The Kidney-Heart Connection in Obesity
There is a strong relationship between the kidney and the heart, where if one of these organs fails, so does the other, in the so-called cardiorenal syndrome (CRS). Besides, there are also interactions with the rest of the body leading to a metabolic state that establishes a feedback loop that is perpetuated. The CRS is characterized by hemodynamic changes, activation of neuro-humoral systems, natriuretic peptides, and changes in mineral metabolism. In this scenario, the kidney and heart, connected by a dysfunctional endothelium, inevitably fail. In obesity, this syndrome is exacerbated due to the complications of adipose ...
Source: Nephron - April 13, 2021 Category: Urology & Nephrology Source Type: research
Cardiovascular and Renal Outcomes in Patients with Type-2 Diabetes and Chronic Kidney Disease Identified in a United States Administrative Claims Database: A Population Cohort Study
Conclusions: Multimorbidity and advance stages of CKD increase the risk of cardiovascular and renal complications among patients with T2D diabetes. Earlier CKD diagnosis as well as interventions and coordinated care addressing other comorbid conditions present at diagnosis may reduce the overall disease burden in this population.Nephron (Source: Nephron)
Source: Nephron - March 31, 2021 Category: Urology & Nephrology Source Type: research
Preventing Coronavirus Disease 2019 in Kidney Transplant Recipients: Where Should We Begin?
This study shows that the rate of SARS-CoV-2 infection in kidney transplant recipients is similar to the one observed in the general population in the same area (13%), indicating that transplant recipients are not at increased risk of COVID-19. However, the investigators raise the interesting point that since transplant individuals were advised to shelter earlier than the general population, they may be in fact more susceptible. This statement is hard to substantiate, but the identification of specific risk factors for infection and poor outcomes is crucial to tailor strategies to prevent spread of the infection. This is p...
Source: Nephron - March 31, 2021 Category: Urology & Nephrology Source Type: research
Augmented Renal Clearance in COVID-19
Nephron (Source: Nephron)
Source: Nephron - March 30, 2021 Category: Urology & Nephrology Source Type: research
Risk Factors for Development of Acute Kidney Injury in COVID-19 Patients: A Retrospective Observational Cohort Study
Conclusion: Severe COVID-19 is independently associated with increased risk of AKI beyond premorbid conditions and age. Appropriate avoidance of vancomycin and NSAIDs are potentially modifiable means to prevent AKI in patients with COVID-19.Nephron (Source: Nephron)
Source: Nephron - March 29, 2021 Category: Urology & Nephrology Source Type: research
Towards Modelling Genetic Kidney Diseases with Human Pluripotent Stem Cells
Background: Kidney disease causes major suffering and premature mortality worldwide. With no cure for kidney failure currently available, and with limited options for treatment, there is an urgent need to develop effective pharmaceutical interventions to slow or prevent kidney disease progression.Summary: In this review, we consider the feasibility of using human pluripotent stem cell-derived kidney tissues, or organoids, to model genetic kidney disease. Notable successes have been made in modelling genetic tubular diseases (e.g., cystinosis), polycystic kidney disease, and medullary cystic kidney disease. Organoid models ...
Source: Nephron - March 26, 2021 Category: Urology & Nephrology Source Type: research
< b > < i > Nephrology Worldwide < /i > < /b > – A Book Review
Nephron (Source: Nephron)
Source: Nephron - March 23, 2021 Category: Urology & Nephrology Source Type: research
Potassium Trajectories prior to Dialysis and Mortality following Dialysis Initiation in Patients with Advanced CKD
Conclusion: The average intraindividual plasmaK trajectory is remarkably stable in patients with advanced NDD-CKD. A decreasingK slope is associated with higher all-cause mortality risk.Nephron (Source: Nephron)
Source: Nephron - March 22, 2021 Category: Urology & Nephrology Source Type: research
Vascular Permeability: Regulation Pathways and Role in Kidney Diseases
Background: Vascular permeability (VP) is a fundamental aspect of vascular biology. A growing number of studies have revealed that many signalling pathways govern VP in both physiological and pathophysiological conditions. Furthermore, emerging evidence identifies VP alteration as a pivotal pathogenic factor in acute kidney injury, chronic kidney disease, diabetic kidney disease, and other proteinuric diseases. Therefore, perceiving the connections between these pathways and the aetiology of kidney disease is an important task as such knowledge may trigger the development of novel therapeutic or preventive medical approach...
