Increased expression of IDO1 is associated with improved survival and increased number of TILs in patients with high-grade serous ovarian cancer
CONCLUSIONS: Our study provides evidence that IDO1 expression serves as a positive prognostic marker in HGSOC and is associated with an increased number of CD3+, CD4+ and CD8+ TILs. Understanding the intricate relationship between IDO1, TILs, and the tumor microenvironment may hold the key to improving outcomes in HGSOC.PMID:37703626 | DOI:10.1016/j.neo.2023.100934 (Source: Neoplasia)
Source: Neoplasia - September 13, 2023 Category: Cancer & Oncology Authors: Inga Hoffmann Mihnea P Dragomir Nanna Monj é Carlotta Keunecke Catarina Alisa Kunze Simon Schallenberg Sofya Marchenko Wolfgang D Schmitt Hagen Kulbe Jalid Sehouli Ioana Elena Braicu Paul Jank Carsten Denkert Silvia Darb-Esfahani David Horst Bruno V Sinn Source Type: research
Increased expression of IDO1 is associated with improved survival and increased number of TILs in patients with high-grade serous ovarian cancer
CONCLUSIONS: Our study provides evidence that IDO1 expression serves as a positive prognostic marker in HGSOC and is associated with an increased number of CD3+, CD4+ and CD8+ TILs. Understanding the intricate relationship between IDO1, TILs, and the tumor microenvironment may hold the key to improving outcomes in HGSOC.PMID:37703626 | DOI:10.1016/j.neo.2023.100934 (Source: Neoplasia)
Source: Neoplasia - September 13, 2023 Category: Cancer & Oncology Authors: Inga Hoffmann Mihnea P Dragomir Nanna Monj é Carlotta Keunecke Catarina Alisa Kunze Simon Schallenberg Sofya Marchenko Wolfgang D Schmitt Hagen Kulbe Jalid Sehouli Ioana Elena Braicu Paul Jank Carsten Denkert Silvia Darb-Esfahani David Horst Bruno V Sinn Source Type: research
Mutational signatures and their association with survival and gene expression in urological carcinomas
Neoplasia. 2023 Sep 5;44:100933. doi: 10.1016/j.neo.2023.100933. Online ahead of print.ABSTRACTDifferent sources of mutagenesis cause consistently identifiable patterns of mutations and mutational signatures that mirror the various carcinogenetic processes. We used publicly available data from the Cancer Genome Atlas to evaluate the associations between the activity of the mutational signatures and various survival endpoints in six types of urological cancers after adjusting for established prognostic factors. The predictive power of the signatures was evaluated with dynamic area under curve models. In addition, links betw...
Source: Neoplasia - September 7, 2023 Category: Cancer & Oncology Authors: Peeter Karihtala Outi Kilpivaara Katja Porvari Source Type: research
Mutational signatures and their association with survival and gene expression in urological carcinomas
Neoplasia. 2023 Sep 5;44:100933. doi: 10.1016/j.neo.2023.100933. Online ahead of print.ABSTRACTDifferent sources of mutagenesis cause consistently identifiable patterns of mutations and mutational signatures that mirror the various carcinogenetic processes. We used publicly available data from the Cancer Genome Atlas to evaluate the associations between the activity of the mutational signatures and various survival endpoints in six types of urological cancers after adjusting for established prognostic factors. The predictive power of the signatures was evaluated with dynamic area under curve models. In addition, links betw...
Source: Neoplasia - September 7, 2023 Category: Cancer & Oncology Authors: Peeter Karihtala Outi Kilpivaara Katja Porvari Source Type: research
Mutational signatures and their association with survival and gene expression in urological carcinomas
Neoplasia. 2023 Sep 5;44:100933. doi: 10.1016/j.neo.2023.100933. Online ahead of print.ABSTRACTDifferent sources of mutagenesis cause consistently identifiable patterns of mutations and mutational signatures that mirror the various carcinogenetic processes. We used publicly available data from the Cancer Genome Atlas to evaluate the associations between the activity of the mutational signatures and various survival endpoints in six types of urological cancers after adjusting for established prognostic factors. The predictive power of the signatures was evaluated with dynamic area under curve models. In addition, links betw...
Source: Neoplasia - September 7, 2023 Category: Cancer & Oncology Authors: Peeter Karihtala Outi Kilpivaara Katja Porvari Source Type: research
Mutational signatures and their association with survival and gene expression in urological carcinomas
Neoplasia. 2023 Sep 5;44:100933. doi: 10.1016/j.neo.2023.100933. Online ahead of print.ABSTRACTDifferent sources of mutagenesis cause consistently identifiable patterns of mutations and mutational signatures that mirror the various carcinogenetic processes. We used publicly available data from the Cancer Genome Atlas to evaluate the associations between the activity of the mutational signatures and various survival endpoints in six types of urological cancers after adjusting for established prognostic factors. The predictive power of the signatures was evaluated with dynamic area under curve models. In addition, links betw...
