Effects of PYCR1 on prognosis and immunotherapy plus tyrosine kinase inhibition responsiveness in metastatic renal cell carcinoma patients
CONCLUSIONS: Immunosuppression and IO+TKI resistance were correlated with high PYCR1 expression. T cell exhaustion and dysfunction were also related with the expression of PYCR1. PYCR1 has the potential to be employed as a biomarker to discriminate between IO+TKI and TKI monotherapy as the optimal patient treatment strategy.PMID:37517099 | PMC:PMC10404727 | DOI:10.1016/j.neo.2023.100919 (Source: Neoplasia)
Source: Neoplasia - July 30, 2023 Category: Cancer & Oncology Authors: Xianglai Xu Ying Wang Xinyu Hu Yanjun Zhu Jiajun Wang Jianming Guo Source Type: research
Effects of PYCR1 on prognosis and immunotherapy plus tyrosine kinase inhibition responsiveness in metastatic renal cell carcinoma patients
CONCLUSIONS: Immunosuppression and IO+TKI resistance were correlated with high PYCR1 expression. T cell exhaustion and dysfunction were also related with the expression of PYCR1. PYCR1 has the potential to be employed as a biomarker to discriminate between IO+TKI and TKI monotherapy as the optimal patient treatment strategy.PMID:37517099 | PMC:PMC10404727 | DOI:10.1016/j.neo.2023.100919 (Source: Neoplasia)
Source: Neoplasia - July 30, 2023 Category: Cancer & Oncology Authors: Xianglai Xu Ying Wang Xinyu Hu Yanjun Zhu Jiajun Wang Jianming Guo Source Type: research
Effects of PYCR1 on prognosis and immunotherapy plus tyrosine kinase inhibition responsiveness in metastatic renal cell carcinoma patients
CONCLUSIONS: Immunosuppression and IO+TKI resistance were correlated with high PYCR1 expression. T cell exhaustion and dysfunction were also related with the expression of PYCR1. PYCR1 has the potential to be employed as a biomarker to discriminate between IO+TKI and TKI monotherapy as the optimal patient treatment strategy.PMID:37517099 | DOI:10.1016/j.neo.2023.100919 (Source: Neoplasia)
Source: Neoplasia - July 30, 2023 Category: Cancer & Oncology Authors: Xianglai Xu Ying Wang Xinyu Hu Yanjun Zhu Jiajun Wang Jianming Guo Source Type: research
Effects of PYCR1 on prognosis and immunotherapy plus tyrosine kinase inhibition responsiveness in metastatic renal cell carcinoma patients
CONCLUSIONS: Immunosuppression and IO+TKI resistance were correlated with high PYCR1 expression. T cell exhaustion and dysfunction were also related with the expression of PYCR1. PYCR1 has the potential to be employed as a biomarker to discriminate between IO+TKI and TKI monotherapy as the optimal patient treatment strategy.PMID:37517099 | DOI:10.1016/j.neo.2023.100919 (Source: Neoplasia)
Source: Neoplasia - July 30, 2023 Category: Cancer & Oncology Authors: Xianglai Xu Ying Wang Xinyu Hu Yanjun Zhu Jiajun Wang Jianming Guo Source Type: research
Effects of PYCR1 on prognosis and immunotherapy plus tyrosine kinase inhibition responsiveness in metastatic renal cell carcinoma patients
CONCLUSIONS: Immunosuppression and IO+TKI resistance were correlated with high PYCR1 expression. T cell exhaustion and dysfunction were also related with the expression of PYCR1. PYCR1 has the potential to be employed as a biomarker to discriminate between IO+TKI and TKI monotherapy as the optimal patient treatment strategy.PMID:37517099 | DOI:10.1016/j.neo.2023.100919 (Source: Neoplasia)
Source: Neoplasia - July 30, 2023 Category: Cancer & Oncology Authors: Xianglai Xu Ying Wang Xinyu Hu Yanjun Zhu Jiajun Wang Jianming Guo Source Type: research
Effects of PYCR1 on prognosis and immunotherapy plus tyrosine kinase inhibition responsiveness in metastatic renal cell carcinoma patients
