Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan
Neoplasia. 2024 Mar 26;51:100989. doi: 10.1016/j.neo.2024.100989. Online ahead of print.ABSTRACTGene mutations are a source of genetic instability which fuels the progression of cancer. Mutations in BRCA1 and BRCA2 are considered as major drivers in the progression of breast cancer and their detection indispensable for devising therapeutic and management approaches. The current study aims to identify novel pathogenic and recurrent mutations in BRCA1 and BRCA2 in Pakhtun population from the Khyber Pakhtunkhwa. To determine the BRCA1 and BRCA2 pathogenic mutation prevalence in Pakhtun population from KP, whole exome sequenci...
Source: Neoplasia - March 27, 2024 Category: Cancer & Oncology Authors: Hilal Ahmad Asif Ali Roshan Ali Ali Talha Khalil Ishaq Khan Mah Muneer Khan Mohammed Alorini Source Type: research
Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan
Neoplasia. 2024 Mar 26;51:100989. doi: 10.1016/j.neo.2024.100989. Online ahead of print.ABSTRACTGene mutations are a source of genetic instability which fuels the progression of cancer. Mutations in BRCA1 and BRCA2 are considered as major drivers in the progression of breast cancer and their detection indispensable for devising therapeutic and management approaches. The current study aims to identify novel pathogenic and recurrent mutations in BRCA1 and BRCA2 in Pakhtun population from the Khyber Pakhtunkhwa. To determine the BRCA1 and BRCA2 pathogenic mutation prevalence in Pakhtun population from KP, whole exome sequenci...
Source: Neoplasia - March 27, 2024 Category: Cancer & Oncology Authors: Hilal Ahmad Asif Ali Roshan Ali Ali Talha Khalil Ishaq Khan Mah Muneer Khan Mohammed Alorini Source Type: research
Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan
Neoplasia. 2024 Mar 26;51:100989. doi: 10.1016/j.neo.2024.100989. Online ahead of print.ABSTRACTGene mutations are a source of genetic instability which fuels the progression of cancer. Mutations in BRCA1 and BRCA2 are considered as major drivers in the progression of breast cancer and their detection indispensable for devising therapeutic and management approaches. The current study aims to identify novel pathogenic and recurrent mutations in BRCA1 and BRCA2 in Pakhtun population from the Khyber Pakhtunkhwa. To determine the BRCA1 and BRCA2 pathogenic mutation prevalence in Pakhtun population from KP, whole exome sequenci...
Source: Neoplasia - March 27, 2024 Category: Cancer & Oncology Authors: Hilal Ahmad Asif Ali Roshan Ali Ali Talha Khalil Ishaq Khan Mah Muneer Khan Mohammed Alorini Source Type: research
Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan
Neoplasia. 2024 Mar 26;51:100989. doi: 10.1016/j.neo.2024.100989. Online ahead of print.ABSTRACTGene mutations are a source of genetic instability which fuels the progression of cancer. Mutations in BRCA1 and BRCA2 are considered as major drivers in the progression of breast cancer and their detection indispensable for devising therapeutic and management approaches. The current study aims to identify novel pathogenic and recurrent mutations in BRCA1 and BRCA2 in Pakhtun population from the Khyber Pakhtunkhwa. To determine the BRCA1 and BRCA2 pathogenic mutation prevalence in Pakhtun population from KP, whole exome sequenci...
Source: Neoplasia - March 27, 2024 Category: Cancer & Oncology Authors: Hilal Ahmad Asif Ali Roshan Ali Ali Talha Khalil Ishaq Khan Mah Muneer Khan Mohammed Alorini Source Type: research
Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan
Neoplasia. 2024 Mar 26;51:100989. doi: 10.1016/j.neo.2024.100989. Online ahead of print.ABSTRACTGene mutations are a source of genetic instability which fuels the progression of cancer. Mutations in BRCA1 and BRCA2 are considered as major drivers in the progression of breast cancer and their detection indispensable for devising therapeutic and management approaches. The current study aims to identify novel pathogenic and recurrent mutations in BRCA1 and BRCA2 in Pakhtun population from the Khyber Pakhtunkhwa. To determine the BRCA1 and BRCA2 pathogenic mutation prevalence in Pakhtun population from KP, whole exome sequenci...
