Therapeutic HDAC inhibition in hypermutant diffuse intrinsic pontine glioma
Neoplasia. 2023 Aug 19;43:100921. doi: 10.1016/j.neo.2023.100921. Online ahead of print.ABSTRACTConstitutional mismatch repair deficiency (CMMRD) is a cancer predisposition syndrome associated with the development of hypermutant pediatric high-grade glioma, and confers a poor prognosis. While therapeutic histone deacetylase (HDAC) inhibition of diffuse intrinsic pontine glioma (DIPG) has been reported; here, we use a clinically relevant biopsy-derived hypermutant DIPG model (PBT-24FH) and a CRISPR-Cas9 induced genetic model to evaluate the efficacy of HDAC inhibition against hypermutant DIPG. We screened PBT-24FH cells for...
Source: Neoplasia - August 21, 2023 Category: Cancer & Oncology Authors: Alyssa Noll Carrie Myers Matthew C Biery Michael Meechan Sophie Tahiri Asmitha Rajendran Michael E Berens Danyelle Paine Sara Byron Jiaming Zhang Conrad Winter Fiona Pakiam Sarah E S Leary Bonnie L Cole Evangeline R Jackson Matthew D Dun Jessica B Foster Source Type: research
KCTD1 is a new modulator of the KCASH family of Hedgehog suppressors
Neoplasia. 2023 Aug 17;43:100926. doi: 10.1016/j.neo.2023.100926. Online ahead of print.ABSTRACTThe Sonic Hedgehog (Hh) signal transduction pathway plays a critical role in many developmental processes and, when deregulated, may contribute to several cancers, including basal cell carcinoma, medulloblastoma, colorectal, prostate, and pancreatic cancer. In recent years, several Hh inhibitors have been developed, mainly acting on the Smo receptor. However, drug resistance due to Smo mutations or non-canonical Hh pathway activation highlights the need to identify further mechanisms of Hh pathway modulation. Among these, deacet...
Source: Neoplasia - August 19, 2023 Category: Cancer & Oncology Authors: A Di Fiore S Bellardinelli L Pirone R Russo A Angrisani G Terriaca M Bowen F Bordin Z M Besharat G Canettieri F Fabretti S Di Gaetano L Di Marcotullio E Pedone M Moretti E De Smaele Source Type: research
KCTD1 is a new modulator of the KCASH family of Hedgehog suppressors
Neoplasia. 2023 Aug 17;43:100926. doi: 10.1016/j.neo.2023.100926. Online ahead of print.ABSTRACTThe Sonic Hedgehog (Hh) signal transduction pathway plays a critical role in many developmental processes and, when deregulated, may contribute to several cancers, including basal cell carcinoma, medulloblastoma, colorectal, prostate, and pancreatic cancer. In recent years, several Hh inhibitors have been developed, mainly acting on the Smo receptor. However, drug resistance due to Smo mutations or non-canonical Hh pathway activation highlights the need to identify further mechanisms of Hh pathway modulation. Among these, deacet...
Source: Neoplasia - August 19, 2023 Category: Cancer & Oncology Authors: A Di Fiore S Bellardinelli L Pirone R Russo A Angrisani G Terriaca M Bowen F Bordin Z M Besharat G Canettieri F Fabretti S Di Gaetano L Di Marcotullio E Pedone M Moretti E De Smaele Source Type: research
Gut microbiota-derived short-chain fatty acids promote prostate cancer progression via inducing cancer cell autophagy and M2 macrophage polarization
Neoplasia. 2023 Aug 12;43:100928. doi: 10.1016/j.neo.2023.100928. Online ahead of print.ABSTRACTWe have previously demonstrated abnormal gut microbial composition in castration-resistant prostate cancer (CRPC) patients, here we revealed the mechanism of gut microbiota-derived short-chain fatty acids (SCFAs) as a mediator linking CRPC microbiota dysbiosis and prostate cancer (PCa) progression. By using transgenic TRAMP mouse model, PCa patient samples, in vitro PCa cell transwell and macrophage recruitment assays, we examined the effects of CRPC fecal microbiota transplantation (FMT) and SCFAs on PCa progression. Our result...
Source: Neoplasia - August 14, 2023 Category: Cancer & Oncology Authors: Yufei Liu Quan Zhou Fangdie Ye Chen Yang Haowen Jiang Source Type: research
Gut microbiota-derived short-chain fatty acids promote prostate cancer progression via inducing cancer cell autophagy and M2 macrophage polarization
Neoplasia. 2023 Aug 12;43:100928. doi: 10.1016/j.neo.2023.100928. Online ahead of print.ABSTRACTWe have previously demonstrated abnormal gut microbial composition in castration-resistant prostate cancer (CRPC) patients, here we revealed the mechanism of gut microbiota-derived short-chain fatty acids (SCFAs) as a mediator linking CRPC microbiota dysbiosis and prostate cancer (PCa) progression. By using transgenic TRAMP mouse model, PCa patient samples, in vitro PCa cell transwell and macrophage recruitment assays, we examined the effects of CRPC fecal microbiota transplantation (FMT) and SCFAs on PCa progression. Our result...