Source: Nephron - March 19, 2021 Category: Urology & Nephrology Source Type: research
Whole-Exome Sequencing Solved over 2-Decade Kidney Disease Enigma
Chronic kidney disease of unknown etiology (CKDu) has been a problem in renal practice as indefinite diagnosis may lead to inappropriate management. Here, we report a 54-year-old father diagnosed with CKDu at 33 years old and his 8-year-old son with steroid-resistant nephrotic syndrome. Using whole-exome sequencing, both were found to be heterozygous for c.737G#x3e;A (p.Arg246Gln) inLMX1B. The diagnosis ofLMX1B-associated nephropathy has led to changes in the treatment plan with appropriate genetic counseling. The previously reported cases with this particular mutation were also reviewed. Most children withLMX1B-associated...
Source: Nephron - March 16, 2021 Category: Urology & Nephrology Source Type: research
Association of Obesity with Cardiovascular Risk Factors and Kidney Disease Outcomes in Primary Proteinuric Glomerulopathies
Conclusion: Obesity was associated with higher cardiovascular risk and less proteinuria remission from nephrotic syndrome in adults and children with proteinuric glomerulopathies. Weight-loss strategies may forestall cardiovascular disease and progressive kidney function decline in this high-risk patient group.Nephron (Source: Nephron)
Source: Nephron - March 5, 2021 Category: Urology & Nephrology Source Type: research
Which Patients with Obesity Are at Risk for Renal Disease?
Obesity-related glomerulopathy (ORG) is an increasingly recognized cause of end-stage kidney disease. The most common clinical presentation is a slowly increasing nonnephrotic proteinuria that is followed by a progressive decline of kidney function. Key histological findings are glomerulomegaly and lesions of focal and segmental glomerulosclerosis. A central pathogenic mechanism is the increased sodium reabsorption by proximal tubules that typically accompanies obesity. This causes a decrease in the offer of sodium to the macula densa in the distal nephron, which results in a vasodilation of afferent glomerular arterioles ...
Source: Nephron - March 5, 2021 Category: Urology & Nephrology Source Type: research
Serum Phosphorus Levels are Associated with Intradialytic Hypotension in Hemodialysis Patients
Conclusion: In HD patients, higher phosphorus levels were associated with an increased occurrence of IDH.Nephron (Source: Nephron)
Source: Nephron - March 4, 2021 Category: Urology & Nephrology Source Type: research
Association of Race with In-Hospital and Post-Hospitalization Mortality in Patients with Acute Kidney Injury
Conclusions: Black patients with AKI had lower in-hospital mortality, 90-day post-hospitalization mortality, and better long-term survival rates compared to white patients with AKI.Nephron (Source: Nephron)
Source: Nephron - March 3, 2021 Category: Urology & Nephrology Source Type: research
Living Well with Kidney Disease by Patient and Care-Partner Empowerment: Kidney Health for Everyone Everywhere
Living with chronic kidney disease (CKD) is associated with hardships for patients and their care-partners. Empowering patients and their care-partners, including family members or friends involved in their care, may help minimize the burden and consequences of CKD-related symptoms to enable life participation. There is a need to broaden the focus on living well with kidney disease and re-engagement in life, including an emphasis on patients being in control. The World Kidney Day (WKD) Joint Steering Committee has declared 2021 the year of “Living Well with Kidney Disease” in an effort to increase education and awarene...
Source: Nephron - February 25, 2021 Category: Urology & Nephrology Source Type: research