Source: Neoplasia - March 27, 2024 Category: Cancer & Oncology Authors: Hilal Ahmad Asif Ali Roshan Ali Ali Talha Khalil Ishaq Khan Mah Muneer Khan Mohammed Alorini Source Type: research
Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan
Neoplasia. 2024 Mar 26;51:100989. doi: 10.1016/j.neo.2024.100989. Online ahead of print.ABSTRACTGene mutations are a source of genetic instability which fuels the progression of cancer. Mutations in BRCA1 and BRCA2 are considered as major drivers in the progression of breast cancer and their detection indispensable for devising therapeutic and management approaches. The current study aims to identify novel pathogenic and recurrent mutations in BRCA1 and BRCA2 in Pakhtun population from the Khyber Pakhtunkhwa. To determine the BRCA1 and BRCA2 pathogenic mutation prevalence in Pakhtun population from KP, whole exome sequenci...
Source: Neoplasia - March 27, 2024 Category: Cancer & Oncology Authors: Hilal Ahmad Asif Ali Roshan Ali Ali Talha Khalil Ishaq Khan Mah Muneer Khan Mohammed Alorini Source Type: research
A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas
In conclusion, our research underscores the unique and synergistic potential of combining mechanotherapeutics and sonopermeation. Both approaches are undergoing clinical trials to enhance cancer therapy and have the potential to significantly improve nano-immunotherapy in sarcomas.PMID:38520790 | DOI:10.1016/j.neo.2024.100990 (Source: Neoplasia)
Source: Neoplasia - March 23, 2024 Category: Cancer & Oncology Authors: Fotios Mpekris Myrofora Panagi Antonia Charalambous Chrysovalantis Voutouri Christina Michael Antonia Papoui Triantafyllos Stylianopoulos Source Type: research
A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas
In conclusion, our research underscores the unique and synergistic potential of combining mechanotherapeutics and sonopermeation. Both approaches are undergoing clinical trials to enhance cancer therapy and have the potential to significantly improve nano-immunotherapy in sarcomas.PMID:38520790 | DOI:10.1016/j.neo.2024.100990 (Source: Neoplasia)
Source: Neoplasia - March 23, 2024 Category: Cancer & Oncology Authors: Fotios Mpekris Myrofora Panagi Antonia Charalambous Chrysovalantis Voutouri Christina Michael Antonia Papoui Triantafyllos Stylianopoulos Source Type: research
A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas
In conclusion, our research underscores the unique and synergistic potential of combining mechanotherapeutics and sonopermeation. Both approaches are undergoing clinical trials to enhance cancer therapy and have the potential to significantly improve nano-immunotherapy in sarcomas.PMID:38520790 | DOI:10.1016/j.neo.2024.100990 (Source: Neoplasia)
Source: Neoplasia - March 23, 2024 Category: Cancer & Oncology Authors: Fotios Mpekris Myrofora Panagi Antonia Charalambous Chrysovalantis Voutouri Christina Michael Antonia Papoui Triantafyllos Stylianopoulos Source Type: research
A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas
In conclusion, our research underscores the unique and synergistic potential of combining mechanotherapeutics and sonopermeation. Both approaches are undergoing clinical trials to enhance cancer therapy and have the potential to significantly improve nano-immunotherapy in sarcomas.PMID:38520790 | DOI:10.1016/j.neo.2024.100990 (Source: Neoplasia)
Source: Neoplasia - March 23, 2024 Category: Cancer & Oncology Authors: Fotios Mpekris Myrofora Panagi Antonia Charalambous Chrysovalantis Voutouri Christina Michael Antonia Papoui Triantafyllos Stylianopoulos Source Type: research
Disease burden and projection of total and early-onset colorectal cancer in Gulf cooperation council countries from 1990 to 2019