Source: Neoplasia - August 14, 2023 Category: Cancer & Oncology Authors: Yufei Liu Quan Zhou Fangdie Ye Chen Yang Haowen Jiang Source Type: research
Gut microbiota-derived short-chain fatty acids promote prostate cancer progression via inducing cancer cell autophagy and M2 macrophage polarization
Neoplasia. 2023 Aug 12;43:100928. doi: 10.1016/j.neo.2023.100928. Online ahead of print.ABSTRACTWe have previously demonstrated abnormal gut microbial composition in castration-resistant prostate cancer (CRPC) patients, here we revealed the mechanism of gut microbiota-derived short-chain fatty acids (SCFAs) as a mediator linking CRPC microbiota dysbiosis and prostate cancer (PCa) progression. By using transgenic TRAMP mouse model, PCa patient samples, in vitro PCa cell transwell and macrophage recruitment assays, we examined the effects of CRPC fecal microbiota transplantation (FMT) and SCFAs on PCa progression. Our result...
Source: Neoplasia - August 14, 2023 Category: Cancer & Oncology Authors: Yufei Liu Quan Zhou Fangdie Ye Chen Yang Haowen Jiang Source Type: research
Gut microbiota-derived short-chain fatty acids promote prostate cancer progression via inducing cancer cell autophagy and M2 macrophage polarization
Neoplasia. 2023 Aug 12;43:100928. doi: 10.1016/j.neo.2023.100928. Online ahead of print.ABSTRACTWe have previously demonstrated abnormal gut microbial composition in castration-resistant prostate cancer (CRPC) patients, here we revealed the mechanism of gut microbiota-derived short-chain fatty acids (SCFAs) as a mediator linking CRPC microbiota dysbiosis and prostate cancer (PCa) progression. By using transgenic TRAMP mouse model, PCa patient samples, in vitro PCa cell transwell and macrophage recruitment assays, we examined the effects of CRPC fecal microbiota transplantation (FMT) and SCFAs on PCa progression. Our result...
Source: Neoplasia - August 14, 2023 Category: Cancer & Oncology Authors: Yufei Liu Quan Zhou Fangdie Ye Chen Yang Haowen Jiang Source Type: research
Gut microbiota-derived short-chain fatty acids promote prostate cancer progression via inducing cancer cell autophagy and M2 macrophage polarization
Neoplasia. 2023 Aug 12;43:100928. doi: 10.1016/j.neo.2023.100928. Online ahead of print.ABSTRACTWe have previously demonstrated abnormal gut microbial composition in castration-resistant prostate cancer (CRPC) patients, here we revealed the mechanism of gut microbiota-derived short-chain fatty acids (SCFAs) as a mediator linking CRPC microbiota dysbiosis and prostate cancer (PCa) progression. By using transgenic TRAMP mouse model, PCa patient samples, in vitro PCa cell transwell and macrophage recruitment assays, we examined the effects of CRPC fecal microbiota transplantation (FMT) and SCFAs on PCa progression. Our result...