CONCLUSIONS: Immunosuppression and IO+TKI resistance were correlated with high PYCR1 expression. T cell exhaustion and dysfunction were also related with the expression of PYCR1. PYCR1 has the potential to be employed as a biomarker to discriminate between IO+TKI and TKI monotherapy as the optimal patient treatment strategy.PMID:37517099 | DOI:10.1016/j.neo.2023.100919 (Source: Neoplasia)
Source: Neoplasia - July 30, 2023 Category: Cancer & Oncology Authors: Xianglai Xu Ying Wang Xinyu Hu Yanjun Zhu Jiajun Wang Jianming Guo Source Type: research
Effects of PYCR1 on prognosis and immunotherapy plus tyrosine kinase inhibition responsiveness in metastatic renal cell carcinoma patients
CONCLUSIONS: Immunosuppression and IO+TKI resistance were correlated with high PYCR1 expression. T cell exhaustion and dysfunction were also related with the expression of PYCR1. PYCR1 has the potential to be employed as a biomarker to discriminate between IO+TKI and TKI monotherapy as the optimal patient treatment strategy.PMID:37517099 | DOI:10.1016/j.neo.2023.100919 (Source: Neoplasia)
Source: Neoplasia - July 30, 2023 Category: Cancer & Oncology Authors: Xianglai Xu Ying Wang Xinyu Hu Yanjun Zhu Jiajun Wang Jianming Guo Source Type: research
Effects of PYCR1 on prognosis and immunotherapy plus tyrosine kinase inhibition responsiveness in metastatic renal cell carcinoma patients
CONCLUSIONS: Immunosuppression and IO+TKI resistance were correlated with high PYCR1 expression. T cell exhaustion and dysfunction were also related with the expression of PYCR1. PYCR1 has the potential to be employed as a biomarker to discriminate between IO+TKI and TKI monotherapy as the optimal patient treatment strategy.PMID:37517099 | DOI:10.1016/j.neo.2023.100919 (Source: Neoplasia)
Source: Neoplasia - July 30, 2023 Category: Cancer & Oncology Authors: Xianglai Xu Ying Wang Xinyu Hu Yanjun Zhu Jiajun Wang Jianming Guo Source Type: research
Effects of PYCR1 on prognosis and immunotherapy plus tyrosine kinase inhibition responsiveness in metastatic renal cell carcinoma patients
CONCLUSIONS: Immunosuppression and IO+TKI resistance were correlated with high PYCR1 expression. T cell exhaustion and dysfunction were also related with the expression of PYCR1. PYCR1 has the potential to be employed as a biomarker to discriminate between IO+TKI and TKI monotherapy as the optimal patient treatment strategy.PMID:37517099 | DOI:10.1016/j.neo.2023.100919 (Source: Neoplasia)
Source: Neoplasia - July 30, 2023 Category: Cancer & Oncology Authors: Xianglai Xu Ying Wang Xinyu Hu Yanjun Zhu Jiajun Wang Jianming Guo Source Type: research
PI3K-CCL2-CCR2-MDSCs axis: A potential pathway for tumor Clostridia-promoted CD 8 < sup > + < /sup > T lymphocyte infiltration in bile tract cancers
CONCLUSIONS: The tumor microbiome is related to CD8+ T lymphocyte infiltration in patients with resected BTCs. The relationship between tumor Clostridia and high infiltration of CD8+ T lymphocytes might reflect decreased recruitment of myeloid-derived suppressor cells via the PI3K-CCL2-CCR2 axis.PMID:37515847 | DOI:10.1016/j.neo.2023.100920 (Source: Neoplasia)
Source: Neoplasia - July 29, 2023 Category: Cancer & Oncology Authors: Wen-Jie Ma Zheng-Hua Li Zhen-Ru Wu Fei Liu Jun-Ke Wang Yu-Jun Shi Yan-Wen Jin Fu-Yu Li Source Type: research
The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors
Neoplasia. 2023 Jul 25;43:100918. doi: 10.1016/j.neo.2023.100918. Online ahead of print.ABSTRACTCertain Enterobacteriaceae strains contain a 54-kb biosynthetic gene cluster referred to as "pks" encoding the biosynthesis of a secondary metabolite, colibactin. Colibactin-producing E. coli promote colorectal cancer (CRC) in preclinical models, and in vitro induce a specific mutational signature that is also detected in human CRC genomes. Yet, how colibactin exposure affects the mutational landscape of CRC in vivo remains unclear. Here we show that colibactin-producing E. coli-driven colonic tumors in mice have a significantly...