CONCLUSION: This study sheds light on the alarming rise in CRC and EO-CRC across Gulf countries from 1990 to 2019, emphasizing Saudi Arabia's significant burden. It projects a concerning increase in CRC incidence and mortality by 2030, primarily in Saudi Arabia, and highlights the need for immediate public health interventions.PMID:38513469 | DOI:10.1016/j.neo.2024.100988 (Source: Neoplasia)
Source: Neoplasia - March 21, 2024 Category: Cancer & Oncology Authors: Majed Ramadan Hanin Ghamdi Doaa Aboalola Noha Alorainan Ragad Alsalmi Ahmed Afash Albaraa Hariri Atheer Alboloshi Alaa Samkari Rawiah Alsiary Source Type: research
Disease burden and projection of total and early-onset colorectal cancer in Gulf cooperation council countries from 1990 to 2019
CONCLUSION: This study sheds light on the alarming rise in CRC and EO-CRC across Gulf countries from 1990 to 2019, emphasizing Saudi Arabia's significant burden. It projects a concerning increase in CRC incidence and mortality by 2030, primarily in Saudi Arabia, and highlights the need for immediate public health interventions.PMID:38513469 | DOI:10.1016/j.neo.2024.100988 (Source: Neoplasia)
Source: Neoplasia - March 21, 2024 Category: Cancer & Oncology Authors: Majed Ramadan Hanin Ghamdi Doaa Aboalola Noha Alorainan Ragad Alsalmi Ahmed Afash Albaraa Hariri Atheer Alboloshi Alaa Samkari Rawiah Alsiary Source Type: research
Disease burden and projection of total and early-onset colorectal cancer in Gulf cooperation council countries from 1990 to 2019
CONCLUSION: This study sheds light on the alarming rise in CRC and EO-CRC across Gulf countries from 1990 to 2019, emphasizing Saudi Arabia's significant burden. It projects a concerning increase in CRC incidence and mortality by 2030, primarily in Saudi Arabia, and highlights the need for immediate public health interventions.PMID:38513469 | DOI:10.1016/j.neo.2024.100988 (Source: Neoplasia)
Source: Neoplasia - March 21, 2024 Category: Cancer & Oncology Authors: Majed Ramadan Hanin Ghamdi Doaa Aboalola Noha Alorainan Ragad Alsalmi Ahmed Afash Albaraa Hariri Atheer Alboloshi Alaa Samkari Rawiah Alsiary Source Type: research
Dihydroartemisinin, a potential PTGS1 inhibitor, potentiated cisplatin-induced cell death in non-small cell lung cancer through activating ROS-mediated multiple signaling pathways
Neoplasia. 2024 Mar 19;51:100991. doi: 10.1016/j.neo.2024.100991. Online ahead of print.ABSTRACTDihydroartemisinin (DHA) exerts an anti-tumor effect in multiple cancers, however, the molecular mechanism of DHA and whether DHA facilitates the anti-tumor efficacy of cisplatin in non-small cell lung cancer (NSCLC) are unclear. Here, we found that DHA potentiated the anti-tumor effects of cisplatin in NSCLC cells by stimulating reactive oxygen species (ROS)-mediated endoplasmic reticulum (ER) stress, C-Jun-amino-terminal kinase (JNK) and p38 MAPK signaling pathways both in vitro and in vivo. Of note, we demonstrated for the fi...
Source: Neoplasia - March 20, 2024 Category: Cancer & Oncology Authors: Lianli Ni Xinping Zhu Qi Zhao Yiwei Shen Lu Tao Ji Zhang Han Lin Weishan Zhuge Young-Chang Cho Ri Cui Wangyu Zhu Source Type: research
Corrigendum to "Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment" [Neoplasia, Volume 22, Issue 2 (2020) 111-119]
Neoplasia. 2024 Mar 15;51:100986. doi: 10.1016/j.neo.2024.100986. Online ahead of print.NO ABSTRACTPMID:38492449 | DOI:10.1016/j.neo.2024.100986 (Source: Neoplasia)
Source: Neoplasia - March 16, 2024 Category: Cancer & Oncology Authors: Steven Kregel Chao Wang Xin Han Lanbo Xiao Ester Fernandez-Salas Pushpinder Bawa Brooke L McCollum Kari Wilder-Romans Ingrid J Apel Xuhong Cao Corey Speers Shaomeng Wang Arul M Chinnaiyan Source Type: research
