Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma
Neoplasia. 2023 Nov 30;47:100951. doi: 10.1016/j.neo.2023.100951. Online ahead of print.ABSTRACTThyroid hormone receptor-interacting protein 13 (TRIP13) is involved in cancer progression, but its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. Thus, we assessed the expression, functional role, and mechanism of action of TRIP13 in PDAC. We further examined the efficacy of TRIP13 inhibitor, DCZ0415, alone or in combination with gemcitabine on malignant phenotypes, tumor progression, and immune response. We found that TRIP13 was overexpressed in human PDACs relative to corresponding normal pancreatic tissues. TRIP...
Source: Neoplasia - December 1, 2023 Category: Cancer & Oncology Authors: Farrukh Afaq Sumit Agarwal Prachi Bajpai Sameer Al Diffalha Hyung-Gyoon Kim Shajan Peter Moh'd Khushman Subhash C Chauhan Priyabrata Mukherjee Sooryanarayana Varambally Upender Manne Source Type: research
Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma
Neoplasia. 2023 Nov 30;47:100951. doi: 10.1016/j.neo.2023.100951. Online ahead of print.ABSTRACTThyroid hormone receptor-interacting protein 13 (TRIP13) is involved in cancer progression, but its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. Thus, we assessed the expression, functional role, and mechanism of action of TRIP13 in PDAC. We further examined the efficacy of TRIP13 inhibitor, DCZ0415, alone or in combination with gemcitabine on malignant phenotypes, tumor progression, and immune response. We found that TRIP13 was overexpressed in human PDACs relative to corresponding normal pancreatic tissues. TRIP...
Source: Neoplasia - December 1, 2023 Category: Cancer & Oncology Authors: Farrukh Afaq Sumit Agarwal Prachi Bajpai Sameer Al Diffalha Hyung-Gyoon Kim Shajan Peter Moh'd Khushman Subhash C Chauhan Priyabrata Mukherjee Sooryanarayana Varambally Upender Manne Source Type: research
Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma
Neoplasia. 2023 Nov 30;47:100951. doi: 10.1016/j.neo.2023.100951. Online ahead of print.ABSTRACTThyroid hormone receptor-interacting protein 13 (TRIP13) is involved in cancer progression, but its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. Thus, we assessed the expression, functional role, and mechanism of action of TRIP13 in PDAC. We further examined the efficacy of TRIP13 inhibitor, DCZ0415, alone or in combination with gemcitabine on malignant phenotypes, tumor progression, and immune response. We found that TRIP13 was overexpressed in human PDACs relative to corresponding normal pancreatic tissues. TRIP...
Source: Neoplasia - December 1, 2023 Category: Cancer & Oncology Authors: Farrukh Afaq Sumit Agarwal Prachi Bajpai Sameer Al Diffalha Hyung-Gyoon Kim Shajan Peter Moh'd Khushman Subhash C Chauhan Priyabrata Mukherjee Sooryanarayana Varambally Upender Manne Source Type: research
Evidence based on Mendelian randomization: Causal relationship between mitochondrial biological function and lung cancer and its subtypes
CONCLUSION: This study established a causal relationship between mitochondrial biological function and lung cancer, including its subtypes.PMID:37976568 | PMC:PMC10685044 | DOI:10.1016/j.neo.2023.100950 (Source: Neoplasia)
Source: Neoplasia - November 17, 2023 Category: Cancer & Oncology Authors: Kangle Zhu Jingwei Shi Rusong Yang Chu Zhou Zhengcheng Liu Source Type: research
Hepatocellular loss of mTOR aggravates tumor burden in nonalcoholic steatohepatitis-related HCC
Neoplasia. 2023 Dec;46:100945. doi: 10.1016/j.neo.2023.100945. Epub 2023 Nov 15.ABSTRACTObesity and associated nonalcoholic steatohepatitis (NASH) are on the rise globally. NASH became an important driver of hepatocellular carcinoma (HCC) in recent years. Activation of the central metabolic regulator mTOR (mechanistic target of rapamycin) is frequently observed in HCCs. However, mTOR inhibition failed to improve the outcome of HCC therapies, demonstrating the need for a better understanding of the molecular and functional consequences of mTOR blockade. We established a murine NASH-driven HCC model based on long-term wester...