Source: Neoplasia - September 7, 2023 Category: Cancer & Oncology Authors: Peeter Karihtala Outi Kilpivaara Katja Porvari Source Type: research
Mutational signatures and their association with survival and gene expression in urological carcinomas
Neoplasia. 2023 Sep 5;44:100933. doi: 10.1016/j.neo.2023.100933. Online ahead of print.ABSTRACTDifferent sources of mutagenesis cause consistently identifiable patterns of mutations and mutational signatures that mirror the various carcinogenetic processes. We used publicly available data from the Cancer Genome Atlas to evaluate the associations between the activity of the mutational signatures and various survival endpoints in six types of urological cancers after adjusting for established prognostic factors. The predictive power of the signatures was evaluated with dynamic area under curve models. In addition, links betw...
Source: Neoplasia - September 7, 2023 Category: Cancer & Oncology Authors: Peeter Karihtala Outi Kilpivaara Katja Porvari Source Type: research
Histone H3 K27M-mediated regulation of cancer cell stemness and differentiation in diffuse midline glioma
Neoplasia. 2023 Aug 28;44:100931. doi: 10.1016/j.neo.2023.100931. Online ahead of print.ABSTRACTTherapeutic resistance remains a major obstacle to preventing progression of H3K27M-altered Diffuse Midline Glioma (DMG). Resistance is driven in part by ALDH-positive cancer stem cells (CSC), with high ALDH1A3 expression observed in H3K27M-mutant DMG biopsies. We hypothesized that ALDH-mediated stemness and resistance may in part be driven by the oncohistone itself. Upon deletion of H3K27M, ALDH1A3 expression decreased dramatically and was accompanied by a gain in astrocytic marker expression and a loss of neurosphere forming p...
Source: Neoplasia - August 30, 2023 Category: Cancer & Oncology Authors: Monika Sharma Ivana Barravecchia Brian Magnuson Sarah F Ferris April Apfelbaum Nneka E Mbah Jeanette Cruz Varunkumar Krishnamoorthy Robert Teis McKenzie Kauss Carl Koschmann Costas A Lyssiotis Mats Ljungman Stefanie Galban Source Type: research
Histone H3 K27M-mediated regulation of cancer cell stemness and differentiation in diffuse midline glioma
Neoplasia. 2023 Aug 28;44:100931. doi: 10.1016/j.neo.2023.100931. Online ahead of print.ABSTRACTTherapeutic resistance remains a major obstacle to preventing progression of H3K27M-altered Diffuse Midline Glioma (DMG). Resistance is driven in part by ALDH-positive cancer stem cells (CSC), with high ALDH1A3 expression observed in H3K27M-mutant DMG biopsies. We hypothesized that ALDH-mediated stemness and resistance may in part be driven by the oncohistone itself. Upon deletion of H3K27M, ALDH1A3 expression decreased dramatically and was accompanied by a gain in astrocytic marker expression and a loss of neurosphere forming p...
Source: Neoplasia - August 30, 2023 Category: Cancer & Oncology Authors: Monika Sharma Ivana Barravecchia Brian Magnuson Sarah F Ferris April Apfelbaum Nneka E Mbah Jeanette Cruz Varunkumar Krishnamoorthy Robert Teis McKenzie Kauss Carl Koschmann Costas A Lyssiotis Mats Ljungman Stefanie Galban Source Type: research
Histone H3 K27M-mediated regulation of cancer cell stemness and differentiation in diffuse midline glioma
Neoplasia. 2023 Aug 28;44:100931. doi: 10.1016/j.neo.2023.100931. Online ahead of print.ABSTRACTTherapeutic resistance remains a major obstacle to preventing progression of H3K27M-altered Diffuse Midline Glioma (DMG). Resistance is driven in part by ALDH-positive cancer stem cells (CSC), with high ALDH1A3 expression observed in H3K27M-mutant DMG biopsies. We hypothesized that ALDH-mediated stemness and resistance may in part be driven by the oncohistone itself. Upon deletion of H3K27M, ALDH1A3 expression decreased dramatically and was accompanied by a gain in astrocytic marker expression and a loss of neurosphere forming p...
Source: Neoplasia - August 30, 2023 Category: Cancer & Oncology Authors: Monika Sharma Ivana Barravecchia Brian Magnuson Sarah F Ferris April Apfelbaum Nneka E Mbah Jeanette Cruz Varunkumar Krishnamoorthy Robert Teis McKenzie Kauss Carl Koschmann Costas A Lyssiotis Mats Ljungman Stefanie Galban Source Type: research
Histone H3 K27M-mediated regulation of cancer cell stemness and differentiation in diffuse midline glioma
Neoplasia. 2023 Aug 28;44:100931. doi: 10.1016/j.neo.2023.100931. Online ahead of print.ABSTRACTTherapeutic resistance remains a major obstacle to preventing progression of H3K27M-altered Diffuse Midline Glioma (DMG). Resistance is driven in part by ALDH-positive cancer stem cells (CSC), with high ALDH1A3 expression observed in H3K27M-mutant DMG biopsies. We hypothesized that ALDH-mediated stemness and resistance may in part be driven by the oncohistone itself. Upon deletion of H3K27M, ALDH1A3 expression decreased dramatically and was accompanied by a gain in astrocytic marker expression and a loss of neurosphere forming p...
