Erratum
Nephron (Source: Nephron)
Source: Nephron - December 18, 2020 Category: Urology & Nephrology Source Type: research
Estimation of Missing Baseline Serum Creatinine for Acute Kidney Injury Diagnosis in Hospitalized Patients
Conclusions: Multivariable imputation of preadmission SCr, taking into account elementary admission data, improved accuracy in AKI diagnosis over commonly used surrogate methods. Random forest-based models can serve as an effective tool in research.Nephron (Source: Nephron)
Source: Nephron - December 18, 2020 Category: Urology & Nephrology Source Type: research
COVID-19 in Renal Transplant Recipients: Case Series and a Brief Review of Current Evidence
We report 8 cases of kidney transplant recipients infected with COVID-19 (median age = 48.5 years; range = 21 –71 years), including 4 males and 4 females. The most frequently associated comorbidity was hypertension. The most common presenting features were fever and cough. The main radiological investigation was a portable chest X-ray. Other common features included lymphopenia, high C-reactive protein, a nd a very high ferritin level. Overall, 1 patient was managed as an outpatient, the remaining 7 required hospital admission, 1 of them referred to the intensive therapy unit. Management included supportive treatment (in...
Source: Nephron - December 8, 2020 Category: Urology & Nephrology Source Type: research
Atypical Hemolytic Uremic Syndrome and Nephrotic Syndrome Associated with Cytomegalovirus Infection
We report a case of a man with a homozygotic deletion ofCFHR3-1 whose initial presentation was aHUS and nephrotic syndromes associated with CMV infection.Nephron (Source: Nephron)
Source: Nephron - December 8, 2020 Category: Urology & Nephrology Source Type: research
Prevalence of Inflammatory Bowel Disease and Celiac Disease in Patients with IgA Nephropathy over Time
Conclusion: The prevalence of IBD increased over time in IgAN patients, which exceeds the prevalence of 0.6% in Finnish general population. In parallel, the prevalence of celiac disease and screen-detected celiac disease autoimmunity decreased over time. The coexistence of IBD and IgAN is not negligible. Whether this finding is caused by the increase in the prevalence of IBD in the population or shared pathophysiology between IgAN and IBD remains a matter of further studies.Nephron (Source: Nephron)
Source: Nephron - December 3, 2020 Category: Urology & Nephrology Source Type: research
The Use of HbA1c, Glycated Albumin and Continuous Glucose Monitoring to Assess Glucose Control in the Chronic Kidney Disease Population Including Dialysis
Background: Glycated haemoglobin A1c (HbA1c) has limitations as a glycemic marker for patients with diabetes and CKD and for those receiving dialysis. Glycated albumin is an alternative glycemic marker, and some studies have found that glycated albumin more accurately reflects glycemic control than HbA1c in these groups. However, several factors are known to influence the value of glycated albumin including proteinuria. Continuous glucose monitoring (CGM) is another alternative to HbA1c. CGM allows one to assess mean glucose, glucose variability, and the time spent in hypo-, normo-, and hyperglycemia. Currently, several di...
Source: Nephron - December 2, 2020 Category: Urology & Nephrology Source Type: research
Impact of Metabolic Surgery on Renal Injury in Pre-Clinical Models of Diabetic Kidney Disease
Background: Surgical approaches to the treatment of obesity and type 2 diabetes, most notably the Roux-en-Y gastric bypass (RYGB) procedure, have been shown to be renoprotective, reducing the incidence of albuminuria and end-stage kidney disease over 15- to 20-year follow-up in patients with obesity. The tissue level effects of metabolic surgery on the diabetic kidney are not easily interrogated in clinical samples. However, elucidation of the cellular and molecular basis for the renoprotective effects of metabolic surgery is now emerging from a body of pre-clinical work in rodent models of diabetic kidney disease (DKD).Su...
Source: Nephron - December 2, 2020 Category: Urology & Nephrology Source Type: research
Elevated Troponin T and Enlarged Left Atrium Are Associated with the Incidence of Atrial Fibrillation in Patients with CKD Stage 4 –5
Conclusion: The prevalence and incidence of AF was markedly high in this prospective study on patients with CKD stage 4 –5. Elevated TnT and increased LAVI were independently associated with the occurrence of new-onset AF in patients with severe CKD.Nephron (Source: Nephron)
Source: Nephron - December 2, 2020 Category: Urology & Nephrology Source Type: research
Exercise and Prediabetes after Renal Transplantation (EXPRED): Protocol Description
This study will last for 12 months.Nephron (Source: Nephron)
Source: Nephron - December 2, 2020 Category: Urology & Nephrology Source Type: research
Clinicopathological Analysis of Acute/Active Antibody-Mediated Rejection in Renal Allografts According to the Banff 2013 Classification
Conclusion: PAABMR was mainly found by the protocol biopsy. The short-term follow-up of SAABMR patients did not show worsening clinically and light microscopically, but ultrastructural examination by EM was useful to detect early lesions of endothelial injury and progression of glomerular and peritubular capillary basement membrane alterations.Nephron (Source: Nephron)
Source: Nephron - December 2, 2020 Category: Urology & Nephrology Source Type: research
Update on Recurrent Focal Segmental Glomerulosclerosis in Kidney Transplantation
Background: Focal segmental glomerulosclerosis (FSGS) is a clinicopathological syndrome characterized by nephrotic-range proteinuria with high incidence of progression to end-stage renal disease (ESRD). In primary FSGS, 40 –60% of patients develop ESRD within 10–20 years.Summary: Recurrence of FSGS after kidney transplantation is frequent and is associated with poor allograft survival. The risk factors for recurrent FSGS include onset of FSGS during childhood, rapid progression of primary FSGS to ESRD, history of recurrent FSGS in previous allograft, and diffuse mesangial hypercellularity or collapsing variant of FSGS ...
Source: Nephron - December 1, 2020 Category: Urology & Nephrology Source Type: research
Introduction
Nephron (Source: Nephron)
Source: Nephron - December 1, 2020 Category: Urology & Nephrology Source Type: research
Pathological Analysis of Early Transplant Glomerulopathy in Renal Allografts Using Low-Vacuum Scanning Electron Microscopy
Conclusion: LVSEM revealed early GBM duplication in AABMR. Early GBM duplication might progress in the very early phase of AABMR. GBM duplication was more frequently detected by LVSEM than by LM in biopsy specimens with early chronic, active antibody mediated rejection. Thus, LVSEM may be useful in diagnosis of early transplant glomerulopathy.Nephron (Source: Nephron)
Source: Nephron - December 1, 2020 Category: Urology & Nephrology Source Type: research
Contents Vol. 144, 2020
Nephron 2020;144:I –VIII (Source: Nephron)
Source: Nephron - December 1, 2020 Category: Urology & Nephrology Source Type: research
Acknowledgement to the Reviewers
Nephron 2020;144:683 –684 (Source: Nephron)
Source: Nephron - December 1, 2020 Category: Urology & Nephrology Source Type: research
