Effects of Tissue Sodium Storage on Plasma Sodium Concentration in Response to Hypo- and Hypertonic Stimuli
Nephron (Source: Nephron)
Source: Nephron - June 18, 2021 Category: Urology & Nephrology Source Type: research
Polypharmacy and Frailty among Hemodialysis Patients
Conclusions: Using a higher number of medications was associated with frailty and the incidence of frailty among hemodialysis patients. Minimizing polypharmacy may reduce the incidence and prevalence of frailty among dialysis patients.Nephron (Source: Nephron)
Source: Nephron - June 17, 2021 Category: Urology & Nephrology Source Type: research
Long-Term Outcomes of Kidney Transplants from Older/Marginal Donors: A Cohort Study
Conclusions: Biopsy-guided selection and allocation of kidneys from older/marginal donors can safely increase transplant activity in clinical practice without affecting long-term outcomes. This may help manage the growing gap between organ demand and supply without affecting long-term recipient and graft outcomes.Nephron (Source: Nephron)
Source: Nephron - June 15, 2021 Category: Urology & Nephrology Source Type: research
Overhydration May Be the Missing Link between Peritoneal Protein Clearance and Mortality
Conclusions: The uni- and multivariable strong associations between fluid overload and PPCl support the importance of hydrostatic pressure-induced convection for PPCl. Also, peritoneal small solute transport was associated with PPCl. Both are amenable by adjusted dialysis prescription, especially focused on fluid status and avoidance of overhydration. The assumption of an association with inflammation and malnutrition was not confirmed.Nephron (Source: Nephron)
Source: Nephron - June 15, 2021 Category: Urology & Nephrology Source Type: research
Protective Effect of Calcium Dobesilate on Induced AKI in Severely Burned Mice
Conclusion: This study has established, for the first time, the protective effect of CaD against early AKI in severely burned mice. CaD may exert its protective effect through alleviating oxidative stress, apoptosis, and inflammation, as well as modulating some signaling pathways in the kidney.Nephron (Source: Nephron)
Source: Nephron - June 14, 2021 Category: Urology & Nephrology Source Type: research
Clinical Implications of the New Equation to Estimate Glomerular Filtration Rate
Recently, a new full-age spectrum equation was proposed by the European Kidney Function Consortium (EKFC) to overcome the difficulty of using multiple glomerular filtration rate (GFR) estimation equations and problems of implausible changes in GFR during the transition from adolescence to adulthood and address GFR overestimation in young adults and in the older adults. To verify the impact on patient classifications, we applied the new equation to data of 38,188 adult patients, comparing GFR estimation using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and EKFC equations. As expected, our data indicate t...
Source: Nephron - June 11, 2021 Category: Urology & Nephrology Source Type: research
Serum Testosterone Levels Are Not Modified by Vitamin D Supplementation in Dialysis Patients and Healthy Subjects
Conclusion: Serum testosterone levels in hemodialysis patients and healthy individuals are independent from vitamin D status and cannot be significantly increased by cholecalciferol supplementation.Nephron (Source: Nephron)
Source: Nephron - June 9, 2021 Category: Urology & Nephrology Source Type: research
Incidence of Uncommon Clinical Events in USA Patients with Dialysis-Dependent and Nondialysis-Dependent Chronic Kidney Disease: Analysis of Electronic Health Records from TriNetX
Conclusions: Our results help establish baseline rates of uncommon adverse clinical events and provide additional evidence of increased morbidity for patients with DD-CKD versus NDD-CKD.Nephron (Source: Nephron)
Source: Nephron - June 3, 2021 Category: Urology & Nephrology Source Type: research
NLRP3 Deletion Attenuated Angiotensin II-Induced Renal Fibrosis by Improving Mitochondrial Dysfunction and Endoplasmic Reticulum Stress
Conclusions: NLRP3 deletion may attenuate angiotensin II-induced renal fibrosis by improving mitochondrial dysfunction and ER stress.Nephron (Source: Nephron)
Source: Nephron - June 1, 2021 Category: Urology & Nephrology Source Type: research
Five-Year Follow-Up and Successful Kidney Transplantation in a Girl with a Severe Phenotype of Pierson Syndrome
We report a case of 5-year-old girl with severe phenotype of PIERSS cau sed by biallelic functional null variants of the LAMB2 gene. Due to consequences of CNS, the patient required bilateral nephrectomy and peritoneal dialysis since early infancy. The course was additionally complicated by tubulopathy, life-threatening infections, severe hypertension, erythropoietin-re sistant anemia, generalized muscular hypotonia, neurogenic bladder, profound neurodevelopmental delay, epilepsy, gastrointestinal problems, secondary hypothyroidism, and necessity of repeated ocular surgery due to microcoria, cataract, and nystagmus. Due to...