Source: Neoplasia - November 17, 2023 Category: Cancer & Oncology Authors: Andreas Kroh Jeanette Walter Athanassios Fragoulis Diana M öckel Twan Lammers Fabian Kiessling Julia Andruszkow Christian Preisinger Maren Egbert Long Jiao Roman M Eickhoff Daniel Heise Nikolaus Berndt Thorsten Cramer Ulf Peter Neumann Antje Egners Tom F Source Type: research
Evidence based on Mendelian randomization: Causal relationship between mitochondrial biological function and lung cancer and its subtypes
CONCLUSION: This study established a causal relationship between mitochondrial biological function and lung cancer, including its subtypes.PMID:37976568 | PMC:PMC10685044 | DOI:10.1016/j.neo.2023.100950 (Source: Neoplasia)
Source: Neoplasia - November 17, 2023 Category: Cancer & Oncology Authors: Kangle Zhu Jingwei Shi Rusong Yang Chu Zhou Zhengcheng Liu Source Type: research
Hepatocellular loss of mTOR aggravates tumor burden in nonalcoholic steatohepatitis-related HCC
Neoplasia. 2023 Dec;46:100945. doi: 10.1016/j.neo.2023.100945. Epub 2023 Nov 15.ABSTRACTObesity and associated nonalcoholic steatohepatitis (NASH) are on the rise globally. NASH became an important driver of hepatocellular carcinoma (HCC) in recent years. Activation of the central metabolic regulator mTOR (mechanistic target of rapamycin) is frequently observed in HCCs. However, mTOR inhibition failed to improve the outcome of HCC therapies, demonstrating the need for a better understanding of the molecular and functional consequences of mTOR blockade. We established a murine NASH-driven HCC model based on long-term wester...
Source: Neoplasia - November 17, 2023 Category: Cancer & Oncology Authors: Andreas Kroh Jeanette Walter Athanassios Fragoulis Diana M öckel Twan Lammers Fabian Kiessling Julia Andruszkow Christian Preisinger Maren Egbert Long Jiao Roman M Eickhoff Daniel Heise Nikolaus Berndt Thorsten Cramer Ulf Peter Neumann Antje Egners Tom F Source Type: research
Evidence based on Mendelian randomization: Causal relationship between mitochondrial biological function and lung cancer and its subtypes
CONCLUSION: This study established a causal relationship between mitochondrial biological function and lung cancer, including its subtypes.PMID:37976568 | DOI:10.1016/j.neo.2023.100950 (Source: Neoplasia)
Source: Neoplasia - November 17, 2023 Category: Cancer & Oncology Authors: Kangle Zhu Jingwei Shi Rusong Yang Chu Zhou Zhengcheng Liu Source Type: research
Hepatocellular loss of mTOR aggravates tumor burden in nonalcoholic steatohepatitis-related HCC
Neoplasia. 2023 Nov 14;46:100945. doi: 10.1016/j.neo.2023.100945. Online ahead of print.ABSTRACTObesity and associated nonalcoholic steatohepatitis (NASH) are on the rise globally. NASH became an important driver of hepatocellular carcinoma (HCC) in recent years. Activation of the central metabolic regulator mTOR (mechanistic target of rapamycin) is frequently observed in HCCs. However, mTOR inhibition failed to improve the outcome of HCC therapies, demonstrating the need for a better understanding of the molecular and functional consequences of mTOR blockade. We established a murine NASH-driven HCC model based on long-ter...
Source: Neoplasia - November 17, 2023 Category: Cancer & Oncology Authors: Andreas Kroh Jeanette Walter Athanassios Fragoulis Diana M öckel Twan Lammers Fabian Kiessling Julia Andruszkow Christian Preisinger Maren Egbert Long Jiao Roman M Eickhoff Daniel Heise Nikolaus Berndt Thorsten Cramer Ulf Peter Neumann Antje Egners Tom F Source Type: research
Evidence based on Mendelian randomization: Causal relationship between mitochondrial biological function and lung cancer and its subtypes
CONCLUSION: This study established a causal relationship between mitochondrial biological function and lung cancer, including its subtypes.PMID:37976568 | DOI:10.1016/j.neo.2023.100950 (Source: Neoplasia)
Source: Neoplasia - November 17, 2023 Category: Cancer & Oncology Authors: Kangle Zhu Jingwei Shi Rusong Yang Chu Zhou Zhengcheng Liu Source Type: research
Hepatocellular loss of mTOR aggravates tumor burden in nonalcoholic steatohepatitis-related HCC
Neoplasia. 2023 Nov 14;46:100945. doi: 10.1016/j.neo.2023.100945. Online ahead of print.ABSTRACTObesity and associated nonalcoholic steatohepatitis (NASH) are on the rise globally. NASH became an important driver of hepatocellular carcinoma (HCC) in recent years. Activation of the central metabolic regulator mTOR (mechanistic target of rapamycin) is frequently observed in HCCs. However, mTOR inhibition failed to improve the outcome of HCC therapies, demonstrating the need for a better understanding of the molecular and functional consequences of mTOR blockade. We established a murine NASH-driven HCC model based on long-ter...