Source: Neoplasia - August 14, 2023 Category: Cancer & Oncology Authors: Yufei Liu Quan Zhou Fangdie Ye Chen Yang Haowen Jiang Source Type: research
Medication adjustment of afatinib and combination therapy with sitagliptin for alleviating afatinib-induced diarrhea in rats
In conclusion, sitagliptin exhibits promising potential as a therapeutic option for managing afatinib-induced diarrhea. Taken together, our study provides valuable insights into alleviating afatinib-induced diarrhea through both afatinib medication adjustment and sitagliptin combination therapy.PMID:37567055 | DOI:10.1016/j.neo.2023.100922 (Source: Neoplasia)
Source: Neoplasia - August 11, 2023 Category: Cancer & Oncology Authors: Li Zhang Anna Hu Yan Wang Yuxin Yang Yalan Liu Lian Xu Lei Wang Zeneng Cheng Source Type: research
Medication adjustment of afatinib and combination therapy with sitagliptin for alleviating afatinib-induced diarrhea in rats
In conclusion, sitagliptin exhibits promising potential as a therapeutic option for managing afatinib-induced diarrhea. Taken together, our study provides valuable insights into alleviating afatinib-induced diarrhea through both afatinib medication adjustment and sitagliptin combination therapy.PMID:37567055 | DOI:10.1016/j.neo.2023.100922 (Source: Neoplasia)
Source: Neoplasia - August 11, 2023 Category: Cancer & Oncology Authors: Li Zhang Anna Hu Yan Wang Yuxin Yang Yalan Liu Lian Xu Lei Wang Zeneng Cheng Source Type: research
Medication adjustment of afatinib and combination therapy with sitagliptin for alleviating afatinib-induced diarrhea in rats
In conclusion, sitagliptin exhibits promising potential as a therapeutic option for managing afatinib-induced diarrhea. Taken together, our study provides valuable insights into alleviating afatinib-induced diarrhea through both afatinib medication adjustment and sitagliptin combination therapy.PMID:37567055 | DOI:10.1016/j.neo.2023.100922 (Source: Neoplasia)
Source: Neoplasia - August 11, 2023 Category: Cancer & Oncology Authors: Li Zhang Anna Hu Yan Wang Yuxin Yang Yalan Liu Lian Xu Lei Wang Zeneng Cheng Source Type: research
Altered endosomal-lysosomal biogenesis in melanoma
This study demonstrated the dysregulation of Syntenin-1, Sortilin and Rab25 may provide a differentiating feature between cutaneous melanoma and squamous cell carcinoma, while IGF2R may indicate malignant propensity in these skin cancers.PMID:37562257 | DOI:10.1016/j.neo.2023.100924 (Source: Neoplasia)
Source: Neoplasia - August 10, 2023 Category: Cancer & Oncology Authors: Giang T Lam Alexandra Sorvina Carmela Martini Sarita Prabhakaran Ben S-Y Ung Joanna Lazniewska Courtney R Moore Andrew R Beck Ashley M Hopkins Ian R D Johnson Maria C Caruso Shane M Hickey Robert D Brooks Louise Jackett Litsa Karageorgos Erwin J Foster-Sm Source Type: research
Visualizing mast cell migration to tumor sites using sodium iodide symporter of nuclear medicine reporter gene
CONCLUSION: These findings suggest that the sodium iodide symporter can serve as a reliable nuclear medicine reporter gene for non-invasively imaging the biological activity of mast cells in mice with lung tumors. Visualizing mast cells in the tumor microenvironment via a nuclear medicine reporter gene would provide valuable insights into their biological functions.PMID:37562258 | DOI:10.1016/j.neo.2023.100925 (Source: Neoplasia)
Source: Neoplasia - August 10, 2023 Category: Cancer & Oncology Authors: Seul-Gi Oh Jun Young Choi Jae-Eon Lee SoYeon Jeon Bo-Ra Lee Kwang Hee Son Sang Bong Lee Beum-Soo An Dae Youn Hwang Seong-Jang Kim Ki-Tae Ha Jaetae Lee Yong Hyun Jeon Source Type: research
Altered endosomal-lysosomal biogenesis in melanoma
This study demonstrated the dysregulation of Syntenin-1, Sortilin and Rab25 may provide a differentiating feature between cutaneous melanoma and squamous cell carcinoma, while IGF2R may indicate malignant propensity in these skin cancers.PMID:37562257 | DOI:10.1016/j.neo.2023.100924 (Source: Neoplasia)
Source: Neoplasia - August 10, 2023 Category: Cancer & Oncology Authors: Giang T Lam Alexandra Sorvina Carmela Martini Sarita Prabhakaran Ben S-Y Ung Joanna Lazniewska Courtney R Moore Andrew R Beck Ashley M Hopkins Ian R D Johnson Maria C Caruso Shane M Hickey Robert D Brooks Louise Jackett Litsa Karageorgos Erwin J Foster-Sm Source Type: research
Visualizing mast cell migration to tumor sites using sodium iodide symporter of nuclear medicine reporter gene
CONCLUSION: These findings suggest that the sodium iodide symporter can serve as a reliable nuclear medicine reporter gene for non-invasively imaging the biological activity of mast cells in mice with lung tumors. Visualizing mast cells in the tumor microenvironment via a nuclear medicine reporter gene would provide valuable insights into their biological functions.PMID:37562258 | DOI:10.1016/j.neo.2023.100925 (Source: Neoplasia)
Source: Neoplasia - August 10, 2023 Category: Cancer & Oncology Authors: Seul-Gi Oh Jun Young Choi Jae-Eon Lee SoYeon Jeon Bo-Ra Lee Kwang Hee Son Sang Bong Lee Beum-Soo An Dae Youn Hwang Seong-Jang Kim Ki-Tae Ha Jaetae Lee Yong Hyun Jeon Source Type: research