Source: Nephron - May 31, 2021 Category: Urology & Nephrology Source Type: research
An Unusual Course of a 2,8-Dihydroxyadeninuria Crystalline Nephropathy Secondary to Adenine Phosphoribosyltransferase Deficiency
Adenine phosphoribosyltransferase (APRT) deficiency is a rare disorder caused by an autosomal recessive genetic disease leading to the deposition of 2,8-dihydroxyadenine (2,8-DHA) in the kidney. The disease remains under-recognized, oftentimes diagnosed in late stages of renal insufficiency or a failed kidney allograft with biopsy-proven disease recurrence. Here, we present the case of a 59-year-old middle eastern male patient diagnosed with 2,8-DHA nephropathy after a very unusual presentation, and we show how the initiation of an appropriate therapy slowed down his evolution toward kidney replacement therapies. His disea...
Source: Nephron - May 27, 2021 Category: Urology & Nephrology Source Type: research
Endothelial Dysfunction for Acute Kidney Injury in Coronavirus Disease 2019: How Concerned Should We Be?
Context: The outbreak of coronavirus disease 2019 (CO VID-19) has rapidly evolved into a global pandemic. Kidney dysfunction is common among patients with COVID-19, and patients who develop acute kidney injury (AKI) have inferior outcomes. There is a growing body of evidence that AKI occurs in a substantial number of patients with COVID-19 and that d eveloping AKI is associated with significantly worse outcomes for COVID-19 patients. The risk for death was amplified when AKI resulted in kidney replacement therapy (KRT).Subject of Review: The Study of the Treatment and Outcomes in Critically Ill Patients with COVID-19 (ST...
Source: Nephron - May 27, 2021 Category: Urology & Nephrology Source Type: research
Obesity in Renal Transplantation
Background: Data from the WHO show an increasing rate of overweight and obesity in general population in the last decades. This increase in obesity also affects population with end-stage renal disease (ESRD) and kidney transplant (KT) candidates.Summary: In this review, we focused on how obesity impacts on KT stages: access to KT and outcomes of KT candidates; how to reduce weight and its consequences; short and long-term outcomes in obese recipients and the impact of weight variations; and the implications of obesity in living donor KT. We searched MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials until ...
Source: Nephron - May 11, 2021 Category: Urology & Nephrology Source Type: research
Hsa Circ 001839 Promoted Inflammation in Renal Ischemia-Reperfusion Injury Through NLRP3 by miR-432-3p
Conclusions: These findings suggested that circ 001839 promoted inflammation in RI-RI through NLRP3 by miR-432-3p.Nephron (Source: Nephron)
Source: Nephron - May 11, 2021 Category: Urology & Nephrology Source Type: research
Cyclosporine A Treatment of Proteinuria in a New Case of MAFB-Associated Glomerulopathy without Extrarenal Involvement: A Case Report
TheMAFB gene encodes an important basic leucine zipper transcription factor that functions in glomerular podocytes, macrophages, and osteoclasts. Recently,MAFB was identified as the gene that was responsible for causing nephropathy with focal segmental glomerulosclerosis (FSGS) with multicentric carpotarsal osteolysis (MCTO) or Duane retraction syndrome (DRS). Here, we describe a patient with nephropathy associated with FSGS who exhibited a novel stop-gain variant in theMAFB gene (NM_005461:c.590C#x3e;A (p.Ser197Ter)). The patient ’s father exhibited proteinuria with FSGS with possible DRS, whereas the patient exhibited ...
Source: Nephron - May 11, 2021 Category: Urology & Nephrology Source Type: research