Source: Neoplasia - July 27, 2023 Category: Cancer & Oncology Authors: Michael W Dougherty Rafael Vald és-Mas Kevin M Wernke Raad Z Gharaibeh Ye Yang Jason O Brant Alberto Riva Marcus Muehlbauer Eran Elinav Jens Puschhof Seth B Herzon Christian Jobin Source Type: research
The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors
Neoplasia. 2023 Jul 25;43:100918. doi: 10.1016/j.neo.2023.100918. Online ahead of print.ABSTRACTCertain Enterobacteriaceae strains contain a 54-kb biosynthetic gene cluster referred to as "pks" encoding the biosynthesis of a secondary metabolite, colibactin. Colibactin-producing E. coli promote colorectal cancer (CRC) in preclinical models, and in vitro induce a specific mutational signature that is also detected in human CRC genomes. Yet, how colibactin exposure affects the mutational landscape of CRC in vivo remains unclear. Here we show that colibactin-producing E. coli-driven colonic tumors in mice have a significantly...
Source: Neoplasia - July 27, 2023 Category: Cancer & Oncology Authors: Michael W Dougherty Rafael Vald és-Mas Kevin M Wernke Raad Z Gharaibeh Ye Yang Jason O Brant Alberto Riva Marcus Muehlbauer Eran Elinav Jens Puschhof Seth B Herzon Christian Jobin Source Type: research
The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors
Neoplasia. 2023 Jul 25;43:100918. doi: 10.1016/j.neo.2023.100918. Online ahead of print.ABSTRACTCertain Enterobacteriaceae strains contain a 54-kb biosynthetic gene cluster referred to as "pks" encoding the biosynthesis of a secondary metabolite, colibactin. Colibactin-producing E. coli promote colorectal cancer (CRC) in preclinical models, and in vitro induce a specific mutational signature that is also detected in human CRC genomes. Yet, how colibactin exposure affects the mutational landscape of CRC in vivo remains unclear. Here we show that colibactin-producing E. coli-driven colonic tumors in mice have a significantly...
Source: Neoplasia - July 27, 2023 Category: Cancer & Oncology Authors: Michael W Dougherty Rafael Vald és-Mas Kevin M Wernke Raad Z Gharaibeh Ye Yang Jason O Brant Alberto Riva Marcus Muehlbauer Eran Elinav Jens Puschhof Seth B Herzon Christian Jobin Source Type: research
Challenges in synergizing radiotherapy with immunotherapy to unlock the abscopal effect in metastatic NSCLC: A systematic review
DISCUSSION: Early work combining radiotherapy with immunotherapy show promise in unlocking the abscopal effect. Preliminary evidence suggests that radiotherapy regimens with <5 fractions and smaller fields may be superior to regimens with 15 fractions and larger fields. There does not appear to be enough evidence to draw conclusions about the optimal timing of radiotherapy in relation to immunotherapy or the optimal anatomical location of radiation to induce the abscopal effect. Several studies suggest selecting patients with a higher absolute lymphocyte count (ALC) and lower neutrophil-to-lymphocyte ratio (NLR) may hel...
Source: Neoplasia - June 22, 2023 Category: Cancer & Oncology Authors: Jason Liu Howard West Heather M McGee Terence M Williams Percy Lee Arya Amini Source Type: research
P110 α inhibitor alpelisib exhibits a synergistic effect with pyrotinib and reverses pyrotinib resistant in HER2+ breast cancer
In this study, we hypothesised that combining pyrotinib with alpelisib would yield superior results compared to single-drug treatment. Our data demonstrated that the combination of alpelisib and pyrotinib exhibited a synergistic effect in HER2+ breast cancer both in vitro and in vivo. This combination led to decreased cell proliferation and migration, G0-G1 cell cycle arrest, and increased apoptosis rates. Additionally, the deactivation of ErbB receptors and sustained activation of PI3K/AKT pathway by upstream compensatory pathways induced acquired pyrotinib resistant cells resistant to pyrotinib treatment, thus alpelisib ...
Source: Neoplasia - June 22, 2023 Category: Cancer & Oncology Authors: Hao Chen Yuhao Si Jialiang Wen Chunlei Hu Erjie Xia Yinghao Wang Ouchen Wang Source Type: research