Source: Neoplasia - November 17, 2023 Category: Cancer & Oncology Authors: Andreas Kroh Jeanette Walter Athanassios Fragoulis Diana M öckel Twan Lammers Fabian Kiessling Julia Andruszkow Christian Preisinger Maren Egbert Long Jiao Roman M Eickhoff Daniel Heise Nikolaus Berndt Thorsten Cramer Ulf Peter Neumann Antje Egners Tom F Source Type: research
Evidence based on Mendelian randomization: Causal relationship between mitochondrial biological function and lung cancer and its subtypes
CONCLUSION: This study established a causal relationship between mitochondrial biological function and lung cancer, including its subtypes.PMID:37976568 | DOI:10.1016/j.neo.2023.100950 (Source: Neoplasia)
Source: Neoplasia - November 17, 2023 Category: Cancer & Oncology Authors: Kangle Zhu Jingwei Shi Rusong Yang Chu Zhou Zhengcheng Liu Source Type: research
Hepatocellular loss of mTOR aggravates tumor burden in nonalcoholic steatohepatitis-related HCC
Neoplasia. 2023 Nov 14;46:100945. doi: 10.1016/j.neo.2023.100945. Online ahead of print.ABSTRACTObesity and associated nonalcoholic steatohepatitis (NASH) are on the rise globally. NASH became an important driver of hepatocellular carcinoma (HCC) in recent years. Activation of the central metabolic regulator mTOR (mechanistic target of rapamycin) is frequently observed in HCCs. However, mTOR inhibition failed to improve the outcome of HCC therapies, demonstrating the need for a better understanding of the molecular and functional consequences of mTOR blockade. We established a murine NASH-driven HCC model based on long-ter...
Source: Neoplasia - November 17, 2023 Category: Cancer & Oncology Authors: Andreas Kroh Jeanette Walter Athanassios Fragoulis Diana M öckel Twan Lammers Fabian Kiessling Julia Andruszkow Christian Preisinger Maren Egbert Long Jiao Roman M Eickhoff Daniel Heise Nikolaus Berndt Thorsten Cramer Ulf Peter Neumann Antje Egners Tom F Source Type: research
Evidence based on Mendelian randomization: Causal relationship between mitochondrial biological function and lung cancer and its subtypes
CONCLUSION: This study established a causal relationship between mitochondrial biological function and lung cancer, including its subtypes.PMID:37976568 | DOI:10.1016/j.neo.2023.100950 (Source: Neoplasia)
Source: Neoplasia - November 17, 2023 Category: Cancer & Oncology Authors: Kangle Zhu Jingwei Shi Rusong Yang Chu Zhou Zhengcheng Liu Source Type: research
Hepatocellular loss of mTOR aggravates tumor burden in nonalcoholic steatohepatitis-related HCC
Neoplasia. 2023 Nov 14;46:100945. doi: 10.1016/j.neo.2023.100945. Online ahead of print.ABSTRACTObesity and associated nonalcoholic steatohepatitis (NASH) are on the rise globally. NASH became an important driver of hepatocellular carcinoma (HCC) in recent years. Activation of the central metabolic regulator mTOR (mechanistic target of rapamycin) is frequently observed in HCCs. However, mTOR inhibition failed to improve the outcome of HCC therapies, demonstrating the need for a better understanding of the molecular and functional consequences of mTOR blockade. We established a murine NASH-driven HCC model based on long-ter...
Source: Neoplasia - November 17, 2023 Category: Cancer & Oncology Authors: Andreas Kroh Jeanette Walter Athanassios Fragoulis Diana M öckel Twan Lammers Fabian Kiessling Julia Andruszkow Christian Preisinger Maren Egbert Long Jiao Roman M Eickhoff Daniel Heise Nikolaus Berndt Thorsten Cramer Ulf Peter Neumann Antje Egners Tom F Source Type: research
