & Nephrology Source Type: research
The Long Noncoding RNA-H19 Mediates the Progression of Fibrosis from Acute Kidney Injury to Chronic Kidney Disease by Regulating the miR-196a/Wnt/ β-Catenin Signaling
Conclusion: lncRNA-H19 induces kidney fibrosis during AKI-CKD by regulating the miR-196a-5p/Wnt/ β-catenin signaling pathway.Nephron (Source: Nephron)
Source: Nephron - November 17, 2021 Category: Urology & Nephrology Source Type: research
Fludrocortisone Is an Effective Treatment for Hyperkalaemic Metabolic Acidosis in Kidney Transplant Recipients on Tacrolimus: A Case Series
Conclusions: Treatment of hyperkalaemic metabolic acidosis in transplant patients on tacrolimus with low-dose fludrocortisone resulted in rapid correction of hyperkalaemia and acidosis without significant effects on blood pressure or serum sodium. Fludrocortisone can be an effective short-term option for the treatment of hyperkalaemic metabolic acidosis in kidney transplant recipients on tacrolimus; however, patient selection remains important in order to reduce to risk of potential adverse effects.Nephron (Source: Nephron)
Source: Nephron - November 16, 2021 Category: Urology & Nephrology Source Type: research
Soft Target Weight: Theory and Simulation of a Novel Haemodialysis Protocol Which Reduces Excessive Ultrafiltration
Conclusion: Considering natural weight variation allows the development of a novel protocol for ultrafiltration in which target weight does not have to be achieved precisely: it is therefore a soft target. This protocol, which is predicted to substantially reduce excessive ultrafiltration variation, is a zero-cost intervention with the potential to improve symptoms and clinical outcome for haemodialysis patients.Nephron (Source: Nephron)
Source: Nephron - November 16, 2021 Category: Urology & Nephrology Source Type: research
Contents Vol. 145, 2021
Nephron 2021;145:I –X (Source: Nephron)
Source: Nephron - November 11, 2021 Category: Urology & Nephrology Source Type: research
Acknowledgement to the Reviewers
Nephron 2021;145:783 –784 (Source: Nephron)
Source: Nephron - November 11, 2021 Category: Urology & Nephrology Source Type: research
Hemoglobin A1c and Fructosamine Evaluated in Patients with Type 2 Diabetes Receiving Peritoneal Dialysis Using Long-Term Continuous Glucose Monitoring
Conclusion: HbA1c underestimates mean plasma glucose levels in patients with type 2 diabetes receiving PD. However, the clinical significance of this finding is undetermined. Fructosamine seems to more accurately reflect glycemic status. CGM or fructosamine could complement HbA1c to increase the accuracy of glycemic monitoring in the PD population.Nephron (Source: Nephron)
Source: Nephron - November 3, 2021 Category: Urology & Nephrology Source Type: research
Immunosuppressive Therapy in Primary Membranous Nephropathy with Compromised Renal Function
Conclusion: To conclude, both cCYC/GC and rituximab are equally effective in inducing remission of nephrotic state with compromised renal function due to PMN. Immunosuppression induces remission in up to 50% PMN patients with CKD-stage 3 –4.Nephron (Source: Nephron)
Source: Nephron - November 3, 2021 Category: Urology & Nephrology Source Type: research
Pirfenidone Attenuates Renal Tubulointerstitial Fibrosis through Inhibiting miR-21
Conclusions: PFD improves TIF by downregulating the expression of miR-21, then elevating Smad7, and finally inhibiting the activation of the TGF- β1/Smad3 signaling pathway in UUO rats.Nephron (Source: Nephron)
Source: Nephron - November 1, 2021 Category: Urology & Nephrology Source Type: research
Atypical Hemolytic Uremic Syndrome after ChAdOx1 nCoV-19 Vaccination in a Patient with Homozygous CFHR3/CFHR1 Gene Deletion
We report a case of a 54-year-old female, with a past medical history of pulmonary tuberculosis, who was admitted to the emergency service with general malaise and reduction in urine output, 5 days after vaccination with ChAdOx1 nCoV-19. Laboratory results revealed microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Given the clinical picture of TMA, plasma exchange (PEX) was immediately started, along with hemodialysis. Complementary laboratory workup for TMA excluded thrombotic thrombocytopenic purpura and secondary causes. Complement study revealed normal levels of factors H, B, and I, normal a...
Source: Nephron - November 1, 2021 Category: Urology & Nephrology Source Type: research