Source: Neoplasia - August 30, 2023 Category: Cancer & Oncology Authors: Monika Sharma Ivana Barravecchia Brian Magnuson Sarah F Ferris April Apfelbaum Nneka E Mbah Jeanette Cruz Varunkumar Krishnamoorthy Robert Teis McKenzie Kauss Carl Koschmann Costas A Lyssiotis Mats Ljungman Stefanie Galban Source Type: research
Histone H3 K27M-mediated regulation of cancer cell stemness and differentiation in diffuse midline glioma
Neoplasia. 2023 Aug 28;44:100931. doi: 10.1016/j.neo.2023.100931. Online ahead of print.ABSTRACTTherapeutic resistance remains a major obstacle to preventing progression of H3K27M-altered Diffuse Midline Glioma (DMG). Resistance is driven in part by ALDH-positive cancer stem cells (CSC), with high ALDH1A3 expression observed in H3K27M-mutant DMG biopsies. We hypothesized that ALDH-mediated stemness and resistance may in part be driven by the oncohistone itself. Upon deletion of H3K27M, ALDH1A3 expression decreased dramatically and was accompanied by a gain in astrocytic marker expression and a loss of neurosphere forming p...
Source: Neoplasia - August 30, 2023 Category: Cancer & Oncology Authors: Monika Sharma Ivana Barravecchia Brian Magnuson Sarah F Ferris April Apfelbaum Nneka E Mbah Jeanette Cruz Varunkumar Krishnamoorthy Robert Teis McKenzie Kauss Carl Koschmann Costas A Lyssiotis Mats Ljungman Stefanie Galban Source Type: research
Histone H3 K27M-mediated regulation of cancer cell stemness and differentiation in diffuse midline glioma
Neoplasia. 2023 Aug 28;44:100931. doi: 10.1016/j.neo.2023.100931. Online ahead of print.ABSTRACTTherapeutic resistance remains a major obstacle to preventing progression of H3K27M-altered Diffuse Midline Glioma (DMG). Resistance is driven in part by ALDH-positive cancer stem cells (CSC), with high ALDH1A3 expression observed in H3K27M-mutant DMG biopsies. We hypothesized that ALDH-mediated stemness and resistance may in part be driven by the oncohistone itself. Upon deletion of H3K27M, ALDH1A3 expression decreased dramatically and was accompanied by a gain in astrocytic marker expression and a loss of neurosphere forming p...
Source: Neoplasia - August 30, 2023 Category: Cancer & Oncology Authors: Monika Sharma Ivana Barravecchia Brian Magnuson Sarah F Ferris April Apfelbaum Nneka E Mbah Jeanette Cruz Varunkumar Krishnamoorthy Robert Teis McKenzie Kauss Carl Koschmann Costas A Lyssiotis Mats Ljungman Stefanie Galban Source Type: research
Histone H3 K27M-mediated regulation of cancer cell stemness and differentiation in diffuse midline glioma
Neoplasia. 2023 Aug 28;44:100931. doi: 10.1016/j.neo.2023.100931. Online ahead of print.ABSTRACTTherapeutic resistance remains a major obstacle to preventing progression of H3K27M-altered Diffuse Midline Glioma (DMG). Resistance is driven in part by ALDH-positive cancer stem cells (CSC), with high ALDH1A3 expression observed in H3K27M-mutant DMG biopsies. We hypothesized that ALDH-mediated stemness and resistance may in part be driven by the oncohistone itself. Upon deletion of H3K27M, ALDH1A3 expression decreased dramatically and was accompanied by a gain in astrocytic marker expression and a loss of neurosphere forming p...
Source: Neoplasia - August 30, 2023 Category: Cancer & Oncology Authors: Monika Sharma Ivana Barravecchia Brian Magnuson Sarah F Ferris April Apfelbaum Nneka E Mbah Jeanette Cruz Varunkumar Krishnamoorthy Robert Teis McKenzie Kauss Carl Koschmann Costas A Lyssiotis Mats Ljungman Stefanie Galban Source Type: research
Downregulation of MGMT expression by targeted editing of DNA methylation enhances temozolomide sensitivity in glioblastoma
In conclusion, we demonstrate targeted RNA-guided methylation of the MGMT promoter as a promising tool to overcome chemoresistance and improve the cytotoxic effect of TMZ in glioblastoma.PMID:37634280 | DOI:10.1016/j.neo.2023.100929 (Source: Neoplasia)
Source: Neoplasia - August 27, 2023 Category: Cancer & Oncology Authors: Xinyu Han Mohammed O E Abdallah Peter Breuer Fabian Stahl Yousuf Bakhit Anna-Laura Potthoff Barbara E F Pregler Matthias Schneider Andreas Waha Ullrich W üllner Bernd O Evert Source Type: research
